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Gene: Akr1b7 (aldo-keto reductase family 1, member B7) Rattus norvegicus

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Symbol:

Akr1b7

Name:

aldo-keto reductase family 1, member B7

RGD ID:

620257

Description:

Predicted to enable aldose reductase (NADPH) activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Akr1b14; aldehyde reductase; aldo-keto reductase family 1 member B7; aldose reductase-like protein AKR1B14; aldose reductase-related protein 1; androgen regulated vas deferens protein; Avdp; LOC103692098; MVDP; uncharacterized LOC103692098

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Akr1b7 (aldo-keto reductase family 1, member B7)	RGD	RGD
Other homologs ²
Homo sapiens (human):	AKR1B10 (aldo-keto reductase family 1 member B10)	HGNC	Ensembl, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	AKR1B15 (aldo-keto reductase family 1 member B15)	HGNC	Panther, PhylomeDB, Treefam
Homo sapiens (human):	AKR1B1 (aldo-keto reductase family 1 member B)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Akr1b7 (aldo-keto reductase family 1, member B7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1B10 (aldo-keto reductase family 1 member B10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1B10 (aldo-keto reductase family 1 member B10)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1B15 (aldo-keto reductase family 1 member B15)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1B15 (aldo-keto reductase family 1 member B15)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	akr1b1.2 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	akr1b1.2 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	akr1b1.1 (aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG12766	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG2767	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6083	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6083	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6084	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9436	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T08H10.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y39G8B.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	Y39G8B.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ARY	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10638	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ARA1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10863	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C07D8.6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C07D8.6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YDL124W	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C56G3.2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	akr1b1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr1b1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	64,043,901 - 64,083,751 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	64,020,686 - 64,064,909 (+)	Ensembl				GRCr8
mRatBN7.2	4	63,053,560 - 63,100,934 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	63,076,800 - 63,089,502 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	68,035,027 - 68,047,739 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	63,950,724 - 63,963,436 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	62,353,139 - 62,365,851 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	61,850,256 - 61,879,733 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	61,850,348 - 61,862,526 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	61,587,891 - 61,600,050 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	61,794,352 - 61,806,916 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	58,130,320 - 58,142,884 (+)	NCBI		Celera
RGSC_v3.1	4	62,070,338 - 62,083,041 (+)	NCBI
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4,6-trinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4-Hydroxybenzophenone (ISO)

4-nitrophenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinal (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

choline (ISO)

clothianidin (ISO)

cobalt dichloride (EXP)

corn oil (EXP)

cyanocob(III)alamin (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (EXP)

delphinidin (ISO)

deoxynivalenol (ISO)

dexamethasone (EXP)

dibenzofurans (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

diethylstilbestrol (EXP)

doramapimod (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flavonoids (EXP)

flurbiprofen (ISO)

folic acid (ISO)

fumonisin B1 (ISO)

furan (EXP)

glycine betaine (ISO)

GW 4064 (ISO)

ibuprofen (ISO)

inulin (ISO)

ketoconazole (EXP)

L-methionine (ISO)

Mesaconitine (EXP)

N-nitrosodiethylamine (EXP,ISO)

ochratoxin A (EXP)

organophosphorus compound (EXP)

p-chloromercuribenzenesulfonic acid (EXP)

paclitaxel (EXP)

paracetamol (EXP)

PCB138 (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

prednisolone (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rotenone (ISO)

selenomethionine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (EXP)

trovafloxacin (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

prostaglandin metabolic process (IEA)

response to testosterone (IEP)

Cellular Component

cytoplasm (IEA)

cytosol (IBA)

mitochondrion (IBA)

Molecular Function

aldose reductase (NADPH) activity (IBA,IEA)

oxidoreductase activity (IEA)

prostaglandin H2 endoperoxidase reductase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Activation of the glucocorticoid receptor or liver X receptors interferes with growth hormone-induced akr1b7 gene expression in rat hepatocytes.	Kotokorpi P, etal., Endocrinology 2004 Dec;145(12):5704-13. Epub 2004 Sep 9.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	A 77-base pair LINE-like sequence elicits androgen-dependent mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable for adrenal expression in rats.	Val P, etal., Endocrinology 2002 Sep;143(9):3435-48.

Additional References at PubMed

PMID:12477932	PMID:19342790	PMID:19809495	PMID:21586312	PMID:22505406	PMID:25577493

Genomics

Comparative Map Data

Akr1b7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	64,043,901 - 64,083,751 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	64,020,686 - 64,064,909 (+)	Ensembl				GRCr8
mRatBN7.2	4	63,053,560 - 63,100,934 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	63,076,800 - 63,089,502 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	68,035,027 - 68,047,739 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	63,950,724 - 63,963,436 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	62,353,139 - 62,365,851 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	61,850,256 - 61,879,733 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	61,850,348 - 61,862,526 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	61,587,891 - 61,600,050 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	61,794,352 - 61,806,916 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	58,130,320 - 58,142,884 (+)	NCBI		Celera
RGSC_v3.1	4	62,070,338 - 62,083,041 (+)	NCBI
Cytogenetic Map	4	q22	NCBI

Akr1b7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	34,389,297 - 34,400,072 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	34,389,269 - 34,400,077 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	34,412,362 - 34,423,137 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	34,412,334 - 34,423,142 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	34,362,362 - 34,373,137 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	34,342,548 - 34,353,300 (+)	NCBI		MGSCv36	mm8
Celera	6	34,408,772 - 34,419,547 (+)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI
cM Map	6	14.95	NCBI

Variants

Variants in Akr1b7
118 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	28
Count of miRNA genes:	27
Interacting mature miRNAs:	28
Transcripts:	ENSRNOT00000013423
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	59753119	104753119	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	57613242	102613242	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	40490442	75726188	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58079875	82597589	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58817672	103817672	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58080146	80212111	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	59836842	104836842	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	61041057	94638356	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	40471453	75939996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	51085655	113588029	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58079875	92690793	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63224393	108224393	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	63900458	88813920	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	57613242	102613242	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	57613242	102613242	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	59603319	80216952	Rat

Markers in Region

RH140894

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	63,089,196 - 63,089,376 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	61,862,221 - 61,862,400	NCBI	Rnor6.0
Rnor_5.0	4	61,599,740 - 61,599,919	UniSTS	Rnor5.0
RGSC_v3.4	4	61,806,606 - 61,806,785	UniSTS	RGSC3.4
Celera	4	58,142,574 - 58,142,753	UniSTS
RH 3.4 Map	4	374.0	UniSTS
Cytogenetic Map	4	q22	UniSTS

BF390404

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	63,082,594 - 63,082,744 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	61,855,559 - 61,855,708	NCBI	Rnor6.0
Rnor_5.0	4	61,593,078 - 61,593,227	UniSTS	Rnor5.0
RGSC_v3.4	4	61,800,004 - 61,800,153	UniSTS	RGSC3.4
Celera	4	58,135,972 - 58,136,121	UniSTS
RH 3.4 Map	4	398.2	UniSTS
Cytogenetic Map	4	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	11	39	125	78	76	46	33	46	6	203	102	7	104	40	66	30	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF182168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013133 ⟹ ENSRNOP00000013133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	64,043,970 - 64,064,909 (+)	Ensembl
mRatBN7.2 Ensembl	4	63,076,800 - 63,086,580 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000013423 ⟹ ENSRNOP00000013423

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	64,043,970 - 64,056,677 (+)	Ensembl
mRatBN7.2 Ensembl	4	63,076,800 - 63,089,502 (+)	Ensembl
Rnor_6.0 Ensembl	4	61,850,348 - 61,862,526 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102062 ⟹ ENSRNOP00000085173

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	64,044,283 - 64,056,677 (+)	Ensembl
mRatBN7.2 Ensembl	4	63,076,800 - 63,087,204 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114062 ⟹ ENSRNOP00000079554

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	64,020,686 - 64,056,677 (+)	Ensembl

RefSeq Acc Id:

NM_053781 ⟹ NP_446233

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,970 - 64,056,677 (+)	NCBI
mRatBN7.2	4	63,076,800 - 63,089,507 (+)	NCBI
Rnor_6.0	4	61,850,491 - 61,862,531 (+)	NCBI
Rnor_5.0	4	61,587,891 - 61,600,050 (+)	NCBI
RGSC_v3.4	4	61,794,352 - 61,806,916 (+)	RGD
Celera	4	58,130,320 - 58,142,884 (+)	RGD

Sequence:

show sequence

CATACTTTGCAGCAACCATGACAACCTTCGTGAAGCTCAGAACCAAAGCCAAGATGCCCCTGGT
GGGCCTGGGCACCTGGAAGTCTCCCCCAGGCCAAGTCAAGGAAGCTGTGAAGGCAGCCATTGAT
GCTGGATATCGCCACTTTGACTGTGCCTATGTGTATCAGAATGAGAGTGAGGTGGGAGAAGCCA
TCCAAGAGAAGATCAAAGAGAAGGCTGTGAGGCGGGAGGACCTCTTCATCGTCAGCAAGCTGTG
GTCCACTTTCTTTGAGAAAAGCCTGATGAAGGAAGCCTTCCAGAAAACTCTCTCAGATCTGAAG
CTGGACTATCTGGACCTGTATCTAATTCACTGGCCACAGGGACTTCAGGCTGGGAAAGAATTCC
TACCCAAAGACAGTCAAGGCAAAGTTCTCATGAGTAAATCCACGTTCTTGGATGCCTGGGAGGG
CATGGAGGAACTGGTGGACCAGGGGCTGGTGAAAGCTTTGGGCGTCTCCAACTTCAACCACTTC
CAGATCGAAAGGCTCCTGAATAAGCCTGGACTGAAACATAAGCCAGTGACCAATCAGGTCGAGT
GCCACCCTTACCTCACCCAGGAAAAACTGATCCAGTACTGTCACTCCAAGGGCATCGCGGTCAT
AGCCTACAGTCCCCTGGGCTCCCCAGACAGGCCTTATGCTAAGCCTGAGGACCCCGTAGTGCTA
GAGATTCCCAAGATCAAAGAGATTGCTGCAAAGCATAAGAAAACAATAGCTCAGGTTCTGATTC
GATTCCATGTCCAAAGGAACGTGGCAGTGATCCCCAAGTCTGTGACACTCTCACACATAAAGGA
GAACATTCAGGTCTTTGACTTCCAGTTGAGTGAGGAGGACATGGCCGCCATTCTCAGCCTCAAC
AGGAACTGGAGGGCCTGTGGCCTGTTTGTCACAAGCGATGAAGAGGACTTTCCTTTCCACGAGG
AATACTGATGTTGGTTCGCTTGATGAGATTCAAGCCGGGTAGATTCCTTTGTCCTTGTGTGAGA
CTCACTCCTCCTGAAGCAGATTTTAGCCACGTCTCTCTAAAATCAACCTGGATGTAGGCTACCA
TTTGGCCATGTAGGATTTAAATTTTTGTGTTCATCAAGGTGCAGACTCTCACAGGGAAAAGTGA
GTCCAGAGAAACTAAGGTCAATGGTTTTCACTAATGAGGGCTGAGCAAATGTTTCTCATCAGGA
ATGCATTACCATGGTAACACTGGAGACACAGAGATAAAACAATAAAATGTAATAACAGTAAAAA
CAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063285402 ⟹ XP_063141472

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,074,413 (+)	NCBI

RefSeq Acc Id:

XR_010065591

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065592

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065593

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065594

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065595

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065596

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065597

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065598

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065599

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065600

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065601

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065602

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065603

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,908 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065604

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,901 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065605

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,044,417 - 64,083,751 (+)	NCBI

RefSeq Acc Id:

XR_010065606

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,912 - 64,052,697 (+)	NCBI

RefSeq Acc Id:

XR_010065607

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,043,913 - 64,052,697 (+)	NCBI

RefSeq Acc Id:

XR_010065608

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	64,048,841 - 64,083,751 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446233	(Get FASTA)	NCBI Sequence Viewer
	XP_063141472	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD56034	(Get FASTA)	NCBI Sequence Viewer
	AAH86563	(Get FASTA)	NCBI Sequence Viewer
	EDM15308	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013423
	ENSRNOP00000013423.2
GenBank Protein	Q5RJP0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446233 ⟸ NM_053781

- UniProtKB:

Q5RJP0 (UniProtKB/Swiss-Prot), Q9QZI2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIK
EKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQ
GKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLT
QEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQR
NVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY

hide sequence

Ensembl Acc Id:

ENSRNOP00000013423 ⟸ ENSRNOT00000013423

Ensembl Acc Id:

ENSRNOP00000013133 ⟸ ENSRNOT00000013133

Ensembl Acc Id:

ENSRNOP00000085173 ⟸ ENSRNOT00000102062

RefSeq Acc Id:	XP_063141472 ⟸ XM_063285402
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A3C9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000079554 ⟸ ENSRNOT00000114062

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RJP0-F1-model_v2	AlphaFold	Q5RJP0	1-316	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620257	AgrOrtholog
BioCyc Gene	G2FUF-45276	BioCyc
Ensembl Genes	ENSRNOG00000009875	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000013423	ENTREZGENE
	ENSRNOT00000013423.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7307075	IMAGE-MGC_LOAD
InterPro	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot
	Aldo/keto_reductase	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:116463	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105361	IMAGE-MGC_LOAD
NCBI Gene	116463	ENTREZGENE
PANTHER	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot
PhenoGen	Akr1b7	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/Swiss-Prot
	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009875	RatGTEx
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot
UniProt	A0A8I6A3C9	ENTREZGENE, UniProtKB/TrEMBL
	ALD1_RAT	UniProtKB/Swiss-Prot
	F7EMK8_RAT	UniProtKB/TrEMBL
	Q5RJP0	ENTREZGENE
	Q9QZI2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Akr1b7	aldo-keto reductase family 1, member B7	LOC103692098	uncharacterized LOC103692098	Data merged from RGD:9435424	737654	PROVISIONAL
2014-08-25	LOC103692098	uncharacterized LOC103692098			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Akr1b7	aldo-keto reductase family 1, member B7	Avdp	androgen regulated vas deferens protein	Symbol and Name updated	1299863	APPROVED
2002-08-07	Avdp	androgen regulated vas deferens protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in adrenal cortex and vas deferens	628357
gene_function	reduces isocaproaldehyde produced by cholesterol side chain cleavage in steroidogenesis
gene_process	involved in detoxification of steroidogenesis byproduct	628357
gene_process	reduces isocaproaldehyde produced by cholesterol side chain cleavage in steroidogenesis	628357
gene_product	member of aldo-keto-redcutase superfamily	628357
gene_protein	316 aa (predicted)	628357
gene_regulation	expression regulated by ACTH; androgen-insensitive expression in rat vas deferens	628357
gene_transcript	948 bp long ORF;rat promoter lacks 77-bp LINE-derived sequence seen in mouse and rat gene transcription initiation sites different from that of mouse	628357

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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