Akr1b7 (aldo-keto reductase family 1, member B7) - Rat Genome Database

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Pathways
Gene: Akr1b7 (aldo-keto reductase family 1, member B7) Rattus norvegicus
Analyze
Symbol: Akr1b7
Name: aldo-keto reductase family 1, member B7
RGD ID: 620257
Description: Predicted to enable aldose reductase (NADPH) activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Akr1b14; aldehyde reductase; aldo-keto reductase family 1 member B7; aldose reductase-like protein AKR1B14; aldose reductase-related protein 1; androgen regulated vas deferens protein; Avdp; LOC103692098; MVDP; uncharacterized LOC103692098
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8464,043,901 - 64,083,751 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl464,020,686 - 64,064,909 (+)EnsemblGRCr8
mRatBN7.2463,053,560 - 63,100,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl463,076,800 - 63,089,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx468,035,027 - 68,047,739 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,950,724 - 63,963,436 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,353,139 - 62,365,851 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,850,256 - 61,879,733 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,850,348 - 61,862,526 (+)Ensemblrn6Rnor6.0
Rnor_5.0461,587,891 - 61,600,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4461,794,352 - 61,806,916 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera458,130,320 - 58,142,884 (+)NCBICelera
RGSC_v3.1462,070,338 - 62,083,041 (+)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-Hydroxybenzophenone  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinal  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP)
corn oil  (EXP)
cyanocob(III)alamin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
delphinidin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
doramapimod  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glycine betaine  (ISO)
GW 4064  (ISO)
ibuprofen  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
Mesaconitine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
ochratoxin A  (EXP)
organophosphorus compound  (EXP)
p-chloromercuribenzenesulfonic acid  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
selenomethionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)
mitochondrion  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Activation of the glucocorticoid receptor or liver X receptors interferes with growth hormone-induced akr1b7 gene expression in rat hepatocytes. Kotokorpi P, etal., Endocrinology 2004 Dec;145(12):5704-13. Epub 2004 Sep 9.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. A 77-base pair LINE-like sequence elicits androgen-dependent mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable for adrenal expression in rats. Val P, etal., Endocrinology 2002 Sep;143(9):3435-48.
Additional References at PubMed
PMID:12477932   PMID:19342790   PMID:19809495   PMID:21586312   PMID:22505406   PMID:25577493  


Genomics

Comparative Map Data
Akr1b7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8464,043,901 - 64,083,751 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl464,020,686 - 64,064,909 (+)EnsemblGRCr8
mRatBN7.2463,053,560 - 63,100,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl463,076,800 - 63,089,502 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx468,035,027 - 68,047,739 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,950,724 - 63,963,436 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,353,139 - 62,365,851 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,850,256 - 61,879,733 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,850,348 - 61,862,526 (+)Ensemblrn6Rnor6.0
Rnor_5.0461,587,891 - 61,600,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4461,794,352 - 61,806,916 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera458,130,320 - 58,142,884 (+)NCBICelera
RGSC_v3.1462,070,338 - 62,083,041 (+)NCBI
Cytogenetic Map4q22NCBI
Akr1b7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,389,297 - 34,400,072 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,389,269 - 34,400,077 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38634,412,362 - 34,423,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,412,334 - 34,423,142 (+)Ensemblmm10GRCm38
MGSCv37634,362,362 - 34,373,137 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36634,342,548 - 34,353,300 (+)NCBIMGSCv36mm8
Celera634,408,772 - 34,419,547 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.95NCBI

Variants

.
Variants in Akr1b7
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000013423
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
RH140894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2463,089,196 - 63,089,376 (+)MAPPERmRatBN7.2
Rnor_6.0461,862,221 - 61,862,400NCBIRnor6.0
Rnor_5.0461,599,740 - 61,599,919UniSTSRnor5.0
RGSC_v3.4461,806,606 - 61,806,785UniSTSRGSC3.4
Celera458,142,574 - 58,142,753UniSTS
RH 3.4 Map4374.0UniSTS
Cytogenetic Map4q22UniSTS
BF390404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2463,082,594 - 63,082,744 (+)MAPPERmRatBN7.2
Rnor_6.0461,855,559 - 61,855,708NCBIRnor6.0
Rnor_5.0461,593,078 - 61,593,227UniSTSRnor5.0
RGSC_v3.4461,800,004 - 61,800,153UniSTSRGSC3.4
Celera458,135,972 - 58,136,121UniSTS
RH 3.4 Map4398.2UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 11 39 125 78 76 46 33 46 6 203 102 7 104 40 66 30 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF182168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013133   ⟹   ENSRNOP00000013133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl464,043,970 - 64,064,909 (+)Ensembl
mRatBN7.2 Ensembl463,076,800 - 63,086,580 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000013423   ⟹   ENSRNOP00000013423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl464,043,970 - 64,056,677 (+)Ensembl
mRatBN7.2 Ensembl463,076,800 - 63,089,502 (+)Ensembl
Rnor_6.0 Ensembl461,850,348 - 61,862,526 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102062   ⟹   ENSRNOP00000085173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl464,044,283 - 64,056,677 (+)Ensembl
mRatBN7.2 Ensembl463,076,800 - 63,087,204 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114062   ⟹   ENSRNOP00000079554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl464,020,686 - 64,056,677 (+)Ensembl
RefSeq Acc Id: NM_053781   ⟹   NP_446233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,970 - 64,056,677 (+)NCBI
mRatBN7.2463,076,800 - 63,089,507 (+)NCBI
Rnor_6.0461,850,491 - 61,862,531 (+)NCBI
Rnor_5.0461,587,891 - 61,600,050 (+)NCBI
RGSC_v3.4461,794,352 - 61,806,916 (+)RGD
Celera458,130,320 - 58,142,884 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285402   ⟹   XP_063141472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,074,413 (+)NCBI
RefSeq Acc Id: XR_010065591
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065592
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065593
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065594
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065595
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065596
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065597
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065598
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065599
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065600
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065601
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065602
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065603
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,908 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065604
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,901 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065605
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,044,417 - 64,083,751 (+)NCBI
RefSeq Acc Id: XR_010065606
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,912 - 64,052,697 (+)NCBI
RefSeq Acc Id: XR_010065607
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,043,913 - 64,052,697 (+)NCBI
RefSeq Acc Id: XR_010065608
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8464,048,841 - 64,083,751 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446233 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141472 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD56034 (Get FASTA)   NCBI Sequence Viewer  
  AAH86563 (Get FASTA)   NCBI Sequence Viewer  
  EDM15308 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013423
  ENSRNOP00000013423.2
GenBank Protein Q5RJP0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446233   ⟸   NM_053781
- UniProtKB: Q5RJP0 (UniProtKB/Swiss-Prot),   Q9QZI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013423   ⟸   ENSRNOT00000013423
Ensembl Acc Id: ENSRNOP00000013133   ⟸   ENSRNOT00000013133
Ensembl Acc Id: ENSRNOP00000085173   ⟸   ENSRNOT00000102062
RefSeq Acc Id: XP_063141472   ⟸   XM_063285402
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3C9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079554   ⟸   ENSRNOT00000114062
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJP0-F1-model_v2 AlphaFold Q5RJP0 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620257 AgrOrtholog
BioCyc Gene G2FUF-45276 BioCyc
Ensembl Genes ENSRNOG00000009875 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013423 ENTREZGENE
  ENSRNOT00000013423.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7307075 IMAGE-MGC_LOAD
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:116463 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105361 IMAGE-MGC_LOAD
NCBI Gene 116463 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Akr1b7 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009875 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt A0A8I6A3C9 ENTREZGENE, UniProtKB/TrEMBL
  ALD1_RAT UniProtKB/Swiss-Prot
  F7EMK8_RAT UniProtKB/TrEMBL
  Q5RJP0 ENTREZGENE
  Q9QZI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Akr1b7  aldo-keto reductase family 1, member B7  LOC103692098  uncharacterized LOC103692098  Data merged from RGD:9435424 737654 PROVISIONAL
2014-08-25 LOC103692098  uncharacterized LOC103692098      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Akr1b7  aldo-keto reductase family 1, member B7  Avdp  androgen regulated vas deferens protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Avdp  androgen regulated vas deferens protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adrenal cortex and vas deferens 628357
gene_function reduces isocaproaldehyde produced by cholesterol side chain cleavage in steroidogenesis  
gene_process involved in detoxification of steroidogenesis byproduct 628357
gene_process reduces isocaproaldehyde produced by cholesterol side chain cleavage in steroidogenesis 628357
gene_product member of aldo-keto-redcutase superfamily 628357
gene_protein 316 aa (predicted) 628357
gene_regulation expression regulated by ACTH; androgen-insensitive expression in rat vas deferens 628357
gene_transcript 948 bp long ORF;rat promoter lacks 77-bp LINE-derived sequence seen in mouse and rat gene transcription initiation sites different from that of mouse 628357