 Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:730835 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of AKR1B7 mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | increases expression | ISO | RGD:730835 | 6480464 | 2 more ... | CTD | PMID:20005886, PMID:21851831 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:730835 | 6480464 | [2 more ... | CTD | PMID:21851831, PMID:25510870 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:20056577 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:730835 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:730835 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AKR1B7 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:730835 | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [2 more ... | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:730835 | 6480464 | Tetrachlorodibenzodioxin affects the expression of AKR1B7 mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of AKR1B7 mRNA | CTD | PMID:21346803 | 4-nitrobenzaldehyde | increases metabolic processing | ISO | RGD:3516654 | 6480464 | AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde | CTD | PMID:21276782 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of AKR1B7 mRNA | CTD | PMID:24780913 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of AKR1B7 mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases methylation | ISO | RGD:3516654 | 6480464 | Aflatoxin B1 results in increased methylation of AKR1B15 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of AKR1B7 mRNA | CTD | PMID:23630614, PMID:25378103 | aflatoxin B1 | decreases expression | ISO | RGD:730835 | 6480464 | Aflatoxin B1 results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | all-trans-retinal | increases metabolic processing | ISO | RGD:730835 | 6480464 | AKR1B7 protein results in increased metabolism of Retinaldehyde | CTD | PMID:21329680 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AKR1B7 mRNA | CTD | PMID:16483693 | antimycin A | increases expression | ISO | RGD:730835 | 6480464 | Antimycin A results in increased expression of AKR1B7 mRNA | CTD | PMID:19304788 | arsane | affects methylation | ISO | RGD:3516654 | 6480464 | Arsenic affects the methylation of AKR1B15 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:3516654 | 6480464 | Arsenic affects the methylation of AKR1B15 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of AKR1B7 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | increases expression | ISO | RGD:3516654 | 6480464 | Benzo(a)pyrene results in increased expression of AKR1B15 mRNA | CTD | PMID:22316170, PMID:32234424 | benzo[a]pyrene | decreases expression | ISO | RGD:730835 | 6480464 | Benzo(a)pyrene results in decreased expression of AKR1B7 mRNA | CTD | PMID:19770486 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:730835 | 6480464 | Diethylhexyl Phthalate results in decreased expression of AKR1B7 mRNA | CTD | PMID:27405655 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AKR1B15 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of AKR1B7 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of AKR1B7 mRNA | CTD | PMID:25181051 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of AKR1B7 mRNA | CTD | PMID:25993096 | cannabidiol | increases expression | ISO | RGD:730835 | 6480464 | Cannabidiol results in increased expression of AKR1B7 mRNA | CTD | PMID:21542829 | carbon nanotube | decreases expression | ISO | RGD:730835 | 6480464 | Nanotubes, Carbon analog results in decreased expression of AKR1B7 mRNA, Nanotubes, Carbon results in decreased expression of AKR1B7 mRNA | CTD | PMID:25554681, PMID:25620056 | carbon nanotube | affects expression | ISO | RGD:730835 | 6480464 | Nanotubes, Carbon analog affects the expression of AKR1B7 mRNA | CTD | PMID:25620056 | choline | multiple interactions | ISO | RGD:730835 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 | cisplatin | increases expression | ISO | RGD:3516654 | 6480464 | Cisplatin results in increased expression of AKR1B15 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | RGD:3516654 | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of AKR1B15 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of AKR1B7 mRNA | CTD | PMID:24386269 | copper(II) sulfate | increases expression | ISO | RGD:3516654 | 6480464 | Copper Sulfate results in increased expression of AKR1B15 mRNA | CTD | PMID:19549813 | cyproconazole | increases expression | ISO | RGD:730835 | 6480464 | cyproconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:22334560, PMID:23970803 | cytarabine | decreases expression | ISO | RGD:3516654 | 6480464 | Cytarabine results in decreased expression of AKR1B15 mRNA | CTD | PMID:21198554 | D-glyceraldehyde | increases metabolic processing | ISO | RGD:3516654 | 6480464 | AKR1B15 protein results in increased metabolism of Glyceraldehyde | CTD | PMID:21276782 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of AKR1B7 mRNA | CTD | PMID:23914054 | dexamethasone | multiple interactions | EXP | | 6480464 | Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of AKR1B7 mRNA] | CTD | PMID:21149847 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of AKR1B7 mRNA | CTD | PMID:21266533 | doramapimod | increases expression | ISO | RGD:730835 | 6480464 | BIRB 796 results in increased expression of AKR1B7 mRNA | CTD | PMID:21328587 | epoxiconazole | increases expression | ISO | RGD:730835 | 6480464 | epoxiconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:22334560, PMID:23970803 | ethanol | increases expression | ISO | RGD:730835 | 6480464 | Ethanol results in increased expression of AKR1B7 mRNA | CTD | PMID:19167417 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of AKR1B7 mRNA | CTD | PMID:18035473 | flurbiprofen | decreases expression | ISO | RGD:730835 | 6480464 | Flurbiprofen results in decreased expression of AKR1B7 mRNA | CTD | PMID:16949054 | folic acid | multiple interactions | ISO | RGD:730835 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 | fumonisin B1 | increases expression | ISO | RGD:730835 | 6480464 | fumonisin B1 results in increased expression of AKR1B7 mRNA | CTD | PMID:16221962 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of AKR1B7 gene | CTD | PMID:22079235 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of AKR1B7 mRNA | CTD | PMID:25539665, PMID:26194646 | glyceraldehyde | increases metabolic processing | ISO | RGD:3516654 | 6480464 | AKR1B15 protein results in increased metabolism of Glyceraldehyde | CTD | PMID:21276782 | GW 4064 | increases expression | ISO | RGD:730835 | 6480464 | GW 4064 results in increased expression of AKR1B7 mRNA | CTD | PMID:26655953 | L-methionine | multiple interactions | ISO | RGD:730835 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B7 mRNA | CTD | PMID:20938992 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of AKR1B7 mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:730835 | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA | CTD | PMID:24535843 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of AKR1B7 mRNA | CTD | PMID:28943392 | N-Nitrosopyrrolidine | increases expression | ISO | RGD:3516654 | 6480464 | N-Nitrosopyrrolidine results in increased expression of AKR1B15 mRNA | CTD | PMID:32234424 | O-methyleugenol | increases expression | ISO | RGD:3516654 | 6480464 | methyleugenol results in increased expression of AKR1B15 mRNA | CTD | PMID:32234424 | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of AKR1B7 mRNA | CTD | PMID:30449730 | p-chloromercuribenzenesulfonic acid | decreases activity | EXP | | 6480464 | 4-Chloromercuribenzenesulfonate results in decreased activity of AKR1B7 protein | CTD | PMID:23261715 | paclitaxel | increases expression | EXP | | 6480464 | Paclitaxel analog results in increased expression of AKR1B7 mRNA | CTD | PMID:15585946 | perfluorononanoic acid | multiple interactions | ISO | RGD:730835 | 6480464 | [PPARA gene mutant form results in increased susceptibility to perfluorononanoic acid] which results in increased expression of AKR1B7 mRNA | CTD | PMID:25949234 | perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:730835 | 6480464 | perfluorooctane sulfonic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:27153767 | perfluorooctanoic acid | increases expression | ISO | RGD:730835 | 6480464 | perfluorooctanoic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:18281256, PMID:27153767 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:28511854 | perfluorooctanoic acid | multiple interactions | ISO | RGD:730835 | 6480464 | PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of AKR1B7 mRNA] | CTD | PMID:18281256 | phenobarbital | multiple interactions | ISO | RGD:730835 | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA, NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AKR1B7 mRNA] | CTD | PMID:19482888, PMID:24535843 | phenobarbital | affects expression | ISO | RGD:730835 | 6480464 | Phenobarbital affects the expression of AKR1B7 mRNA | CTD | PMID:19136022 | phenobarbital | increases expression | ISO | RGD:730835 | 6480464 | Phenobarbital results in increased expression of AKR1B7 mRNA | CTD | PMID:19270015 more ... | pirinixic acid | affects expression | ISO | RGD:730835 | 6480464 | pirinixic acid affects the expression of AKR1B7 mRNA | CTD | PMID:19136022 | pirinixic acid | multiple interactions | ISO | RGD:730835 | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of AKR1B7 mRNA | CTD | PMID:20813756 | pirinixic acid | increases expression | ISO | RGD:730835 | 6480464 | pirinixic acid results in increased expression of AKR1B7 mRNA | CTD | PMID:20813756, PMID:23811191 | potassium dichromate | increases expression | ISO | RGD:730835 | 6480464 | Potassium Dichromate results in increased expression of AKR1B7 mRNA | CTD | PMID:23608068 | prednisolone | multiple interactions | EXP | | 6480464 | Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of AKR1B7 mRNA] | CTD | PMID:21149847 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | RGD:730835 | 6480464 | Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA | CTD | PMID:25949234 more ... | pregnenolone 16alpha-carbonitrile | multiple interactions | ISO | RGD:730835 | 6480464 | NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA] | CTD | PMID:25949234 | propiconazole | increases expression | ISO | RGD:730835 | 6480464 | propiconazole results in increased expression of AKR1B7 mRNA | CTD | PMID:21278054 more ... | rotenone | increases expression | ISO | RGD:730835 | 6480464 | Rotenone results in increased expression of AKR1B7 mRNA | CTD | PMID:19304788 | silver atom | increases expression | ISO | RGD:730835 | 6480464 | Silver results in increased expression of AKR1B7 mRNA | CTD | PMID:27131904 | silver(0) | increases expression | ISO | RGD:730835 | 6480464 | Silver results in increased expression of AKR1B7 mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | RGD:3516654 | 6480464 | sodium arsenite results in increased expression of AKR1B15 mRNA | CTD | PMID:28595984 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of AKR1B7 mRNA | CTD | PMID:22110744 | sodium fluoride | decreases expression | ISO | RGD:730835 | 6480464 | Sodium Fluoride results in decreased expression of AKR1B7 protein | CTD | PMID:28918527 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of AKR1B7 mRNA | CTD | PMID:21515302 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of AKR1B7 mRNA | CTD | PMID:31150632 | thioacetamide | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of AKR1B7 mRNA | CTD | PMID:28943392 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of AKR1B7 mRNA | CTD | PMID:23411599 | titanium dioxide | decreases expression | ISO | RGD:730835 | 6480464 | titanium dioxide results in decreased expression of AKR1B7 mRNA | CTD | PMID:23131501 | titanium dioxide | increases expression | ISO | RGD:730835 | 6480464 | titanium dioxide results in increased expression of AKR1B7 mRNA | CTD | PMID:23557971 | tributylstannane | increases expression | ISO | RGD:730835 | 6480464 | tributyltin results in increased expression of AKR1B7 mRNA | CTD | PMID:31939706 | trichloroethene | increases expression | ISO | RGD:730835 | 6480464 | Trichloroethylene results in increased expression of AKR1B7 mRNA | CTD | PMID:25549359 | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of AKR1B7 mRNA | CTD | PMID:30589522 | troglitazone | increases expression | ISO | RGD:3516654 | 6480464 | troglitazone results in increased expression of AKR1B15 mRNA | CTD | PMID:25572481 | urethane | decreases expression | ISO | RGD:3516654 | 6480464 | Urethane results in decreased expression of AKR1B15 mRNA | CTD | PMID:28818685 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of AKR1B7 mRNA | CTD | 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Gene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
