Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) - Rat Genome Database

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Gene: Aldh1l1 (aldehyde dehydrogenase 1 family, member L1) Rattus norvegicus
Analyze
Symbol: Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
RGD ID: 621294
Description: Enables aldehyde dehydrogenase (NADP+) activity and formyltetrahydrofolate dehydrogenase activity. Involved in NADPH regeneration; bile acid signaling pathway; and folic acid-containing compound metabolic process. Located in cytosol. Part of protein-containing complex. Biomarker of cholestasis. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1); PARTICIPATES IN bile acid signaling pathway; altered folate cycle metabolic pathway; folate cycle metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; aldehyde dehydrogenase family 1 member L1; cytosolic 10-formyltetrahydrofolate dehydrogenase; FBP-CI; FDH; formyltetrahydrofolate dehydrogenase; Fthfd; MGC105431
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84124,617,182 - 124,663,674 (+)NCBIGRCr8
mRatBN7.24123,059,989 - 123,106,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,060,008 - 123,106,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4128,527,602 - 128,574,093 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04124,302,026 - 124,348,513 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04122,926,598 - 122,973,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04123,516,553 - 123,564,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,516,788 - 123,557,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04186,990,816 - 187,030,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4111,983,791 - 112,029,897 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diiodine  (EXP)
diquat  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
glafenine  (EXP)
hydrazine  (EXP)
indometacin  (ISO)
iodide salt  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
microcystin-LR  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
propanal  (ISO)
pyrazinecarboxamide  (EXP)
quinolin-8-ol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium perchlorate  (EXP)
succimer  (ISO)
sulindac  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IDA,IEA,ISO)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. Chumanevich AA, etal., J Biol Chem 2004 Apr 2;279(14):14355-64. Epub 2004 Jan 16.
2. Isolation and characterization of cDNA clones for rat liver 10-formyltetrahydrofolate dehydrogenase. Cook RJ, etal., J Biol Chem 1991 Mar 15;266(8):4965-73.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B. Kim HS, etal., J Biochem Mol Biol. 2007 Jul 31;40(4):604-9.
7. Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase. Krupenko SA and Wagner C, J Biol Chem. 1999 Dec 10;274(50):35777-84. doi: 10.1074/jbc.274.50.35777.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. Stover PJ J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
15. Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases. Tsybovsky Y, etal., Biochemistry. 2007 Mar 20;46(11):2917-29. Epub 2007 Feb 16.
Additional References at PubMed
PMID:3392008   PMID:7822273   PMID:12477932   PMID:16396499   PMID:18614015   PMID:19056867   PMID:20498374   PMID:21238436   PMID:23376485   PMID:23533145   PMID:35013550   PMID:36675153  


Genomics

Comparative Map Data
Aldh1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84124,617,182 - 124,663,674 (+)NCBIGRCr8
mRatBN7.24123,059,989 - 123,106,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4123,060,008 - 123,106,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4128,527,602 - 128,574,093 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04124,302,026 - 124,348,513 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04122,926,598 - 122,973,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04123,516,553 - 123,564,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,516,788 - 123,557,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04186,990,816 - 187,030,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4111,983,791 - 112,029,897 (+)NCBICelera
Cytogenetic Map4q34NCBI
ALDH1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383126,103,570 - 126,197,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3126,103,562 - 126,197,994 (-)EnsemblGRCh38hg38GRCh38
GRCh373125,822,413 - 125,900,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,305,098 - 127,382,175 (-)NCBINCBI36Build 36hg18NCBI36
Celera3124,246,087 - 124,323,172 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3123,202,976 - 123,280,599 (-)NCBIHuRef
CHM1_13125,785,177 - 125,862,716 (-)NCBICHM1_1
T2T-CHM13v2.03128,835,963 - 128,930,120 (-)NCBIT2T-CHM13v2.0
Aldh1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39690,527,751 - 90,576,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl690,463,409 - 90,577,185 (+)EnsemblGRCm39 Ensembl
GRCm38690,550,768 - 90,599,171 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl690,486,427 - 90,600,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv37690,500,842 - 90,549,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36690,516,352 - 90,564,675 (+)NCBIMGSCv36mm8
Celera692,439,210 - 92,482,963 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.16NCBI
Aldh1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542121,420,147 - 21,527,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542121,420,264 - 21,506,004 (-)NCBIChiLan1.0ChiLan1.0
ALDH1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,047,200 - 124,124,841 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13124,051,981 - 124,129,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03123,166,630 - 123,244,257 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13130,484,862 - 130,562,958 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,484,862 - 130,562,934 (-)Ensemblpanpan1.1panPan2
ALDH1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,722 - 99,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2061,349 - 99,160 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha20318,809 - 429,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.020291,997 - 402,986 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl20288,804 - 402,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12023,804 - 134,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.020354,338 - 463,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020313,350 - 422,524 (-)NCBIUU_Cfam_GSD_1.0
Aldh1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494219,186,039 - 19,234,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936898456,521 - 484,282 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936898456,299 - 484,681 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,748,653 - 53,794,706 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,748,585 - 53,794,777 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALDH1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,848,868 - 54,933,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2254,848,901 - 54,934,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041111,375,948 - 111,461,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624773385,594 - 468,270 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624773385,583 - 468,270 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1l1
230 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:108
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000075042
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat

Markers in Region
D4Got298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,069,574 - 123,069,704 (-)MAPPERmRatBN7.2
Rnor_6.04123,552,272 - 123,552,401NCBIRnor6.0
Rnor_5.04186,995,660 - 186,995,789UniSTSRnor5.0
Celera4111,993,064 - 111,993,193UniSTS
RH127817  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,106,251 - 123,106,446 (-)MAPPERmRatBN7.2
Rnor_6.04123,516,578 - 123,516,772NCBIRnor6.0
Rnor_5.04187,030,736 - 187,030,930UniSTSRnor5.0
Celera4112,029,678 - 112,029,872UniSTS
RH 3.4 Map4733.42UniSTS
BI284419  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,075,227 - 123,075,424 (-)MAPPERmRatBN7.2
Rnor_6.04123,546,495 - 123,546,691NCBIRnor6.0
Rnor_5.04187,001,242 - 187,001,438UniSTSRnor5.0
Celera4111,998,717 - 111,998,913UniSTS
RH 3.4 Map4733.52UniSTS
Aldh1l1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24123,078,906 - 123,078,974 (-)MAPPERmRatBN7.2
Rnor_6.04123,542,962 - 123,543,029NCBIRnor6.0
Rnor_5.04187,004,610 - 187,004,677UniSTSRnor5.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 45 35 2 35 6 9 50 29 14 1 6
Low 1 7 12 6 16 6 2 2 12 6 22 10 2
Below cutoff 36 1 12 5

Sequence


RefSeq Acc Id: ENSRNOT00000075042   ⟹   ENSRNOP00000065882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,060,008 - 123,106,464 (+)Ensembl
Rnor_6.0 Ensembl4123,516,788 - 123,557,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085966   ⟹   ENSRNOP00000071405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,060,008 - 123,106,464 (+)Ensembl
Rnor_6.0 Ensembl4123,516,788 - 123,557,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096748   ⟹   ENSRNOP00000089314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,060,008 - 123,106,464 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105191   ⟹   ENSRNOP00000088467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4123,060,008 - 123,106,465 (+)Ensembl
RefSeq Acc Id: NM_022547   ⟹   NP_071992
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,617,220 - 124,663,674 (+)NCBI
mRatBN7.24123,060,017 - 123,106,471 (+)NCBI
Rnor_6.04123,516,553 - 123,564,067 (-)NCBI
Rnor_5.04186,990,816 - 187,030,955 (+)NCBI
Celera4111,983,791 - 112,029,897 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108319   ⟹   XP_038964247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,617,182 - 124,661,502 (+)NCBI
mRatBN7.24123,059,989 - 123,104,299 (+)NCBI
RefSeq Acc Id: XM_063286665   ⟹   XP_063142735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84124,617,182 - 124,663,668 (+)NCBI
RefSeq Acc Id: NP_071992   ⟸   NM_022547
- UniProtKB: P28037 (UniProtKB/Swiss-Prot),   Q5HZB2 (UniProtKB/Swiss-Prot),   A0A8I6GG93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065882   ⟸   ENSRNOT00000075042
RefSeq Acc Id: ENSRNOP00000071405   ⟸   ENSRNOT00000085966
RefSeq Acc Id: XP_038964247   ⟸   XM_039108319
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GG93 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089314   ⟸   ENSRNOT00000096748
RefSeq Acc Id: ENSRNOP00000088467   ⟸   ENSRNOT00000105191
RefSeq Acc Id: XP_063142735   ⟸   XM_063286665
- Peptide Label: isoform X1
Protein Domains
Carrier

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28037-F1-model_v2 AlphaFold P28037 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621294 AgrOrtholog
BioCyc Gene G2FUF-43731 BioCyc
Ensembl Genes ENSRNOG00000047023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075042.3 UniProtKB/TrEMBL
  ENSRNOT00000085966.2 UniProtKB/TrEMBL
  ENSRNOT00000096748 ENTREZGENE
  ENSRNOT00000096748.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105191.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.25.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl transferase, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7306458 IMAGE-MGC_LOAD
InterPro 10_FTHF_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACP-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_trans_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_transf_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_transf_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_transferase-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GART_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP-bd_ACP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64392 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105431 IMAGE-MGC_LOAD
NCBI Gene 64392 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formyl_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALDH1L1 RGD
PhenoGen Aldh1l1 PhenoGen
PIRSF 10-FTHFDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARRIER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GART UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047023 RatGTEx
Superfamily-SCOP SSF47336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0D8_RAT UniProtKB/TrEMBL
  A0A8I6GG93 ENTREZGENE, UniProtKB/TrEMBL
  AL1L1_RAT UniProtKB/Swiss-Prot
  M0R8T2_RAT UniProtKB/TrEMBL
  P28037 ENTREZGENE
  Q5HZB2 ENTREZGENE
UniProt Secondary Q5HZB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-19 Aldh1l1  aldehyde dehydrogenase 1 family, member L1  Fthfd  formyltetrahydrofolate dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fthfd  formyltetrahydrofolate dehydrogenase    10-formyltetrahydrofolate dehydrogenase  Name updated 1299863 APPROVED
2002-08-07 Fthfd  10-formyltetrahydrofolate dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol  
gene_domains contains two putative catalytic domains: phosphoribosylglycinamide formyltransferase and aldehyde dehydrogenase (NADP+) 632027
gene_expression expressed in liver 632027
gene_protein 902 amino acids; Mr 99,015  
gene_protein 902 amino acids; 99 kDa 632027