Gene: Smo (smoothened, frizzled class receptor) Rattus norvegicus
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Symbol:
Smo
Name:
smoothened, frizzled class receptor
Description:
Predicted to have drug binding activity and patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Predicted to colocalize with Golgi apparatus and caveola. Used to study middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Smoh; Smoothened; smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled family receptor
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SMO (smoothened, frizzled class receptor) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Smo (smoothened, frizzled class receptor) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Smo (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SMO (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SMO (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Smo (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SMO (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SMO (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Smo (smoothened, frizzled class receptor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SMO (smoothened, frizzled class receptor)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Smo (smoothened, frizzled class receptor)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
smo (smoothened, frizzled class receptor)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Drosophila melanogaster (fruit fly):
smo
Alliance
DIOPT (PANTHER|Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|TreeFam)
Is Marker For:
Strains:
BB/OK
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 4 57,019,941 - 57,041,779 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 57,019,941 - 57,042,770 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 4 56,787,102 - 56,809,935 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 4 56,623,494 - 56,645,571 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 4 56,898,313 - 56,920,866 (+) NCBI Celera 4 53,450,322 - 53,474,674 (+) NCBI Celera Cytogenetic Map 4 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
basal cell carcinoma ISO RGD:733306 8554872 ClinVar Annotator: match by term: Basal cell carcinoma, sporadic ClinVar PMID:9422511 basal cell carcinoma ISO RGD:733306 8554872 ClinVar Annotator: match by term: Carcinoma, Basal Cell ClinVar PMID:19726788 more ... medulloblastoma ISO RGD:733306 8554872 ClinVar Annotator: match by term: Medulloblastoma ClinVar PMID:19726788 more ... pleomorphic xanthoastrocytoma ISO RGD:733306 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358 Winter Shortland Temple Syndrome ISO RGD:733306 8554872 ClinVar Annotator: match by term: Craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development ClinVar PMID:16531740 more ... Winter Shortland Temple Syndrome ISO RGD:733306 8554872 ClinVar Annotator: match by term: Craniofacial malformations, asymmetric, with polysyndactyly and abnormal skin and gut development ClinVar PMID:24728327
Imported Annotations - CTD
acute promyelocytic leukemia ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23867347 ameloblastoma ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24859340 basal cell carcinoma ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9581815 , PMID:26950094 Brain Neoplasms ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9581815 Female Infertility ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28560483 gastrointestinal stromal tumor ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27793025 Jaw Abnormalities ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16580747 Maxillary Neoplasms ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24859340 meningioma ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23334667 Osteoarthritis, Hip ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30374069 Primitive Neuroectodermal Tumors ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9581815 Skin Neoplasms ISO RGD:733306 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9581815 Imported Annotations - MGI
medulloblastoma ISS RGD:735969 13592920 OMIM:155255 MouseDO pulmonary emphysema ISS RGD:735969 13592920 OMIM:130700 MouseDO Imported Annotations - OMIM
basal cell carcinoma susceptibility ISO RGD:733306 7240710 OMIM Winter Shortland Temple Syndrome ISO RGD:733306 7240710 OMIM
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:735969 6480464 epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA], epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein] CTD PMID:27058323 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735969 6480464 Tetrachlorodibenzodioxin results in increased expression of SMO mRNA CTD PMID:17586704 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735969 6480464 Tetrachlorodibenzodioxin affects the expression of SMO mRNA CTD PMID:21570461 , PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SMO mRNA CTD PMID:22298810 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of SMO mRNA CTD PMID:17187413 4-hydroxyphenyl retinamide decreases expression ISO RGD:735969 6480464 Fenretinide results in decreased expression of SMO mRNA CTD PMID:28973697 5-fluorouracil decreases expression ISO RGD:733306 6480464 Fluorouracil results in decreased expression of SMO mRNA, Fluorouracil results in decreased expression of SMO protein CTD PMID:18776995 , PMID:25190613 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of SMO mRNA CTD PMID:25378103 aldehydo-D-glucose multiple interactions ISO RGD:735969 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein more ... CTD PMID:27481074 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SMO mRNA CTD PMID:16483693 arsenous acid decreases activity ISO RGD:733306 6480464 Arsenic Trioxide results in decreased activity of SMO protein mutant form CTD PMID:24859340 benzo[a]pyrene decreases expression ISO RGD:733306 6480464 Benzo(a)pyrene results in decreased expression of SMO mRNA CTD PMID:26238291 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SMO promoter CTD PMID:23359474 bis(2-ethylhexyl) phthalate increases expression ISO RGD:735969 6480464 Diethylhexyl Phthalate results in increased expression of SMO mRNA CTD PMID:28123099 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SMO promoter CTD PMID:23359474 bisphenol A affects expression ISO RGD:733306 6480464 bisphenol A affects the expression of SMO mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SMO mRNA CTD PMID:25181051 calciol increases expression ISO RGD:735969 6480464 Cholecalciferol results in increased expression of SMO mRNA CTD PMID:17170073 captopril multiple interactions EXP 6480464 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein], Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] CTD PMID:31181250 captopril multiple interactions ISO RGD:733306 6480464 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein] CTD PMID:31181250 carbon nanotube decreases expression ISO RGD:735969 6480464 Nanotubes, Carbon analog results in decreased expression of SMO mRNA CTD PMID:25554681 carboplatin increases expression ISO RGD:733306 6480464 Carboplatin results in increased expression of SMO mRNA CTD PMID:25605917 choline multiple interactions ISO RGD:735969 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMO gene CTD PMID:20938992 chromium(6+) multiple interactions ISO RGD:735969 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of SMO mRNA more ... CTD PMID:31756458 cisplatin increases expression ISO RGD:733306 6480464 Cisplatin results in increased expression of SMO mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:733306 6480464 Cisplatin promotes the reaction [jinfukang results in increased expression of SMO mRNA], jinfukang promotes the reaction [Cisplatin results in increased expression of SMO mRNA] CTD PMID:27392435 clofibrate multiple interactions ISO RGD:735969 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA] CTD PMID:17585979 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA] CTD PMID:27590029 copper(II) sulfate decreases expression ISO RGD:733306 6480464 Copper Sulfate results in decreased expression of SMO mRNA CTD PMID:19549813 Cyclopamine increases expression ISO RGD:733306 6480464 cyclopamine results in increased expression of SMO mRNA CTD PMID:26710974 Cyclopamine multiple interactions ISO RGD:735969 6480464 cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein] CTD PMID:27481074 Cyclopamine multiple interactions EXP 6480464 cyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein] more ... CTD PMID:24388991 , PMID:24464877 Cyclopamine multiple interactions ISO RGD:733306 6480464 mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA] CTD PMID:26710974 D-glucose multiple interactions ISO RGD:735969 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein more ... CTD PMID:27481074 dexamethasone decreases expression ISO RGD:733306 6480464 Dexamethasone results in decreased expression of SMO mRNA CTD PMID:25047013 dextran sulfate multiple interactions ISO RGD:735969 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SMO mRNA CTD PMID:29950665 diarsenic trioxide decreases activity ISO RGD:733306 6480464 Arsenic Trioxide results in decreased activity of SMO protein mutant form CTD PMID:24859340 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SMO mRNA CTD PMID:21266533 dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SMO promoter CTD PMID:23359474 diethylstilbestrol decreases expression ISO RGD:735969 6480464 Diethylstilbestrol results in decreased expression of SMO mRNA CTD PMID:22467019 dioxygen multiple interactions ISO RGD:735969 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein more ... CTD PMID:27481074 disodium selenite decreases expression ISO RGD:733306 6480464 Sodium Selenite results in decreased expression of SMO mRNA CTD PMID:18175754 dorsomorphin multiple interactions ISO RGD:733306 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMO mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:733306 6480464 Doxorubicin results in decreased expression of SMO mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of SMO mRNA CTD PMID:29391264 folic acid multiple interactions ISO RGD:735969 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMO gene CTD PMID:20938992 gemcitabine increases expression ISO RGD:733306 6480464 gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 glucose multiple interactions ISO RGD:735969 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SMO protein more ... CTD PMID:27481074 hydralazine multiple interactions ISO RGD:733306 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of SMO mRNA CTD PMID:17183730 hydrogen peroxide multiple interactions EXP 6480464 hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA], hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein] CTD PMID:31326407 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of SMO mRNA, Hydrogen Peroxide results in increased expression of SMO protein CTD PMID:31326407 L-methionine multiple interactions ISO RGD:735969 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMO gene CTD PMID:20938992 leflunomide decreases expression ISO RGD:733306 6480464 leflunomide results in decreased expression of SMO mRNA CTD PMID:28988120 menadione affects expression ISO RGD:733306 6480464 Vitamin K 3 affects the expression of SMO mRNA CTD PMID:20044591 methotrexate affects expression ISO RGD:735969 6480464 Methotrexate affects the expression of SMO mRNA CTD PMID:18502557 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:733306 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Androgens deficiency] results in increased expression of SMO mRNA, mono-(2-ethylhexyl)phthalate inhibits the reaction [cyclopamine results in increased expression of SMO mRNA] CTD PMID:26710974 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:735969 6480464 Ethylnitrosourea results in increased mutagenesis of SMO gene CTD PMID:15755804 , PMID:16724327 N-nitrosodiethylamine increases expression ISO RGD:735969 6480464 Diethylnitrosamine results in increased expression of SMO mRNA, Diethylnitrosamine results in increased expression of SMO protein CTD PMID:27058323 N-nitrosodiethylamine multiple interactions ISO RGD:735969 6480464 epigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA] more ... CTD PMID:27058323 paracetamol multiple interactions ISO RGD:735969 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SMO mRNA] CTD PMID:17585979 paracetamol affects expression ISO RGD:735969 6480464 Acetaminophen affects the expression of SMO mRNA CTD PMID:17562736 phenobarbital multiple interactions ISO RGD:735969 6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SMO mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:733306 6480464 Phenobarbital affects the expression of SMO mRNA CTD PMID:19159669 phenobarbital decreases expression ISO RGD:735969 6480464 Phenobarbital results in decreased expression of SMO mRNA CTD PMID:19482888 piperonyl butoxide multiple interactions ISO RGD:735969 6480464 Piperonyl Butoxide inhibits the reaction [SMO protein results in increased expression of GLI1 protein] CTD PMID:31642701 pirinixic acid multiple interactions ISO RGD:735969 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of SMO mRNA] CTD PMID:17950772 pirinixic acid increases expression ISO RGD:735969 6480464 pirinixic acid results in increased expression of SMO mRNA CTD PMID:17950772 , PMID:23811191 potassium chromate increases expression ISO RGD:733306 6480464 potassium chromate(VI) results in increased expression of SMO mRNA CTD PMID:22714537 potassium dichromate multiple interactions ISO RGD:735969 6480464 [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of SMO mRNA more ... CTD PMID:31756458 quercetin 3-O-beta-D-galactopyranoside multiple interactions EXP 6480464 hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO mRNA], hyperoside promotes the reaction [Hydrogen Peroxide results in increased expression of SMO protein] CTD PMID:31326407 quercetin 3-O-beta-D-galactopyranoside increases expression EXP 6480464 hyperoside results in increased expression of SMO mRNA, hyperoside results in increased expression of SMO protein CTD PMID:31326407 resveratrol decreases expression ISO RGD:733306 6480464 resveratrol results in decreased expression of SMO more ... CTD PMID:22301921 more ... resveratrol multiple interactions EXP 6480464 cyclopamine inhibits the reaction [resveratrol results in increased expression of SMO protein], resveratrol results in increased expression of and affects the localization of SMO protein CTD PMID:24464877 Salinomycin decreases expression ISO RGD:733306 6480464 salinomycin results in decreased expression of SMO mRNA, salinomycin results in decreased expression of SMO protein CTD PMID:25499043 , PMID:30273566 SB 431542 multiple interactions ISO RGD:733306 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMO mRNA CTD PMID:27188386 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of SMO protein CTD PMID:31181250 silicon dioxide multiple interactions EXP 6480464 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] more ... CTD PMID:31181250 sodium fluoride multiple interactions EXP 6480464 cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO mRNA], cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SMO protein] CTD PMID:24388991 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of SMO mRNA, Sodium Fluoride results in increased expression of SMO protein CTD PMID:24388991 sonidegib decreases response to substance ISO RGD:735969 6480464 SMO protein mutant form results in decreased susceptibility to sonidegib CTD PMID:24973920 sunitinib increases expression ISO RGD:733306 6480464 sunitinib results in increased expression of SMO mRNA CTD PMID:25605917 sunitinib decreases expression ISO RGD:733306 6480464 Sunitinib results in decreased expression of SMO mRNA CTD PMID:31533062 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMO mRNA CTD PMID:27590029 tetrachloromethane multiple interactions ISO RGD:735969 6480464 GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA], GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO protein] CTD PMID:31816328 tetrachloromethane increases expression ISO RGD:735969 6480464 Carbon Tetrachloride results in increased expression of SMO mRNA, Carbon Tetrachloride results in increased expression of SMO protein CTD PMID:31816328 tetrachloromethane multiple interactions EXP 6480464 Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA] CTD PMID:27590029 theaflavin multiple interactions ISO RGD:735969 6480464 theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO mRNA], theaflavin inhibits the reaction [Diethylnitrosamine results in increased expression of SMO protein] CTD PMID:27058323 titanium dioxide multiple interactions ISO RGD:735969 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SMO mRNA CTD PMID:29950665 valproic acid multiple interactions ISO RGD:733306 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of SMO mRNA more ... CTD PMID:17183730 , PMID:27188386 valproic acid decreases expression ISO RGD:733306 6480464 Valproic Acid results in decreased expression of SMO mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:733306 6480464 Valproic Acid results in decreased methylation of SMO gene CTD PMID:29154799 valproic acid affects expression ISO RGD:733306 6480464 Valproic Acid affects the expression of SMO mRNA CTD PMID:25979313 vismodegib decreases expression ISO RGD:733306 6480464 HhAntag691 results in decreased expression of SMO mRNA CTD PMID:22087285 vismodegib decreases response to substance ISO RGD:735969 6480464 SMO protein mutant form results in decreased susceptibility to HhAntag691 CTD PMID:24973920 zinc atom increases expression ISO RGD:733306 6480464 Zinc results in increased expression of SMO mRNA CTD PMID:19071009 zinc(0) increases expression ISO RGD:733306 6480464 Zinc results in increased expression of SMO mRNA CTD PMID:19071009
Biological Process anterior/posterior pattern specification ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:5438143 , PMID:22987639 anterior/posterior pattern specification IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 astrocyte activation ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:5510940 , PMID:23680462) RGD MGI:MGI:5510940 , PMID:23680462 astrocyte activation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrial septum morphogenesis ISO RGD:735969 1624291 MGI:MGI:102541 (MGI:MGI:5437816 , PMID:22898775) RGD MGI:MGI:5437816 , PMID:22898775 atrial septum morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 axon extension involved in axon guidance IMP 2324988 RGD cell development ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:2429663 , PMID:12403705 cell fate specification ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:3806189 , PMID:18590716) RGD MGI:MGI:3806189 , PMID:18590716 cell fate specification IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to cholesterol ISO RGD:735969 1624291 (PMID:21931618) RGD PMID:21931618 cellular response to cholesterol IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 central nervous system development ISO RGD:735969 1624291 MGI:MGI:95729 (MGI:MGI:2445271 , PMID:12435628) RGD MGI:MGI:2445271 , PMID:12435628 central nervous system development IBA MGI:MGI:108075 more ... 13792537 PMID:21873635 GO_Central central nervous system neuron differentiation ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:3624182 , PMID:16571630 central nervous system neuron differentiation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 cerebellar cortex morphogenesis ISO RGD:735969 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3624180 , PMID:16571625 cerebellar cortex morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 cerebral cortex development ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:5510940 , PMID:23680462) RGD MGI:MGI:5510940 , PMID:23680462 cerebral cortex development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 commissural neuron axon guidance IMP 12879429 RGD commissural neuron axon guidance IBA PANTHER:PTN000885245 , RGD:3726 13792537 PMID:21873635 GO_Central contact inhibition ISO RGD:733306 1624291 (PMID:9422511) RGD PMID:9422511 contact inhibition IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 dentate gyrus development ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:3794243 , PMID:18297065 dentate gyrus development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 determination of left/right asymmetry in lateral mesoderm ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 determination of left/right asymmetry in lateral mesoderm ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 determination of left/right asymmetry in lateral mesoderm IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 determination of left/right symmetry ISO RGD:735969 1624291 MGI:MGI:2137553 more ... RGD MGI:MGI:2389012 more ... developmental growth ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:3624182 , PMID:16571630 digestive tract development ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:4355651 , PMID:19619492) RGD MGI:MGI:4355651 , PMID:19619492 dorsal/ventral neural tube patterning ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:3806189 , PMID:18590716) RGD MGI:MGI:3806189 , PMID:18590716 dorsal/ventral neural tube patterning IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 dorsal/ventral pattern formation ISO RGD:735969 1624291 MGI:MGI:2137553 more ... RGD MGI:MGI:3577662 more ... embryonic organ development ISO RGD:735969 1624291 MGI:MGI:2144467 (MGI:MGI:5544506 , PMID:24302887) RGD MGI:MGI:5544506 , PMID:24302887 epithelial-mesenchymal cell signaling ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3840017 , PMID:19304890) RGD MGI:MGI:3840017 , PMID:19304890 epithelial-mesenchymal cell signaling IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 facial nerve development IEP 1580344 RGD forebrain morphogenesis ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 forebrain morphogenesis ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 forebrain morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 hair follicle morphogenesis ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3696007 , PMID:17199044 hair follicle morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart looping ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 heart looping ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heart looping IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart morphogenesis ISO RGD:735969 1624291 MGI:MGI:101791 (MGI:MGI:3640718 , PMID:16687132) RGD MGI:MGI:3640718 , PMID:16687132 homeostasis of number of cells within a tissue ISO RGD:735969 1624291 (MGI:MGI:5510940, PMID:23680462) RGD MGI:MGI:5510940 , PMID:23680462 homeostasis of number of cells within a tissue IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 in utero embryonic development ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:3766861 , PMID:17881493) RGD MGI:MGI:3766861 , PMID:17881493 in utero embryonic development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 left/right axis specification ISO RGD:735969 1624291 MGI:MGI:2137553 (MGI:MGI:1267118 , PMID:9636176) RGD MGI:MGI:1267118 , PMID:9636176 left/right axis specification IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 mammary gland epithelial cell differentiation ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3696007 , PMID:17199044 mammary gland epithelial cell differentiation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 mesenchymal to epithelial transition involved in metanephric renal vesicle formation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISO RGD:735969 1624291 (MGI:MGI:3611729, PMID:16396903) RGD MGI:MGI:3611729 , PMID:16396903 midgut development ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 midgut development ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 midgut development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 multicellular organism development IEA UniProtKB-KW:KW-0217 1600115 GO_REF:0000043 UniProt GO_REF:0000043 multicellular organism growth ISO RGD:735969 1624291 MGI:MGI:1341070 more ... RGD MGI:MGI:3806189 , PMID:18590716 multicellular organism growth IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 myoblast migration ISO RGD:735969 1624291 MGI:MGI:1927138 (MGI:MGI:5438143 , PMID:22987639) RGD MGI:MGI:5438143 , PMID:22987639 myoblast migration IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:3624182 , PMID:16571630 negative regulation of apoptotic process IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of DNA binding ISO RGD:735969 1624291 MGI:MGI:95729 (MGI:MGI:3611729 , PMID:16396903) RGD MGI:MGI:3611729 , PMID:16396903 negative regulation of DNA binding ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of DNA binding IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of epithelial cell differentiation ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3696007 , PMID:17199044 negative regulation of epithelial cell differentiation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression ISO RGD:735969 1624291 (MGI:MGI:3611729, PMID:16396903) RGD MGI:MGI:3611729 , PMID:16396903 negative regulation of gene expression ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of hair follicle development ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3696007 , PMID:17199044 negative regulation of hair follicle development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron apoptotic process IMP 12879463 RGD negative regulation of neuron death IMP 10400908 RGD negative regulation of transcription by RNA polymerase II ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3840017 , PMID:19304890) RGD MGI:MGI:3840017 , PMID:19304890 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription, DNA-templated ISO RGD:735969 1624291 (MGI:MGI:5619427, PMID:24548465) RGD MGI:MGI:5619427 , PMID:24548465 neural crest cell migration ISO RGD:735969 1624291 MGI:MGI:101791 (MGI:MGI:3640718 , PMID:16687132) RGD MGI:MGI:3640718 , PMID:16687132 neural crest cell migration IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection regeneration IEP 1580344 RGD odontogenesis of dentin-containing tooth ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:2429663 more ... odontogenesis of dentin-containing tooth IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 ossification ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:2154465 , PMID:11748145 osteoblast differentiation IEP 2324984 RGD osteoblast differentiation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 osteoblast differentiation ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3036410 , PMID:14973297) RGD MGI:MGI:3036410 , PMID:14973297 osteoblast proliferation IEP 2324984 RGD pancreas morphogenesis ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:4833770 , PMID:20185815 pancreas morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 pattern specification process ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3040160 , PMID:15107405) RGD MGI:MGI:3040160 , PMID:15107405 positive regulation of branching involved in ureteric bud morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of branching involved in ureteric bud morphogenesis ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of branching involved in ureteric bud morphogenesis ISO RGD:735969 1624291 (MGI:MGI:3611729, PMID:16396903) RGD MGI:MGI:3611729 , PMID:16396903 positive regulation of cell migration IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell migration ISO RGD:733306 1624291 (PMID:21671467) RGD PMID:21671467 positive regulation of cell population proliferation ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:2429663 more ... positive regulation of epithelial cell proliferation ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3840017 , PMID:19304890) RGD MGI:MGI:3840017 , PMID:19304890 positive regulation of epithelial cell proliferation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3611729 more ... RGD MGI:MGI:3611729 more ... positive regulation of gene expression ISO RGD:733306 1624291 (PMID:21671467) RGD PMID:21671467 positive regulation of gene expression ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of hh target transcription factor activity ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 positive regulation of hh target transcription factor activity ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of hh target transcription factor activity IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of mesenchymal cell proliferation ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3840017 , PMID:19304890) RGD MGI:MGI:3840017 , PMID:19304890 positive regulation of mesenchymal cell proliferation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of multicellular organism growth ISO RGD:735969 1624291 (MGI:MGI:5619427, PMID:24548465) RGD MGI:MGI:5619427 , PMID:24548465 positive regulation of multicellular organism growth IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of neural precursor cell proliferation IMP 12832759 RGD positive regulation of neuroblast proliferation ISO RGD:735969 1624291 MGI:MGI:88274 (MGI:MGI:3619284 , PMID:16543460) RGD MGI:MGI:3619284 , PMID:16543460 positive regulation of neuroblast proliferation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of organ growth ISO RGD:735969 1624291 (MGI:MGI:5619427, PMID:24548465) RGD MGI:MGI:5619427 , PMID:24548465 positive regulation of organ growth IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein import into nucleus ISO RGD:735969 1624291 MGI:MGI:95729 more ... RGD MGI:MGI:3686547 , PMID:17043310 positive regulation of protein import into nucleus IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of smoothened signaling pathway ISO RGD:735969 1624291 (MGI:MGI:3616743, PMID:16459297) RGD MGI:MGI:3616743 , PMID:16459297 positive regulation of smoothened signaling pathway IBA MGI:MGI:108075 more ... 13792537 PMID:21873635 GO_Central positive regulation of smoothened signaling pathway IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:735969 1624291 MGI:MGI:2176256 (MGI:MGI:3580742 more ... RGD MGI:MGI:3580742 more ... positive regulation of transcription by RNA polymerase II IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:735969 1624291 (MGI:MGI:5619427, PMID:24548465) RGD MGI:MGI:5619427 , PMID:24548465 positive regulation of vascular associated smooth muscle cell migration IMP 12879462 RGD protein localization to nucleus ISO RGD:735969 1624291 (MGI:MGI:4398748, PMID:19952108) RGD MGI:MGI:4398748 , PMID:19952108 protein localization to nucleus IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein stabilization ISO RGD:735969 1624291 (MGI:MGI:3836883, PMID:19124651) RGD MGI:MGI:3836883 , PMID:19124651 protein stabilization IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of gene expression ISO RGD:735969 1624291 MGI:MGI:1341070 (MGI:MGI:3806189 , PMID:18590716) RGD MGI:MGI:3806189 , PMID:18590716 regulation of heart morphogenesis ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 regulation of heart morphogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of stem cell population maintenance ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3696007 , PMID:17199044 regulation of stem cell population maintenance IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to organic substance IEP 2324989 para-chloroamphetamine, para-chlorophenylalanine RGD response to wounding IEP 1580344 RGD skeletal muscle fiber development ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:5438143 , PMID:22987639 skeletal muscle fiber development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 smooth muscle tissue development ISO RGD:733306 1624291 (PMID:17850284) RGD PMID:17850284 smooth muscle tissue development IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 smoothened signaling pathway IEA InterPro:IPR026544 1600115 GO_REF:0000002 InterPro GO_REF:0000002 smoothened signaling pathway IBA FB:FBgn0003444 more ... 13792537 PMID:21873635 GO_Central smoothened signaling pathway ISO RGD:735969 1624291 MGI:MGI:1934268 more ... RGD MGI:MGI:3040160 more ... smoothened signaling pathway ISS UniProtKB:Q99835 1600115 GO_REF:0000024 UniProt GO_REF:0000024 smoothened signaling pathway ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 smoothened signaling pathway ISO RGD:733306 1624291 (PMID:17850284), (PMID:19304771), (PMID:21177415), (PMID:9422511) RGD PMID:17850284 more ... smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation ISO RGD:735969 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3624180 , PMID:16571625 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 smoothened signaling pathway involved in ventral spinal cord patterning ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:3841503 more ... RGD MGI:MGI:3841503 more ... smoothened signaling pathway involved in ventral spinal cord patterning IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 somite development ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 somite development ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 somite development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 spermatogenesis IEP 2324985 RGD thalamus development ISO RGD:735969 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3840719 , PMID:19357274 thalamus development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 type B pancreatic cell development ISO RGD:735969 1624291 MGI:MGI:2176256 more ... RGD MGI:MGI:4833770 , PMID:20185815 type B pancreatic cell development IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 vasculogenesis ISO RGD:735969 1624291 MGI:MGI:2176255 (MGI:MGI:3051693 more ... RGD MGI:MGI:3051693 more ... vasculogenesis IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventral midline determination ISO RGD:735969 1624291 (MGI:MGI:5142377, PMID:11517919) RGD MGI:MGI:5142377 , PMID:11517919 ventral midline determination IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component 9+0 non-motile cilium IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 axonal growth cone IDA 5509937 young hippocampal neurons RGD caveola colocalizes_with ISO RGD:733306 1624291 (PMID:11278759) RGD PMID:11278759 caveola IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 ciliary membrane ISO RGD:735969 1624291 (MGI:MGI:5300833, PMID:22179047) RGD MGI:MGI:5300833 , PMID:22179047 ciliary membrane IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 cilium ISO RGD:733306 1624291 (PMID:27727273) RGD PMID:27727273 cilium IBA FB:FBgn0003444 more ... 13792537 PMID:21873635 GO_Central cilium ISO RGD:735969 1624291 (MGI:MGI:3606828 more ... RGD MGI:MGI:3606828 more ... cilium ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytoplasm IDA 2324985 RGD cytoplasm ISO RGD:735969 1624291 (MGI:MGI:3804352, PMID:18488998) RGD MGI:MGI:3804352 , PMID:18488998 dendrite IDA 5509937 mature hippocampal neurons RGD dendrite IBA FB:FBgn0003444 more ... 13792537 PMID:21873635 GO_Central dendritic growth cone IDA 5509937 young hippocampal neurons RGD Golgi apparatus colocalizes_with ISO RGD:733306 1624291 (PMID:11278759) RGD PMID:11278759 Golgi apparatus IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IBA FB:FBgn0001085 more ... 13792537 PMID:21873635 GO_Central integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 intracellular membrane-bounded organelle ISO RGD:733306 1624291 (PMID:11278759) RGD PMID:11278759 neuronal cell body IDA 1580344 RGD nucleus IDA 12832755 RGD plasma membrane ISO RGD:733306 1624291 (PMID:19304771) RGD PMID:19304771 plasma membrane IBA FB:FBgn0016797 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISS UniProtKB:Q99835 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane TAS 1600115 Reactome:R-NUL-517521 Reactome Reactome:R-NUL-517521 plasma membrane ISO RGD:735969 1624291 (MGI:MGI:5306540, PMID:21931618) RGD MGI:MGI:5306540 , PMID:21931618 postsynaptic density IDA 5509937 mature hippocampal neurons RGD Molecular Function drug binding ISO RGD:733306 1624291 (PMID:21177415) RGD PMID:21177415 drug binding ISS UniProtKB:Q99835 1600115 GO_REF:0000024 UniProt GO_REF:0000024 drug binding ISS UniProtKB:P56726 1600115 GO_REF:0000024 UniProt GO_REF:0000024 drug binding ISO RGD:735969 1624291 (MGI:MGI:5285138, PMID:21177415) RGD MGI:MGI:5285138 , PMID:21177415 drug binding IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 drug binding IEA UniProtKB:P56726 , ensembl:ENSMUSP000000018121600115 GO_REF:0000107 Ensembl GO_REF:0000107 G protein-coupled receptor activity IEA UniProtKB-KW:KW-0297 1600115 GO_REF:0000043 UniProt GO_REF:0000043 molecular_function ND 1598407 11/2011: no relevant rat data RGD patched binding ISO RGD:733306 1624291 UniProtKB:Q13635 , UniProtKB:Q9Y6C5 (PMID:9811851) RGD PMID:9811851 patched binding IBA PANTHER:PTN000885245 , UniProtKB:Q99835 13792537 PMID:21873635 GO_Central patched binding IEA UniProtKB:Q99835 , ensembl:ENSP000002493731600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:733306 1624291 UniProtKB:O95995 , UniProtKB:Q2M1P5 (PMID:19592253), (PMID:21659505) RGD PMID:19592253 , PMID:21659505 protein binding ISO RGD:735969 1624291 UniProtKB:B7ZNG0 more ... RGD MGI:MGI:5617062 more ... transmembrane signaling receptor activity IEA InterPro:IPR017981 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
