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Gene: Smo (smoothened, frizzled class receptor) Rattus norvegicus
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Symbol: Smo
Name: smoothened, frizzled class receptor
Description: Predicted to have drug binding activity and patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including the growth cone; neuronal cell body; and postsynaptic density. Predicted to colocalize with the Golgi apparatus and caveola. Used to study middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Smoh; Smoothened; smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled family receptor
Orthologs:
Homo sapiens (human) : SMO (smoothened, frizzled class receptor)  HGNC  Alliance
Mus musculus (house mouse) : Smo (smoothened, frizzled class receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smo (smoothened, frizzled class receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : SMO (smoothened, frizzled class receptor)
Canis lupus familiaris (dog) : SMO (smoothened, frizzled class receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smo (smoothened, frizzled class receptor)
Sus scrofa (pig) : SMO (smoothened, frizzled class receptor)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0457,019,941 - 57,041,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0456,787,102 - 56,809,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,623,494 - 56,645,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,898,313 - 56,920,866 (+)NCBI
Celera453,450,322 - 53,474,674 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Comparative Map Data
QTLs in Region (Rnor_6.0)
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Sequence

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Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Smo
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3726
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.