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Gene: Smo (smoothened, frizzled class receptor) Rattus norvegicus
Symbol: Smo
Name: smoothened, frizzled class receptor
Description: Predicted to have drug binding activity and patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Predicted to colocalize with Golgi apparatus and caveola. Used to study middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; aflatoxin B1.
Type: protein-coding
Also known as: Smoh; Smoothened; smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled family receptor
Homo sapiens (human) : SMO (smoothened, frizzled class receptor)  HGNC  Alliance
Mus musculus (house mouse) : Smo (smoothened, frizzled class receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smo (smoothened, frizzled class receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : SMO (smoothened, frizzled class receptor)
Canis lupus familiaris (dog) : SMO (smoothened, frizzled class receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smo (smoothened, frizzled class receptor)
Sus scrofa (pig) : SMO (smoothened, frizzled class receptor)
Chlorocebus sabaeus (African green monkey) : SMO (smoothened, frizzled class receptor)
Heterocephalus glaber (naked mole-rat) : Smo (smoothened, frizzled class receptor)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0457,019,941 - 57,041,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,019,941 - 57,042,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,787,102 - 56,809,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4456,623,494 - 56,645,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,898,313 - 56,920,866 (+)NCBI
Celera453,450,322 - 53,474,674 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smo
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3726
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.