Mest (mesoderm specific transcript)

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Gene: Mest (mesoderm specific transcript) Rattus norvegicus

Analyze

Symbol:

Mest

Name:

mesoderm specific transcript

RGD ID:

1594589

Description:

Predicted to enable hydrolase activity. Predicted to be involved in regulation of lipid storage and response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human MEST (mesoderm specific transcript); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,7-dihydropurine-6-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

mesoderm specific transcript homolog; mesoderm specific transcript homolog (mouse); mesoderm-specific transcript homolog protein; MGC73011

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEST (mesoderm specific transcript)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Mest (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mest (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEST (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEST (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mest (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEST (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEST (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mest (mesoderm specific transcript)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MEST (mesoderm specific transcript)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mest (mesoderm specific transcript)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mest (mesoderm specific transcript)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	59,354,445 - 59,364,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	59,354,447 - 59,366,145 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	64,332,471 - 64,342,948 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	60,248,654 - 60,259,132 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	58,650,583 - 58,661,061 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	58,052,786 - 58,063,227 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	58,053,041 - 58,063,138 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	57,811,101 - 57,821,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	54,452,983 - 54,463,392 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Barth syndrome (ISS)

Childhood Schizophrenia (ISO)

pleomorphic xanthoastrocytoma (ISO)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,7-dihydropurine-6-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

casticin (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

Didecyldimethylammonium (ISO)

diosgenin (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

lead diacetate (ISO)

mercaptopurine (EXP)

methoxychlor (ISO)

methyl methanesulfonate (ISO)

mitoxantrone (ISO)

N-nitrosodiethylamine (EXP)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

purine-6-thiol (EXP)

rimonabant (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sotorasib (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (ISO)

trametinib (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of lipid storage (ISO)

response to retinoic acid (ISO)

Cellular Component

endoplasmic reticulum (IBA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

catalytic activity (IEA)

hydrolase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18439490	PMID:18644838	PMID:19199708

Genomics

Comparative Map Data

Mest
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	59,354,445 - 59,364,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	59,354,447 - 59,366,145 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	64,332,471 - 64,342,948 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	60,248,654 - 60,259,132 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	58,650,583 - 58,661,061 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	58,052,786 - 58,063,227 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	58,053,041 - 58,063,138 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	57,811,101 - 57,821,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	54,452,983 - 54,463,392 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

MEST
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	130,486,175 - 130,506,465 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	130,486,171 - 130,506,465 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	130,126,016 - 130,146,306 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	129,913,282 - 129,933,369 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	129,725,123 - 129,740,080	NCBI
Celera	7	124,921,818 - 124,941,908 (+)	NCBI		Celera
Cytogenetic Map	7	q32.2	NCBI
HuRef	7	124,488,506 - 124,508,626 (+)	NCBI		HuRef
CHM1_1	7	130,059,437 - 130,079,559 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	131,799,896 - 131,820,184 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	129,511,419 - 129,531,544 (+)	NCBI

Mest
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	30,733,505 - 30,783,580 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	30,723,546 - 30,748,464 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	30,733,506 - 30,748,466 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	30,723,547 - 30,748,465 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	30,688,063 - 30,698,457 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	30,688,073 - 30,698,467 (+)	NCBI		MGSCv36	mm8
Celera	6	30,747,989 - 30,758,382 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	12.53	NCBI

Mest
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	11,122,007 - 11,135,061 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	11,116,705 - 11,135,061 (+)	NCBI	ChiLan1.0	ChiLan1.0

MEST
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	134,968,531 - 134,988,560 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	134,968,638 - 134,988,564 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	122,450,524 - 122,470,855 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MEST
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	6,435,693 - 6,454,358 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	6,436,649 - 6,449,099 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	6,125,719 - 6,144,389 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	6,199,967 - 6,218,643 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	6,199,384 - 6,213,400 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	6,405,014 - 6,423,685 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	6,150,268 - 6,168,916 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	6,293,802 - 6,312,481 (-)	NCBI		UU_Cfam_GSD_1.0

Mest
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	24,648,250 - 24,668,374 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936579	4,782,761 - 4,800,971 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEST
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	18,327,536 - 18,345,843 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	18,319,126 - 18,358,655 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	19,327,977 - 19,348,140 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEST
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	99,121,330 - 99,141,861 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	99,127,403 - 99,140,638 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	4,258,347 - 4,279,119 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mest
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	5,799,057 - 5,811,110 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	5,798,141 - 5,816,595 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mest
53 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	34
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000072698
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	39505275	73892441	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	39524264	74726312	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	102114432	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	58432133	92991462	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	58635877	78886137	Rat

Markers in Region

BE110063

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	59,365,190 - 59,365,342 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	58,063,499 - 58,063,650	NCBI	Rnor6.0
Rnor_5.0	4	57,822,156 - 57,822,307	UniSTS	Rnor5.0
Celera	4	54,463,664 - 54,463,815	UniSTS
RH 3.4 Map	4	347.3	UniSTS
Cytogenetic Map	4	q44	UniSTS
Cytogenetic Map	4	q22	UniSTS

BE110207

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	59,363,826 - 59,364,000 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	58,062,135 - 58,062,308	NCBI	Rnor6.0
Rnor_5.0	4	57,820,792 - 57,820,965	UniSTS	Rnor5.0
Celera	4	54,462,300 - 54,462,473	UniSTS
RH 3.4 Map	4	346.31	UniSTS
Cytogenetic Map	4	q44	UniSTS

BF396313

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	59,362,587 - 59,362,807 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	58,060,896 - 58,061,115	NCBI	Rnor6.0
Rnor_5.0	4	57,819,553 - 57,819,772	UniSTS	Rnor5.0
Celera	4	54,461,061 - 54,461,280	UniSTS
RH 3.4 Map	4	345.32	UniSTS
Cytogenetic Map	4	q44	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High		6							6		5
Medium		26	43	33	10	33	4	5	68	22	27	5	4
Low	3	11	14	8	9	8	4	6		13	8	6	4
Below cutoff											1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC062800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000072698 ⟹ ENSRNOP00000065620

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	59,354,447 - 59,366,145 (+)	Ensembl
Rnor_6.0 Ensembl	4	58,053,041 - 58,063,138 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098738 ⟹ ENSRNOP00000088966

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	59,356,171 - 59,366,145 (+)	Ensembl

RefSeq Acc Id:

NM_001009617 ⟹ NP_001009617

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	59,354,445 - 59,364,919 (+)	NCBI
Rnor_6.0	4	58,052,786 - 58,063,227 (+)	NCBI
Rnor_5.0	4	57,811,101 - 57,821,884 (+)	NCBI
Celera	4	54,452,983 - 54,463,392 (+)	RGD

Sequence:

show sequence

GGGGGCCTCGGCCACCAGCACATCCCGGTGCATCCTCACAGGCGCAGCAGCCTTCCTCTGCGGC
AGCCGCACCTCGCCACCCGGCGTAGTGCTGCAGGCTCGCCCGAGTTGCCGCTTGCTGCCTCTTT
TGTCGCTGCCGCGGGCCGCCCTGCGGACCGTGGGCTGCGCCGAGGCCATCCCCGATCCTGTACC
GCTGTAGGCGCCTCGGCGCGCCCTGTGATCCGCAATCCTGCGGCGGGCGGCATGGGATAATGCG
GCCATGGTGCGCCGAGATCGCTTGCGCAGGATGAGGGAGTGGTGGGTCCAAGTAGGGCTCCTGG
CTGTGCCCTTGCTGGCTGCGTACCTGCACATCCCACCCCCTCAGCTCTCCCCTGCTCTGCACTC
ATGGAAGACTTCTGGCAAGTTTTTCACCTACAAGGGACTACGCATCTTCTACCAAGATTCTGTC
GGCGTGGTGGGAAGCCCTGAGATAGTTGTGCTTTTACATGGCTTTCCGACATCCAGCTATGACT
GGTACAAGATCTGGGAAGGGCTGACCCTGAGGTTCCATCGAGTGATTGCCCTGGATTTCTTAGG
CTTTGGCTTCAGTGACAAGCCGAGACCACATCAGTATTCCATATTTGAGCAGGCCAGCATCGTA
GAGTCCCTTCTGCGGCACCTGGGGCTCCAGAACCGCAGAATCAACCTACTGTCTCACGACTATG
GGGATATTGTTGCTCAGGAGCTGCTGTACAGGTACAAGCAGAATCGTTCTGGCCGTCTCACCAT
AAAGAGTCTCTGTCTGTCGAATGGAGGTATCTTTCCTGAGACCCATCGTCCTCTCCTTCTCCAA
AAGCTCCTCAAAGACGGAGGTGTGCTTTCACCCATCCTCACCAGGCTCATGAACTTCTTTGTGT
TCTCTCGAGGTCTCACTCCAGTCTTTGGACCATATACTCGACCCACTGAGAGTGAGCTGTGGGA
CATGTGGGCTGGGATTCGCAACAATGACGGGAACCTGGTCATTGACAGTCTTTTACAGTACATC
AATCAAAGGAAGAAATTTAGAAGACGCTGGGTGGGAGCACTTGCTTCTGTGACCATCCCCATTC
ATTTTATCTATGGGCCATTGGATCCTATAAATCCGTATCCAGAGTTTTTGGAGCTGTACAGGAA
AACGCTGCCGCGGTCCACAGTGTCGATTCTGGATGACCACATTAGCCACTACCCACAGCTAGAG
GATCCCATGGGCTTCTTGAATGCATATATGGGCTTCATCAACTCCTTCTGAGCTGGAAAGAGTA
GCTTCCCTGTATTACCTCCCCCATTCTCGTATCTGTGTGTATTCCACTTAGAAATGCCCCAAAG
AGGTCCTGGTCAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001009617	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62800	(Get FASTA)	NCBI Sequence Viewer
	EDM15263	(Get FASTA)	NCBI Sequence Viewer
	EDM15264	(Get FASTA)	NCBI Sequence Viewer
	EDM15265	(Get FASTA)	NCBI Sequence Viewer
	Q6P5P5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001009617 ⟸ NM_001009617

- UniProtKB:

Q6P5P5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVG
VVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVE
SLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQK
LLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAGIRNNDGNLVIDSLLQYIN
QRKKFRRRWVGALASVTIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLED
PMGFLNAYMGFINSF

hide sequence

RefSeq Acc Id:

ENSRNOP00000065620 ⟸ ENSRNOT00000072698

RefSeq Acc Id:

ENSRNOP00000088966 ⟸ ENSRNOT00000098738

Protein Domains

AB hydrolase-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P5P5-F1-model_v2	AlphaFold	Q6P5P5	1-335	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1594589	AgrOrtholog
BioCyc Gene	G2FUF-45339	BioCyc
Ensembl Genes	ENSRNOG00000048088	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000065620	ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOP00000088966.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072698	ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOT00000098738.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6889877	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AB_hydrolase_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Epox_hydrolase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:58827	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:73011	IMAGE-MGC_LOAD
NCBI Gene	58827	ENTREZGENE
Pfam	Abhydrolase_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mest	PhenoGen
PRINTS	EPOXHYDRLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A954_RAT	UniProtKB/TrEMBL
	M0R830_RAT	UniProtKB/TrEMBL
	MEST_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-14	Mest	mesoderm specific transcript	Mest	mesoderm specific transcript homolog (mouse)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-12-15	Mest	mesoderm specific transcript homolog (mouse)	Mest	mesoderm specific transcript	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	Mest	mesoderm specific transcript			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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