Vhl (von Hippel-Lindau tumor suppressor) - Rat Genome Database

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Gene: Vhl (von Hippel-Lindau tumor suppressor) Rattus norvegicus
Analyze
Symbol: Vhl
Name: von Hippel-Lindau tumor suppressor
RGD ID: 3960
Description: Predicted to enable several functions, including DNA-binding transcription factor binding activity; transcription elongation regulator activity; and ubiquitin ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of catecholamine metabolic process; and response to ethanol. Located in cytosol; mitochondrion; and nucleus. Part of VCB complex. Used to study Parkinsonism. Biomarker of nephroblastoma and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor); PARTICIPATES IN hypoxia inducible factor pathway; altered hypoxia inducible factor pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pVHL; Vhlh; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome; von Hippel-Lindau syndrome homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Vhll  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,772,483 - 146,779,376 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4146,772,468 - 146,779,377 (+)Ensembl
Rnor_6.04145,580,869 - 145,587,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,580,799 - 145,587,845 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,877,266 - 208,884,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,529,396 - 149,536,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,774,236 - 149,781,130 (+)NCBI
Celera4135,326,806 - 135,333,699 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
blood vessel endothelial cell migration  (ISO)
camera-type eye morphogenesis  (ISO)
ciliary body morphogenesis  (ISO)
endothelial cell differentiation  (IEA,ISO)
extracellular matrix organization  (ISO)
eye pigmentation  (ISO)
homeostasis of number of retina cells  (ISO)
hypoxia-inducible factor-1alpha signaling pathway  (IEA,ISO)
iris morphogenesis  (ISO)
melanin metabolic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hypoxia-inducible factor-1alpha signaling pathway  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of thymocyte apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of transcription elongation from RNA polymerase II promoter  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  (ISO)
neuron differentiation  (IDA)
pancreatic A cell differentiation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
proteasomal protein catabolic process  (ISO)
protein catabolic process  (ISO)
protein transport  (ISO)
protein ubiquitination  (IBA,IEA,ISO)
regulation of apoptotic signaling pathway  (ISO)
regulation of catecholamine metabolic process  (IMP)
regulation of gene expression  (ISO)
regulation of postsynapse organization  (ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
regulation of protein localization  (ISO)
regulation of thymocyte apoptotic process  (ISO)
regulation of transcription, DNA-templated  (IDA,ISO)
response to ethanol  (IEP)
response to hypoxia  (IMP)
type B pancreatic cell differentiation  (ISO)

Cellular Component

References

References - curated
1. Assadi F and Brackbill EL, Am J Kidney Dis. 2003 Jan;41(1):E3.
2. Audenet F, etal., BJU Int. 2012 Jun;109(12):1864-70. doi: 10.1111/j.1464-410X.2011.10661.x. Epub 2011 Oct 28.
3. Bauer AL, etal., Cancer Res 2002 Mar 15;62(6):1682-7.
4. Chen G, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Apr;29(2):220-6. Epub 2009 Apr 28.
5. Choy MK, etal., J Cell Physiol. 2010 Mar;222(3):635-9.
6. Curley SA, etal., Ann Surg. 1998 Feb;227(2):229-35.
7. Duan DR, etal., Proc Natl Acad Sci U S A 1995 Jul 3;92(14):6459-63.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Higashida T, etal., J Neurosurg. 2010 Mar 19.
10. Kamura T, etal., Genes Dev. 2004 Dec 15;18(24):3055-65.
11. Kamura T, etal., Science. 1999 Apr 23;284(5414):657-61.
12. Kikuchi Y, etal., Jpn J Cancer Res. 1995 Oct;86(10):905-9.
13. Kim WY and Kaelin WG, J Clin Oncol 2004 Dec 15;22(24):4991-5004.
14. Li J, etal., Exp Mol Pathol. 2004 Dec;77(3):184-92.
15. Melnikov AA, etal., J Surg Oncol. 2009 Feb 1;99(2):119-22.
16. MGD data from the GO Consortium
17. NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline
19. Pause A, etal., Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.
20. Perrotta S, etal., Blood. 2006 Jan 15;107(2):514-9. Epub 2005 Oct 6.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Rafty LA and Khachigian LM, J Cell Biochem 2002;85(3):490-5.
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Schmitt AM, etal., Endocr Relat Cancer. 2009 Dec;16(4):1219-27. Epub 2009 Aug 18.
28. Schnell PO, etal., J Neurochem 2003 Apr;85(2):483-91.
29. Seeburg PH, etal., Cold Spring Harb Symp Quant Biol 1990;55(48):29-40.
30. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
31. Shiao YH, etal., Cancer Lett 2002 May 8;179(1):33-8.
32. Shiao YH, etal., Cancer Res. 2000 Jun 1;60(11):2816-9.
33. Wang YQ, etal., Biochem Biophys Res Commun. 2004 Apr 30;317(2):358-62.
34. Yamazaki Y, etal., Neuroreport. 2010 Mar 10;21(4):287-92.
Additional References at PubMed
PMID:7660122   PMID:8599582   PMID:11641274   PMID:12169691   PMID:12604794   PMID:12832481   PMID:15010533   PMID:15094462   PMID:15181450   PMID:15456877   PMID:15824735   PMID:16129783  
PMID:16537898   PMID:17519558   PMID:17825299   PMID:17942596   PMID:17973242   PMID:17981124   PMID:22506063   PMID:22627278   PMID:23338840   PMID:24899725   PMID:25186293   PMID:25779090  
PMID:26972007   PMID:27324785   PMID:29401731   PMID:33309718  


Genomics

Comparative Map Data
Vhl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,772,483 - 146,779,376 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4146,772,468 - 146,779,377 (+)Ensembl
Rnor_6.04145,580,869 - 145,587,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,580,799 - 145,587,845 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,877,266 - 208,884,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,529,396 - 149,536,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,774,236 - 149,781,130 (+)NCBI
Celera4135,326,806 - 135,333,699 (+)NCBICelera
Cytogenetic Map4q42NCBI
VHL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38310,141,778 - 10,153,667 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl310,141,778 - 10,153,667 (+)EnsemblGRCh38hg38GRCh38
GRCh37310,183,462 - 10,195,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,158,319 - 10,168,762 (+)NCBINCBI36hg18NCBI36
Build 34310,158,318 - 10,168,744NCBI
Celera310,118,983 - 10,129,426 (+)NCBI
Cytogenetic Map3p25.3NCBI
HuRef310,119,232 - 10,131,274 (+)NCBIHuRef
CHM1_1310,133,330 - 10,145,363 (+)NCBICHM1_1
Vhl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,600,955 - 113,608,595 (+)NCBIGRCm39mm39
GRCm39 Ensembl6113,600,920 - 113,608,594 (+)Ensembl
GRCm386113,623,994 - 113,631,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,623,959 - 113,631,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,574,015 - 113,581,627 (+)NCBIGRCm37mm9NCBIm37
MGSCv366113,589,798 - 113,597,410 (+)NCBImm8
Celera6115,450,882 - 115,458,459 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.81NCBI
Vhl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,573,525 - 1,580,511 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,573,525 - 1,578,295 (+)NCBIChiLan1.0ChiLan1.0
VHL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1310,430,143 - 10,440,234 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,430,143 - 10,440,234 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0310,077,630 - 10,089,499 (+)NCBIMhudiblu_PPA_v0panPan3
VHL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,206,616 - 8,211,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,206,616 - 8,211,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,240,602 - 8,245,270 (-)NCBI
ROS_Cfam_1.0208,235,897 - 8,240,567 (-)NCBI
ROS_Cfam_1.0 Ensembl208,234,824 - 8,240,587 (-)Ensembl
UMICH_Zoey_3.1207,958,176 - 7,962,844 (-)NCBI
UNSW_CanFamBas_1.0208,303,525 - 8,308,231 (-)NCBI
UU_Cfam_GSD_1.0208,277,313 - 8,281,981 (-)NCBI
Vhl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,769,090 - 15,776,167 (+)NCBI
SpeTri2.0NW_0049366023,135,790 - 3,140,622 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VHL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,334,591 - 66,342,654 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,334,535 - 66,342,401 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,406,841 - 73,414,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VHL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,184,621 - 46,203,065 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2246,184,756 - 46,204,428 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041120,354,296 - 120,362,332 (-)NCBIVero_WHO_p1.0
Vhl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247315,350,912 - 5,359,286 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH128791  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,779,079 - 146,779,291 (+)MAPPERmRatBN7.2
Rnor_6.04145,587,539 - 145,587,750NCBIRnor6.0
Rnor_5.04208,883,938 - 208,884,149UniSTSRnor5.0
RGSC_v3.44149,535,993 - 149,536,204UniSTSRGSC3.4
Celera4135,333,403 - 135,333,614UniSTS
RH 3.4 Map4947.8UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
UniSTS:235523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,778,951 - 146,779,160 (+)MAPPERmRatBN7.2
Rnor_6.04145,587,411 - 145,587,619NCBIRnor6.0
Rnor_5.04208,883,810 - 208,884,018UniSTSRnor5.0
RGSC_v3.44149,535,865 - 149,536,073UniSTSRGSC3.4
Celera4135,333,275 - 135,333,483UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS
PMC23053P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,772,705 - 146,772,815 (+)MAPPERmRatBN7.2
Rnor_6.04145,581,092 - 145,581,201NCBIRnor6.0
Rnor_5.04208,877,489 - 208,877,598UniSTSRnor5.0
RGSC_v3.44149,529,619 - 149,529,728UniSTSRGSC3.4
Celera4135,327,029 - 135,327,138UniSTS
Cytogenetic Map4q41.3-q42.1UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:184
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000013727
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 26 10 19 10 1 1 74 35 41 11 1
Low 9 31 31 31 7 10 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013727   ⟹   ENSRNOP00000013727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,772,468 - 146,779,377 (+)Ensembl
Rnor_6.0 Ensembl4145,580,799 - 145,587,845 (+)Ensembl
RefSeq Acc Id: NM_052801   ⟹   NP_434688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24146,772,483 - 146,779,376 (+)NCBI
Rnor_6.04145,580,869 - 145,587,835 (+)NCBI
Rnor_5.04208,877,266 - 208,884,234 (+)NCBI
RGSC_v3.44149,529,396 - 149,536,289 (+)RGD
Celera4135,326,806 - 135,333,699 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_434688   ⟸   NM_052801
- UniProtKB: Q64259 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013727   ⟸   ENSRNOT00000013727

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64259-F1-model_v2 AlphaFold Q64259 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693310
Promoter ID:EPDNEW_R3834
Type:multiple initiation site
Name:Vhl_1
Description:von Hippel-Lindau tumor suppressor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,580,848 - 145,580,908EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3960 AgrOrtholog
BioCyc Gene G2FUF-43370 BioCyc
Ensembl Genes ENSRNOG00000010258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013727 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013727 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.750.10 UniProtKB/Swiss-Prot
  2.60.40.780 UniProtKB/Swiss-Prot
InterPro VHL UniProtKB/Swiss-Prot
  VHL_alpha_dom UniProtKB/Swiss-Prot
  VHL_alpha_dom_sf UniProtKB/Swiss-Prot
  VHL_beta_dom UniProtKB/Swiss-Prot
  VHL_beta_dom_sf UniProtKB/Swiss-Prot
  VHL_sf UniProtKB/Swiss-Prot
  VHL_tumour_suppress_b/a_dom UniProtKB/Swiss-Prot
KEGG Report rno:24874 UniProtKB/Swiss-Prot
NCBI Gene 24874 ENTREZGENE
PANTHER PTHR15160:SF10 UniProtKB/Swiss-Prot
Pfam VHL UniProtKB/Swiss-Prot
  VHL_C UniProtKB/Swiss-Prot
PharmGKB VHL RGD
PhenoGen Vhl PhenoGen
Superfamily-SCOP SSF49468 UniProtKB/Swiss-Prot
UniProt Q64259 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q64197 UniProtKB/Swiss-Prot
  Q80WY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Vhl  von Hippel-Lindau tumor suppressor  Vhl  von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-26 Vhl  von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase  Vhl  von Hippel-Lindau tumor suppressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Vhl  von Hippel-Lindau tumor suppressor  Vhlh  von Hippel-Lindau syndrome homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Vhlh  von Hippel-Lindau syndrome homolog  Vhl  von Hippel-Lindau tumor suppressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Vhl  von Hippel-Lindau tumor suppressor  Vhl  von Hippel-Lindau syndrome homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Vhl  von Hippel-Lindau syndrome homolog    von Hippel-Lindau syndrome  Name updated 629478 APPROVED
2002-06-10 Vhl  von Hippel-Lindau syndrome      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may translocate between the nucleus and cytosol 730251
gene_disease human homolog often observed to be mutated in renal clear cell type carcinoma 625549
gene_disease downregulated in nitrosoamine-induced eosinophilic epithelial tumors and nitrosoethyl urea induced nephroblastomas 625549
gene_disease mutation of the human homolog is associated with von Hippel-Lindau disease and with sporadic renal carcinoma 730251
gene_expression expressed in adult kidney and 16-day fetal kidney 625549
gene_product 20 and 22kDa protein 625549