Igf2bp3 (insulin-like growth factor 2 mRNA binding protein 3) - Rat Genome Database

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Gene: Igf2bp3 (insulin-like growth factor 2 mRNA binding protein 3) Rattus norvegicus
Analyze
Symbol: Igf2bp3
Name: insulin-like growth factor 2 mRNA binding protein 3
RGD ID: 1306512
Description: Predicted to enable N6-methyladenosine-containing RNA reader activity; mRNA 3'-UTR binding activity; and mRNA 5'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be active in cytosol and nucleus. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-255; insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; LOC312320; RGD1306512; similar to igf2 mRNA-binding protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,391,367 - 79,525,923 (-)NCBIGRCr8
mRatBN7.2478,060,494 - 78,195,007 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl478,060,494 - 78,194,865 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,269,661 - 83,402,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0479,045,139 - 79,177,835 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,485,441 - 77,618,137 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,744,683 - 78,879,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,746,547 - 78,879,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,433,379 - 143,568,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4477,213,559 - 77,228,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,487,753 - 77,623,158 (-)NCBI
Celera472,996,368 - 73,130,584 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
N-nitrosodimethylamine  (EXP)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytoplasmic stress granule  (ISO)
cytosol  (IBA,ISO)
nucleus  (IBA)
P-body  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9891060   PMID:20080952   PMID:22658674   PMID:22681889   PMID:23621518   PMID:35352799  


Genomics

Comparative Map Data
Igf2bp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,391,367 - 79,525,923 (-)NCBIGRCr8
mRatBN7.2478,060,494 - 78,195,007 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl478,060,494 - 78,194,865 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,269,661 - 83,402,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0479,045,139 - 79,177,835 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,485,441 - 77,618,137 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,744,683 - 78,879,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,746,547 - 78,879,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,433,379 - 143,568,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4477,213,559 - 77,228,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,487,753 - 77,623,158 (-)NCBI
Celera472,996,368 - 73,130,584 (-)NCBICelera
Cytogenetic Map4q24NCBI
IGF2BP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38723,310,209 - 23,470,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl723,310,209 - 23,470,491 (-)EnsemblGRCh38hg38GRCh38
GRCh37723,349,828 - 23,510,110 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36723,316,353 - 23,476,520 (-)NCBINCBI36Build 36hg18NCBI36
Celera723,336,115 - 23,496,228 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef723,232,126 - 23,392,057 (-)NCBIHuRef
CHM1_1723,350,413 - 23,510,906 (-)NCBICHM1_1
T2T-CHM13v2.0723,446,649 - 23,606,903 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2723,401,705 - 23,561,835 (-)NCBI
Igf2bp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39649,062,152 - 49,200,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl649,062,157 - 49,191,891 (-)EnsemblGRCm39 Ensembl
GRCm38649,085,218 - 49,215,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl649,085,223 - 49,214,957 (-)EnsemblGRCm38mm10GRCm38
MGSCv37649,035,217 - 49,164,953 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36649,014,807 - 49,144,299 (-)NCBIMGSCv36mm8
Celera649,595,319 - 49,724,863 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.82NCBI
Igf2bp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541025,605,323 - 25,731,169 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541025,605,323 - 25,734,845 (-)NCBIChiLan1.0ChiLan1.0
IGF2BP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2628,176,554 - 28,330,030 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1776,501,280 - 76,654,760 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,994,839 - 24,148,709 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,602,905 - 23,755,414 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl723,602,905 - 23,755,473 (-)Ensemblpanpan1.1panPan2
IGF2BP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,969,128 - 37,120,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,971,420 - 37,120,193 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,509,804 - 36,661,057 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,899,592 - 37,050,855 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,901,884 - 37,051,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11437,014,655 - 37,165,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,710,919 - 36,862,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01437,048,010 - 37,199,653 (-)NCBIUU_Cfam_GSD_1.0
Igf2bp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511881,245,124 - 81,384,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936478458,871 - 595,742 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936478456,369 - 595,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2BP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl992,104,848 - 92,272,211 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1992,104,786 - 92,272,264 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,678,002 - 101,811,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGF2BP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12134,846,383 - 34,999,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2134,954,129 - 34,997,439 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604269,607,584 - 69,762,351 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf2bp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,158,020 - 7,319,720 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247397,154,893 - 7,319,724 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf2bp3
926 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:79
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000050994
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat

Markers in Region
D4Rhw15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,122,291 - 78,122,541 (+)MAPPERmRatBN7.2
Rnor_6.0478,806,472 - 78,806,721NCBIRnor6.0
Rnor_5.04143,495,503 - 143,495,752UniSTSRnor5.0
RGSC_v3.4477,274,454 - 77,274,703UniSTSRGSC3.4
Celera473,058,120 - 73,058,369UniSTS
Cytogenetic Map4q24RGD
D4Rhw14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,179,858 - 78,180,075 (+)MAPPERmRatBN7.2
Rnor_6.0478,864,418 - 78,864,634NCBIRnor6.0
Rnor_5.04143,553,288 - 143,553,504UniSTSRnor5.0
RGSC_v3.4477,332,017 - 77,332,233UniSTSRGSC3.4
Celera473,115,544 - 73,115,756UniSTS
Cytogenetic Map4q24RGD
RH137367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,062,297 - 78,062,485 (+)MAPPERmRatBN7.2
Rnor_6.0478,746,487 - 78,746,674NCBIRnor6.0
Rnor_5.04143,435,177 - 143,435,364UniSTSRnor5.0
RGSC_v3.4477,213,425 - 77,213,612UniSTSRGSC3.4
Celera472,998,172 - 72,998,359UniSTS
RH 3.4 Map4490.1UniSTS
Cytogenetic Map4q24UniSTS
RH138505  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04143,535,723 - 143,535,852NCBIRnor5.0
RGSC_v3.4477,314,457 - 77,314,585UniSTSRGSC3.4
RH 3.4 Map4499.71UniSTS
Cytogenetic Map4q24UniSTS
BQ201662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,066,904 - 78,067,105 (+)MAPPERmRatBN7.2
Rnor_6.0478,751,094 - 78,751,294NCBIRnor6.0
Rnor_5.04143,439,784 - 143,439,984UniSTSRnor5.0
RGSC_v3.4477,218,032 - 77,218,232UniSTSRGSC3.4
Celera473,002,779 - 73,002,979UniSTS
RH 3.4 Map4490.1UniSTS
Cytogenetic Map4q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 43 41 4 41 43 18 31
Low 3 12 4 10 2 2 20 11 7 8 2
Below cutoff 7 10 5 6 8 11 6 3 3 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001372112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA998402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY724479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000050994   ⟹   ENSRNOP00000044701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl478,062,432 - 78,075,225 (-)Ensembl
Rnor_6.0 Ensembl478,746,621 - 78,759,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084543   ⟹   ENSRNOP00000071626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl478,060,494 - 78,194,865 (-)Ensembl
Rnor_6.0 Ensembl478,746,547 - 78,879,294 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108206   ⟹   ENSRNOP00000088592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl478,062,432 - 78,071,228 (-)Ensembl
RefSeq Acc Id: NM_001372112   ⟹   NP_001359041
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,393,066 - 79,525,730 (-)NCBI
mRatBN7.2478,062,193 - 78,194,865 (-)NCBI
RefSeq Acc Id: XM_017592993   ⟹   XP_017448482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,391,367 - 79,525,840 (-)NCBI
mRatBN7.2478,060,494 - 78,194,974 (-)NCBI
Rnor_6.0478,744,683 - 78,879,457 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286030   ⟹   XP_063142100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,391,367 - 79,524,892 (-)NCBI
RefSeq Acc Id: XM_063286031   ⟹   XP_063142101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,391,367 - 79,525,075 (-)NCBI
RefSeq Acc Id: XM_063286032   ⟹   XP_063142102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,393,057 - 79,457,231 (-)NCBI
RefSeq Acc Id: XM_063286033   ⟹   XP_063142103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,411,997 - 79,525,923 (-)NCBI
RefSeq Acc Id: XM_063286034   ⟹   XP_063142104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,393,057 - 79,445,547 (-)NCBI
RefSeq Acc Id: XP_017448482   ⟸   XM_017592993
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071626   ⟸   ENSRNOT00000084543
RefSeq Acc Id: ENSRNOP00000044701   ⟸   ENSRNOT00000050994
RefSeq Acc Id: NP_001359041   ⟸   NM_001372112
- UniProtKB: A0A0G2K0Y2 (UniProtKB/TrEMBL),   A6K0K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088592   ⟸   ENSRNOT00000108206
RefSeq Acc Id: XP_063142101   ⟸   XM_063286031
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142100   ⟸   XM_063286030
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142102   ⟸   XM_063286032
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142104   ⟸   XM_063286034
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063142103   ⟸   XM_063286033
- Peptide Label: isoform X4
Protein Domains
K Homology   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0Y2-F1-model_v2 AlphaFold A0A0G2K0Y2 1-579 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306512 AgrOrtholog
BioCyc Gene G2FUF-44923 BioCyc
Ensembl Genes ENSRNOG00000009052 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050994.5 UniProtKB/TrEMBL
  ENSRNOT00000084543 ENTREZGENE
  ENSRNOT00000084543.2 UniProtKB/TrEMBL
  ENSRNOT00000108206.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.10 UniProtKB/TrEMBL
  3.30.310.210 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro IPR004087 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  KH_type_1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
NCBI Gene 312320 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 3 UniProtKB/TrEMBL
  KH DOMAIN CONTAINING RNA BINDING PROTEIN UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Igf2bp3 PhenoGen
PROSITE KH_TYPE_1 UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009052 RatGTEx
SMART RRM UniProtKB/TrEMBL
  SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A0G2K0Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9R3_RAT UniProtKB/TrEMBL
  A6K0K4 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP50_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Igf2bp3  insulin-like growth factor 2 mRNA binding protein 3  Igf2bp3  insulin-like growth factor 2, binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Igf2bp3  insulin-like growth factor 2, binding protein 3  RGD1306512  similar to igf2 mRNA-binding protein 3  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1306512  similar to igf2 mRNA-binding protein 3  RGD1306512_predicted  similar to igf2 mRNA-binding protein 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306512_predicted  similar to igf2 mRNA-binding protein 3 (predicted)  LOC312320_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC312320_predicted  similar to igf2 mRNA-binding protein 3 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL