Pdia4 (protein disulfide isomerase family A, member 4) - Rat Genome Database

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Gene: Pdia4 (protein disulfide isomerase family A, member 4) Rattus norvegicus
Analyze
Symbol: Pdia4
Name: protein disulfide isomerase family A, member 4
RGD ID: 619835
Description: Enables protein disulfide isomerase activity. Involved in chaperone-mediated protein folding and positive regulation of protein folding. Located in smooth endoplasmic reticulum. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: caBP2; calcium-binding protein 2; endoplasmic reticulum resident protein 70; endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; ERp-72; Erp70; Erp72; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide-isomerase A4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8478,134,144 - 78,153,191 (-)NCBIGRCr8
mRatBN7.2476,803,198 - 76,822,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl476,803,198 - 76,822,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,015,477 - 82,034,526 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0477,789,815 - 77,808,864 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0476,231,277 - 76,250,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0477,470,636 - 77,489,535 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl477,470,636 - 77,489,535 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04142,140,946 - 142,159,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,929,398 - 75,948,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1476,205,527 - 76,224,429 (-)NCBI
Celera471,752,429 - 71,771,331 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
ceruletide  (EXP)
CGP 52608  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clotrimazole  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diamminedichloroplatinum  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methylparaben  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (EXP)
orotic acid  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
potassium dichromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
transplatin  (ISO)
triadimefon  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
3. Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. Kuznetsov G, etal., J Biol Chem. 1994 Sep 16;269(37):22990-5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Differential cooperative enzymatic activities of protein disulfide isomerase family in protein folding. Satoh M, etal., Cell Stress Chaperones. 2005 Autumn;10(3):211-20.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity. Van PN, etal., Eur J Biochem 1993 Apr 15;213(2):789-95.
Additional References at PubMed
PMID:9006956   PMID:9493907   PMID:12475965   PMID:15489334   PMID:16677074   PMID:17200118   PMID:19446521   PMID:19995400   PMID:22658674   PMID:24239381  


Genomics

Comparative Map Data
Pdia4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8478,134,144 - 78,153,191 (-)NCBIGRCr8
mRatBN7.2476,803,198 - 76,822,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl476,803,198 - 76,822,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,015,477 - 82,034,526 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0477,789,815 - 77,808,864 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0476,231,277 - 76,250,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0477,470,636 - 77,489,535 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl477,470,636 - 77,489,535 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04142,140,946 - 142,159,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,929,398 - 75,948,299 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1476,205,527 - 76,224,429 (-)NCBI
Celera471,752,429 - 71,771,331 (-)NCBICelera
Cytogenetic Map4q24NCBI
PDIA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387149,003,051 - 149,028,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7149,003,062 - 149,028,662 (-)EnsemblGRCh38hg38GRCh38
GRCh377148,700,143 - 148,725,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,331,087 - 148,356,715 (-)NCBINCBI36Build 36hg18NCBI36
Celera7143,370,993 - 143,396,607 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7142,778,950 - 142,804,531 (-)NCBIHuRef
CHM1_17148,708,552 - 148,734,184 (-)NCBICHM1_1
T2T-CHM13v2.07150,185,192 - 150,210,630 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27148,038,519 - 148,064,131 (-)NCBI
Pdia4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,773,075 - 47,790,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl647,773,075 - 47,790,364 (-)EnsemblGRCm39 Ensembl
GRCm38647,796,141 - 47,813,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,796,141 - 47,813,430 (-)EnsemblGRCm38mm10GRCm38
MGSCv37647,746,140 - 47,763,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36647,725,727 - 47,743,098 (-)NCBIMGSCv36mm8
Celera648,328,916 - 48,346,203 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.94NCBI
Pdia4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,344,874 - 4,360,205 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,344,874 - 4,360,205 (-)NCBIChiLan1.0ChiLan1.0
PDIA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26185,587,296 - 185,613,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1737,597,560 - 37,623,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07140,731,333 - 140,757,599 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17153,210,542 - 153,236,721 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7153,210,553 - 153,236,721 (-)Ensemblpanpan1.1panPan2
PDIA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,797,537 - 1,818,877 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,797,552 - 1,818,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha162,896,760 - 2,918,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,601,971 - 1,623,305 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1161,588,802 - 1,610,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0161,448,287 - 1,469,581 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,452,161 - 1,473,485 (+)NCBIUU_Cfam_GSD_1.0
Pdia4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051187,692,798 - 7,714,242 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365275,188,463 - 5,210,629 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365275,189,189 - 5,210,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDIA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9109,252,011 - 109,280,247 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19109,260,850 - 109,280,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29120,198,256 - 120,217,661 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDIA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,574,932 - 117,601,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21117,574,427 - 117,601,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607213,525,893 - 13,553,262 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdia4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248006,723,548 - 6,742,024 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248006,723,567 - 6,742,024 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdia4
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:131
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000008728
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
RH135278  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2476,809,011 - 76,809,170 (+)MAPPERmRatBN7.2
Rnor_6.0477,476,304 - 77,476,462NCBIRnor6.0
Rnor_5.04142,146,614 - 142,146,772UniSTSRnor5.0
RGSC_v3.4475,935,066 - 75,935,224UniSTSRGSC3.4
Celera471,758,098 - 71,758,256UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000008728   ⟹   ENSRNOP00000008728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl476,803,254 - 76,822,107 (-)Ensembl
Rnor_6.0 Ensembl477,470,636 - 77,489,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100487   ⟹   ENSRNOP00000090963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl476,803,198 - 76,817,747 (-)Ensembl
RefSeq Acc Id: NM_053849   ⟹   NP_446301
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8478,134,144 - 78,153,191 (-)NCBI
mRatBN7.2476,803,198 - 76,822,245 (-)NCBI
Rnor_6.0477,470,636 - 77,489,535 (-)NCBI
Rnor_5.04142,140,946 - 142,159,845 (-)NCBI
RGSC_v3.4475,929,398 - 75,948,299 (-)RGD
Celera471,752,429 - 71,771,331 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446301 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19217 (Get FASTA)   NCBI Sequence Viewer  
  AAH61535 (Get FASTA)   NCBI Sequence Viewer  
  EDL88288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008728.4
  ENSRNOP00000090963.1
  ENSRNOP00055036851
  ENSRNOP00060042781
  ENSRNOP00065019935
GenBank Protein P38659 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446301   ⟸   NM_053849
- Peptide Label: precursor
- UniProtKB: Q6P7S5 (UniProtKB/Swiss-Prot),   P38659 (UniProtKB/Swiss-Prot),   G3V6T7 (UniProtKB/TrEMBL),   A6K0C9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008728   ⟸   ENSRNOT00000008728
Ensembl Acc Id: ENSRNOP00000090963   ⟸   ENSRNOT00000100487
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38659-F1-model_v2 AlphaFold P38659 1-643 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693020
Promoter ID:EPDNEW_R3543
Type:initiation region
Name:Pdia4_1
Description:protein disulfide isomerase family A, member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0477,489,376 - 77,489,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619835 AgrOrtholog
BioCyc Gene G2FUF-45008 BioCyc
Ensembl Genes ENSRNOG00000006228 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055026029 UniProtKB/Swiss-Prot
  ENSRNOG00060029601 UniProtKB/Swiss-Prot
  ENSRNOG00065015319 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008728.6 UniProtKB/TrEMBL
  ENSRNOT00000100487.1 UniProtKB/TrEMBL
  ENSRNOT00055044952 UniProtKB/Swiss-Prot
  ENSRNOT00060051427 UniProtKB/Swiss-Prot
  ENSRNOT00065025411 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922170 IMAGE-MGC_LOAD
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDIA4_PDI_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_diS-isomerase_A4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116598 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72734 IMAGE-MGC_LOAD
NCBI Gene 116598 ENTREZGENE
PANTHER PROTEIN DISULFIDE ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN DISULFIDE-ISOMERASE A4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdia4 PhenoGen
PIRSF Disulphide_isom_A4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006228 RatGTEx
  ENSRNOG00055026029 RatGTEx
  ENSRNOG00060029601 RatGTEx
  ENSRNOG00065015319 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AEH8_RAT UniProtKB/TrEMBL
  A6K0C9 ENTREZGENE, UniProtKB/TrEMBL
  G3V6T7 ENTREZGENE, UniProtKB/TrEMBL
  P38659 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P7S5 ENTREZGENE
UniProt Secondary Q6P7S5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-10 Pdia4  protein disulfide isomerase family A, member 4  Pdia4  protein disulfide isomerase associated 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pdia4  protein disulfide isomerase associated 4  Erp70  protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)  Symbol and Name updated 1299863 APPROVED
2005-01-20 Erp70  protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Erp70  protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein protein has three repeats of thioredoxin-like motive and a C-terminal -KEEL retention sequence 632673
gene_regulation expression increases with the increase of immunoglobin heavy-chain-binding protein leading to impaired glycosylation 632673