Cttnbp2 (cortactin binding protein 2) - Rat Genome Database

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Gene: Cttnbp2 (cortactin binding protein 2) Rattus norvegicus
Analyze
Symbol: Cttnbp2
Name: cortactin binding protein 2
RGD ID: 628691
Description: Enables SH3 domain binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Located in synaptic vesicle. Is active in glutamatergic synapse. Orthologous to human CTTNBP2 (cortactin binding protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: brain specific cortactin-binding protein CBP90; Cbp90; cortactin-binding protein 2; Cortbp2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,766,867 - 47,930,598 (-)NCBIGRCr8
mRatBN7.2446,800,975 - 46,964,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,800,981 - 46,964,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx451,794,547 - 51,957,758 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0447,715,681 - 47,878,895 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0446,139,573 - 46,302,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0442,932,897 - 43,096,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl442,932,903 - 43,096,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0442,516,933 - 42,680,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4444,114,097 - 44,277,748 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1444,402,924 - 44,507,501 (-)NCBI
Celera442,060,024 - 42,223,096 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. Chen YK and Hsueh YP, J Neurosci. 2012 Jan 18;32(3):1043-55. doi: 10.1523/JNEUROSCI.4405-11.2012.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Ohoka Y and Takai Y, Genes Cells 1998 Sep;3(9):603-12.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12917688   PMID:24928895   PMID:30053369   PMID:33168105  


Genomics

Comparative Map Data
Cttnbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8447,766,867 - 47,930,598 (-)NCBIGRCr8
mRatBN7.2446,800,975 - 46,964,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl446,800,981 - 46,964,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx451,794,547 - 51,957,758 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0447,715,681 - 47,878,895 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0446,139,573 - 46,302,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0442,932,897 - 43,096,454 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl442,932,903 - 43,096,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0442,516,933 - 42,680,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4444,114,097 - 44,277,748 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1444,402,924 - 44,507,501 (-)NCBI
Celera442,060,024 - 42,223,096 (-)NCBICelera
Cytogenetic Map4q22NCBI
CTTNBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387117,710,651 - 117,873,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7117,710,651 - 117,874,139 (-)EnsemblGRCh38hg38GRCh38
GRCh377117,350,705 - 117,513,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367117,137,941 - 117,300,797 (-)NCBINCBI36Build 36hg18NCBI36
Build 347116,944,658 - 117,107,512NCBI
Celera7112,158,873 - 112,321,703 (-)NCBICelera
Cytogenetic Map7q31.31NCBI
HuRef7111,716,178 - 111,879,317 (-)NCBIHuRef
CHM1_17117,284,164 - 117,447,123 (-)NCBICHM1_1
T2T-CHM13v2.07119,026,042 - 119,189,157 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27116,746,141 - 116,908,979 (-)NCBI
Cttnbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39618,366,470 - 18,515,216 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl618,366,477 - 18,514,842 (-)EnsemblGRCm39 Ensembl
GRCm38618,366,471 - 18,515,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl618,366,478 - 18,514,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv37618,316,477 - 18,464,825 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36618,316,472 - 18,464,869 (-)NCBIMGSCv36mm8
Celera618,439,130 - 18,588,875 (-)NCBICelera
Cytogenetic Map6A2NCBI
cM Map68.12NCBI
Cttnbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543223,364,933 - 23,518,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543223,364,193 - 23,527,300 (-)NCBIChiLan1.0ChiLan1.0
CTTNBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26154,535,118 - 154,697,070 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan176,545,375 - 6,707,311 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07109,675,275 - 109,837,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17122,369,733 - 122,531,604 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7122,370,616 - 122,520,397 (-)Ensemblpanpan1.1panPan2
CTTNBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11456,514,114 - 56,665,437 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1456,514,381 - 56,657,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1455,909,374 - 56,053,305 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01456,553,566 - 56,624,854 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11456,592,187 - 56,735,831 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01456,273,353 - 56,344,334 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01456,644,651 - 56,715,671 (-)NCBIUU_Cfam_GSD_1.0
Cttnbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511845,166,957 - 45,304,112 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365891,393,141 - 1,522,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365891,385,342 - 1,522,911 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTTNBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1828,415,067 - 28,573,159 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11828,130,213 - 28,573,166 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21830,230,103 - 30,342,035 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTTNBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12186,376,005 - 86,539,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2186,376,011 - 86,527,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604217,181,391 - 17,344,562 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cttnbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248271,481,082 - 1,655,871 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248271,481,082 - 1,656,279 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cttnbp2
886 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:60
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000011135
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
RH144522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,858,896 - 46,859,143 (+)MAPPERmRatBN7.2
Rnor_6.0442,990,819 - 42,991,065NCBIRnor6.0
Rnor_5.0442,574,855 - 42,575,101UniSTSRnor5.0
RGSC_v3.4444,172,013 - 44,172,259UniSTSRGSC3.4
Celera442,117,901 - 42,118,147UniSTS
RH 3.4 Map4285.9UniSTS
Cytogenetic Map4q21UniSTS
BF401529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,949,056 - 46,949,227 (+)MAPPERmRatBN7.2
Rnor_6.0443,080,963 - 43,081,133NCBIRnor6.0
Rnor_5.0442,665,169 - 42,665,339UniSTSRnor5.0
RGSC_v3.4444,262,157 - 44,262,327UniSTSRGSC3.4
Celera442,207,705 - 42,207,875UniSTS
RH 3.4 Map4284.8UniSTS
Cytogenetic Map4q21UniSTS
AI045527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,801,275 - 46,801,468 (+)MAPPERmRatBN7.2
Rnor_6.0442,933,198 - 42,933,390NCBIRnor6.0
Rnor_5.0442,517,234 - 42,517,426UniSTSRnor5.0
RGSC_v3.4444,114,392 - 44,114,584UniSTSRGSC3.4
Celera442,060,319 - 42,060,511UniSTS
RH 3.4 Map4298.61UniSTS
Cytogenetic Map4q21UniSTS
BF413676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,909,248 - 46,909,422 (+)MAPPERmRatBN7.2
Rnor_6.0443,041,167 - 43,041,340NCBIRnor6.0
Rnor_5.0442,625,203 - 42,625,376UniSTSRnor5.0
RGSC_v3.4444,222,361 - 44,222,534UniSTSRGSC3.4
Celera442,168,227 - 42,168,400UniSTS
RH 3.4 Map4283.41UniSTS
Cytogenetic Map4q21UniSTS
REN62252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,877,044 - 46,877,276 (+)MAPPERmRatBN7.2
Rnor_6.0443,008,965 - 43,009,196NCBIRnor6.0
Rnor_5.0442,593,001 - 42,593,232UniSTSRnor5.0
RGSC_v3.4444,190,159 - 44,190,390UniSTSRGSC3.4
Celera442,136,047 - 42,136,278UniSTS
Cytogenetic Map4q21UniSTS
REN62251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,877,256 - 46,877,501 (+)MAPPERmRatBN7.2
Rnor_6.0443,009,177 - 43,009,421NCBIRnor6.0
Rnor_5.0442,593,213 - 42,593,457UniSTSRnor5.0
RGSC_v3.4444,190,371 - 44,190,615UniSTSRGSC3.4
Celera442,136,259 - 42,136,503UniSTS
Cytogenetic Map4q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 211 39 9
Low 21 134 176 119 69 119 32 38 39 115 106 48 24
Below cutoff 7 28 28 28 7

Sequence


Ensembl Acc Id: ENSRNOT00000087167   ⟹   ENSRNOP00000072761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl446,800,981 - 46,964,631 (-)Ensembl
Rnor_6.0 Ensembl442,932,903 - 43,096,399 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120156   ⟹   ENSRNOP00000077746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl446,800,981 - 46,964,631 (-)Ensembl
RefSeq Acc Id: NM_001114401   ⟹   NP_001107873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,766,870 - 47,930,540 (-)NCBI
mRatBN7.2446,800,981 - 46,964,631 (-)NCBI
Rnor_6.0442,932,903 - 43,096,399 (-)NCBI
Rnor_5.0442,516,933 - 42,680,639 (-)NCBI
RGSC_v3.4444,114,097 - 44,277,748 (-)RGD
Celera442,060,024 - 42,223,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592494   ⟹   XP_017447983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,766,867 - 47,930,591 (-)NCBI
mRatBN7.2446,800,975 - 46,964,681 (-)NCBI
Rnor_6.0442,932,897 - 43,096,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107159   ⟹   XP_038963087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,766,867 - 47,930,591 (-)NCBI
mRatBN7.2446,800,975 - 46,964,681 (-)NCBI
RefSeq Acc Id: XM_039107160   ⟹   XP_038963088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,781,785 - 47,930,595 (-)NCBI
mRatBN7.2446,815,896 - 46,964,681 (-)NCBI
RefSeq Acc Id: XM_039107161   ⟹   XP_038963089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,813,448 - 47,930,596 (-)NCBI
mRatBN7.2446,847,564 - 46,964,681 (-)NCBI
RefSeq Acc Id: XM_039107162   ⟹   XP_038963090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8447,834,054 - 47,930,598 (-)NCBI
mRatBN7.2446,867,525 - 46,964,681 (-)NCBI
RefSeq Acc Id: NP_001107873   ⟸   NM_001114401
- UniProtKB: O88864 (UniProtKB/Swiss-Prot),   Q2IBD4 (UniProtKB/Swiss-Prot),   A0A8I5YC08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447983   ⟸   XM_017592494
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YC08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072761   ⟸   ENSRNOT00000087167
RefSeq Acc Id: XP_038963087   ⟸   XM_039107159
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YC08 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963088   ⟸   XM_039107160
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963089   ⟸   XM_039107161
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038963090   ⟸   XM_039107162
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000077746   ⟸   ENSRNOT00000120156
Protein Domains
Cortactin-binding protein-2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2IBD4-F1-model_v2 AlphaFold Q2IBD4 1-1649 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692888
Promoter ID:EPDNEW_R3412
Type:single initiation site
Name:Cttnbp2_1
Description:cortactin binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0443,096,333 - 43,096,393EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628691 AgrOrtholog
BioCyc Gene G2FUF-45538 BioCyc
Ensembl Genes ENSRNOG00000061845 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087167.2 UniProtKB/Swiss-Prot
  ENSRNOT00000120156.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cortactin-Actin_Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cortactin-binding_p2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:282587 UniProtKB/Swiss-Prot
NCBI Gene 282587 ENTREZGENE
PANTHER CTTNBP2 N-TERMINAL-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FILAMIN/GPBP-INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot
  CortBP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cttnbp2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061845 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YC08 ENTREZGENE, UniProtKB/TrEMBL
  CTTB2_RAT UniProtKB/Swiss-Prot
  O88864 ENTREZGENE
  Q2IBD4 ENTREZGENE
UniProt Secondary O88864 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cttnbp2  cortactin binding protein 2  Cbp90  brain specific cortactin-binding protein CBP90  Symbol and Name updated 1299863 APPROVED
2003-02-27 Cbp90  brain specific cortactin-binding protein CBP90      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain only 632437
gene_physical_interaction able to bind to all cortactin isoforms 632437
gene_protein predicted protein masses 90 kDa 632437