Tas2r118 (taste receptor, type 2, member 118) - Rat Genome Database

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Gene: Tas2r118 (taste receptor, type 2, member 118) Rattus norvegicus
Analyze
Symbol: Tas2r118
Name: taste receptor, type 2, member 118
RGD ID: 620735
Description: Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in endoplasmic reticulum; external side of plasma membrane; and trans-Golgi network. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human TAS2R16 (taste 2 receptor member 16); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: T2R16; T2R18; T2R3; Tas2r16; taste receptor; taste receptor type 2 member 16; taste receptor, type 2, member 16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8453,414,815 - 53,415,714 (-)NCBIGRCr8
mRatBN7.2452,449,208 - 52,450,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl452,449,208 - 52,450,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx457,436,130 - 57,437,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,350,306 - 53,351,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0451,778,870 - 51,779,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,002,218 - 51,003,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,002,218 - 51,003,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0450,781,192 - 50,782,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4450,342,537 - 50,343,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1450,573,110 - 50,574,010 (-)NCBI
Celera447,635,254 - 47,636,153 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel family of mammalian taste receptors. Adler E, etal., Cell 2000 Mar 17;100(6):693-702.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10761935   PMID:11696554   PMID:11854532   PMID:12139982   PMID:12581520   PMID:16720576   PMID:20022913  


Genomics

Comparative Map Data
Tas2r118
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8453,414,815 - 53,415,714 (-)NCBIGRCr8
mRatBN7.2452,449,208 - 52,450,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl452,449,208 - 52,450,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx457,436,130 - 57,437,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,350,306 - 53,351,205 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0451,778,870 - 51,779,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,002,218 - 51,003,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,002,218 - 51,003,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0450,781,192 - 50,782,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4450,342,537 - 50,343,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1450,573,110 - 50,574,010 (-)NCBI
Celera447,635,254 - 47,636,153 (-)NCBICelera
Cytogenetic Map4q22NCBI
TAS2R16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387122,994,704 - 122,995,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7122,994,704 - 122,995,700 (-)EnsemblGRCh38hg38GRCh38
GRCh377122,634,758 - 122,635,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367122,421,995 - 122,422,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 347122,228,763 - 122,229,639NCBI
Celera7117,439,504 - 117,440,499 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7116,997,714 - 116,998,709 (-)NCBIHuRef
CHM1_17122,568,066 - 122,569,061 (-)NCBICHM1_1
T2T-CHM13v2.07124,311,252 - 124,312,248 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,023,644 - 122,024,639 (-)NCBI
Tas2r118
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39623,969,160 - 23,970,059 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl623,969,160 - 23,970,059 (-)EnsemblGRCm39 Ensembl
GRCm38623,969,161 - 23,970,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl623,969,161 - 23,970,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv37623,919,161 - 23,920,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36623,919,163 - 23,920,062 (-)NCBIMGSCv36mm8
Celera623,993,940 - 23,994,839 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.18NCBI
Tas2r16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554794,591,015 - 4,591,920 (-)NCBIChiLan1.0ChiLan1.0
TAS2R16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26159,864,811 - 159,865,807 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1711,875,065 - 11,876,061 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,003,966 - 115,004,950 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17127,687,850 - 127,688,834 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7127,687,899 - 127,688,774 (-)Ensemblpanpan1.1panPan2
Tas2r16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511849,804,785 - 49,805,690 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366052,398,240 - 2,399,145 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAS2R16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1824,286,430 - 24,287,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11824,281,944 - 24,290,222 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,883,118 - 25,884,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAS2R16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12191,781,827 - 91,785,831 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2191,783,091 - 91,783,963 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604211,700,462 - 11,701,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tas2r16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478312,993,230 - 12,994,135 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tas2r118
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000034936
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
reproductive system
2 2 2 2 2 2 2 6

Sequence


Ensembl Acc Id: ENSRNOT00000034936   ⟹   ENSRNOP00000031530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl452,449,208 - 52,450,107 (-)Ensembl
Rnor_6.0 Ensembl451,002,218 - 51,003,117 (-)Ensembl
RefSeq Acc Id: NM_023994   ⟹   NP_076484
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8453,414,815 - 53,415,714 (-)NCBI
mRatBN7.2452,449,208 - 52,450,107 (-)NCBI
Rnor_6.0451,002,218 - 51,003,117 (-)NCBI
Rnor_5.0450,781,192 - 50,782,091 (-)NCBI
RGSC_v3.4450,342,537 - 50,343,436 (-)RGD
Celera447,635,254 - 47,636,153 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_076484 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF43914 (Get FASTA)   NCBI Sequence Viewer  
  EDM15165 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031530.1
  ENSRNOP00055031714
  ENSRNOP00060028840
  ENSRNOP00065037911
GenBank Protein Q9JKU0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_076484   ⟸   NM_023994
- UniProtKB: Q9JKU0 (UniProtKB/Swiss-Prot),   A6IE78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031530   ⟸   ENSRNOT00000034936

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKU0-F1-model_v2 AlphaFold Q9JKU0 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620735 AgrOrtholog
BioCyc Gene G2FUF-45490 BioCyc
Ensembl Genes ENSRNOG00000021799 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055022748 UniProtKB/Swiss-Prot
  ENSRNOG00060020284 UniProtKB/Swiss-Prot
  ENSRNOG00065026790 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034936.2 UniProtKB/Swiss-Prot
  ENSRNOT00055039047 UniProtKB/Swiss-Prot
  ENSRNOT00060035090 UniProtKB/Swiss-Prot
  ENSRNOT00065046203 UniProtKB/Swiss-Prot
InterPro T2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 78980 ENTREZGENE
PANTHER TASTE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASTE RECEPTOR TYPE 2 MEMBER 16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TAS2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tas2r118 PhenoGen
RatGTEx ENSRNOG00000021799 RatGTEx
  ENSRNOG00055022748 RatGTEx
  ENSRNOG00060020284 RatGTEx
  ENSRNOG00065026790 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IE78 ENTREZGENE, UniProtKB/TrEMBL
  Q9JKU0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Tas2r118  taste receptor, type 2, member 118  Tas2r16  taste receptor, type 2, member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tas2r16  taste receptor, type 2, member 16  T2R3  taste receptor  Symbol and Name updated 1299863 APPROVED
2002-08-07 T2R3  taste receptor      Symbol and Name status set to provisional 70820 PROVISIONAL