Chrm2 (cholinergic receptor, muscarinic 2) - Rat Genome Database

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Gene: Chrm2 (cholinergic receptor, muscarinic 2) Rattus norvegicus
Analyze
Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2
RGD ID: 620023
Description: Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; regulation of smooth muscle contraction; and response to ethanol. Located in several cellular components, including asymmetric synapse; neuronal cell body; and symmetric synapse. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7TM receptor; Acm2; cholinergic receptor, muscarinic 2, cardiac; LOC100912433; M2 muscarinic acetylcholine receptor; muscarinic acetylcholine receptor M2; muscarinic acetylcholine receptor M2-like; muscarinic receptor m2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8465,981,136 - 66,116,128 (+)NCBIGRCr8
mRatBN7.2465,015,408 - 65,149,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,014,144 - 65,149,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx469,958,956 - 70,092,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0465,881,926 - 66,015,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,277,075 - 64,410,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,089,028 - 64,091,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,088,900 - 64,091,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0463,799,489 - 63,801,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4463,911,292 - 63,913,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,190,944 - 64,191,339 (+)NCBI
Celera460,177,151 - 60,179,213 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-DAMP(1+)  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atropine  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bethanechol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
brucine  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
caracurine VII  (ISO)
carbachol  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP)
curcumin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP)
darifenacin  (ISO)
DDE  (EXP)
diazinon  (EXP)
dichlorvos  (EXP)
dieldrin  (EXP)
dimethoate  (EXP)
dioxygen  (ISO)
disulfoton  (EXP)
doxorubicin  (ISO)
Eburnamonine  (ISO)
fructose  (EXP)
furan  (EXP)
furtrethonium  (ISO)
glucose  (EXP)
glyphosate  (ISO)
hexacosan-1-ol  (EXP)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
iron(III) nitrilotriacetate  (EXP)
ketamine  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
levetiracetam  (ISO)
maneb  (ISO)
methoctramine tetrahydrochloride  (ISO)
methscopolamine  (EXP,ISO)
mevinphos  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
Omadacycline  (ISO)
Oxotremorine  (ISO)
oxotremorine M  (ISO)
oxybutynin  (ISO)
ozone  (EXP)
pancuronium  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
parathion-methyl  (EXP)
permethrin  (EXP)
phlorizin  (EXP)
picrotoxin  (EXP)
pioglitazone  (ISO)
Pipecuronium  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidines  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rocuronium  (ISO)
rotenone  (EXP)
sabcomeline  (ISO)
sarin  (EXP)
sodium arsenite  (EXP)
sparteine  (EXP)
staurosporine  (ISO)
streptozocin  (EXP)
strychnine  (ISO)
sunitinib  (ISO)
tacrine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tiotropium bromide  (ISO)
tolterodine tartrate  (ISO)
triazines  (ISO)
trichlorfon  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tropicamide  (ISO)
valproic acid  (EXP)
vecuronium bromide  (ISO)
VX nerve agent  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphai family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours. Blaveri E, etal., PLoS One. 2010 Sep 7;5(9):e12596.
2. Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. Braverman AS, etal., Am J Physiol Regul Integr Comp Physiol 2002 Sep;283(3):R663-8.
3. Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder. Cannon DM, etal., Mol Psychiatry. 2011 Apr;16(4):407-18. Epub 2010 Mar 30.
4. Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women. Comings DE, etal., Am J Med Genet 2002 Jul 8;114(5):527-9.
5. Increased function of inhibitory neuronal M2 muscarinic receptors in trachea and ileum of diabetic rats. Coulson FR, etal., Br J Pharmacol 2002 Mar;135(6):1355-62.
6. HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype. Crews FT, etal., Mol Psychiatry. 2023 Dec;28(12):5159-5172. doi: 10.1038/s41380-023-02160-6. Epub 2023 Jul 4.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects. Gibbons AS, etal., J Affect Disord. 2009 Aug;116(3):184-91. Epub 2008 Dec 21.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family. Gocayne J, etal., Proc Natl Acad Sci U S A 1987 Dec;84(23):8296-300.
11. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
12. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. Hersch SM, etal., J Neurosci. 1994 May;14(5 Pt 2):3351-63.
13. Genetic associations of brain structural networks in schizophrenia: a preliminary study. Jagannathan K, etal., Biol Psychiatry. 2010 Oct 1;68(7):657-66. Epub 2010 Aug 5.
14. Desensitization and sequestration of human m2 muscarinic acetylcholine receptors by autoantibodies from patients with Chagas' disease. Leiros CP, etal., J Biol Chem. 1997 May 16;272(20):12989-93.
15. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
16. Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function. McGowan SE, etal., Am J Physiol Lung Cell Mol Physiol 2002 May;282(5):L1031-9.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat. Santafe MM, etal., Eur J Neurosci 2003 Jan;17(1):119-27.
25. [Association of A/T polymorphism of the CHRM2 gene with bronchodilator response to ipratropium bromide in asthmatic children]. Szczepankiewicz A, etal., Pneumonol Alergol Pol. 2009;77(1):5-10.
26. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
27. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Tseng J, etal., Hear Res 2002 Dec;174(1-2):86-92.
28. Sleep, activity, temperature and arousal responses of mice deficient for muscarinic receptor M2 or M4. Turner J, etal., Life Sci. 2010 Jan 30;86(5-6):158-69. Epub 2009 Dec 1.
29. The M3-muscarinic cholinoceptor subtype in rat prostate and its down regulation by aging. Yazawa H and Honda K, Jpn J Pharmacol. 1993 Apr;61(4):319-24.
Additional References at PubMed
PMID:9972520   PMID:9990086   PMID:11566136   PMID:11880500   PMID:12717708   PMID:14715385   PMID:15062561   PMID:15379890   PMID:15632090   PMID:15748786   PMID:15927789   PMID:16541262  
PMID:16548883   PMID:16709645   PMID:16820015   PMID:16953191   PMID:17012364   PMID:17065150   PMID:17845913   PMID:18443764   PMID:18709662   PMID:18938154   PMID:19427366   PMID:19889856  
PMID:20016095   PMID:20300620   PMID:20445960   PMID:20600670   PMID:21061016   PMID:21114972   PMID:22293779   PMID:23041487   PMID:24256733   PMID:24421355   PMID:24480931   PMID:24517892  
PMID:25474381   PMID:25681120   PMID:26086781   PMID:26475745   PMID:29227527   PMID:34370080  


Genomics

Comparative Map Data
Chrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8465,981,136 - 66,116,128 (+)NCBIGRCr8
mRatBN7.2465,015,408 - 65,149,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,014,144 - 65,149,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx469,958,956 - 70,092,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0465,881,926 - 66,015,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,277,075 - 64,410,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,089,028 - 64,091,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,088,900 - 64,091,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0463,799,489 - 63,801,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4463,911,292 - 63,913,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,190,944 - 64,191,339 (+)NCBI
Celera460,177,151 - 60,179,213 (+)NCBICelera
Cytogenetic Map4q22NCBI
CHRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387136,868,652 - 137,020,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7136,868,652 - 137,020,255 (+)EnsemblGRCh38hg38GRCh38
GRCh377136,553,399 - 136,704,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,203,939 - 136,352,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 347136,011,086 - 136,013,965NCBI
Celera7131,292,618 - 131,440,990 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7130,859,052 - 131,007,065 (+)NCBIHuRef
CHM1_17136,487,338 - 136,635,497 (+)NCBICHM1_1
T2T-CHM13v2.07138,178,337 - 138,329,898 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27135,897,754 - 136,046,127 (+)NCBI
Chrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39636,364,928 - 36,505,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl636,365,019 - 36,505,349 (+)EnsemblGRCm39 Ensembl
GRCm38636,387,991 - 36,528,638 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl636,388,084 - 36,528,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv37636,473,170 - 36,474,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36636,453,362 - 36,454,762 (+)NCBIMGSCv36mm8
Celera636,492,872 - 36,494,476 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map615.48NCBI
Chrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,847,156 - 5,848,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,845,581 - 5,975,614 (-)NCBIChiLan1.0ChiLan1.0
CHRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26173,681,317 - 173,832,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1725,691,568 - 25,842,959 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07128,827,089 - 128,978,496 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17141,321,238 - 141,468,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,466,396 - 141,467,796 (+)Ensemblpanpan1.1panPan2
CHRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11611,515,727 - 11,665,651 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1611,515,426 - 11,664,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1612,526,682 - 12,678,872 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01611,480,293 - 11,633,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1611,477,520 - 11,632,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,939,562 - 12,085,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01611,039,665 - 11,185,727 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01611,179,681 - 11,325,556 (-)NCBIUU_Cfam_GSD_1.0
Chrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511817,696,611 - 17,822,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365921,521,547 - 1,522,947 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365921,396,939 - 1,525,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1812,455,145 - 12,600,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11812,455,139 - 12,600,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121105,574,879 - 105,730,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21105,726,175 - 105,727,575 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660722,441,810 - 2,594,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476517,333,678 - 17,340,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476517,211,162 - 17,342,505 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrm2
805 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:252
Count of miRNA genes:162
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000015863, ENSRNOT00000075341
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
CHRM2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8466,111,066 - 66,111,660 (+)Marker Load Pipeline
mRatBN7.2465,144,029 - 65,144,624 (+)MAPPERmRatBN7.2
Rnor_6.0464,089,405 - 64,089,999NCBIRnor6.0
Rnor_5.0463,799,866 - 63,800,460UniSTSRnor5.0
Rnor_5.0463,913,835 - 63,914,429UniSTSRnor5.0
RGSC_v3.4463,911,669 - 63,912,263UniSTSRGSC3.4
Celera460,177,528 - 60,178,122UniSTS
Cytogenetic Map4q22UniSTS
UniSTS:492976  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,143,671 - 65,145,141 (+)MAPPERmRatBN7.2
Rnor_6.0464,089,047 - 64,090,516NCBIRnor6.0
Rnor_5.0463,913,477 - 63,914,946UniSTSRnor5.0
Rnor_5.0463,799,508 - 63,800,977UniSTSRnor5.0
RGSC_v3.4463,911,311 - 63,912,780UniSTSRGSC3.4
Celera460,177,170 - 60,178,639UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 49 112 86 85 55 25 55 5 198 90 93 37 48 30

Sequence


Ensembl Acc Id: ENSRNOT00000075341   ⟹   ENSRNOP00000065178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,138,141 - 65,149,103 (+)Ensembl
Rnor_6.0 Ensembl464,088,900 - 64,091,090 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115807   ⟹   ENSRNOP00000082007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,014,144 - 65,149,103 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118028   ⟹   ENSRNOP00000088860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,016,319 - 65,149,103 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118281   ⟹   ENSRNOP00000095668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,016,001 - 65,149,103 (+)Ensembl
RefSeq Acc Id: NM_031016   ⟹   NP_112278
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8465,982,450 - 66,115,906 (+)NCBI
mRatBN7.2465,015,408 - 65,148,870 (+)NCBI
Rnor_6.0464,089,028 - 64,091,090 (+)NCBI
Rnor_5.0463,799,489 - 63,801,551 (+)NCBI
RGSC_v3.4463,911,292 - 63,913,354 (+)RGD
Celera460,177,151 - 60,179,213 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108421   ⟹   XP_038964349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8465,982,714 - 66,116,128 (+)NCBI
mRatBN7.2465,016,668 - 65,149,104 (+)NCBI
RefSeq Acc Id: XM_063286746   ⟹   XP_063142816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8465,981,136 - 66,116,128 (+)NCBI
RefSeq Acc Id: NP_112278   ⟸   NM_031016
- UniProtKB: P10980 (UniProtKB/Swiss-Prot),   Q9Z2Z1 (UniProtKB/Swiss-Prot),   A6IEP6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065178   ⟸   ENSRNOT00000075341
RefSeq Acc Id: XP_038964349   ⟸   XM_039108421
- Peptide Label: isoform X1
- UniProtKB: P10980 (UniProtKB/Swiss-Prot),   Q9Z2Z1 (UniProtKB/Swiss-Prot),   A6IEP6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088860   ⟸   ENSRNOT00000118028
Ensembl Acc Id: ENSRNOP00000095668   ⟸   ENSRNOT00000118281
Ensembl Acc Id: ENSRNOP00000082007   ⟸   ENSRNOT00000115807
RefSeq Acc Id: XP_063142816   ⟸   XM_063286746
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Z1 (UniProtKB/Swiss-Prot),   P10980 (UniProtKB/Swiss-Prot),   A6IEP6 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10980-F1-model_v2 AlphaFold P10980 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620023 AgrOrtholog
BioCyc Gene G2FUF-45229 BioCyc
Ensembl Genes ENSRNOG00000046972 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075341 ENTREZGENE
  ENSRNOT00000075341.3 UniProtKB/Swiss-Prot
  ENSRNOT00000115807 ENTREZGENE
  ENSRNOT00000115807.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118028.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118281.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M2_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:81645 UniProtKB/Swiss-Prot
NCBI Gene 81645 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  MUSCARINIC ACETYLCHOLINE RECEPTOR M2 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CHRM2 RGD
PhenoGen Chrm2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046972 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6IEP6 ENTREZGENE, UniProtKB/TrEMBL
  ACM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z2Z1 ENTREZGENE
UniProt Secondary Q9Z2Z1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Chrm2  cholinergic receptor, muscarinic 2  LOC100912433  muscarinic acetylcholine receptor M2-like  Data merged from RGD:6486928 737654 PROVISIONAL
2012-07-05 LOC100912433  muscarinic acetylcholine receptor M2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Chrm2  cholinergic receptor, muscarinic 2  Chrm2  cholinergic receptor, muscarinic 2, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Chrm2  cholinergic receptor, muscarinic 2, cardiac  Chrm2  cholinergic receptor, muscarinic 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Chrm2  cholinergic receptor, muscarinic 2    muscarinic receptor m2  Name updated 1299863 APPROVED
2002-08-07 Chrm2  muscarinic receptor m2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process acts with M3 receptor to effect bladder smooth muscle contraction 724728