Chrm2 (cholinergic receptor muscarinic 2) - Rat Genome Database

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Gene: Chrm2 (cholinergic receptor muscarinic 2) Chinchilla lanigera
Analyze
Symbol: Chrm2
Name: cholinergic receptor muscarinic 2
RGD ID: 8972200
Description: ENCODES a protein that exhibits arrestin family protein binding (ortholog); G protein-coupled acetylcholine receptor activity (ortholog); INVOLVED IN G protein-coupled acetylcholine receptor signaling pathway (ortholog); presynaptic modulation of chemical synaptic transmission (ortholog); regulation of smooth muscle contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH asthma (ortholog); bipolar disorder (ortholog); Bradycardia (ortholog); FOUND IN asymmetric synapse (ortholog); axon terminus (ortholog); cholinergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cholinergic receptor, muscarinic 2; muscarinic acetylcholine receptor M2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,847,156 - 5,848,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,845,581 - 5,975,614 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphai family  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Chrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,847,156 - 5,848,556 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,845,581 - 5,975,614 (-)NCBIChiLan1.0ChiLan1.0
CHRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387136,868,652 - 137,020,213 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7136,868,652 - 137,020,255 (+)EnsemblGRCh38hg38GRCh38
GRCh377136,553,399 - 136,704,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,203,939 - 136,352,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 347136,011,086 - 136,013,965NCBI
Celera7131,292,618 - 131,440,990 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7130,859,052 - 131,007,065 (+)NCBIHuRef
CHM1_17136,487,338 - 136,635,497 (+)NCBICHM1_1
T2T-CHM13v2.07138,178,337 - 138,329,898 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27135,897,754 - 136,046,127 (+)NCBI
Chrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39636,364,928 - 36,505,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl636,365,019 - 36,505,349 (+)EnsemblGRCm39 Ensembl
GRCm38636,387,991 - 36,528,638 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl636,388,084 - 36,528,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv37636,473,170 - 36,474,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36636,453,362 - 36,454,762 (+)NCBIMGSCv36mm8
Celera636,492,872 - 36,494,476 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map615.48NCBI
Chrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8465,981,136 - 66,116,128 (+)NCBIGRCr8
mRatBN7.2465,015,408 - 65,149,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,014,144 - 65,149,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx469,958,956 - 70,092,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0465,881,926 - 66,015,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,277,075 - 64,410,729 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,089,028 - 64,091,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,088,900 - 64,091,090 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0463,799,489 - 63,801,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4463,911,292 - 63,913,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,190,944 - 64,191,339 (+)NCBI
Celera460,177,151 - 60,179,213 (+)NCBICelera
Cytogenetic Map4q22NCBI
CHRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26173,681,317 - 173,832,713 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1725,691,568 - 25,842,959 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07128,827,089 - 128,978,496 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17141,321,238 - 141,468,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,466,396 - 141,467,796 (+)Ensemblpanpan1.1panPan2
CHRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11611,515,727 - 11,665,651 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1611,515,426 - 11,664,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1612,526,682 - 12,678,872 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01611,480,293 - 11,633,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1611,477,520 - 11,632,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,939,562 - 12,085,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01611,039,665 - 11,185,727 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01611,179,681 - 11,325,556 (-)NCBIUU_Cfam_GSD_1.0
Chrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511817,696,611 - 17,822,502 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365921,521,547 - 1,522,947 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365921,396,939 - 1,525,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1812,455,145 - 12,600,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11812,455,139 - 12,600,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CHRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121105,574,879 - 105,730,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21105,726,175 - 105,727,575 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660722,441,810 - 2,594,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476517,333,678 - 17,340,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476517,211,162 - 17,342,505 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000025622   ⟹   ENSCLAP00000025373
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554945,847,156 - 5,848,556 (-)Ensembl
RefSeq Acc Id: XM_005405469   ⟹   XP_005405526
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554945,845,581 - 5,975,614 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000025373
  ENSCLAP00000025373.1
Reference Protein Sequences
RefSeq Acc Id: XP_005405526   ⟸   XM_005405469
- UniProtKB: A0A8C2W5A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000025373   ⟸   ENSCLAT00000025622
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017448 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025622 ENTREZGENE
  ENSCLAT00000025622.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Musac_Ach_M2_rcpt UniProtKB/TrEMBL
  Musac_Ach_rcpt UniProtKB/TrEMBL
NCBI Gene Chrm2 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/TrEMBL
  MUSCARINIC ACETYLCHOLINE RECEPTOR M2 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MUSCARINICR UniProtKB/TrEMBL
  MUSCRINICM2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2W5A3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Chrm2  cholinergic receptor muscarinic 2    cholinergic receptor, muscarinic 2  Symbol and/or name change 5135510 APPROVED