Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620023
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2
Acc ID: CHEBI:75701
Term: sarin
Definition: A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.
Chemical ID: MESH:D012524
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm2affects activityEXP 6480464CTDSarin affects the activity of CHRM2 proteinPMID:21419149
Chrm2decreases expressionEXP 6480464CTDSarin results in decreased expression of CHRM2 proteinPMID:29128314
Chrm2multiple interactionsEXP 6480464CTDSarin inhibits the reaction [AFDX 384 binds to CHRM2 protein]PMID:29128314
Go Back to source page   Continue to Ontology report