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Gene: Chrm2 (cholinergic receptor, muscarinic 2, cardiac) Mus musculus
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Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Description: Exhibits G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of synaptic vesicle exocytosis. Localizes to the cholinergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Is expressed in several structures, including alimentary system; central nervous system; heart; retina; and trigeminal nerve. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH 1D-myo-inositol 1,4,5-trisphosphate; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M2; AChR-M2; Chrm-2; M2; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor M2
Orthologs:
Homo sapiens (human) : CHRM2 (cholinergic receptor muscarinic 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm2 (cholinergic receptor, muscarinic 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm2 (cholinergic receptor muscarinic 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM2 (cholinergic receptor muscarinic 2)
Canis lupus familiaris (dog) : CHRM2 (cholinergic receptor muscarinic 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm2 (cholinergic receptor muscarinic 2)
Sus scrofa (pig) : CHRM2 (cholinergic receptor muscarinic 2)
Chlorocebus sabaeus (African green monkey) : CHRM2 (cholinergic receptor muscarinic 2)
Heterocephalus glaber (naked mole-rat) : Chrm2 (cholinergic receptor muscarinic 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl636,388,084 - 36,528,414 (+)EnsemblGRCm38mm10GRCm38
GRCm38636,387,991 - 36,528,638 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37636,473,170 - 36,474,774 (+)NCBIGRCm37mm9NCBIm37
MGSCv36636,453,362 - 36,454,762 (+)NCBImm8
Celera636,492,872 - 36,494,476 (+)NCBICelera
Cytogenetic Map6B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Chrm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552578
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.