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Gene: Chrm2 (cholinergic receptor, muscarinic 2, cardiac) Mus musculus
Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Description: Exhibits G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of synaptic vesicle exocytosis. Localizes to the cholinergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Is expressed in several structures, including alimentary system; central nervous system; heart; retina; and trigeminal nerve. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH 1D-myo-inositol 1,4,5-trisphosphate; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AChR M2; AChR-M2; Chrm-2; M2; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor M2
Homo sapiens (human) : CHRM2 (cholinergic receptor muscarinic 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrm2 (cholinergic receptor, muscarinic 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm2 (cholinergic receptor muscarinic 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM2 (cholinergic receptor muscarinic 2)
Canis lupus familiaris (dog) : CHRM2 (cholinergic receptor muscarinic 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm2 (cholinergic receptor muscarinic 2)
Sus scrofa (pig) : CHRM2 (cholinergic receptor muscarinic 2)
Chlorocebus sabaeus (African green monkey) : CHRM2 (cholinergic receptor muscarinic 2)
Heterocephalus glaber (naked mole-rat) : Chrm2 (cholinergic receptor muscarinic 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl636,388,084 - 36,528,414 (+)EnsemblGRCm38mm10GRCm38
GRCm38636,387,991 - 36,528,638 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37636,473,170 - 36,474,774 (+)NCBIGRCm37mm9NCBIm37
MGSCv36636,453,362 - 36,454,762 (+)NCBImm8
Celera636,492,872 - 36,494,476 (+)NCBICelera
Cytogenetic Map6B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chrm2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552578
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.