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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620023
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm2affects bindingISOCHRM2 (Homo sapiens)6480464CTDAcetylcholine binds to CHRM2 protein; CHRM2 protein binds to AcetylcholinePMID:10069518 PMID:9224827
Chrm2multiple interactionsISOCHRM2 (Homo sapiens)6480464CTDAcetylcholine binds to and results in increased activity of CHRM2 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM2 protein]; eburnamonine promotes the reaction [Acetylcholine binds to CHRM2 protein]; N-chloromethylbrucine inhibits the reaction [Acetylcholine results in increased activity of CHRM2 protein]PMID:10069518 PMID:10101037 PMID:9224827
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