Crhr2 (corticotropin releasing hormone receptor 2) - Rat Genome Database

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Gene: Crhr2 (corticotropin releasing hormone receptor 2) Rattus norvegicus
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Symbol: Crhr2
Name: corticotropin releasing hormone receptor 2
RGD ID: 70547
Description: Exhibits corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Localizes to several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2); PARTICIPATES IN protein kinase A (PKA) signaling pathway; corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: corticotrophin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; corticotropin-releasing hormone receptor 2; CRF-R 2; CRF-R-2; CRF-R2; CRF2; Crf2r; CRFR-2; CRH-R 2; CRH-R-2; CRH-R2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IMP)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
catecholamine biosynthetic process  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to corticotropin-releasing hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEP)
cerebellum development  (IEP)
epithelial cell differentiation  (IMP)
feeding behavior  (NAS)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gastric motility  (IMP)
hormone-mediated signaling pathway  (IEA)
hypothalamus development  (IEP)
long-term synaptic potentiation  (IBA,IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of calcium ion import  (IMP)
negative regulation of cAMP-mediated signaling  (ISO)
negative regulation of defecation  (IMP)
negative regulation of epinephrine secretion  (IMP)
negative regulation of feeding behavior  (IDA)
negative regulation of follicle-stimulating hormone secretion  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
negative regulation of luteinizing hormone secretion  (IMP)
negative regulation of norepinephrine secretion  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of cAMP-mediated signaling  (IDA,IMP,ISO)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of serotonin secretion  (IMP)
positive regulation of stress-activated MAPK cascade  (IMP)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
regulation of ERK1 and ERK2 cascade  (IMP)
sensory perception of pain  (IMP)
skeletal muscle tissue growth  (IDA)

Cellular Component

References

References - curated
1. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
2. Briscoe RJ, etal., Brain Res. 2000 Oct 27;881(2):204-7.
3. Chae JI, etal., Mol Biol (Mosk). 2009 Jan-Feb;43(1):91-6.
4. Chang J, etal., Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G884-94. Epub 2011 Feb 17.
5. Chang J, etal., Peptides. 2007 Jul;28(7):1453-60. Epub 2007 May 21.
6. Chen CY, etal., Gastroenterology. 2005 Jul;129(1):8-25.
7. Coste SC, etal., Nat Genet 2000 Apr;24(4):403-9.
8. Dabrowska J, etal., Psychoneuroendocrinology. 2011 Oct;36(9):1312-26. Epub 2011 Apr 9.
9. Dermitzaki E, etal., Endocrinology. 2007 Apr;148(4):1524-38. Epub 2006 Dec 28.
10. Estienne M, etal., Gut. 2010 Jun;59(6):744-51.
11. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
12. Fedeli A, etal., Peptides. 2006 Dec;27(12):3284-91. Epub 2006 Oct 16.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Gounko NV, etal., Eur J Neurosci. 2006 Jun;23(12):3217-24.
16. Gourcerol G, etal., Gastroenterology. 2011 May;140(5):1586-96.e6. Epub 2011 Jan 26.
17. Guan X, etal., Neuroscience. 2009 Jul 7;161(3):665-70. Epub 2009 Apr 17.
18. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
19. Hinkle RT, etal., BMC Musculoskelet Disord. 2011 Jan 14;12:15.
20. Huang M, etal., J Mol Endocrinol. 2009 May;42(5):397-405. Epub 2009 Feb 11.
21. Huising MO, etal., Endocrinology. 2011 Jan;152(1):138-50. Epub 2010 Nov 24.
22. Iarushkina NI, etal., Ross Fiziol Zh Im I M Sechenova. 2008 Oct;94(10):1118-25.
23. Ikeda K, etal., Peptides. 2005 Dec;26(12):2473-81. Epub 2005 Jul 7.
24. Kim BJ, etal., J Neuroimmunol. 2011 Jul 18.
25. Kim TH, etal., Laryngoscope. 2007 Sep;117(9):1513-8.
26. Kinsey-Jones JS, etal., J Neuroendocrinol. 2010 Feb;22(2):102-9. Epub 2009 Dec 4.
27. Kishimoto T, etal., Nat Genet 2000 Apr;24(4):415-9.
28. Li C, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4206-11. Epub 2007 Feb 27.
29. Li X, etal., Auton Neurosci. 2010 Apr 19;154(1-2):108-11. Epub 2010 Jan 8.
30. Lovenberg TW, etal., Proc Natl Acad Sci U S A 1995 Jan 31;92(3):836-40.
31. Lu L, etal., J Neurochem 2003 Mar;84(6):1378-86.
32. Lukkes JL, etal., Neuroscience. 2011 Jun 2;183:47-63. Epub 2011 Mar 29.
33. McKenzie IF, etal., Immunol Rev 1977;35:179-230.
34. MGD data from the GO Consortium
35. Moffatt JD, etal., FASEB J. 2006 Sep;20(11):1877-9. Epub 2006 Jul 19.
36. Nanmoku T, etal., Neurosci Lett. 2005 Jul 1-8;382(1-2):124-7. Epub 2005 Mar 25.
37. NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Nemoto T, etal., J Endocrinol. 2009 Apr;201(1):105-14. Epub 2009 Feb 4.
39. Nishikimi T, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3031-9.
40. O'Malley D, etal., Peptides. 2010 Apr;31(4):662-70. Epub 2010 Jan 21.
41. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
42. Pollandt S, etal., Eur J Neurosci. 2006 Sep;24(6):1733-43.
43. Poon AH, etal., Pharmacogenet Genomics. 2008 May;18(5):373-82.
44. Proulx K, etal., Endocrinology 2002 Dec;143(12):4683-92.
45. RGD automated data pipeline
46. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. RGD automated import pipeline for gene-chemical interactions
48. Scholl JL, etal., Eur J Pharmacol. 2010 Oct 10;644(1-3):80-7. Epub 2010 Jul 23.
49. Schulz K, etal., J Biol Chem. 2010 Oct 22;285(43):32878-87. Epub 2010 Aug 3.
50. Szabadfi K, etal., Neurosci Lett. 2009 May 8;455(1):42-5. Epub 2009 Mar 11.
51. Tao J, etal., Cell Signal. 2009 Sep;21(9):1436-43. Epub 2009 May 9.
52. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
Additional References at PubMed
PMID:8612563   PMID:9423932   PMID:11416224   PMID:12032352   PMID:12639937   PMID:12746300   PMID:12855401   PMID:12911751   PMID:12959937   PMID:14675144   PMID:15174080   PMID:15178552  
PMID:15201629   PMID:15228587   PMID:15388651   PMID:15514029   PMID:15652653   PMID:15659593   PMID:15664670   PMID:16337313   PMID:16403469   PMID:16413121   PMID:16423352   PMID:16513211  
PMID:16614059   PMID:16741581   PMID:16769145   PMID:16867181   PMID:17019404   PMID:17218420   PMID:17437087   PMID:17512918   PMID:17551262   PMID:17578887   PMID:17680889   PMID:17944898  
PMID:17945210   PMID:18400885   PMID:18534257   PMID:18585412   PMID:18702701   PMID:19120136   PMID:19246489   PMID:19358876   PMID:19707872   PMID:19797401   PMID:19819946   PMID:19952342  
PMID:20072117   PMID:20130533   PMID:21376756   PMID:21627635   PMID:21854167   PMID:21964377   PMID:22227020   PMID:22245585   PMID:22249942   PMID:23183626   PMID:23205497   PMID:23312492  
PMID:23645119   PMID:23962778   PMID:24035863   PMID:24856473   PMID:24859650   PMID:25146701   PMID:25205625   PMID:25275258   PMID:25665407   PMID:25701320   PMID:25712670   PMID:26333123  
PMID:26454419   PMID:26503565   PMID:26662216   PMID:26696011   PMID:27035969   PMID:27538655   PMID:27637621   PMID:27779480   PMID:28612996   PMID:28811708   PMID:29183827   PMID:29857328  
PMID:30898126   PMID:31130301   PMID:31666410   PMID:32215915  


Genomics

Candidate Gene Status
Crhr2 is a candidate Gene for QTL Alc18
Crhr2 is a candidate Gene for QTL Alc21
Crhr2 is a candidate Gene for QTL Alc22
Crhr2 is a candidate Gene for QTL Bw126
Comparative Map Data
Crhr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
CRHR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl730,651,942 - 30,700,129 (-)EnsemblGRCh38hg38GRCh38
GRCh38730,649,406 - 30,700,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,691,558 - 30,739,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,659,388 - 30,688,665 (-)NCBINCBI36hg18NCBI36
Build 34730,465,439 - 30,495,136NCBI
Celera730,682,041 - 30,711,309 (-)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,573,396 - 30,621,616 (-)NCBIHuRef
CHM1_1730,691,838 - 30,739,995 (-)NCBICHM1_1
CRA_TCAGchr7v2730,741,211 - 30,789,281 (-)NCBI
Crhr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,067,033 - 55,110,001 (-)NCBIGRCm39mm39
GRCm39 Ensembl655,067,034 - 55,110,001 (-)Ensembl
GRCm38655,090,048 - 55,133,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,090,049 - 55,133,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv37655,040,042 - 55,082,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv36655,019,665 - 55,062,550 (-)NCBImm8
Celera655,625,289 - 55,668,208 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.33NCBI
Crhr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,828,506 - 31,875,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541031,830,333 - 31,874,384 (-)NCBIChiLan1.0ChiLan1.0
CRHR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1731,386,026 - 31,434,220 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,386,026 - 31,434,220 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0731,265,619 - 31,313,902 (-)NCBIMhudiblu_PPA_v0panPan3
CRHR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,366,849 - 43,414,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,368,340 - 43,415,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,799,432 - 42,846,743 (-)NCBI
ROS_Cfam_1.01443,307,910 - 43,355,188 (-)NCBI
UMICH_Zoey_3.11443,423,758 - 43,471,041 (-)NCBI
UNSW_CanFamBas_1.01443,099,719 - 43,147,031 (-)NCBI
UU_Cfam_GSD_1.01443,461,123 - 43,508,563 (-)NCBI
Crhr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,689,367 - 87,736,056 (-)NCBI
SpeTri2.0NW_0049364786,901,098 - 6,947,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,251,749 - 42,295,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,251,755 - 42,296,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,648,683 - 46,651,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRHR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,703,637 - 27,738,873 (+)NCBI
ChlSab1.1 Ensembl2127,708,113 - 27,739,116 (+)Ensembl
Vero_WHO_p1.0NW_02366604276,965,555 - 77,000,544 (-)NCBI
Crhr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624739114,383 - 161,010 (+)NCBI

Position Markers
D4Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,236,380 - 84,236,623 (+)MAPPER
Rnor_6.0485,299,855 - 85,300,097NCBIRnor6.0
Rnor_5.04149,957,099 - 149,957,341UniSTSRnor5.0
RGSC_v3.4483,852,199 - 83,852,442RGDRGSC3.4
RGSC_v3.4483,852,200 - 83,852,442UniSTSRGSC3.4
RGSC_v3.1484,099,749 - 84,099,992RGD
Celera479,103,518 - 79,103,762UniSTS
SHRSP x BN Map441.93RGD
SHRSP x BN Map441.93UniSTS
Cytogenetic Map4q24UniSTS
BE120072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,230,612 - 84,230,778 (+)MAPPER
Rnor_6.0485,294,086 - 85,294,251NCBIRnor6.0
Rnor_5.04149,951,330 - 149,951,495UniSTSRnor5.0
RGSC_v3.4483,846,432 - 83,846,597UniSTSRGSC3.4
Celera479,097,750 - 79,097,915UniSTS
RH 3.4 Map4525.71UniSTS
Cytogenetic Map4q24UniSTS
CRHR2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,225,247 - 84,225,787 (+)MAPPER
Rnor_6.0485,288,722 - 85,289,260NCBIRnor6.0
Rnor_5.04149,945,966 - 149,946,504UniSTSRnor5.0
RGSC_v3.4483,841,068 - 83,841,606UniSTSRGSC3.4
Celera479,092,386 - 79,092,924UniSTS
Cytogenetic Map4q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44241577787415777Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45579156492484312Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)456092756101092756Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)456092756101092756Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45710107792990863Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458166424103166424Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)46043912799066957Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)460439127113416139Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)461038901127777403Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46170810388565113Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)461708341113100992Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)461975371106975371Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)462947687125671711Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)463938412108938412Rat
2312569Pur19Proteinuria QTL 193.40.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46598924397759057Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470773471132455556Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)471476518116476518Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)471476518116476518Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473786419132455556Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)475258970120258970Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)475258970120258970Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)476567036121567036Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)479555067124555067Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)479557856116916073Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47956245198542106Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481874073119546974Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)481959983152055009Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48447525797479149Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:88
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000014925, ENSRNOT00000033672
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 38 7 9 58 17 4 7
Below cutoff 3 5 20 5 11 5 1 1 16 22 19 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014925   ⟹   ENSRNOP00000014925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000033672   ⟹   ENSRNOP00000035712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,287,476 - 85,314,672 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089492   ⟹   ENSRNOP00000075129
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,299,181 - 85,314,457 (-)Ensembl
RefSeq Acc Id: NM_022714   ⟹   NP_073205
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,224,002 - 84,251,198 (-)NCBI
Rnor_6.0485,287,476 - 85,314,672 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
RGSC_v3.4483,839,822 - 83,867,017 (-)RGD
Celera479,091,140 - 79,118,337 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236556   ⟹   XP_006236618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0485,286,371 - 85,329,374 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236557   ⟹   XP_006236619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0485,286,371 - 85,329,374 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236558   ⟹   XP_006236620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,222,897 - 84,252,290 (-)NCBI
Rnor_6.0485,286,371 - 85,315,108 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_073205   ⟸   NM_022714
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006236619   ⟸   XM_006236557
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006236618   ⟸   XM_006236556
- Peptide Label: isoform X1
- UniProtKB: D4A5C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236620   ⟸   XM_006236558
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000035712   ⟸   ENSRNOT00000033672
RefSeq Acc Id: ENSRNOP00000014925   ⟸   ENSRNOT00000014925
RefSeq Acc Id: ENSRNOP00000075129   ⟸   ENSRNOT00000089492
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70547 AgrOrtholog
Ensembl Genes ENSRNOG00000011145 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014925 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000035712 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075129 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014925 UniProtKB/TrEMBL
  ENSRNOT00000033672 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089492 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64680 UniProtKB/Swiss-Prot
NCBI Gene 64680 ENTREZGENE
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRHR2 RGD
PhenoGen Crhr2 PhenoGen
PRINTS CRFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRFRECEPTOR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9U2_RAT UniProtKB/TrEMBL
  CRFR2_RAT UniProtKB/Swiss-Prot
  D4A5C4 ENTREZGENE, UniProtKB/TrEMBL
  P47866 ENTREZGENE
UniProt Secondary G3V948 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Crhr2  corticotropin releasing hormone receptor 2    corticotrophin releasing hormone receptor 2  Name updated 1299863 APPROVED
2002-06-10 Crhr2  corticotrophin releasing hormone receptor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in specific regions of the brain, also in lung and heart 727728
gene_expression expressed in hippocampal regions 70397
gene_function G-protein coupled receptor 70397
gene_function G-protein coupled receptor 631245
gene_process mediates hippocampal neuron protection from stress-induced injury 70397
gene_process mediates hippocampal neuron protection from stress-induced injury 631245