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Gene: Crhr2 (corticotropin releasing hormone receptor 2) Rattus norvegicus
Symbol: Crhr2
Name: corticotropin releasing hormone receptor 2
Description: Exhibits corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; positive regulation of cell communication; and regulation of gene expression. Localizes to several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2); PARTICIPATES IN protein kinase A (PKA) signaling pathway; corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Also known as: corticotrophin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; corticotropin-releasing hormone receptor 2; CRF-R 2; CRF-R-2; CRF-R2; CRF2; Crf2r; CRFR-2; CRH-R 2; CRH-R-2; CRH-R2
Homo sapiens (human) : CRHR2 (corticotropin releasing hormone receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Crhr2 (corticotropin releasing hormone receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crhr2 (corticotropin releasing hormone receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CRHR2 (corticotropin releasing hormone receptor 2)
Canis lupus familiaris (dog) : CRHR2 (corticotropin releasing hormone receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crhr2 (corticotropin releasing hormone receptor 2)
Sus scrofa (pig) : CRHR2 (corticotropin releasing hormone receptor 2)
Heterocephalus glaber (naked mole-rat) : Crhr2 (corticotropin releasing hormone receptor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Crhr2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70547
Created: 2002-05-20
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.