Mkrn1 (makorin ring finger protein 1)

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Gene: Mkrn1 (makorin ring finger protein 1) Rattus norvegicus

Analyze

Symbol:

Mkrn1

Name:

makorin ring finger protein 1

RGD ID:

1303251

Description:

Predicted to have chromatin binding activity and ubiquitin protein ligase activity. Predicted to be involved in cellular response to leukemia inhibitory factor and protein polyubiquitination. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1); INTERACTS WITH 3,4-methylenedioxymethamphetamine; tolcapone; valdecoxib.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

E3 ubiquitin-protein ligase makorin-1; MGC94941; similar to Mkrn1 protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MKRN1 (makorin ring finger protein 1)	HGNC	Ensembl, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Mkrn1 (makorin, ring finger protein, 1)	HGNC	Treefam, OrthoMCL, NCBI, OMA, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mkrn1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MKRN1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MKRN1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mkrn1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MKRN1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MKRN1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mkrn1 (makorin ring finger protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MKRN3 (makorin ring finger protein 3)	HGNC	OrthoDB
Homo sapiens (human):	MKRN4P (makorin ring finger protein 4, pseudogene)	HGNC	Panther
Alliance orthologs ³
Homo sapiens (human):	MKRN1 (makorin ring finger protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	MKRN4P (makorin ring finger protein 4, pseudogene)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Mkrn1 (makorin, ring finger protein, 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	mkrn1 (makorin, ring finger protein, 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG12477	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	lep-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	LEE1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG5334	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG5347	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Mkrn1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	68,175,909 - 68,197,216 (-)	NCBI
Rnor_6.0 Ensembl	4	67,185,138 - 67,206,426 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	67,185,167 - 67,206,478 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	66,911,794 - 66,929,911 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	67,187,926 - 67,206,041 (-)	NCBI
Celera	4	63,184,121 - 63,202,238 (-)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-butoxyethanol (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

indometacin (ISO)

methyl methanesulfonate (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tolcapone (EXP)

trichostatin A (ISO)

troglitazone (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

protein polyubiquitination (ISO)

protein ubiquitination (IBA)

Molecular Function

chromatin binding (ISO)

metal ion binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MGD data from the GO Consortium
3.	RGD automated data pipeline
4.	RGD automated import pipeline for gene-chemical interactions
5.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15522233	PMID:19536131	PMID:20439489	PMID:22128154	PMID:22658674

Genomics

Comparative Map Data

Mkrn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	68,175,909 - 68,197,216 (-)	NCBI
Rnor_6.0 Ensembl	4	67,185,138 - 67,206,426 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	67,185,167 - 67,206,478 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	66,911,794 - 66,929,911 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	67,187,926 - 67,206,041 (-)	NCBI
Celera	4	63,184,121 - 63,202,238 (-)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

MKRN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	140,453,033 - 140,479,536 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	140,453,033 - 140,479,569 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	140,152,833 - 140,179,369 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	139,799,320 - 139,825,771 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	139,606,043 - 139,632,486	NCBI
Celera	7	134,874,902 - 134,901,432 (-)	NCBI
Cytogenetic Map	7	q34	NCBI
HuRef	7	134,445,963 - 134,472,987 (-)	NCBI		HuRef
CHM1_1	7	140,087,746 - 140,114,255 (-)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	139,481,663 - 139,517,562 (-)	NCBI

Mkrn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	39,374,738 - 39,400,480 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	39,374,738 - 39,397,396 (-)	Ensembl
GRCm38	6	39,397,804 - 39,423,299 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	39,397,804 - 39,420,462 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	39,347,820 - 39,370,368 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	39,327,427 - 39,349,993 (-)	NCBI			mm8
Celera	6	39,382,926 - 39,405,518 (-)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI

Mkrn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	2,847,783 - 2,871,338 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	2,847,783 - 2,871,095 (+)	NCBI	ChiLan1.0	ChiLan1.0

MKRN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	144,867,541 - 144,892,988 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	144,867,541 - 144,893,658 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	132,391,357 - 132,417,395 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

MKRN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	8,508,036 - 8,530,009 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Mkrn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936592	4,533,142 - 4,539,599 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MKRN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	9,333,684 - 9,358,851 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	9,333,637 - 9,358,854 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	9,833,936 - 9,859,145 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MKRN1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	109,234,066 - 109,254,584 (-)	NCBI
ChlSab1.1 Ensembl	21	109,234,065 - 109,247,474 (-)	Ensembl

Mkrn1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624765	20,608,443 - 20,631,712 (-)	NCBI

Position Markers

AI136942

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	67,188,189 - 67,188,376	NCBI	Rnor6.0
Rnor_5.0	4	66,994,956 - 66,995,143	UniSTS	Rnor5.0
RGSC_v3.4	4	66,911,826 - 66,912,013	UniSTS	RGSC3.4
Celera	4	63,184,153 - 63,184,340	UniSTS
RH 3.4 Map	4	405.9	UniSTS
Cytogenetic Map	4	q22	UniSTS

RH134570

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	9	229.6	UniSTS
Cytogenetic Map	4	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	3043231	79575658	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	3043231	145254791	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	7342404	92484039	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	7850904	182171018	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	23850384	169318094	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	23991721	76238799	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	23991721	76238799	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	24631874	69631874	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	26654749	81874227	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	29549895	112807890	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	31825560	83531021	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	31825560	83531021	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	31825560	83531021	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	34277932	99067150	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	36615599	145611886	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	37685175	73066691	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	37703272	75345433	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	37703272	115372927	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	39208222	84208222	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	39208247	84208247	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	42415777	87415777	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	43414605	155469929	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	43414792	146942075	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	43414792	146942075	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	46898276	145611886	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	49906054	145611886	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	55324857	79575658	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	55324857	79575658	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	55324857	79575658	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	55324857	79575658	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	55324953	148360954	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	55375865	125671711	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	55791564	82134846	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	55791564	92484312	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	55791834	79557856	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	56092756	101092756	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	56092756	101092756	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	57101077	92990863	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	57307075	79578854	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58166424	103166424	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58640017	154427984	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	58640017	154427984	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	58640017	154427984	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	60439127	99066957	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	60439127	113416139	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	61038901	127777403	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61708103	88565113	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	61708341	83531021	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in mean arterial blood pressure (CMO:0002035)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	percent change in systolic blood pressure (CMO:0000747)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in pulse pressure (CMO:0001882)	4	61708341	113100992	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	61708341	113100992	Rat
2300179	Bmd50	Bone mineral density QTL 50	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	4	61975371	106975371	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	62947687	125671711	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	63537179	157286626	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	63812687	108812687	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	63812687	108812687	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	63812687	108812687	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	63938412	108938412	Rat
2317577	Eae24	Experimental allergic encephalomyelitis QTL 24			nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	65987814	73372824	Rat
2317577	Eae24	Experimental allergic encephalomyelitis QTL 24			nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	4	65987814	73372824	Rat
2317577	Eae24	Experimental allergic encephalomyelitis QTL 24			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	4	65987814	73372824	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	65989243	97759057	Rat
2306547	Iddm38	Insulin dependent diabetes mellitus QTL 38			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	66394000	70773654	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	298
Count of miRNA genes:	189
Interacting mature miRNAs:	205
Transcripts:	ENSRNOT00000013124
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	57	41	19	41	1	1	74	35	41	11	1
Low		2					7	10					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013124 ⟹ ENSRNOP00000013124

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	67,185,138 - 67,206,426 (-)	Ensembl

RefSeq Acc Id:

NM_001004233 ⟹ NP_001004233

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	68,178,905 - 68,197,024 (-)	NCBI
Rnor_6.0	4	67,188,157 - 67,206,273 (-)	NCBI
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI
RGSC_v3.4	4	66,911,794 - 66,929,911 (-)	RGD
Celera	4	63,184,121 - 63,202,238 (-)	RGD

Sequence:

show sequence

GTAATGGCGGAGGCTGCGGCTCCCGGAACAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGG
CGGCGGTGGCAGCGGCCTCCCTCACCTCTATCCCCACAGTCGCTGCCCCGTCCCCGGGGGCGGG
AGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACGAAACAGGTCACCTGCAGATAT
TTTATGCATGGGGTTTGTAAGGAAGGAGATAACTGTCGATACTCTCATGACCTCTCTGACAGTC
CATATGGTGTAGTGTGCAAGTATTTTCAAAGAGGGTACTGTGTTTATGGAGACCGCTGCAGATA
CGAACACAGCAAGCCACTGAAACAGGAAGAAGTGACTGCTACAGACCTGAGTGCAAAGCCATCC
CCTGCTGCTTCCTCAAGTCTCCCTTCTGGTGTTGGATCACTTGCTGAAATGAATCCAGGCGAAG
CTGAGTCACGAAACCCAAACTTTCCAACTGTAGGAGCGGGTTCAGAGGACTGGGTGAATGCCAT
TGAGTTTGTCCCTGGGCAGCCCTACTGTGGCCGTACTGCCCCTTCCTGCACTGAAGTGCCCCTG
CAGGGCTCAGTGACCAAGGAAGAGTCAGAGAAGGAGCCAACTACGGTGGAGACAGAGAAGCAGC
TTTGCCCCTATGCTGCAGTGGGAGAGTGTCGCTATGGGGAAAACTGTGTGTATCTCCACGGAGA
CTCCTGTGACATGTGTGGCCTGCAGGTCCTACACCCAATGGATGCTGCCCAGAGGTCACAGCAC
ATAAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCTTTTGCTGTTCAGCGCAGCA
AGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCCCAGCGAGCGTCG
TTTTGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGTATTCGCAAGTGGAGAAGT
GCTAAACAATTTGAGAGCAAGATCATAAAGTGAGACTCCTCCCCAATCTTCATTTGTGCTTTCT
ATTTTCGGGAAGAATTTAGTGTCTTGTGCCAACTTCCAACCAGAAGGACCACATTTAAATGCAT
GTATTTTATCATGAACCTGGGTGTTCTAATTGGGATTTCTTCTTTGTATTTCAGCTAGCTGCTA
GGTTAGTTGGTCTGTCTATTTTATTTGAATGAGGAAACCCTGTGTATCAGTTAGTAGAGTCTTC
ATTGCTTTTTGAGGAGATTGTGTTTAATGGATTAGACAGTTTAGGTTTCTTGAACAAACATATC
TAGCTCTGAATGTATGTTTCCTGGTGTTTTCTACTTTCCACTTTCCTATATCATCCATTAAGCT
AGCCAAAAATCCACCATCCGTTAAATCTGTTCTCATAATTGAACAAAAGCCACATAATCCAGAG
CAAAGTTAACAAGAAATAAATTTATTTAAACGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236301 ⟹ XP_006236363

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	68,175,909 - 68,197,213 (-)	NCBI
Rnor_6.0	4	67,185,167 - 67,206,477 (-)	NCBI
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI

Sequence:

show sequence

GGAGGGCCGCGGGCGCCCAGCGGAGCCTGCAGTTCCCGAGACCAGAGCGCTCCGAGACGCGGTG
ACACGGCACGGGACTGGCGTGGAGCTCTCGGGCTCTTCAGCCTCCCTCCCCTCCCCTCCCTTCG
CTGTCTTCTCCTTCTTAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCATTGCTGT
GTGGGATAAACAGTAATGGCGGAGGCTGCGGCTCCCGGAACAACAGCCACAACATCAGGAGCAG
GAGCGGCAGCGGCGGCGGTGGCAGCGGCCTCCCTCACCTCTATCCCCACAGTCGCTGCCCCGTC
CCCGGGGGCGGGAGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACGAAACAGGTC
ACCTGCAGATATTTTATGCATGGGGTTTGTAAGGAAGGAGATAACTGTCGATACTCTCATGACC
TCTCTGACAGTCCATATGGTGTAGTGTGCAAGTATTTTCAAAGAGGGTACTGTGTTTATGGAGA
CCGCTGCAGATACGAACACAGCAAGCCACTGAAACAGGAAGAAGTGACTGCTACAGACCTGAGT
GCAAAGCCATCCCCTGCTGCTTCCTCAAGTCTCCCTTCTGGTGTTGGATCACTTGCTGAAATGA
ATCCAGGCGAAGCTGAGTCACGAAACCCAAACTTTCCAACTGTAGGAGCGGGTTCAGAGGACTG
GGTGAATGCCATTGAGTTTGTCCCTGGGCAGCCCTACTGTGGCCGTACTGCCCCTTCCTGCACT
GAAGTGCCCCTGCAGGGCTCAGTGACCAAGGAAGAGTCAGAGAAGGAGCCAACTACGGTGGAGA
CAGAGAAGCAGCTTTGCCCCTATGCTGCAGTGGGAGAGTGTCGCTATGGGGAAAACTGTGTGTA
TCTCCACGGAGACTCCTGTGACATGTGTGGCCTGCAGGTCCTACACCCAATGGATGCTGCCCAG
AGGTCACAGCACATAAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCTTTTGCTG
TTCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCC
CAGCGAGCGTCGTTTTGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGTATTCGC
AAGTGGAGAAGTGCTAAACAATTTGAGAGCAAGATCATAAAGTCCTGCCCCGAATGCCGGATCA
CATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAAGAGAAAGAAGAGAAGCAGAAACTCAT
TCAGAAATACAAGGAGGCCATGAGCAACAAGGCGTGCAGGTATTTTGATGAAGGACGTGGGAGC
TGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGCCGTAGAGAGGAGCCAC
AGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGAGCCACTTCTGGGAGCT
CATTGAGGAGAGAGAGAACAACCCCTTTGACAACGACGAAGAGGAGGTTGTCACCTTTGAGCTG
GGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAGCTGACAGACTCTGAGGACG
AGTGGGACTTGTTTCACGATGAGCTGGAGGATTTTTATGACTTGGAGCTATAGCAGCTTTGCGT
GGCGCAGGAACTGGTCTGCGGAGCCTCAGACAGTAGCTGTCCCCTGTGCTGTATGGCAGTGCGT
GTGGCTCTCCTAGGCAGGCCTCTCAAACTCCAGGTGCTGTGATCACTACCCAGGGCCTGTTCCT
CTACCCTCACCTTTCCCCCAAGAGTGTGTTGTTTTCTCTGTTTCAAAAGTTACAAAAATAAATC
TTAAAGTTAGTTTTTTTGTAACATGAATTTAACTGTCAGACAGTTAGTGTAGGTTTGTTGCGTC
ATCTGTTTTTGGCCAGGTTGTGTTCATGGACTTTGCACACTCATTTTGAGACCCCTTTGAGGTT
CAAAGGAAAAAGCACTGACTGTGCTTTGGGGTCCAAGGATAGGGGCAATTGGGAAAAAAAAGGG
ACCTAACTTGGCAAGTCGCTCTCTGCGATAGGTGTAGGAAGGTTCCCCGAGGTTTCTGTGAGAC
CTGCACTGCACCTTCACAGTTTTATCTATGTTCCCTACCCTGTAATCCCCATCAACATGTGCTT
GTGCTGTGGTTTTGGGCTCTTGTTTAATTGCACGCAAGAACTACTACTGGGTAACCAGAACCAG
GTGCAAATGTGTTGAGGTTGACATGAGAAAATCTAAAAACATGAAGGATGCGGTGGTGTTCCCT
CAGTGCAGAGCTGGCGGTTAACTCCCAAGGGTGGATGGACTTGGTGGGTGAGCATGGGCGCGCA
CGGGCGAGCATGGGAGCAGCTTCCCATCGGTGCATAGGTGCAGTATTCTTAGCTTTAGTGGGCA
GATGTGGGTTAGTGGTTTCAGCCACATGTGTCAGGTAGATCTAAAGGACCAAGCAGTATGTCAG
TAGTTGTTAACGTAGCAGTAGCTGTCTGTCTGTATGCTAGAGAAATGGGATCAGCTGTAGAGGT
TAAATGACCTACTTGTCCCTTTCAGTACAAGGTGGGTCTTGGACACACTGATGTTTTGAATGTT
TTACAGTCTAGCCTTTTCAGTCCAGGCACTTTTTGGAAAAAAACTTTGTCCTCATTTGAGGGGG
CCTGTTGTGAGGTTCTGTGCTTGTTTTTGTGGGTATCTGCCTCATTCCATCCCTGCCTGAGCTC
TGACAGTAAGACAGGTGGATTCCAAACTGAGGTGTTGATTGTGCTAGAGGTTTGCAGAAGTAAT
GAACCCCTTTCCCGGTAAAGAGAAGGGAGGGTGTGGCCATCCACAAGACAAGCAAGAGTTGCTA
AAATTCCTTGGCGGGAATTTCACCTTTGCATTCTGTTGCTCTTTCCTGAAATAACGTGGGAGAT
GCTCGGATCTGTCCCTCTGCCCTGCTTACCCGGAACTCACCCAGTCTTTCACTTAAGAAAAACA
CGTCATCGTTGCAGAGGTCTCTGTTTTGCAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATA
AAACAATTTTGAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236302 ⟹ XP_006236364

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	68,175,909 - 68,197,216 (-)	NCBI
Rnor_6.0	4	67,185,167 - 67,206,478 (-)	NCBI
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI

Sequence:

show sequence

AGGAGGGCCGCGGGCGCCCAGCGGAGCCTGCAGTTCCCGAGACCAGAGCGCTCCGAGACGCGGT
GACACGGCACGGGACTGGCGTGGAGCTCTCGGGCTCTTCAGCCTCCCTCCCCTCCCCTCCCTTC
GCTGTCTTCTCCTTCTTAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCATTGCTG
TGTGGGATAAACAGTAATGGCGGAGGCTGCGGCTCCCGGAACAACAGCCACAACATCAGGAGCA
GGAGCGGCAGCGGCGGCGGTGGCAGCGGCCTCCCTCACCTCTATCCCCACAGTCGCTGCCCCGT
CCCCGGGGGCGGGAGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACGAAACAGGT
CACCTGCAGATACGAACACAGCAAGCCACTGAAACAGGAAGAAGTGACTGCTACAGACCTGAGT
GCAAAGCCATCCCCTGCTGCTTCCTCAAGTCTCCCTTCTGGTGTTGGATCACTTGCTGAAATGA
ATCCAGGCGAAGCTGAGTCACGAAACCCAAACTTTCCAACTGTAGGAGCGGGTTCAGAGGACTG
GGTGAATGCCATTGAGTTTGTCCCTGGGCAGCCCTACTGTGGCCGTACTGCCCCTTCCTGCACT
GAAGTGCCCCTGCAGGGCTCAGTGACCAAGGAAGAGTCAGAGAAGGAGCCAACTACGGTGGAGA
CAGAGAAGCAGCTTTGCCCCTATGCTGCAGTGGGAGAGTGTCGCTATGGGGAAAACTGTGTGTA
TCTCCACGGAGACTCCTGTGACATGTGTGGCCTGCAGGTCCTACACCCAATGGATGCTGCCCAG
AGGTCACAGCACATAAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCTTTTGCTG
TTCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCC
CAGCGAGCGTCGTTTTGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGTATTCGC
AAGTGGAGAAGTGCTAAACAATTTGAGAGCAAGATCATAAAGTCCTGCCCCGAATGCCGGATCA
CATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAAGAGAAAGAAGAGAAGCAGAAACTCAT
TCAGAAATACAAGGAGGCCATGAGCAACAAGGCGTGCAGGTATTTTGATGAAGGACGTGGGAGC
TGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGCCGTAGAGAGGAGCCAC
AGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGAGCCACTTCTGGGAGCT
CATTGAGGAGAGAGAGAACAACCCCTTTGACAACGACGAAGAGGAGGTTGTCACCTTTGAGCTG
GGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAGCTGACAGACTCTGAGGACG
AGTGGGACTTGTTTCACGATGAGCTGGAGGATTTTTATGACTTGGAGCTATAGCAGCTTTGCGT
GGCGCAGGAACTGGTCTGCGGAGCCTCAGACAGTAGCTGTCCCCTGTGCTGTATGGCAGTGCGT
GTGGCTCTCCTAGGCAGGCCTCTCAAACTCCAGGTGCTGTGATCACTACCCAGGGCCTGTTCCT
CTACCCTCACCTTTCCCCCAAGAGTGTGTTGTTTTCTCTGTTTCAAAAGTTACAAAAATAAATC
TTAAAGTTAGTTTTTTTGTAACATGAATTTAACTGTCAGACAGTTAGTGTAGGTTTGTTGCGTC
ATCTGTTTTTGGCCAGGTTGTGTTCATGGACTTTGCACACTCATTTTGAGACCCCTTTGAGGTT
CAAAGGAAAAAGCACTGACTGTGCTTTGGGGTCCAAGGATAGGGGCAATTGGGAAAAAAAAGGG
ACCTAACTTGGCAAGTCGCTCTCTGCGATAGGTGTAGGAAGGTTCCCCGAGGTTTCTGTGAGAC
CTGCACTGCACCTTCACAGTTTTATCTATGTTCCCTACCCTGTAATCCCCATCAACATGTGCTT
GTGCTGTGGTTTTGGGCTCTTGTTTAATTGCACGCAAGAACTACTACTGGGTAACCAGAACCAG
GTGCAAATGTGTTGAGGTTGACATGAGAAAATCTAAAAACATGAAGGATGCGGTGGTGTTCCCT
CAGTGCAGAGCTGGCGGTTAACTCCCAAGGGTGGATGGACTTGGTGGGTGAGCATGGGCGCGCA
CGGGCGAGCATGGGAGCAGCTTCCCATCGGTGCATAGGTGCAGTATTCTTAGCTTTAGTGGGCA
GATGTGGGTTAGTGGTTTCAGCCACATGTGTCAGGTAGATCTAAAGGACCAAGCAGTATGTCAG
TAGTTGTTAACGTAGCAGTAGCTGTCTGTCTGTATGCTAGAGAAATGGGATCAGCTGTAGAGGT
TAAATGACCTACTTGTCCCTTTCAGTACAAGGTGGGTCTTGGACACACTGATGTTTTGAATGTT
TTACAGTCTAGCCTTTTCAGTCCAGGCACTTTTTGGAAAAAAACTTTGTCCTCATTTGAGGGGG
CCTGTTGTGAGGTTCTGTGCTTGTTTTTGTGGGTATCTGCCTCATTCCATCCCTGCCTGAGCTC
TGACAGTAAGACAGGTGGATTCCAAACTGAGGTGTTGATTGTGCTAGAGGTTTGCAGAAGTAAT
GAACCCCTTTCCCGGTAAAGAGAAGGGAGGGTGTGGCCATCCACAAGACAAGCAAGAGTTGCTA
AAATTCCTTGGCGGGAATTTCACCTTTGCATTCTGTTGCTCTTTCCTGAAATAACGTGGGAGAT
GCTCGGATCTGTCCCTCTGCCCTGCTTACCCGGAACTCACCCAGTCTTTCACTTAAGAAAAACA
CGTCATCGTTGCAGAGGTCTCTGTTTTGCAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATA
AAACAATTTTGAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236303 ⟹ XP_006236365

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	68,175,909 - 68,196,508 (-)	NCBI
Rnor_6.0	4	67,185,167 - 67,205,797 (-)	NCBI
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI

Sequence:

show sequence

GCGAATCGGGCTCTAACGACCCTCGGTGCGCCCTGAGACCCTCCAAGGGTCCCGGCGAGCTCGG
CCGGCCCCGGGGCTCCGCGCCGGGCTATCCGTTTGTAACGTTTTTTCTGCTCTCTGCGCCGTTC
ACCCCCGCCCCGCCGGGAGCAGCCGCTTTTGTATGCCTTTGTATGTGAGTCGGTGGTCGGCGGT
TCCGAGCTTTGTCCCCGAACCGAGCGTTCGGAGCCGGCGTTAGGCTCCTCCAACCTTGGTTGTA
TGAACTGCCATTATTATTACTGTCCCTTTGAGCGGCGTTCCTCTTTGCGAGAAAGGAGATCCGA
GGAGAGAGGTTTGGTTCTTGTTTGATATTTTATGCATGGGGTTTGTAAGGAAGGAGATAACTGT
CGATACTCTCATGACCTCTCTGACAGTCCATATGGTGTAGTGTGCAAGTATTTTCAAAGAGGGT
ACTGTGTTTATGGAGACCGCTGCAGATACGAACACAGCAAGCCACTGAAACAGGAAGAAGTGAC
TGCTACAGACCTGAGTGCAAAGCCATCCCCTGCTGCTTCCTCAAGTCTCCCTTCTGGTGTTGGA
TCACTTGCTGAAATGAATCCAGGCGAAGCTGAGTCACGAAACCCAAACTTTCCAACTGTAGGAG
CGGGTTCAGAGGACTGGGTGAATGCCATTGAGTTTGTCCCTGGGCAGCCCTACTGTGGCCGTAC
TGCCCCTTCCTGCACTGAAGTGCCCCTGCAGGGCTCAGTGACCAAGGAAGAGTCAGAGAAGGAG
CCAACTACGGTGGAGACAGAGAAGCAGCTTTGCCCCTATGCTGCAGTGGGAGAGTGTCGCTATG
GGGAAAACTGTGTGTATCTCCACGGAGACTCCTGTGACATGTGTGGCCTGCAGGTCCTACACCC
AATGGATGCTGCCCAGAGGTCACAGCACATAAAATCGTGCATTGAGGCCCATGAGAAGGACATG
GAGCTCTCTTTTGCTGTTCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCT
ATGAGAAAGCCAACCCCAGCGAGCGTCGTTTTGGGATCCTCTCCAACTGCAACCACACCTACTG
TCTCAAGTGTATTCGCAAGTGGAGAAGTGCTAAACAATTTGAGAGCAAGATCATAAAGTCCTGC
CCCGAATGCCGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAAGAGAAAGAAG
AGAAGCAGAAACTCATTCAGAAATACAAGGAGGCCATGAGCAACAAGGCGTGCAGGTATTTTGA
TGAAGGACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGC
CGTAGAGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGA
GCCACTTCTGGGAGCTCATTGAGGAGAGAGAGAACAACCCCTTTGACAACGACGAAGAGGAGGT
TGTCACCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAGCTG
ACAGACTCTGAGGACGAGTGGGACTTGTTTCACGATGAGCTGGAGGATTTTTATGACTTGGAGC
TATAGCAGCTTTGCGTGGCGCAGGAACTGGTCTGCGGAGCCTCAGACAGTAGCTGTCCCCTGTG
CTGTATGGCAGTGCGTGTGGCTCTCCTAGGCAGGCCTCTCAAACTCCAGGTGCTGTGATCACTA
CCCAGGGCCTGTTCCTCTACCCTCACCTTTCCCCCAAGAGTGTGTTGTTTTCTCTGTTTCAAAA
GTTACAAAAATAAATCTTAAAGTTAGTTTTTTTGTAACATGAATTTAACTGTCAGACAGTTAGT
GTAGGTTTGTTGCGTCATCTGTTTTTGGCCAGGTTGTGTTCATGGACTTTGCACACTCATTTTG
AGACCCCTTTGAGGTTCAAAGGAAAAAGCACTGACTGTGCTTTGGGGTCCAAGGATAGGGGCAA
TTGGGAAAAAAAAGGGACCTAACTTGGCAAGTCGCTCTCTGCGATAGGTGTAGGAAGGTTCCCC
GAGGTTTCTGTGAGACCTGCACTGCACCTTCACAGTTTTATCTATGTTCCCTACCCTGTAATCC
CCATCAACATGTGCTTGTGCTGTGGTTTTGGGCTCTTGTTTAATTGCACGCAAGAACTACTACT
GGGTAACCAGAACCAGGTGCAAATGTGTTGAGGTTGACATGAGAAAATCTAAAAACATGAAGGA
TGCGGTGGTGTTCCCTCAGTGCAGAGCTGGCGGTTAACTCCCAAGGGTGGATGGACTTGGTGGG
TGAGCATGGGCGCGCACGGGCGAGCATGGGAGCAGCTTCCCATCGGTGCATAGGTGCAGTATTC
TTAGCTTTAGTGGGCAGATGTGGGTTAGTGGTTTCAGCCACATGTGTCAGGTAGATCTAAAGGA
CCAAGCAGTATGTCAGTAGTTGTTAACGTAGCAGTAGCTGTCTGTCTGTATGCTAGAGAAATGG
GATCAGCTGTAGAGGTTAAATGACCTACTTGTCCCTTTCAGTACAAGGTGGGTCTTGGACACAC
TGATGTTTTGAATGTTTTACAGTCTAGCCTTTTCAGTCCAGGCACTTTTTGGAAAAAAACTTTG
TCCTCATTTGAGGGGGCCTGTTGTGAGGTTCTGTGCTTGTTTTTGTGGGTATCTGCCTCATTCC
ATCCCTGCCTGAGCTCTGACAGTAAGACAGGTGGATTCCAAACTGAGGTGTTGATTGTGCTAGA
GGTTTGCAGAAGTAATGAACCCCTTTCCCGGTAAAGAGAAGGGAGGGTGTGGCCATCCACAAGA
CAAGCAAGAGTTGCTAAAATTCCTTGGCGGGAATTTCACCTTTGCATTCTGTTGCTCTTTCCTG
AAATAACGTGGGAGATGCTCGGATCTGTCCCTCTGCCCTGCTTACCCGGAACTCACCCAGTCTT
TCACTTAAGAAAAACACGTCATCGTTGCAGAGGTCTCTGTTTTGCAGCTGCCCTTTTGTAAGAA
GCACTTTTCCCAAATAAAACAATTTTGAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236304 ⟹ XP_006236366

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	68,175,909 - 68,196,768 (-)	NCBI
Rnor_6.0	4	67,185,167 - 67,206,037 (-)	NCBI
Rnor_5.0	4	66,991,930 - 67,013,553 (-)	NCBI

Sequence:

show sequence

AGGAGGCGGAGGCGGGCGTCGCGGGGTCCCTGCTGCGGCCGCCCTCCCAGCATCGCTGCGTCAG
CCTCCGCAGAGGTTGGCCGCGACATCGCTGCGGGTTTCAGACTGCGGGCTCGGACTGCGGGGCT
GTCCCGTCACCTCCCCTCGCCTAGCGGCTCCCCGGTGTGTGCTGAGAGGACCGGTGTCCCCGCC
CCGACCTCCATCGCCACAGATATTTTATGCATGGGGTTTGTAAGGAAGGAGATAACTGTCGATA
CTCTCATGACCTCTCTGACAGTCCATATGGTGTAGTGTGCAAGTATTTTCAAAGAGGGTACTGT
GTTTATGGAGACCGCTGCAGATACGAACACAGCAAGCCACTGAAACAGGAAGAAGTGACTGCTA
CAGACCTGAGTGCAAAGCCATCCCCTGCTGCTTCCTCAAGTCTCCCTTCTGGTGTTGGATCACT
TGCTGAAATGAATCCAGGCGAAGCTGAGTCACGAAACCCAAACTTTCCAACTGTAGGAGCGGGT
TCAGAGGACTGGGTGAATGCCATTGAGTTTGTCCCTGGGCAGCCCTACTGTGGCCGTACTGCCC
CTTCCTGCACTGAAGTGCCCCTGCAGGGCTCAGTGACCAAGGAAGAGTCAGAGAAGGAGCCAAC
TACGGTGGAGACAGAGAAGCAGCTTTGCCCCTATGCTGCAGTGGGAGAGTGTCGCTATGGGGAA
AACTGTGTGTATCTCCACGGAGACTCCTGTGACATGTGTGGCCTGCAGGTCCTACACCCAATGG
ATGCTGCCCAGAGGTCACAGCACATAAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCT
CTCTTTTGCTGTTCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAG
AAAGCCAACCCCAGCGAGCGTCGTTTTGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCA
AGTGTATTCGCAAGTGGAGAAGTGCTAAACAATTTGAGAGCAAGATCATAAAGTCCTGCCCCGA
ATGCCGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAAGAGAAAGAAGAGAAG
CAGAAACTCATTCAGAAATACAAGGAGGCCATGAGCAACAAGGCGTGCAGGTATTTTGATGAAG
GACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGCCGTAG
AGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGAGCCAC
TTCTGGGAGCTCATTGAGGAGAGAGAGAACAACCCCTTTGACAACGACGAAGAGGAGGTTGTCA
CCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAGCTGACAGA
CTCTGAGGACGAGTGGGACTTGTTTCACGATGAGCTGGAGGATTTTTATGACTTGGAGCTATAG
CAGCTTTGCGTGGCGCAGGAACTGGTCTGCGGAGCCTCAGACAGTAGCTGTCCCCTGTGCTGTA
TGGCAGTGCGTGTGGCTCTCCTAGGCAGGCCTCTCAAACTCCAGGTGCTGTGATCACTACCCAG
GGCCTGTTCCTCTACCCTCACCTTTCCCCCAAGAGTGTGTTGTTTTCTCTGTTTCAAAAGTTAC
AAAAATAAATCTTAAAGTTAGTTTTTTTGTAACATGAATTTAACTGTCAGACAGTTAGTGTAGG
TTTGTTGCGTCATCTGTTTTTGGCCAGGTTGTGTTCATGGACTTTGCACACTCATTTTGAGACC
CCTTTGAGGTTCAAAGGAAAAAGCACTGACTGTGCTTTGGGGTCCAAGGATAGGGGCAATTGGG
AAAAAAAAGGGACCTAACTTGGCAAGTCGCTCTCTGCGATAGGTGTAGGAAGGTTCCCCGAGGT
TTCTGTGAGACCTGCACTGCACCTTCACAGTTTTATCTATGTTCCCTACCCTGTAATCCCCATC
AACATGTGCTTGTGCTGTGGTTTTGGGCTCTTGTTTAATTGCACGCAAGAACTACTACTGGGTA
ACCAGAACCAGGTGCAAATGTGTTGAGGTTGACATGAGAAAATCTAAAAACATGAAGGATGCGG
TGGTGTTCCCTCAGTGCAGAGCTGGCGGTTAACTCCCAAGGGTGGATGGACTTGGTGGGTGAGC
ATGGGCGCGCACGGGCGAGCATGGGAGCAGCTTCCCATCGGTGCATAGGTGCAGTATTCTTAGC
TTTAGTGGGCAGATGTGGGTTAGTGGTTTCAGCCACATGTGTCAGGTAGATCTAAAGGACCAAG
CAGTATGTCAGTAGTTGTTAACGTAGCAGTAGCTGTCTGTCTGTATGCTAGAGAAATGGGATCA
GCTGTAGAGGTTAAATGACCTACTTGTCCCTTTCAGTACAAGGTGGGTCTTGGACACACTGATG
TTTTGAATGTTTTACAGTCTAGCCTTTTCAGTCCAGGCACTTTTTGGAAAAAAACTTTGTCCTC
ATTTGAGGGGGCCTGTTGTGAGGTTCTGTGCTTGTTTTTGTGGGTATCTGCCTCATTCCATCCC
TGCCTGAGCTCTGACAGTAAGACAGGTGGATTCCAAACTGAGGTGTTGATTGTGCTAGAGGTTT
GCAGAAGTAATGAACCCCTTTCCCGGTAAAGAGAAGGGAGGGTGTGGCCATCCACAAGACAAGC
AAGAGTTGCTAAAATTCCTTGGCGGGAATTTCACCTTTGCATTCTGTTGCTCTTTCCTGAAATA
ACGTGGGAGATGCTCGGATCTGTCCCTCTGCCCTGCTTACCCGGAACTCACCCAGTCTTTCACT
TAAGAAAAACACGTCATCGTTGCAGAGGTCTCTGTTTTGCAGCTGCCCTTTTGTAAGAAGCACT
TTTCCCAAATAAAACAATTTTGAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004233	(Get FASTA)	NCBI Sequence Viewer
	XP_006236363	(Get FASTA)	NCBI Sequence Viewer
	XP_006236364	(Get FASTA)	NCBI Sequence Viewer
	XP_006236365	(Get FASTA)	NCBI Sequence Viewer
	XP_006236366	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79407	(Get FASTA)	NCBI Sequence Viewer
	EDM15385	(Get FASTA)	NCBI Sequence Viewer
	EDM15387	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001004233 ⟸ NM_001004233

- UniProtKB:

Q68FR1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYF
MHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSP
AASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQ
GSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHI
KSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSA
KQFESKIIK

hide sequence

RefSeq Acc Id:

XP_006236366 ⟸ XM_006236304

- Peptide Label:

isoform X3

- Sequence:

show sequence

MHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSP
AASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQ
GSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHI
KSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSA
KQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGG
NCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLL
MLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL

hide sequence

RefSeq Acc Id:

XP_006236365 ⟸ XM_006236303

- Peptide Label:

isoform X3

- Sequence:

show sequence

MHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSP
AASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQ
GSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHI
KSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSA
KQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGG
NCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLL
MLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL

hide sequence

RefSeq Acc Id:

XP_006236364 ⟸ XM_006236302

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYE
HSKPLKQEEVTATDLSAKPSPAASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIE
FVPGQPYCGRTAPSCTEVPLQGSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDS
CDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRF
GILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKE
AMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERE
NNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL

hide sequence

RefSeq Acc Id:	XP_006236363 ⟸ XM_006236301
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2QC40 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYF MHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSP AASSSLPSGVGSLAEMNPGEAESRNPNFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPLQ GSVTKEESEKEPTTVETEKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHI KSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSA KQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGG NCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLL MLLAAGGDDELTDSEDEWDLFHDELEDFYDLEL hide sequence

RefSeq Acc Id:

ENSRNOP00000013124 ⟸ ENSRNOT00000013124

Protein Domains

C3H1-type RING-type

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692980

Promoter ID:

EPDNEW_R3505

Type:

multiple initiation site

Name:

Mkrn1_1

Description:

makorin ring finger protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R3506

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	67,206,290 - 67,206,350	EPDNEW

RGD ID:

13692981

Promoter ID:

EPDNEW_R3506

Type:

initiation region

Name:

Mkrn1_2

Description:

makorin ring finger protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R3505

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	67,206,434 - 67,206,494	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
4	67187821	67187822	T	G	snv	WN/N (MCW), Buf/N (MCW)
4	67188625	67188626	C	G	snv	BN/SsN (MCW), F344/NRrrc (MCW)
4	67188650	67188651	T	G	snv	BN/SsN (MCW), WKY/N (MCW), F344/NRrrc (MCW), Buf/N (MCW), MR/N (MCW), M520/N (MCW)
4	67192910	67192911	C	G	snv	WKY/N (MCW), MR/N (MCW), BN/SsN (MCW), F344/NRrrc (MCW), ACI/N (MCW), WN/N (MCW), Buf/N (MCW), M520/N (MCW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
4	66912287	66912288	T	G	snv	HCR/2Mco (UMich), ACI/EurMcwi (MCW), LCR/2Mco (UMich), LE/Stm (KNAW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), BN/NHsdMcwi (KNAW), LCR/1Mco (UMich), WKY/N (KNAW), HCR/1Mco (UMich), GH/OmrMcwi (MCW), F344/NRrrc (KNAW), BN/SsN (KNAW), COP/CrCrl (MCW & UW), SS/JrHsdMcwi (MCW), MR/N (KNAW), SR/JrHsd (MCW), M520/N (KNAW), BUF/N (KNAW)
4	66915486	66915487	C	T	snv	SR/JrHsd (MCW), FHL/EurMcwi (MCW), SS/JrHsdMcwi (MCW), COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW)
4	66916547	66916548	C	G	snv	HCR/2Mco (UMich), LCR/1Mco (UMich), HCR/1Mco (UMich), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), ACI/EurMcwi (MCW), WN/N (KNAW), WKY/N (KNAW), MR/N (KNAW), M520/N (KNAW), LE/Stm (KNAW), F344/NRrrc (KNAW), BUF/N (KNAW), BN/NHsdMcwi (KNAW), BN/SsN (KNAW), ACI/N (KNAW), SS/JrHsdMcwi (MDC), SHRSP/Gcrc (MDC), LCR/2Mco (UMich)
4	66916691	66916692	A	G	snv	SHRSP/Gcrc (MDC)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303251	AgrOrtholog
Ensembl Genes	ENSRNOG00000009280	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013124	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013124	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112867	IMAGE-MGC_LOAD
InterPro	MKRN1_C	UniProtKB/TrEMBL
	Znf-CCCH_4	UniProtKB/TrEMBL
	Znf_C3HC4_RING-type	UniProtKB/TrEMBL
	Znf_CCCH	UniProtKB/TrEMBL
	Znf_CCCH_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	rno:296988	UniProtKB/TrEMBL
MGC_CLONE	MGC:94941	IMAGE-MGC_LOAD
NCBI Gene	296988	ENTREZGENE
Pfam	MKRN1_C	UniProtKB/TrEMBL
	zf-C3HC4	UniProtKB/TrEMBL
	zf-CCCH_4	UniProtKB/TrEMBL
PhenoGen	Mkrn1	PhenoGen
PROSITE	ZF_C3H1	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
	ZnF_C3H1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF90229	UniProtKB/TrEMBL
UniProt	A0A0G2QC40	ENTREZGENE, UniProtKB/TrEMBL
	Q68FR1	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	G3V789	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-29	Mkrn1	makorin ring finger protein 1	MGC94941	similar to Mkrn1 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	MGC94941				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar