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Gene: Arhgef5 (Rho guanine nucleotide exchange factor 5) Rattus norvegicus
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Symbol: Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including myeloid dendritic cell chemotaxis; positive regulation of JUN kinase activity; and positive regulation of organelle organization. Predicted to localize to the cytosol; nucleoplasm; and plasma membrane. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5); INTERACTS WITH 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: Rho guanine nucleotide exchange factor (GEF) 5; Tim1
Orthologs:
Homo sapiens (human) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)  HGNC  Alliance
Mus musculus (house mouse) : Arhgef5 (Rho guanine nucleotide exchange factor (GEF) 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef5 (Rho guanine nucleotide exchange factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Canis lupus familiaris (dog) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef5 (Rho guanine nucleotide exchange factor 5)
Sus scrofa (pig) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0472,710,775 - 72,736,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04137,413,739 - 137,438,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,036,550 - 71,053,522 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1471,320,405 - 71,322,300 (+)NCBI
Celera467,033,097 - 67,058,406 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Arhgef5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620718
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.