Tbxas1 (thromboxane A synthase 1) - Rat Genome Database

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Gene: Tbxas1 (thromboxane A synthase 1) Rattus norvegicus
Analyze
Symbol: Tbxas1
Name: thromboxane A synthase 1
RGD ID: 3826
Description: Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in cytosol and endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; ThromboxA ane synthase 1; thromboxane A synthase 1, platelet; thromboxane-A synthase; TXA synthase; TXS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp116
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8468,631,841 - 68,803,959 (+)NCBIGRCr8
mRatBN7.2467,664,963 - 67,837,096 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl467,665,007 - 67,837,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx472,601,545 - 72,761,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0468,522,641 - 68,682,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0466,919,149 - 67,090,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0466,624,181 - 66,846,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,670,618 - 66,846,805 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,481,238 - 66,651,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,502,253 - 66,677,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1466,778,382 - 66,953,668 (+)NCBI
Celera462,678,426 - 62,850,218 (+)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
12-HHTrE  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (EXP)
asbestos  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methoxamine  (EXP)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parthenolide  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
protein kinase inhibitor  (ISO)
quinolone  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thromboxane B2  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The effect of ozagrel sodium on photochemical thrombosis in rat: therapeutic window and combined therapy with heparin sodium. Arii K, etal., Life Sci. 2002 Nov 8;71(25):2983-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The combined use of prostaglandin I2 analogue (OP-2507) and thromboxane A2 synthetase inhibitor (OKY-046) strongly inhibits atherosclerosis of aortic allografts in rats. Hirano T, etal., Surgery. 2001 May;129(5):595-605.
5. The effects of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analogue on experimental acute necrotizing pancreatitis in rats. Iida T, etal., Pancreas. 1998 Aug;17(2):140-7.
6. Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. Imamura T, etal., Arzneimittelforschung. 2003;53(10):688-94.
7. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. Jones AE, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L1072-81. Epub 2003 Mar 14.
8. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Kataoka M, etal., Am J Respir Crit Care Med. 2005 Dec 15;172(12):1575-80. Epub 2005 Sep 28.
9. Inhibition of thromboxane synthesis attenuates insulin hypertension in rats. Keen HL, etal., Am J Hypertens. 1997 Oct;10(10 Pt 1):1125-31.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Effect of thromboxane A2 inhibition and antagonism on prostaglandin and leukotriene synthesis in glomerular immune injury. Lianos EA and Bresnahan BA, J Lab Clin Med. 1999 Nov;134(5):478-82.
12. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive Heymann nephritis in rats. Nagao T, etal., Eur J Pharmacol. 1996 Nov 28;316(1):73-80.
15. Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. Nanji AA, etal., J Pharmacol Exp Ther. 1997 Aug;282(2):1037-43.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. Park SA, etal., BMB Rep. 2009 Apr 30;42(4):200-5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. Sakai H, etal., Br J Pharmacol. 2002 Jun;136(3):383-90.
26. Protective effect of FK506 and thromboxane synthase inhibitor on ischemia-reperfusion injury in non-heart-beating donor in rat orthotopic liver transplantation. Sasaki K, etal., J Med Invest. 2004 Feb;51(1-2):76-83.
27. The effects of thromboxane A2 synthetase inhibitor (OKY-046) on complete hepatic ischemia in rats with obstructive jaundice. Takahashi T Surg Today. 1996;26(1):15-20.
28. Abundant expression of thromboxane synthase in rat macrophages. Tone Y, etal., FEBS Lett 1994 Mar 7;340(3):241-4.
29. Rat kidney thromboxane synthase: cDNA cloning and gene expression regulation in hydronephrotic kidney. Tsutsumi E, etal., Prostaglandins 1997 Jun;53(6):423-31.
30. Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats. Xu H, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G277-83.
Additional References at PubMed
PMID:7688225   PMID:8366093   PMID:11097184   PMID:11297515   PMID:17459323   PMID:26211743   PMID:27923787  


Genomics

Comparative Map Data
Tbxas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8468,631,841 - 68,803,959 (+)NCBIGRCr8
mRatBN7.2467,664,963 - 67,837,096 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl467,665,007 - 67,837,096 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx472,601,545 - 72,761,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0468,522,641 - 68,682,583 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0466,919,149 - 67,090,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0466,624,181 - 66,846,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,670,618 - 66,846,805 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,481,238 - 66,651,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,502,253 - 66,677,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1466,778,382 - 66,953,668 (+)NCBI
Celera462,678,426 - 62,850,218 (+)NCBICelera
Cytogenetic Map4q23NCBI
TBXAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387139,778,242 - 140,020,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7139,777,051 - 140,020,325 (+)EnsemblGRCh38hg38GRCh38
GRCh377139,478,041 - 139,720,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367139,175,421 - 139,366,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 347138,982,135 - 139,173,186NCBI
Celera7134,200,105 - 134,441,970 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7133,772,488 - 134,013,944 (+)NCBIHuRef
CHM1_17139,412,286 - 139,654,615 (+)NCBICHM1_1
T2T-CHM13v2.07141,091,534 - 141,333,885 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27138,807,008 - 139,048,964 (+)NCBI
Tbxas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39638,817,897 - 39,061,524 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl638,852,338 - 39,061,519 (+)EnsemblGRCm39 Ensembl
GRCm38638,864,159 - 39,084,590 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl638,875,404 - 39,084,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37638,868,985 - 39,034,578 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36638,848,593 - 39,014,186 (+)NCBIMGSCv36mm8
Celera638,900,560 - 39,068,678 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map617.85NCBI
Tbxas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554943,160,653 - 3,334,411 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554943,161,032 - 3,321,974 (-)NCBIChiLan1.0ChiLan1.0
TBXAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26176,628,283 - 176,813,856 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1728,638,540 - 28,824,110 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07131,772,947 - 131,958,647 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17144,255,211 - 144,439,523 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7144,255,211 - 144,439,523 (+)Ensemblpanpan1.1panPan2
TBXAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,870,283 - 9,032,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,870,284 - 9,023,462 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha169,713,633 - 9,875,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0168,790,596 - 8,952,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl168,790,601 - 8,943,758 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1168,741,298 - 8,903,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0168,585,677 - 8,747,453 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0168,654,393 - 8,816,178 (-)NCBIUU_Cfam_GSD_1.0
Tbxas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511815,026,973 - 15,181,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365924,038,074 - 4,192,808 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365924,038,163 - 4,192,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBXAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl189,717,294 - 9,886,681 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1189,717,291 - 9,886,699 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21810,223,765 - 10,394,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBXAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121108,584,458 - 108,779,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21108,628,570 - 108,779,163 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660725,240,087 - 5,435,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbxas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476520,146,138 - 20,315,797 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476520,145,769 - 20,314,992 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbxas1
1042 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:40
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000010796
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46738666970362197Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
D4Got49  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,676,592 - 67,676,842 (+)MAPPERmRatBN7.2
Rnor_6.0466,682,247 - 66,682,496NCBIRnor6.0
Rnor_5.0466,492,193 - 66,492,442UniSTSRnor5.0
RGSC_v3.4466,513,096 - 66,513,345RGDRGSC3.4
RGSC_v3.4466,513,097 - 66,513,346UniSTSRGSC3.4
RGSC_v3.1466,789,226 - 66,789,475RGD
Celera462,690,474 - 62,690,723UniSTS
RH 3.4 Map4419.8UniSTS
RH 3.4 Map4419.8RGD
RH 2.0 Map4458.3RGD
Cytogenetic Map4q21-q22UniSTS
D4Got45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,741,191 - 67,741,363 (+)MAPPERmRatBN7.2
Rnor_6.0466,747,347 - 66,747,518NCBIRnor6.0
Rnor_5.0466,556,813 - 66,556,984UniSTSRnor5.0
RGSC_v3.4466,578,364 - 66,578,535UniSTSRGSC3.4
RGSC_v3.4466,578,364 - 66,578,535RGDRGSC3.4
RGSC_v3.1466,854,494 - 66,854,665RGD
Celera462,754,524 - 62,754,695UniSTS
RH 3.4 Map4405.4UniSTS
RH 3.4 Map4405.4RGD
Cytogenetic Map4q21-q22UniSTS
RH131018  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,836,439 - 67,837,043 (+)MAPPERmRatBN7.2
Rnor_6.0466,846,077 - 66,846,680NCBIRnor6.0
Rnor_5.0466,650,945 - 66,651,548UniSTSRnor5.0
RGSC_v3.4466,676,882 - 66,677,485UniSTSRGSC3.4
Celera462,849,562 - 62,850,165UniSTS
RH 3.4 Map4417.7UniSTS
Cytogenetic Map4q21-q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 2 11 2 3 10
Low 2 41 55 39 8 39 8 11 74 35 34 1 8
Below cutoff 2 4

Sequence


Ensembl Acc Id: ENSRNOT00000010796   ⟹   ENSRNOP00000010796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl467,665,007 - 67,837,096 (+)Ensembl
Rnor_6.0 Ensembl466,670,618 - 66,846,805 (+)Ensembl
RefSeq Acc Id: NM_012687   ⟹   NP_036819
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,631,885 - 68,803,959 (+)NCBI
mRatBN7.2467,665,007 - 67,837,096 (+)NCBI
Rnor_6.0466,670,658 - 66,846,733 (+)NCBI
Rnor_5.0466,481,238 - 66,651,613 (+)NCBI
RGSC_v3.4466,502,253 - 66,677,538 (+)RGD
Celera462,678,426 - 62,850,218 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107073   ⟹   XP_038963001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,631,841 - 68,753,936 (+)NCBI
mRatBN7.2467,664,963 - 67,786,877 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036819 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA05962 (Get FASTA)   NCBI Sequence Viewer  
  BAA22574 (Get FASTA)   NCBI Sequence Viewer  
  EDM15371 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010796.2
  ENSRNOP00055044397
  ENSRNOP00060011374
  ENSRNOP00065022159
GenBank Protein P49430 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036819   ⟸   NM_012687
- UniProtKB: P49430 (UniProtKB/Swiss-Prot),   A6IET4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010796   ⟸   ENSRNOT00000010796
RefSeq Acc Id: XP_038963001   ⟸   XM_039107073
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49430-F1-model_v2 AlphaFold P49430 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692976
Promoter ID:EPDNEW_R3501
Type:single initiation site
Name:Tbxas1_1
Description:thromboxane A synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0466,670,701 - 66,670,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3826 AgrOrtholog
BioCyc Gene G2FUF-45201 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000007918 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055030925 UniProtKB/Swiss-Prot
  ENSRNOG00060008792 UniProtKB/Swiss-Prot
  ENSRNOG00065016795 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010796.5 UniProtKB/Swiss-Prot
  ENSRNOT00055053673 UniProtKB/Swiss-Prot
  ENSRNOT00060014722 UniProtKB/Swiss-Prot
  ENSRNOT00065028043 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24886 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24886 ENTREZGENE
PANTHER THROMBOXANE-A SYNTHASE UniProtKB/Swiss-Prot
  THROMBOXANE-A SYNTHASE UniProtKB/Swiss-Prot
  THROMBOXANE-A SYNTHASE UniProtKB/TrEMBL
  THROMBOXANE-A SYNTHASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TBXAS1 RGD
PhenoGen Tbxas1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007918 RatGTEx
  ENSRNOG00055030925 RatGTEx
  ENSRNOG00060008792 RatGTEx
  ENSRNOG00065016795 RatGTEx
Superfamily-SCOP Cytochrome P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IET4 ENTREZGENE, UniProtKB/TrEMBL
  P49430 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tbxas1  thromboxane A synthase 1  Tbxas1  thromboxane A synthase 1, platelet  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Tbxas1  thromboxane A synthase 1, platelet  Tbxas1  thromboxane A synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tbxas1  ThromboxA ane synthase 1      Symbol and Name status set to approved 70586 APPROVED