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Gene: Tbxas1 (thromboxane A synthase 1) Rattus norvegicus
Symbol: Tbxas1
Name: thromboxane A synthase 1
Description: Predicted to have heme binding activity and thromboxane-A synthase activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to localize to endoplasmic reticulum membrane. Used to study artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in cerebral infarction and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.
Type: protein-coding
Also known as: cytochrome P450 5A1; ThromboxA ane synthase 1; thromboxane A synthase 1, platelet; thromboxane-A synthase; TXA synthase; TXS
Homo sapiens (human) : TBXAS1 (thromboxane A synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Tbxas1 (thromboxane A synthase 1, platelet)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbxas1 (thromboxane A synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TBXAS1 (thromboxane A synthase 1)
Canis lupus familiaris (dog) : TBXAS1 (thromboxane A synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbxas1 (thromboxane A synthase 1)
Sus scrofa (pig) : TBXAS1 (thromboxane A synthase 1)
Chlorocebus sabaeus (African green monkey) : TBXAS1 (thromboxane A synthase 1)
Heterocephalus glaber (naked mole-rat) : Tbxas1 (thromboxane A synthase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0466,624,181 - 66,846,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,670,618 - 66,846,805 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,481,238 - 66,651,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,502,253 - 66,677,538 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1466,778,382 - 66,953,668 (+)NCBI
Celera462,678,426 - 62,850,218 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Tbxas1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3826
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.