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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3826
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbxas1
Name: thromboxane A synthase 1
Acc ID: CHEBI:9334
Term: sulfasalazine
Definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Chemical ID: MESH:D012460
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbxas1decreases activityISOTBXAS1 (Homo sapiens)6480464CTDSulfasalazine results in decreased activity of TBXAS1 proteinPMID:2572437
Tbxas1multiple interactionsISOTBXAS1 (Homo sapiens)6480464CTD[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2PMID:2572437
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