Iddm38 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm38 (Insulin dependent diabetes mellitus QTL 38) Rattus norvegicus

Symbol: Iddm38
Name: Insulin dependent diabetes mellitus QTL 38
RGD ID: 2306547
Previously known as: Region 1
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,386,669 - 70,362,197RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0466,394,000 - 70,773,654RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0466,205,169 - 135,563,631RGDRnor5.0
RGSC_v3.4466,220,947 - 69,183,485RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1565373Clec2lC-type lectin domain family 2, member L46739211867414539Rat
1309349Hipk2homeodomain interacting protein kinase 246743932767619223Rat
3826Tbxas1thromboxane A synthase 146766496367837096Rat
41142180LOC120102680small nucleolar RNA SNORA1746776730567767435Rat
1308628Parp12poly (ADP-ribose) polymerase family, member 1246782654867885356Rat
1592650Kdm7alysine demethylase 7A46789940767974264Rat
41161250Rnu6-604RNA, U6 small nuclear 60446803216868032274Rat
1583604Chmp4bl1chromatin modifying protein 4B-like 146804974268050791Rat
1310346Slc37a3solute carrier family 37, member 346810931468153590Rat
1565263Rab19RAB19, member RAS oncogene family46815715968166889Rat
1303251Mkrn1makorin ring finger protein 146817590868197216Rat
40962184LOC120102609small nucleolar RNA SNORA7146819917868199301Rat
1306142Dennd2aDENN domain containing 2A46823301668332235Rat
7643066Srsf3-ps6serine and arginine rich splicing factor 3, pseudogene 646834229268343400Rat
1311058Adck2aarF domain containing kinase 246834885368362725Rat
7626918Tmsb10-ps5thymosin, beta 10, pseudogene 546836299068367488Rat
1308130Ndufb2NADH:ubiquinone oxidoreductase subunit B246836752668374609Rat
619908BrafB-Raf proto-oncogene, serine/threonine kinase46837548468510652Rat
41225554Rpl26-ps11ribosomal protein L26, pseudogene 1146839090368395785Rat
7666339Fth1-ps1ferritin heavy chain 1, pseudogene 146843185768436899Rat
1309217Mrps33mitochondrial ribosomal protein S3346859672968605547Rat
40994299LOC120102257uncharacterized LOC12010225746861471568622669Rat
9116769LOC103692103uncharacterized LOC10369210346862670668655436Rat
1585938Tmem178btransmembrane protein 178B46865942569035690Rat
7574135LOC102555151uncharacterized LOC10255515146892487368939499Rat
1562046Agkacylglycerol kinase46911485069193989Rat
1563986Dennd11DENN domain containing 1146919716169266013Rat
1587197Wee2WEE2 oocyte meiosis inhibiting kinase46923904369261576Rat
3760Ssbp1single stranded DNA binding protein 146926602469276135Rat
1560602Tas2r137taste receptor, type 2, member 13746927927669286935Rat
1561194Tas2r108taste receptor, type 2, member 10846928766769288581Rat
1311823Prss37serine protease 3746932297769334555Rat
1333433Or9a7-ps1olfactory receptor family 9 subfamily A member 7, pseudogene 146936072369361664Rat
1332737Or9a4olfactory receptor family 9 subfamily A member 446940160669402550Rat
1584755Clec5aC-type lectin domain containing 5A46940712569416872Rat
1560649Tas2r138taste receptor, type 2, member 13846942834469429339Rat
9369725Mgammaltase-glucoamylase46944162669602068Rat
1308368Mgam2maltase-glucoamylase 246962402469715782Rat
1564286Moxd2monooxygenase, DBH-like 246972469369733188Rat
1303054Prss58serine protease 5846975264669757306Rat
1302947Prss59protease, serine 5946976420669785111Rat
1563848Prss3bl1protease, serine, 3B like 146979766169803606Rat
7085851810009J06RiklRIKEN cDNA 1810009J06 gene like46981510769826206Rat
6496223Poldip2-ps1DNA polymerase delta interacting protein 2, pseudogene 146985630069858239Rat
708437Prss3bprotease, serine, 3B46987181069875518Rat
6493911Trbvl1T cell receptor beta variable like 147003688070038079Rat
1311446Prss3serine protease 347020308870206562Rat
41142645Cdc42-ps1cell division cycle 42, pseudogene 147020715770207873Rat
1560283Try5trypsin 547021376070217034Rat
1359400Try10trypsin 1047024431470247819Rat
3418Prss2protease, serine, 247027830470283385Rat
1598148Prss2-ps1protease, serine, 2, pseudogene 147031769070320752Rat
7618053LOC102554637anionic trypsin-2-like47033167370335768Rat
1597830Prss2l1protease, serine, 2 like 147034433870348069Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11171D4Hri215547036205170362206Ratregion
11172D4Wox2418547036204170362226Ratregion
11173D4Arb829647036201370362309Ratregion
11174D4Mgh3240447027879370279197Ratregion
11176D4Wox2316947028245670282627Ratregion
11177D4Arb937047027962870279998Ratregion
11342D4Got4318446927604269276226Ratregion
33682D7Mit1820046792233367922521Ratregion
36181D4Rat2616047036201770362197Ratregion
38966D4Rat9320046865345668653663Ratregion
39266D4Rat10225646738666967386927Ratregion
42170D4Arb3417446926030869260484Ratregion
42174D4Arb3617047028245570282627Ratregion
42178D4Arb3817847036204870362226Ratregion
41124D4Rat16221346969588469696096Ratregion
43806D4Got4714846865726268657410Ratregion
43808D4Got4925046767659267676842Ratregion
60440D4Got4517246774119167741363Ratregion
62480D4Uia218246936437569364557Ratregion
1627601D4Got20820646821391568214121Ratregion
1633811D4Got24622046851801768518239Ratregion
5038644BB2834669946903533269035431Ratregion
5038776RH12732618446814184168142025Ratregion
5036749AU04908118546755668767556872Ratregion
5033909RH14057718546749730167497486Ratregion
5033007RH13726018246837884068379022Ratregion
5025014AU02331911146926168769261798Ratregion
5033231RH13806719646919721469197410Ratregion
5028454AI4474699946837913168379230Ratregion
5053793RH14285413346837617868376311Ratregion
5058840BF38714218346903366369033846Ratregion
5058356AI13694218846817893668179124Ratregion
5057834BF38624017346743648667436659Ratregion
5045516RH13122218046919367369193853Ratregion
5045160RH13101860446783643967837043Ratregion
5046656RH13187918146836252168362702Ratregion
5047294RH13224518046922959569229775Ratregion
5042594RH12952919746814247968142676Ratregion
5076450RH13918222346741431367414536Ratregion
5076108RH13898414846817640668176554Ratregion
5074020RH13777313046833046768330597Ratregion
5071230RH13496320046987183269872032Ratregion
5072372RH13681112746823324768233374Ratregion
5070358AI8417968446919732469197408Ratregion
5060404BI29217515046971704669717196Ratregion
5062484BF39797912046867061068670730Ratregion
5082471BF41606225846796623967966497Ratregion
5086475BE10708016046928096969281129Ratregion
5083017BF39066420146747884567479046Ratregion
5084730AI17794412146979702169797142Ratregion
5084344AI23371918446960171069601894Ratregion
5085343BE10205216146919966969199830Ratregion
5085888AW52926320346849411168494314Ratregion
5085988AW53595220046816967568169875Ratregion
5504296D7S2119E10646903540369035508Ratregion
5505588UniSTS:48508494146936072269361663Ratregion
5505560GDB:45854138046748371567483795Ratregion
5502381RH12466932546836137668361701Ratregion
5506827G4626430246877419268774494Ratregion
Position Markers

Flank 1: (D4Rat102)
Rat AssemblyChrPosition (strand)Source
GRCr8468,353,567 - 68,353,823 (+)Marker Load Pipeline
mRatBN7.2467,386,669 - 67,386,927 (+)MAPPER
Rnor_6.0466,394,000 - 66,394,255NCBI
Rnor_5.0466,205,169 - 66,205,424UniSTS
RGSC_v3.4466,220,947 - 66,221,203RGD
RGSC_v3.4466,220,948 - 66,221,203UniSTS
RGSC_v3.1466,497,078 - 66,497,333RGD
Celera462,404,267 - 62,404,518UniSTS
RH 3.4 Map4402.64RGD
RH 3.4 Map4402.64UniSTS
RH 2.0 Map4443.9RGD
SHRSP x BN Map434.02RGD
FHH x ACI Map444.6799RGD
Cytogenetic Map4q22UniSTS
Flank 2: (D4Rat26)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2470,362,017 - 70,362,197 (+)MAPPER
Rnor_6.0470,773,475 - 70,773,654NCBI
Rnor_5.04135,563,452 - 135,563,631UniSTS
RGSC_v3.4469,183,306 - 69,183,485UniSTS
RGSC_v3.4469,183,305 - 69,183,485RGD
RGSC_v3.1469,459,436 - 69,459,615RGD
Celera465,327,193 - 65,327,372UniSTS
RH 3.4 Map4419.41UniSTS
RH 3.4 Map4419.41RGD
RH 2.0 Map4437.5RGD
FHH x ACI Map444.7199RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46738666970362197Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general region responsible for 47% protection and significant delay in the onset of T1 diabetes 2306526
qtl_general measurement method: at 40 days of age animals were weighed and bllod glucose measured; if concentration was >200mg/dl for two days insulin therapy was initiated 2306526
qtl_map approximately 670 Kb 2306526