Iddm38 QTL Report (Rattus norvegicus) - Rat Genome Database
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QTL: Iddm38 (Insulin dependent diabetes mellitus QTL 38) Rattus norvegicus

Symbol: Iddm38
Name: Insulin dependent diabetes mellitus QTL 38
RGD ID: 2306547
Also known as: Region 1
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0466,394,000 - 70,773,654RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0466,205,169 - 135,563,631RGDRnor5.0
RGSC_v3.4466,220,947 - 69,183,485RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: BBDR.F344-(D4Rat102-D4Rhw8),BBDP-(D4Rhw6-D4Rat62)/2Rhw 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
1. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3760Ssbp1single stranded DNA binding protein 146863484468645112Rat
708437Prss3bprotease, serine, 3B46926462869268336Rat
3826Tbxas1thromboxane A synthase 146662418166846745Rat
3418Prss2protease, serine, 247068973770694816Rat
1303251Mkrn1makorin ring finger protein 146718516767206478Rat
708585LOC286960preprotrypsinogen IV46920792769211671Rat
1303054Prss58serine protease 5846914543569152111Rat
1302947Tryx5trypsin X546915626969164906Rat
619908BrafB-Raf proto-oncogene, serine/threonine kinase46738933167520549Rat
620122Chl1cell adhesion molecule L1-like47026941470331313Rat
1308628Parp12poly (ADP-ribose) polymerase family, member 1246683564766900324Rat
1359400Try10trypsin 1047065574970659252Rat
1310346Slc37a3solute carrier family 37, member 346711891867162821Rat
1308368Mgammaltase-glucoamylase46901859269114027Rat
1311446Prss3serine protease 347061452470617998Rat
1309217Mrps33mitochondrial ribosomal protein S3346760697167616056Rat
1308130Ndufb2NADH:ubiquinone oxidoreductase subunit B246737818867385267Rat
1309349Hipk2homeodomain interacting protein kinase 246643839066625183Rat
1333433Olr798-psolfactory receptor pseudogene 79846837576068376701Rat
1306142Dennd2aDENN domain containing 2A46724225767342993Rat
1563848LOC312273Trypsin V-A46919048569196430Rat
1560283Try5trypsin 547062519670628470Rat
1563986Dennd11DENN domain containing 1146856930868597626Rat
1332737Olr799olfactory receptor 79946880466168805605Rat
1311823Prss37serine protease 3746833749868349286Rat
1560649Tas2r138taste receptor, type 2, member 13846883122168832216Rat
1311058Adck2aarF domain containing kinase 246735953167373390Rat
1562046Agkacylglycerol kinase46848334568561518Rat
1560602Tas2r137taste receptor, type 2, member 13746864829668654695Rat
1564286Moxd2monooxygenase, DBH-like 246911747769125972Rat
1561194Tas2r108taste receptor, type 2, member 10846865692868657842Rat
1584755Clec5aC-type lectin domain containing 5A46881033068819921Rat
1587197Wee2WEE2 oocyte meiosis inhibiting kinase46860477068631341Rat
1583670LOC679818similar to Maltase-glucoamylase, intestinal46842454468458991Rat
1565263Rab19RAB19, member RAS oncogene family46716641267176141Rat
1565373Clec2lC-type lectin domain family 2, member L46640488066421656Rat
1585938Tmem178btransmembrane protein 178B46766926668059249Rat
1583604Chmp4bl1chromatin modifying protein 4B-like 146705993967060988Rat
1597830LOC683849similar to Anionic trypsin II precursor (Pretrypsinogen II)47075578070759478Rat
1592650Kdm7alysine demethylase 7A46691560366957971Rat
1598148LOC679922similar to protease, serine, 347072912170732183Rat
1626026Vom2r-ps15vomeronasal 2 receptor, pseudogene 1546817031168171122Rat
2317994LOC100365995rCG28262-like47055144770563005Rat
6492017LOC10091159460S ribosomal protein L4-like47016374970166277Rat
6493361LOC100911317uncharacterized LOC10091131746944412669444900Rat
6495158LOC100911007T-cell receptor beta chain T17T-22-like46938408369388704Rat
6493911LOC100911271uncharacterized LOC10091127146943552169437265Rat
6494965LOC100911086T-cell receptor beta chain T17T-22-like46938322369392373Rat
6496223LOC100910843polymerase delta-interacting protein 2-like46924907069251340Rat
7650176LOC102549986uncharacterized LOC10254998646916949769178241Rat
7666339LOC102555403ferritin heavy chain-like46744251567443283Rat
7594577LOC102551824killer cell lectin-like receptor 4-like47001076270026493Rat
7626918LOC102554668uncharacterized LOC10255466846737687367378101Rat
7643066LOC102554568serine/arginine-rich splicing factor 3-like46735346267353906Rat
7618053LOC102554637anionic trypsin-2-like47074396570747241Rat
7618420LOC102554766uncharacterized LOC10255476646752162467522568Rat
7574135LOC102555151uncharacterized LOC10255515146794749767963203Rat
9116769LOC103692103uncharacterized LOC10369210346764925367662394Rat
9307225LOC103692101uncharacterized LOC10369210146654723066551668Rat
9383372LOC103692105uncharacterized LOC10369210546944418369452280Rat
9369725LOC103690059maltase-glucoamylase, intestinal-like46884901468996940Rat
9463902LOC103692113uncharacterized LOC10369211346715271967164367Rat
9413023LOC103692102uncharacterized LOC10369210246712925067129792Rat
11383946LOC108350697uncharacterized LOC10835069746857843268581763Rat
11422917LOC10835069660S ribosomal protein L26-like46740536567406401Rat
11408653LOC108350698uncharacterized LOC10835069847012613970252711Rat
11484912LOC10835080760S ribosomal protein L30-like46976375869766686Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
11171D4Hri215547077350970773663Ratregion
11172D4Wox2419447077349970773683Ratregion
11173D4Arb829647077347170773766Ratregion
11174D4Mgh3238147069022770690630Ratregion
11176D4Wox2320047069389070694058Ratregion
11177D4Arb937047069106270691431Ratregion
11342D4Got4318446864502068645203Ratregion
33682D7Mit1820046693905766939242Ratregion
36181D4Rat2616047077347570773654Ratregion
40734D4Rat16114946641117266411310Ratregion
38966D4Rat9320046766330067663504Ratregion
39266D4Rat10224646639400066394255Ratregion
42170D4Arb3416546862914368629316Ratregion
42174D4Arb3612047069388970694058Ratregion
42178D4Arb3812047077350670773683Ratregion
41124D4Rat16220546909072669090937Ratregion
41616D4Rat19315746963171469631874Ratregion
43806D4Got4714846766710467667251Ratregion
43808D4Got4925046668224766682496Ratregion
60440D4Got4517246674734766747518Ratregion
60406D4Got10114146985295269853092Ratregion
62480D4Uia217846837941268379589Ratregion
1627601D4Got20820746722316267223367Ratregion
1635138D4Got23212147012453670124656Ratregion
1633811D4Got24622046752847467528693Ratregion
5038644BB2834669946805889268058990Ratregion
5038776RH12732618446715109667151279Ratregion
5036749AU04908118546656238666562570Ratregion
5033909RH14057718546650286566503049Ratregion
5033007RH13726018246738949967389680Ratregion
5025014AU02331911146863052068630630Ratregion
5033231RH13806719646856479968564994Ratregion
5028454AI4474699946738979067389888Ratregion
5053793RH14285413346738683767386969Ratregion
5055345RH14374814947033059670330744Ratregion
5055921RH14407910746783793367838040Ratregion
5058840BF38714218346805722368057405Ratregion
5058356AI13694218846718818967188376Ratregion
5057834BF38624017346644242066442592Ratregion
5045516RH13122218046856125868561437Ratregion
5045160RH13101818146684607766846680Ratregion
5046656RH13187918146737318767373367Ratregion
5047294RH13224518046859843768598616Ratregion
5042594RH12952919746715173467151930Ratregion
5076450RH13918222346642143166421653Ratregion
5076108RH13898414846718565967185806Ratregion
5074020RH13777313146734112967341258Ratregion
5071230RH13496320046926465169264850Ratregion
5072372RH13681112746724249367242619Ratregion
5070358AI8417968446856490968564992Ratregion
5060404BI29217515046910975369109902Ratregion
5062484BF39797912046768046267680581Ratregion
5082471BF41606213046698157366981830Ratregion
5086475BE10708016046864994768650106Ratregion
5083017BF39066420146648411366484313Ratregion
5084730AI17794412046918984669189966Ratregion
5084344AI23371918246899658368996766Ratregion
5085343BE10205216146856725468567414Ratregion
5085888AW52926320346750457167504773Ratregion
5085988AW53595220246717892867179127Ratregion
5504296D7S2119E10546805896368059067Ratregion
5505588UniSTS:48508494146837576068376700Ratregion
5505560GDB:45854138046648928166489360Ratregion
5502381RH12466932546737204267372366Ratregion
5506827G4626430246779542067795721Ratregion
Position Markers

Flank 1: (D4Rat102)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0466,394,000 - 66,394,255NCBI
Rnor_5.0466,205,169 - 66,205,424UniSTS
RGSC_v3.4466,220,947 - 66,221,203RGD
RGSC_v3.4466,220,948 - 66,221,203UniSTS
RGSC_v3.1466,497,078 - 66,497,333RGD
Celera462,404,267 - 62,404,518UniSTS
Cytogenetic Map4q22UniSTS
RH 3.4 Map4402.64UniSTS
RH 3.4 Map4402.64RGD
RH 2.0 Map4443.9RGD
SHRSP x BN Map434.02RGD
FHH x ACI Map444.6799RGD
Flank 2: (D4Rat26)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,773,475 - 70,773,654NCBI
Rnor_5.04135,563,452 - 135,563,631UniSTS
RGSC_v3.4469,183,305 - 69,183,485RGD
RGSC_v3.4469,183,306 - 69,183,485UniSTS
RGSC_v3.1469,459,436 - 69,459,615RGD
Celera465,327,193 - 65,327,372UniSTS
RH 3.4 Map4419.41UniSTS
RH 3.4 Map4419.41RGD
RH 2.0 Map4437.5RGD
FHH x ACI Map444.7199RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42399172176238799Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42399172176238799Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)42463187469631874Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42665474981874227Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43182556083531021Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43768517573066691Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43770327275345433Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)43920822284208222Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)43920824784208247Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44241577787415777Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45532485779575658Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45532485779575658Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45532485779575658Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45532485779575658Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45579156482134846Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45579156492484312Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45579183479557856Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)456092756101092756Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)456092756101092756Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45710107792990863Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45730707579578854Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458166424103166424Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)46043912799066957Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)460439127113416139Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)461038901127777403Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46170810388565113Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46170834183531021Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)461708341113100992Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)461975371106975371Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)462947687125671711Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)463938412108938412Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)46598781473372824Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)46598781473372824Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46598781473372824Rat
2312569Pur19Proteinuria QTL 193.40.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46598924397759057Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46639400070773654Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470773471132455556Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general region responsible for 47% protection and significant delay in the onset of T1 diabetes 2306526
qtl_general measurement method: at 40 days of age animals were weighed and bllod glucose measured; if concentration was >200mg/dl for two days insulin therapy was initiated 2306526
qtl_map approximately 670 Kb 2306526