Ghrhr (growth hormone releasing hormone receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ghrhr (growth hormone releasing hormone receptor) Rattus norvegicus
Analyze
Symbol: Ghrhr
Name: growth hormone releasing hormone receptor
RGD ID: 2688
Description: Enables growth hormone-releasing hormone receptor activity. Involved in several processes, including activation of adenylate cyclase activity; cAMP-mediated signaling; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in cell surface and sarcolemma. Used to study isolated growth hormone deficiency. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; alendronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GHRH receptor; GHRHREC; GRF receptor; GRFR; growth hormone - releasing receptor; growth hormone releasing hormone receptor variant 1; growth hormone releasing hormone receptor variant 2; growth hormone releasing hormone receptor variant 3; growth hormone releasing hormone receptor variant 4; growth hormone releasing hormone receptor variant 5; growth hormone-releasing factor receptor; growth hormone-releasing hormone receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Hcar7 Ept5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,498,159 - 84,532,847 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,500,212 - 84,532,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,718,589 - 89,754,998 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0485,493,999 - 85,530,402 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0483,899,789 - 83,936,121 (+)NCBIRnor_WKY
Rnor_6.0485,587,321 - 85,602,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,588,595 - 85,601,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04150,221,064 - 150,253,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,135,530 - 84,148,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,421,996 - 84,434,974 (+)NCBI
Celera479,386,911 - 79,400,313 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Effects of a high-glucose environment on the pituitary growth hormone-releasing hormone receptor: type 1 diabetes compared with in vitro glucotoxicity. Bedard K, etal., Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E740-51. doi: 10.1152/ajpendo.00141.2007. Epub 2008 Feb 19.
2. Characterization of a growth hormone-releasing hormone binding site in the rat renal medulla. Boulanger L, etal., Peptides 2002 Jan;23(1):43-50.
3. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Cunha SR and Mayo KE, Endocrinology 2002 Dec;143(12):4570-82.
4. Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size but not density of trabecular and mixed bone. Epitacio-Pereira CC, etal., J Clin Endocrinol Metab. 2013 Nov;98(11):E1710-5. doi: 10.1210/jc.2013-2349. Epub 2013 Sep 20.
5. Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats. Gardi J, etal., Neurosci Lett 2002 Aug 23;329(1):69-72.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Granata R, etal., Cardiovasc Res. 2009 Jul 15;83(2):303-12. Epub 2009 Mar 17.
9. Regulation of GHRH receptor gene expression in the neonatal and adult rat pituitary. Korytko AI and Cuttler L, Growth Horm IGF Res 2001 Oct;11(5):282-8.
10. GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats. Leggett J, etal., Endocrinology. 2013 Sep;154(9):3305-18. doi: 10.1210/en.2012-2175. Epub 2013 Jul 3.
11. Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves. Liao F, etal., J Neurosci. 2010 Mar 17;30(11):4151-9. doi: 10.1523/JNEUROSCI.6047-09.2010.
12. A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model. Majeed N, etal., Oncogene. 2005 Jul 7;24(29):4736-40.
13. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. Mayo KE Mol Endocrinol 1992 Oct;6(10):1734-44.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. The rat growth hormone-releasing hormone receptor gene: structure, regulation, and generation of receptor isoforms with different signaling properties. Miller TL, etal., Endocrinology. 1999 Sep;140(9):4152-65.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats. Tarasiuk A, etal., Eur Respir J. 2011 Oct;38(4):870-7. Epub 2011 Mar 15.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Internalization and trafficking of the human and rat growth hormone-releasing hormone receptor. Veyrat-Durebex C, etal., J Cell Physiol 2005 May;203(2):335-44.
25. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Wajnrajch MP, etal., Nat Genet. 1996 Jan;12(1):88-90.
26. Functional GHRH receptor carboxyl terminal isoforms in normal and dwarf (dw) rats. Zeitler P, etal., J Mol Endocrinol. 1998 Dec;21(3):363-71.
Additional References at PubMed
PMID:978118   PMID:1270792   PMID:1329576   PMID:1334535   PMID:1504465   PMID:1778592   PMID:2980124   PMID:3008329   PMID:6116352   PMID:6194978   PMID:6303755   PMID:7390396  
PMID:7510770   PMID:7679139   PMID:7680413   PMID:8391647   PMID:8395283   PMID:9482665   PMID:10459853   PMID:10461027   PMID:10537133   PMID:10689811   PMID:11371619   PMID:11773624  
PMID:12867592   PMID:15059953   PMID:15690087   PMID:16513828   PMID:16867182   PMID:17356054   PMID:17536003   PMID:17537840   PMID:22203988   PMID:23417421   PMID:23770714   PMID:25404316  


Genomics

Comparative Map Data
Ghrhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,498,159 - 84,532,847 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,500,212 - 84,532,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,718,589 - 89,754,998 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0485,493,999 - 85,530,402 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0483,899,789 - 83,936,121 (+)NCBIRnor_WKY
Rnor_6.0485,587,321 - 85,602,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,588,595 - 85,601,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04150,221,064 - 150,253,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,135,530 - 84,148,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,421,996 - 84,434,974 (+)NCBI
Celera479,386,911 - 79,400,313 (+)NCBICelera
Cytogenetic Map4q24NCBI
GHRHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,963,953 - 30,979,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl730,938,669 - 30,993,254 (+)EnsemblGRCh38hg38GRCh38
GRCh37731,003,568 - 31,019,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,970,161 - 30,985,668 (+)NCBINCBI36Build 36hg18NCBI36
Build 34730,776,875 - 30,788,828NCBI
Celera730,992,840 - 31,008,351 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,885,854 - 30,901,378 (+)NCBIHuRef
CHM1_1731,003,564 - 31,019,092 (+)NCBICHM1_1
T2T-CHM13v2.0731,101,596 - 31,117,172 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2731,053,140 - 31,068,651 (+)NCBI
Ghrhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,353,204 - 55,365,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,353,280 - 55,365,515 (+)EnsemblGRCm39 Ensembl
GRCm38655,376,295 - 55,388,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,376,295 - 55,388,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,326,289 - 55,338,524 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36655,305,940 - 55,317,897 (+)NCBIMGSCv36mm8
Celera655,910,067 - 55,922,286 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
Ghrhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541032,102,367 - 32,115,080 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541032,084,210 - 32,114,844 (+)NCBIChiLan1.0ChiLan1.0
GHRHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1731,701,641 - 31,712,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,696,914 - 31,712,200 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0731,582,134 - 31,592,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GHRHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,626,862 - 43,638,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,626,845 - 43,638,753 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1443,059,230 - 43,070,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,567,602 - 43,579,114 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,567,473 - 43,579,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,683,226 - 43,694,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,359,784 - 43,371,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,721,032 - 43,732,545 (+)NCBIUU_Cfam_GSD_1.0
Ghrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,980,695 - 87,991,200 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364787,188,826 - 7,201,932 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364787,188,826 - 7,202,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,030,510 - 42,046,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,030,505 - 42,046,178 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,427,131 - 46,436,821 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHRHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,402,765 - 27,417,536 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,404,886 - 27,417,521 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604277,286,895 - 77,301,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624783200,940 - 214,373 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624783200,935 - 214,453 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ghrhr
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:156
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000016087, ENSRNOT00000044578
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)457114432102114432Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48342841995853334Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 4 4 7 4 22 10
Below cutoff 2 40 37 25 9 25 8 11 15 13 23 1 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF122055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF409106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU253552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ888702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ888703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ888704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ888705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ888706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L01407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016087   ⟹   ENSRNOP00000016087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,519,692 - 84,532,338 (+)Ensembl
Rnor_6.0 Ensembl485,588,711 - 85,601,335 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000044578   ⟹   ENSRNOP00000043884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,519,692 - 84,532,669 (+)Ensembl
Rnor_6.0 Ensembl485,588,689 - 85,601,666 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081953   ⟹   ENSRNOP00000075689
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,519,598 - 84,532,309 (+)Ensembl
Rnor_6.0 Ensembl485,588,595 - 85,601,306 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084855   ⟹   ENSRNOP00000071248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,519,692 - 84,532,517 (+)Ensembl
Rnor_6.0 Ensembl485,588,711 - 85,601,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112196   ⟹   ENSRNOP00000086351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,500,212 - 84,532,776 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112212   ⟹   ENSRNOP00000092627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,500,212 - 84,532,776 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114226   ⟹   ENSRNOP00000081121
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,526,241 - 84,532,338 (+)Ensembl
RefSeq Acc Id: NM_012850   ⟹   NP_036982
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,519,692 - 84,532,669 (+)NCBI
Rnor_6.0485,588,689 - 85,601,666 (+)NCBI
Rnor_5.04150,221,064 - 150,253,706 (+)NCBI
RGSC_v3.4484,135,530 - 84,148,503 (+)RGD
Celera479,386,911 - 79,400,313 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592482   ⟹   XP_017447971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,517,983 - 84,532,847 (+)NCBI
Rnor_6.0485,587,321 - 85,602,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107107   ⟹   XP_038963035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,500,069 - 84,532,847 (+)NCBI
RefSeq Acc Id: XM_039107108   ⟹   XP_038963036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,498,159 - 84,528,364 (+)NCBI
RefSeq Acc Id: XR_005503156
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,517,984 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503157
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,499,334 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503158
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,499,335 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503159
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,499,334 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503160
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,505,568 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503161
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,500,069 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503162
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,500,069 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503163
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,500,069 - 84,530,359 (+)NCBI
RefSeq Acc Id: XR_005503164
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2484,500,069 - 84,532,847 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036982   ⟸   NM_012850
- Peptide Label: precursor
- UniProtKB: Q02644 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447971   ⟸   XM_017592482
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016087   ⟸   ENSRNOT00000016087
RefSeq Acc Id: ENSRNOP00000071248   ⟸   ENSRNOT00000084855
RefSeq Acc Id: ENSRNOP00000043884   ⟸   ENSRNOT00000044578
RefSeq Acc Id: ENSRNOP00000075689   ⟸   ENSRNOT00000081953
RefSeq Acc Id: XP_038963036   ⟸   XM_039107108
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963035   ⟸   XM_039107107
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086351   ⟸   ENSRNOT00000112196
RefSeq Acc Id: ENSRNOP00000092627   ⟸   ENSRNOT00000112212
RefSeq Acc Id: ENSRNOP00000081121   ⟸   ENSRNOT00000114226
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02644-F1-model_v2 AlphaFold Q02644 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2688 AgrOrtholog
BioCyc Gene G2FUF-44732 BioCyc
Ensembl Genes ENSRNOG00000011808 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016087.5 UniProtKB/TrEMBL
  ENSRNOP00000043884 ENTREZGENE
  ENSRNOP00000043884.2 UniProtKB/TrEMBL
  ENSRNOP00000071248 ENTREZGENE
  ENSRNOP00000071248.1 UniProtKB/TrEMBL
  ENSRNOP00000075689.1 UniProtKB/TrEMBL
  ENSRNOP00000081121.1 UniProtKB/TrEMBL
  ENSRNOP00000086351.1 UniProtKB/TrEMBL
  ENSRNOP00000092627 ENTREZGENE
  ENSRNOP00000092627.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016087.7 UniProtKB/TrEMBL
  ENSRNOT00000044578 ENTREZGENE
  ENSRNOT00000044578.3 UniProtKB/TrEMBL
  ENSRNOT00000081953.2 UniProtKB/TrEMBL
  ENSRNOT00000084855 ENTREZGENE
  ENSRNOT00000084855.2 UniProtKB/TrEMBL
  ENSRNOT00000112196 ENTREZGENE
  ENSRNOT00000112196.1 UniProtKB/TrEMBL
  ENSRNOT00000112212 ENTREZGENE
  ENSRNOT00000112212.1 UniProtKB/TrEMBL
  ENSRNOT00000114226.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GHRH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25321 UniProtKB/Swiss-Prot
NCBI Gene 25321 ENTREZGENE
PANTHER PTHR45620:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ghrhr PhenoGen
PRINTS GHRHRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC224151
UniProt A0A1B0H847_RAT UniProtKB/TrEMBL
  A0A1B0H858_RAT UniProtKB/TrEMBL
  A0A1B0HAQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZS70_RAT UniProtKB/TrEMBL
  A0A8L2Q8Q1_RAT UniProtKB/TrEMBL
  A0A8L2QMQ8_RAT UniProtKB/TrEMBL
  GHRHR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91WX4_RAT UniProtKB/TrEMBL
  Q9WU99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ghrhr  Growth hormone - releasing receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression decreased mRNA levels are associated with sleep deprivation 728477
gene_pathway act directly to potentiate the second messenger cAMP pathway through a PKC-independent mechanism 628502