GHRHR (growth hormone releasing hormone receptor) - Rat Genome Database

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Gene: GHRHR (growth hormone releasing hormone receptor) Sus scrofa
Analyze
Symbol: GHRHR
Name: growth hormone releasing hormone receptor
RGD ID: 13970325
Description: ENCODES a protein that exhibits growth hormone-releasing hormone receptor activity (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); adenohypophysis development (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); disorder of sexual development (ortholog); Ehlers-Danlos syndrome kyphoscoliotic type 2 (ortholog); FOUND IN cell surface (ortholog); sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GHRH receptor; GRF receptor; GRFR; growth hormone-releasing factor receptor; growth hormone-releasing hormone receptor; growth hormone-releasing hormone receptor precursor variant 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,030,510 - 42,046,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,030,505 - 42,046,178 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,427,131 - 46,436,821 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8413847   PMID:14681463   PMID:17145712   PMID:19212008   PMID:22301074   PMID:25404316   PMID:30032202  


Genomics

Comparative Map Data
GHRHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,030,510 - 42,046,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,030,505 - 42,046,178 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,427,131 - 46,436,821 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHRHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,963,953 - 30,979,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,938,669 - 30,993,254 (+)EnsemblGRCh38hg38GRCh38
GRCh37731,003,568 - 31,019,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,970,161 - 30,985,668 (+)NCBINCBI36Build 36hg18NCBI36
Build 34730,776,875 - 30,788,828NCBI
Celera730,992,840 - 31,008,351 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,885,854 - 30,901,378 (+)NCBIHuRef
CHM1_1731,003,564 - 31,019,092 (+)NCBICHM1_1
T2T-CHM13v2.0731,101,596 - 31,117,172 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2731,053,140 - 31,068,651 (+)NCBI
Ghrhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,353,204 - 55,365,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,353,280 - 55,365,515 (+)EnsemblGRCm39 Ensembl
GRCm38655,376,295 - 55,388,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,376,295 - 55,388,530 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,326,289 - 55,338,524 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36655,305,940 - 55,317,897 (+)NCBIMGSCv36mm8
Celera655,910,067 - 55,922,286 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
Ghrhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,830,345 - 85,863,127 (+)NCBIGRCr8
mRatBN7.2484,498,159 - 84,532,851 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,500,212 - 84,532,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,718,589 - 89,754,998 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,493,999 - 85,530,402 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,899,789 - 83,936,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,587,321 - 85,602,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,588,595 - 85,601,666 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04150,221,064 - 150,253,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,135,530 - 84,148,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,421,996 - 84,434,974 (+)NCBI
Celera479,386,911 - 79,400,313 (+)NCBICelera
Cytogenetic Map4q24NCBI
Ghrhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541032,102,367 - 32,115,080 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541032,084,210 - 32,114,844 (+)NCBIChiLan1.0ChiLan1.0
GHRHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,775,238 - 35,790,875 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1784,099,966 - 84,115,603 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,582,134 - 31,592,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,701,641 - 31,712,200 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,696,914 - 31,712,200 (+)Ensemblpanpan1.1panPan2
GHRHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,626,862 - 43,638,737 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,626,845 - 43,638,753 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1443,059,230 - 43,070,721 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,567,602 - 43,579,114 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,567,473 - 43,579,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,683,226 - 43,694,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,359,784 - 43,371,271 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,721,032 - 43,732,545 (+)NCBIUU_Cfam_GSD_1.0
Ghrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,980,695 - 87,991,200 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364787,188,826 - 7,201,932 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364787,188,826 - 7,202,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,402,765 - 27,417,536 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,404,886 - 27,417,521 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604277,286,895 - 77,301,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624783200,940 - 214,373 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624783200,935 - 214,453 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GHRHR
709 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system
High
Medium
Low 3 3
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018152   ⟹   ENSSSCP00000017661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,030,510 - 42,046,184 (-)Ensembl
RefSeq Acc Id: NM_214035   ⟹   NP_999200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,032,073 - 42,046,111 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021078506   ⟹   XP_020934165
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,030,505 - 42,046,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021078507   ⟹   XP_020934166
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,030,505 - 42,046,160 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020934165   ⟸   XM_021078506
- Peptide Label: isoform X1
- UniProtKB: A0A8D1SY56 (UniProtKB/TrEMBL),   F1SII9 (UniProtKB/TrEMBL),   A0A8D0V6B2 (UniProtKB/TrEMBL),   E5F1H2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934166   ⟸   XM_021078507
- Peptide Label: isoform X2
- UniProtKB: A0A8D1BSN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999200   ⟸   NM_214035
- Peptide Label: precursor
- UniProtKB: Q28993 (UniProtKB/Swiss-Prot),   P34999 (UniProtKB/Swiss-Prot),   E5F1H3 (UniProtKB/TrEMBL),   A0A4X1SZZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000017661   ⟸   ENSSSCT00000018152
Protein Domains
G-protein coupled receptors family 2 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016673 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015078233 UniProtKB/TrEMBL
  ENSSSCG00025076214 UniProtKB/TrEMBL
  ENSSSCG00030002550 UniProtKB/TrEMBL
  ENSSSCG00035023745 UniProtKB/TrEMBL
  ENSSSCG00040036149 UniProtKB/TrEMBL
  ENSSSCG00045034343 UniProtKB/TrEMBL
  ENSSSCG00050022546 UniProtKB/TrEMBL
  ENSSSCG00055005530 UniProtKB/TrEMBL
  ENSSSCG00060011661 UniProtKB/TrEMBL
  ENSSSCG00065007282 UniProtKB/TrEMBL
  ENSSSCG00070005312 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018152 ENTREZGENE
  ENSSSCT00000018152.3 UniProtKB/TrEMBL
  ENSSSCT00015105916.1 UniProtKB/TrEMBL
  ENSSSCT00025105489.1 UniProtKB/TrEMBL
  ENSSSCT00030003290.1 UniProtKB/TrEMBL
  ENSSSCT00030003299.1 UniProtKB/TrEMBL
  ENSSSCT00035031163.1 UniProtKB/TrEMBL
  ENSSSCT00040048619.1 UniProtKB/TrEMBL
  ENSSSCT00045058833.1 UniProtKB/TrEMBL
  ENSSSCT00050030455.1 UniProtKB/TrEMBL
  ENSSSCT00050030463.1 UniProtKB/TrEMBL
  ENSSSCT00055010805.1 UniProtKB/TrEMBL
  ENSSSCT00060015243.1 UniProtKB/TrEMBL
  ENSSSCT00065009756.1 UniProtKB/TrEMBL
  ENSSSCT00070010373.1 UniProtKB/TrEMBL
  ENSSSCT00070010383.1 UniProtKB/TrEMBL
  ENSSSCT00070010392.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_GHRH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene GHRHR ENTREZGENE
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45620:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GHRHRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SZ10_PIG UniProtKB/TrEMBL
  A0A4X1SZZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T190_PIG UniProtKB/TrEMBL
  A0A8D0QBC6_PIG UniProtKB/TrEMBL
  A0A8D0V6B2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BSN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1K9S8_PIG UniProtKB/TrEMBL
  A0A8D1SY56 ENTREZGENE, UniProtKB/TrEMBL
  E5F1H2 ENTREZGENE, UniProtKB/TrEMBL
  E5F1H3 ENTREZGENE, UniProtKB/TrEMBL
  F1SII9 ENTREZGENE, UniProtKB/TrEMBL
  GHRHR_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q28993 ENTREZGENE
UniProt Secondary Q28993 UniProtKB/Swiss-Prot
VGNC ID VGNC:88443 ENTREZGENE