Ghrhr (growth hormone releasing hormone receptor)

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Gene: Ghrhr (growth hormone releasing hormone receptor) Mus musculus

Analyze

Symbol:

Ghrhr

Name:

growth hormone releasing hormone receptor

RGD ID:

10645

MGI Page

MGI

Description:

Enables growth hormone-releasing hormone receptor activity and peptide hormone binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of growth hormone secretion; and regulation of signal transduction. Located in plasma membrane. Is expressed in alimentary system; brain; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ghr; Ghrfr; GHRH receptor; GRF receptor; GRFR; growth hormone-releasing factor receptor; growth hormone-releasing hormone receptor; lit; little

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	55,353,204 - 55,365,515 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	55,353,280 - 55,365,515 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	55,376,295 - 55,388,530 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	55,376,295 - 55,388,530 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	55,326,289 - 55,338,524 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	55,305,940 - 55,317,897 (+)	NCBI		MGSCv36	mm8
Celera	6	55,910,067 - 55,922,286 (+)	NCBI		Celera
Cytogenetic Map	6	B3	NCBI
cM Map	6	27.38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

disorder of sexual development (ISO)

Ehlers-Danlos syndrome kyphoscoliotic type 2 (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

Genu Valgum (ISO)

isolated growth hormone deficiency (ISO)

isolated growth hormone deficiency type IB (ISO)

pleomorphic xanthoastrocytoma (ISO)

Prostatic Neoplasms (IAGP)

sleep disorder (ISO)

Upper Airway Obstruction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

alendronic acid (ISO)

ammonium chloride (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

clothianidin (ISO)

flavonoids (ISO)

folic acid (ISO)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (EXP)

phosphorus atom (ISO)

phosphorus(.) (ISO)

raloxifene (ISO)

tebuconazole (ISO)

tetrachloromethane (EXP)

thimerosal (EXP)

titanium dioxide (EXP)

trichloroethene (ISO)

troglitazone (ISO)

Zoxazolamine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of adenylate cyclase activity (ISO)

adenohypophysis development (IMP)

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,IGI,IMP,ISO)

cAMP-mediated signaling (ISO)

cell maturation (IMP)

cell surface receptor signaling pathway (IEA)

cellular response to glucose stimulus (ISO)

cellular response to insulin stimulus (IDA)

determination of adult lifespan (IMP)

establishment of localization in cell (IMP)

G protein-coupled receptor signaling pathway (IEA)

growth hormone secretion (IMP)

hormone metabolic process (IMP)

hormone secretion (IMP)

lactation (IMP)

mammary gland development (IMP)

positive regulation of cell population proliferation (IBA,IMP,ISO)

positive regulation of circadian sleep/wake cycle, non-REM sleep (ISO)

positive regulation of growth hormone secretion (IMP,ISO)

positive regulation of hormone secretion (IMP)

positive regulation of multicellular organism growth (IGI,IMP,ISO)

regulation of insulin-like growth factor receptor signaling pathway (IMP)

regulation of intracellular steroid hormone receptor signaling pathway (IMP)

regulation of protein metabolic process (IGI)

response to estrogen (ISO)

response to glucocorticoid (ISO)

response to insulin (ISO)

signal transduction (ISO)

somatotropin secreting cell development (IMP)

Cellular Component

cell surface (ISO)

cytoplasm (ISO)

membrane (IDA,ISO)

nuclear inner membrane (ISO)

nuclear matrix (ISO)

nuclear outer membrane (ISO)

plasma membrane (IBA,IDA)

plasma membrane (ISO)

sarcolemma (ISO)

secretory granule (ISO)

Molecular Function

G protein-coupled peptide receptor activity (IBA)

G protein-coupled receptor activity (IEA)

growth factor binding (IBA,ISO)

growth hormone-releasing hormone receptor activity (IBA,IGI,IMP,ISO)

peptide hormone binding (IBA,IPI,ISO)

protein binding (IPI)

transmembrane signaling receptor activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal auditory brainstem response (IEA)

abnormal bone mineral density (IEA)

abnormal bone structure (IEA)

abnormal eating behavior (IAGP)

abnormal frequency of paradoxical sleep (IAGP)

abnormal glucose homeostasis (IAGP)

abnormal insulin-like growth factor I level (IEA)

abnormal lactation (IAGP)

abnormal metabolism (IAGP)

abnormal postnatal growth (IAGP)

abnormal skeleton development (IAGP)

abnormal sleep behavior (IEA)

abnormal sleep pattern (IAGP)

abnormal somatotroph morphology (IAGP)

absent somatotroph secretory granules (IAGP)

decreased body length (IEA)

decreased body weight (IAGP)

decreased bone mass (IAGP)

decreased bone mineral content (IEA)

decreased bone mineral density (IAGP)

decreased bone mineral density of femur (IEA)

decreased circulating glucose level (IAGP)

decreased circulating growth hormone level (IAGP)

decreased circulating insulin-like growth factor I level (IAGP)

decreased diameter of femur (IAGP)

decreased diameter of tibia (IAGP)

decreased growth hormone level (IAGP)

decreased heart weight (IEA)

decreased lean body mass (IAGP)

decreased mean corpuscular hemoglobin (IEA)

decreased prolactin level (IAGP)

decreased somatotroph cell number (IAGP)

decreased somatotroph cell size (IAGP)

decreased somatotroph secretory granule number (IAGP)

decreased susceptibility to experimental autoimmune encephalomyelitis (IAGP)

decreased vertical activity (IEA)

decreased volumetric bone mineral density (IEA)

hyperactivity (IEA)

impaired glucose tolerance (IAGP)

increased bone mineral density (IAGP)

increased circulating alanine transaminase level (IEA)

increased circulating aspartate transaminase level (IEA)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased circulating triglyceride level (IEA)

increased grip strength (IEA)

increased susceptibility to age related obesity (IAGP)

increased total body fat amount (IAGP)

increased volumetric bone mineral density (IAGP)

insulin resistance (IAGP)

obese (IAGP)

postnatal growth retardation (IAGP)

proportional dwarf (IAGP)

reduced male fertility (IAGP)

short femur (IAGP)

slow postnatal weight gain (IAGP)

small pituitary gland (IAGP)

thrombocytopenia (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Effects of a high-glucose environment on the pituitary growth hormone-releasing hormone receptor: type 1 diabetes compared with in vitro glucotoxicity.	Bedard K, etal., Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E740-51. doi: 10.1152/ajpendo.00141.2007. Epub 2008 Feb 19.
2.	Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size but not density of trabecular and mixed bone.	Epitacio-Pereira CC, etal., J Clin Endocrinol Metab. 2013 Nov;98(11):E1710-5. doi: 10.1210/jc.2013-2349. Epub 2013 Sep 20.
3.	Sleep loss alters hypothalamic growth hormone-releasing hormone receptors in rats.	Gardi J, etal., Neurosci Lett 2002 Aug 23;329(1):69-72.
4.	A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model.	Majeed N, etal., Oncogene. 2005 Jul 7;24(29):4736-40.
5.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
6.	MGDs mouse GO annotations	MGD data from the GO Consortium
7.	MGD IEA	MGD IEA
8.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
11.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats.	Tarasiuk A, etal., Eur Respir J. 2011 Oct;38(4):870-7. Epub 2011 Mar 15.
15.	Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.	Wajnrajch MP, etal., Nat Genet. 1996 Jan;12(1):88-90.
16.	Functional GHRH receptor carboxyl terminal isoforms in normal and dwarf (dw) rats.	Zeitler P, etal., J Mol Endocrinol. 1998 Dec;21(3):363-71.

Additional References at PubMed

PMID:978118	PMID:1270792	PMID:1329576	PMID:1334535	PMID:1504465	PMID:1778592	PMID:2481813	PMID:2980124	PMID:3008329	PMID:6116352	PMID:6194978	PMID:6303755
PMID:6393185	PMID:7069343	PMID:7390396	PMID:7510770	PMID:7595148	PMID:7679139	PMID:7772239	PMID:7910409	PMID:8268652	PMID:8339285	PMID:8391647	PMID:8395283
PMID:8504012	PMID:8618801	PMID:8661743	PMID:8680796	PMID:8769367	PMID:8827514	PMID:8887166	PMID:9300691	PMID:9457688	PMID:9802338	PMID:10349636	PMID:10459853
PMID:10510245	PMID:10521563	PMID:10537133	PMID:10689811	PMID:10746641	PMID:10765562	PMID:10900161	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11371619	PMID:11698349
PMID:11773624	PMID:12388430	PMID:12417729	PMID:12477932	PMID:12537301	PMID:12867592	PMID:12933669	PMID:12960295	PMID:14698815	PMID:14698816	PMID:14726438	PMID:15056934
PMID:15059953	PMID:15165994	PMID:15308683	PMID:15363417	PMID:15388648	PMID:15644570	PMID:15690087	PMID:15963853	PMID:16141072	PMID:16141073	PMID:16355279	PMID:16384867
PMID:16513828	PMID:16602821	PMID:16820890	PMID:17015435	PMID:17363744	PMID:17392792	PMID:17521389	PMID:17605631	PMID:18063435	PMID:18276757	PMID:18618017	PMID:19007875
PMID:19094181	PMID:19821771	PMID:20823455	PMID:21364286	PMID:21873635	PMID:22653878	PMID:23172628	PMID:24109593	PMID:24151243	PMID:24194600	PMID:24838184	PMID:25404316
PMID:26134413	PMID:26219867	PMID:26828925	PMID:27626380	PMID:27631552	PMID:28700664	PMID:31436800	PMID:32229232	PMID:34971379

Genomics

Comparative Map Data

Ghrhr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	55,353,204 - 55,365,515 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	55,353,280 - 55,365,515 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	55,376,295 - 55,388,530 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	55,376,295 - 55,388,530 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	55,326,289 - 55,338,524 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	55,305,940 - 55,317,897 (+)	NCBI		MGSCv36	mm8
Celera	6	55,910,067 - 55,922,286 (+)	NCBI		Celera
Cytogenetic Map	6	B3	NCBI
cM Map	6	27.38	NCBI

GHRHR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	30,963,953 - 30,979,528 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	7	30,938,669 - 30,993,254 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	31,003,568 - 31,019,143 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	30,970,161 - 30,985,668 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	30,776,875 - 30,788,828	NCBI
Celera	7	30,992,840 - 31,008,351 (+)	NCBI		Celera
Cytogenetic Map	7	p14.3	NCBI
HuRef	7	30,885,854 - 30,901,378 (+)	NCBI		HuRef
CHM1_1	7	31,003,564 - 31,019,092 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	31,101,596 - 31,117,172 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	31,053,140 - 31,068,651 (+)	NCBI

Ghrhr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	84,498,159 - 84,532,847 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	84,500,212 - 84,532,776 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	89,718,589 - 89,754,998 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	85,493,999 - 85,530,402 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	83,899,789 - 83,936,121 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	85,587,321 - 85,602,389 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	85,588,595 - 85,601,666 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	150,221,064 - 150,253,706 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	84,135,530 - 84,148,503 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	84,421,996 - 84,434,974 (+)	NCBI
Celera	4	79,386,911 - 79,400,313 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

Ghrhr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	32,102,367 - 32,115,080 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	32,084,210 - 32,114,844 (+)	NCBI	ChiLan1.0	ChiLan1.0

GHRHR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	31,701,641 - 31,712,200 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	31,696,914 - 31,712,200 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	31,582,134 - 31,592,914 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GHRHR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	43,626,862 - 43,638,737 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	43,626,845 - 43,638,753 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	43,059,230 - 43,070,721 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	43,567,602 - 43,579,114 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	43,567,473 - 43,579,402 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	43,683,226 - 43,694,708 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	43,359,784 - 43,371,271 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	43,721,032 - 43,732,545 (+)	NCBI		UU_Cfam_GSD_1.0

Ghrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	87,980,695 - 87,991,200 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	7,188,826 - 7,201,932 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936478	7,188,826 - 7,202,854 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GHRHR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	42,030,510 - 42,046,184 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	42,030,505 - 42,046,178 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	46,427,131 - 46,436,821 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GHRHR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	27,402,765 - 27,417,536 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	27,404,886 - 27,417,521 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	77,286,895 - 77,301,754 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ghrhr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	200,940 - 214,373 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	200,935 - 214,453 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	180
Count of miRNA genes:	162
Interacting mature miRNAs:	169
Transcripts:	ENSMUST00000063578
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	3050001	117476961	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139076998	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87403016	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96633110	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96633110	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96633110	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96633110	Mouse
26884441	Sklq3_m	skull length QTL 3, 5 week (mouse)					6	7600000	80576983	Mouse
1357442	Dbts1_m	diabetes 1 (mouse)			Not determined		6	18234147	73364675	Mouse
10412213	Sxbq2_m	SGC/Knj cross B6 QTL 2 (mouse)			Not determined		6	19912685	71299759	Mouse
14700690	Ccs6_m	colon cancer susceptibility 6 (mouse)					6	23776934	57776934	Mouse
13208564	Bmiq7_m	body mass index QTL 7 (mouse)					6	24999999	79976983	Mouse
4141988	Obrq3_m	obesity resistance QTL 3 (mouse)			Not determined			28290993	62291115	Mouse
4141454	Obrq4_m	obesity resistance QTL 4 (mouse)			Not determined			31703499	65703611	Mouse
12880425	V25Dq5_m	vitamin D inactive form serum level QTL 5 (mouse)					6	32676980	66676980	Mouse
4141782	Mrdq5_m	modifier of retinal degeneration QTL 5 (mouse)			Not determined			32827585	78215957	Mouse
1300959	Lxw2_m	lupus BXSB x NZW 2 (mouse)			Not determined		6	33872261	67872400	Mouse
11252142	Mom12_m	Modifier of Min 12 (mouse)					6	33872261	67872400	Mouse
1300767	Aliq4_m	acute lung injury QTL 4 (mouse)			Not determined		6	36273332	70273435	Mouse
1357539	Bsbob3_m	BSB obesity 3 (mouse)			Not determined		6	36448456	70448576	Mouse
4141094	Hrtr1_m	heart rate 1 (mouse)			Not determined			36741463	70741463	Mouse
14746995	Manh60_m	mandible shape 60 (mouse)					6	37202662	71202662	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38646560	92584431	Mouse
1301326	Trbv4c2_m	T cell receptor beta variable 4 (mouse)			Not determined		6	40868230	71356155	Mouse
12880424	V25Dq4_m	vitamin D inactive form serum level QTL 4 (mouse)					6	41576985	75576985	Mouse
11040600	Lmr4c_m	leishmaniasis resistance 4c (mouse)					6	42093358	76093500	Mouse
11040601	Lmr4a_m	leishmaniasis resistance 4a (mouse)					6	42093358	76093500	Mouse
11533915	Mts4_m	mammary tumor susceptibility 4 (mouse)					6	42093358	76093500	Mouse
1301266	Lmr4_m	leishmaniasis resistance 4 (mouse)			Not determined		6	42093358	76093500	Mouse
12910785	Pwgrq16_m	post-weaning growth rate QTL 16 (mouse)					6	43803747	77788506	Mouse
12910798	Pwgrq5_m	pre-weaning growth rate QTL 5 (mouse)					6	43803747	77788506	Mouse
12910802	Pwbwq12_m	post-weaning body weight QTL 12 (mouse)					6	43803747	77788506	Mouse
12910807	Pwbwq11_m	post-weaning body weight QTL 11 (mouse)					6	43803747	77788506	Mouse
12910809	Pwbwq10_m	post-weaning body weight QTL 10 (mouse)					6	43803747	77788506	Mouse
12910820	Ogrq3_m	overall growth rate QTL 3 (mouse)					6	43803747	77788506	Mouse
10043885	Cia6c_m	collagen induced arthritis QTL 6c (mouse)			Not determined		6	44442805	71096451	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45290993	87403016	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45290993	128811995	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46912919	136400690	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48696934	125336963	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48696934	148351498	Mouse
4140983	Srilp_m	sleep response to influenza, light phase (mouse)			Not determined			48703490	75424693	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48703490	125333748	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51156134	85156284	Mouse
14696807	Rbcn2_m	rod bipolar cell number 2 (mouse)					6	51186980	56186985	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52138693	116132228	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54350411	88356155	Mouse

Markers in Region

Ghrhr

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	B3	UniSTS
cM Map	6	26.0	UniSTS

Ghrhr

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	6	55,378,878 - 55,379,192	UniSTS	GRCm38
MGSCv37	6	55,328,872 - 55,329,186	UniSTS	GRCm37
Celera	6	55,912,626 - 55,912,940	UniSTS
Cytogenetic Map	6	B3	UniSTS
cM Map	6	26.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_036165843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC083946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK030504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK133683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB027246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB618094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC120748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC120774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC144892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L07379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U81979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000063578 ⟹ ENSMUSP00000068120

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	55,353,328 - 55,365,515 (+)	Ensembl
GRCm38.p6 Ensembl	6	55,376,343 - 55,388,530 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000203241 ⟹ ENSMUSP00000145224

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	55,353,350 - 55,365,304 (+)	Ensembl
GRCm38.p6 Ensembl	6	55,376,365 - 55,388,319 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000204988

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	6	55,353,280 - 55,359,845 (+)	Ensembl
GRCm38.p6 Ensembl	6	55,376,295 - 55,382,860 (+)	Ensembl

RefSeq Acc Id:

NM_001003685 ⟹ NP_001003685

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	55,353,280 - 55,365,515 (+)	NCBI
GRCm38	6	55,376,295 - 55,388,530 (+)	NCBI
MGSCv37	6	55,326,289 - 55,338,524 (+)	RGD
Celera	6	55,910,067 - 55,922,286 (+)	RGD
cM Map	6		ENTREZGENE

Sequence:

show sequence

GCTACTGGGAAGGTGAGGCAGCAGAGATGCAGCTAGGTGGCATCACCAGAGACAGCCTGGGAGG
GAAGGCTGACTGCAGACACCATTGCCATGGATGGCCTGATGTGGGCTACCCGTATCCTCTGCTT
GCTGAGCCTGTGCGGAGTTACACTGGGTCACCTCCACCTAGAATGTGACTTCATCACTCAGCTG
AGAGACGATGAGCTTGCATGTCTTCAGGCGGCAGAGGGGACCAACAACACCTCCCTGGGATGCC
CTGGGACCTGGGATGGGCTGCTGTGCTGGCCCCCGACAGGCTCTGGCCAGTGGGTCTCTCTCCC
CTGCCCTGAATTCTTCTCTCACTTCGGCTCAGACACAGGGTTTGTGAAGAGGGACTGCACCATC
ACTGGCTGGTCTAATCCCTTCCCACCATACCCTGTGGCTTGCCCTGTGCCCTTGGAACTGTTAA
CCAAGGAGAAATCGTACTTCTCCACGGTGAAGATCATCTACACCACGGGCCACAGCATCTCCAT
TGTAGCCCTCTGCGTGGCTATTGCCATCCTGGTTGCCCTCAGGAGGCTCCACTGCCCCAGGAAC
TACATCCACACGCAGCTGTTTGCCACCTTCATCCTCAAGGCCAGTGCTGTGTTCTTGAAGGATG
CCGCCATCTTCCAGGGGGATAGCACGGACCACTGCAGCATGTCCACTGTCCTGTGCAAGGTCTC
TGTGGCCATCTCACATTTGGCCACCATGACCAACTTCAGCTGGCTGTTGGCAGAAGCTGTCTAC
CTGAGCTGCCTGTTGGCCTCCACATCCCCCAGGTCCAAACCAGCTTTTTGGTGGCTGGTCCTGG
CTGGCTGGGGGCTCCCCGTGCTATGCACTGGTACGTGGGTGGGCTGCAAACTGGCTTTTGAGGA
CACTGAGTGCTGGGACTTAGACAACAGCTCCCCCTGCTGGTGGATCATCAAAGGACCCATAGTC
CTCTCTGTTGGGGTGAACTTTGGGCTGTTTCTCAATATAATTTGTATCCTGCTGAGGAAGCTGG
AGCCTGCACAAGGCGGCCTACACACACGGGCTCAGTACTGGCGGCTTTCCAAGTCAACACTTCT
CCTTATACCGCTGTTTGGAATTCATTACATCATCTTCAACTTCCTGCCTGACAGTGCTGGCCTT
GACATCCGTGTACCCCTGGAGCTGGGGTTGGGGTCCTTTCAGGGCTTCATTGTTGCTGTCCTCT
ACTGCTTCCTCAATCAAGAGGTGAGGACAGAGATTTCACGCAAATGGTATGGCCACGACCCTGA
ACTTCTGCCAGCTCGACGGACCTGCACTGAGTGGACCACACCTCCCCGATCGAGATTGAAGGTG
CTGACCTCTGAGTGCTAGGCCAGCCATCATCACAAGGGCCAAGCCCCAAACCCTGTGCTCAAAC
TGTCATGGCACCACGGGCAATGCGGTCCTCCCTACCGTTCTCCTTCCCCTTCTCTGCATCTGCT
TTCTCCAGGTCCCCGTATATCAACCTTCGACTTTCTCAGTTCCTGCATCTGCTCCCATCTGTTC
TTTCTTCCCATCTAGGGCTATTGCCCAAGGCCCAGAGAAACCAATAAACTTGTACACGAGTG

hide sequence

RefSeq Acc Id:

XM_036165843 ⟹ XP_036021736

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	55,353,204 - 55,362,372 (+)	NCBI

Sequence:

show sequence

GCGGTAACACAATGTCCCTCCATCCCGTTCAATATTCAGCTGGGTGTCCCTTCTGTTGGCCCCG
CCCACACCAGTTGCTACTGGGAAGGTGAGGCAGCAGAGATGCAGCTAGGTGGCATCACCAGAGA
CAGCCTGGGAGGGAAGGCTGACTGCAGACACCATTGCCATGGATGGCCTGATGTGGGCTACCCG
TATCCTCTGCTTGCTGAGCCTGTGCGGAGTTACACTGGGTCACCTCCACCTAGAATGTGACTTC
ATCACTCAGCTGAGAGACGATGAGCTTGCATGTCTTCAGGCGGCAGAGGGGACCAACAACACCT
CCCTGGGATGCCCTGGGACCTGGGATGGGCTGCTGTGCTGGCCCCCGACAGGCTCTGGCCAGTG
GGTCTCTCTCCCCTGCCCTGAATTCTTCTCTCACTTCGGCTCAGACACAGGGTTTGTGAAGAGG
GACTGCACCATCACTGGCTGGTCTAATCCCTTCCCACCATACCCTGTGGCTTGCCCTGTGCCCT
TGGAACTGTTAACCAAGGAGAAATCGTACTTCTCCACGGTGAAGATCATCTACACCACGGGCCA
CAGCATCTCCATTGTAGCCCTCTGCGTGGCTATTGCCATCCTGGTTGCCCTCAGGAGGCTCCAC
TGCCCCAGGAACTACATCCACACGCAGCTGTTTGCCACCTTCATCCTCAAGGCCAGTGCTGTGT
TCTTGAAGGATGCCGCCATCTTCCAGGGGGATAGCACGGACCACTGCAGCATGTCCACTGTCCT
GTGCAAGGTCTCTGTGGCCATCTCACATTTGGCCACCATGACCAACTTCAGCTGGCTGTTGGCA
GAAGCTGTCTACCTGAGCTGCCTGTTGGCCTCCACATCCCCCAGGTCCAAACCAGCTTTTTGGT
GGCTGGTCCTGGCTGGCTGGGGGCTCCCCGTGCTATGCACTGGTACGTGGGTGGGCTGCAAACT
GGCTTTTGAGGACACTGAGTGCTGGGACTTAGACAACAGCTCCCCCTGCTGGTGGATCATCAAA
GGACCCATAGTCCTCTCTGTTGGGGTGAACTTTGGGCTGTTTCTCAATATAATTTGTATCCTGC
TGAGGAAGCTGGAGCCTGCACAAGGCGGCCTACACACACGGGCTCAGTACTGGTACCATTCATG
TGTGTGTGCATGCACATGTGGATGTGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTATGTATCTGGAGAACCATCATGGAAAGCA
CTTGGAGGGAATGTCATTTGTTTTTGTCTCGTTTGGCAGCTATCCCTTACCCTGGTCCTGTCCT
CTTCCCCATGTCCCTAGAGAGAGAACAGATCTGGGCCCTGCCTCCCATGAGATTACAGTACAGG
GAAGTGGCACACAAAGCTGCCAGTTACCATGGTAAATGGCTGACAAGGGCTGCATCTATTTCTA
TGGGGCCCGGAGAAGGAGATTATGTCTAAATGAGAAAAAGGGGCAATTAGAGAAGGGTTCCTGG
AAGAATTAAACTTTGAAAGATGTACATAGACTCTGGAGTAGCCGGGATAACTGCAGGGCCACAT
AGTGTGATGGCCCTTAAAAGTCAAGAAGCCCAGAGGTCTGTGTGGAGGACAGAGTCTCCAGGAT
GGATGATGATGGACAGCTTCAGAGTCTAGAATTTGTCTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001003685	(Get FASTA)	NCBI Sequence Viewer
	XP_036021736	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI20749	(Get FASTA)	NCBI Sequence Viewer
	AAI20775	(Get FASTA)	NCBI Sequence Viewer
	EDK98729	(Get FASTA)	NCBI Sequence Viewer
	P32082	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001003685 ⟸ NM_001003685
- Peptide Label:	precursor
- UniProtKB:	Q0VB62 (UniProtKB/Swiss-Prot), P32082 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDGLMWATRILCLLSLCGVTLGHLHLECDFITQLRDDELACLQAAEGTNNTSLGCPGTWDGLLC WPPTGSGQWVSLPCPEFFSHFGSDTGFVKRDCTITGWSNPFPPYPVACPVPLELLTKEKSYFST VKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAIFQGDST DHCSMSTVLCKVSVAISHLATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLC TGTWVGCKLAFEDTECWDLDNSSPCWWIIKGPIVLSVGVNFGLFLNIICILLRKLEPAQGGLHT RAQYWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLDIRVPLELGLGSFQGFIVAVLYCFLNQEVR TEISRKWYGHDPELLPARRTCTEWTTPPRSRLKVLTSEC hide sequence

RefSeq Acc Id:

ENSMUSP00000145224 ⟸ ENSMUST00000203241

RefSeq Acc Id:

ENSMUSP00000068120 ⟸ ENSMUST00000063578

RefSeq Acc Id:	XP_036021736 ⟸ XM_036165843
- Peptide Label:	isoform X1

Protein Domains

G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P32082-F1-model_v2	AlphaFold	P32082	1-423	view protein structure

Promoters

RGD ID:

6889808

Promoter ID:

EPDNEW_M8355

Type:

initiation region

Name:

Ghrhr_1

Description:

Mus musculus growth hormone releasing hormone receptor , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	6	55,376,342 - 55,376,402	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:95710	AgrOrtholog
Ensembl Genes	ENSMUSG00000004654	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000068120	ENTREZGENE
	ENSMUSP00000068120.4	UniProtKB/Swiss-Prot
	ENSMUSP00000145224.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000063578	ENTREZGENE
	ENSMUST00000063578.6	UniProtKB/Swiss-Prot
	ENSMUST00000203241.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.1240.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracell_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_extracellular_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_GHRH_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_2_secretin-like_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:14602	UniProtKB/Swiss-Prot
MGD	MGI:95710	ENTREZGENE
NCBI Gene	14602	ENTREZGENE
PANTHER	PDF RECEPTOR-LIKE PROTEIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45620:SF14	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ghrhr	PhenoGen
PRINTS	GHRHRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRSECRETIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_2	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F2_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HormR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
	SSF111418	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0N4SVS4_MOUSE	UniProtKB/TrEMBL
	GHRHR_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q0VB62	ENTREZGENE
UniProt Secondary	Q0VB62	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype