Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Spr (sepiapterin reductase) Rattus norvegicus
Symbol: Spr
Name: sepiapterin reductase
RGD ID: 3753
Description: Exhibits sepiapterin reductase activity. Involved in response to organic substance and tetrahydrobiopterin biosynthetic process. Predicted to localize to cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Homo sapiens (human) : SPR (sepiapterin reductase)  HGNC  Alliance
Mus musculus (house mouse) : Spr (sepiapterin reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spr (sepiapterin reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : SPR (sepiapterin reductase)
Canis lupus familiaris (dog) : SPR (sepiapterin reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spr (sepiapterin reductase)
Sus scrofa (pig) : SPR (sepiapterin reductase)
Chlorocebus sabaeus (African green monkey) : SPR (sepiapterin reductase)
Heterocephalus glaber (naked mole-rat) : Spr (sepiapterin reductase)
more info ...
Is Marker For: Strains:   DA.PVG.1AV1-(D4Rat155-Spr)   BB.SHR-(D4Mit6-Spr)/K  
QTLs:   Bw22   Bp135   Scl4   Bw40  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Spr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3753
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.