Spr (sepiapterin reductase) - Rat Genome Database

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Gene: Spr (sepiapterin reductase) Rattus norvegicus
Analyze
Symbol: Spr
Name: sepiapterin reductase
RGD ID: 3753
Description: Enables sepiapterin reductase (NADP+) activity. Involved in positive regulation of cell population proliferation and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   DA.PVG.1AV1-(D4Rat155-Spr)   BB.SHR-(D4Mit6-Spr)/K  
QTLs:   Bw22   Bp135   Scl4   Bw40  
Candidate Gene For: Bw40
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,229,447 - 119,233,320 (-)NCBIGRCr8
mRatBN7.24117,671,948 - 117,676,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4123,153,277 - 123,157,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,928,408 - 118,932,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04117,541,159 - 117,544,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Bonafe L, etal., Am J Hum Genet. 2001 Aug;69(2):269-77. Epub 2001 Jul 6.
2. Isolation and expression of rat liver sepiapterin reductase cDNA. Citron BA, etal., Proc Natl Acad Sci U S A 1990 Aug;87(16):6436-40.
3. Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. Fujimoto K, etal., Biochim Biophys Acta. 1999 May 18;1431(2):306-14.
4. Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds. Fujimoto K, etal., Chem Biol Interact. 2003 Feb 1;143-144:583-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Immunological evidence for the requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain. Levine RA, etal., J Neurochem. 1990 Apr;54(4):1218-24.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2260974   PMID:8889548   PMID:9405351   PMID:11825621   PMID:12477932   PMID:15197144   PMID:16532389   PMID:18614015   PMID:19056867   PMID:23376485   PMID:23533145   PMID:34800366  
PMID:36908807  


Genomics

Comparative Map Data
Spr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,229,447 - 119,233,320 (-)NCBIGRCr8
mRatBN7.24117,671,948 - 117,676,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4123,153,277 - 123,157,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,928,408 - 118,932,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04117,541,159 - 117,544,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
SPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38272,887,408 - 72,892,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl272,887,382 - 72,892,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37273,114,537 - 73,119,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,968,056 - 72,972,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 34273,026,202 - 73,030,941NCBI
Celera272,965,357 - 72,970,134 (+)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef272,850,110 - 72,854,887 (+)NCBIHuRef
CHM1_1273,044,688 - 73,049,465 (+)NCBICHM1_1
T2T-CHM13v2.0272,900,349 - 72,905,099 (+)NCBIT2T-CHM13v2.0
Spr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,110,662 - 85,114,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,107,158 - 85,114,748 (-)EnsemblGRCm39 Ensembl
GRCm38685,133,680 - 85,137,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,083,674 - 85,087,758 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,099,343 - 85,103,476 (-)NCBIMGSCv36mm8
Celera687,104,831 - 87,108,907 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.15NCBI
Spr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,711,064 - 12,716,000 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,711,064 - 12,716,000 (-)NCBIChiLan1.0ChiLan1.0
SPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21253,488,938 - 53,494,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A53,491,687 - 53,496,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A72,939,621 - 72,944,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A74,433,056 - 74,438,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,433,056 - 74,438,105 (+)Ensemblpanpan1.1panPan2
SPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,950,192 - 49,957,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,950,800 - 49,957,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1749,596,415 - 49,603,643 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01750,816,547 - 50,823,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,816,555 - 50,823,791 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,832,663 - 49,840,008 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,898,076 - 49,905,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01750,458,363 - 50,465,721 (-)NCBIUU_Cfam_GSD_1.0
Spr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629211,872,315 - 11,877,409 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649116,693,940 - 16,699,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,889,452 - 69,894,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,889,448 - 69,894,747 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,090,291 - 73,095,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11434,275,292 - 34,280,579 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1434,275,289 - 34,280,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604577,800,011 - 77,804,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624762728,731 - 734,544 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624762729,294 - 734,761 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spr
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:63
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000020749
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat

Markers in Region
Spr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,675,455 - 117,675,732 (+)MAPPERmRatBN7.2
Rnor_6.04116,915,851 - 116,916,127NCBIRnor6.0
Rnor_5.04181,496,390 - 181,496,666UniSTSRnor5.0
RGSC_v3.44119,369,086 - 119,369,362UniSTSRGSC3.4
Celera4106,659,364 - 106,659,640UniSTS
Cytogenetic Map4q34UniSTS
RH140538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,674,529 - 117,674,738 (-)MAPPERmRatBN7.2
mRatBN7.24117,674,529 - 117,674,738 (+)MAPPERmRatBN7.2
mRatBN7.24117,690,507 - 117,690,719 (-)MAPPERmRatBN7.2
mRatBN7.24117,690,507 - 117,690,719 (+)MAPPERmRatBN7.2
Rnor_6.04116,933,686 - 116,933,894NCBIRnor6.0
Rnor_6.04116,914,925 - 116,915,133NCBIRnor6.0
Rnor_5.04181,495,464 - 181,495,672UniSTSRnor5.0
Rnor_5.04181,513,440 - 181,513,648UniSTSRnor5.0
RGSC_v3.44119,368,160 - 119,368,368UniSTSRGSC3.4
RGSC_v3.44119,385,352 - 119,385,563UniSTSRGSC3.4
Celera4106,674,130 - 106,674,341UniSTS
Celera4106,658,435 - 106,658,646UniSTS
RH 3.4 Map4689.6UniSTS
Cytogenetic Map4q34UniSTS
AA926099  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,672,101 - 117,672,225 (-)MAPPERmRatBN7.2
mRatBN7.24117,672,101 - 117,672,225 (+)MAPPERmRatBN7.2
mRatBN7.24117,693,004 - 117,693,128 (-)MAPPERmRatBN7.2
mRatBN7.24117,693,004 - 117,693,128 (+)MAPPERmRatBN7.2
Rnor_6.04116,936,185 - 116,936,308NCBIRnor6.0
Rnor_6.04116,912,497 - 116,912,620NCBIRnor6.0
Rnor_5.04181,493,036 - 181,493,159UniSTSRnor5.0
Rnor_5.04181,515,939 - 181,516,062UniSTSRnor5.0
RGSC_v3.44119,365,732 - 119,365,855UniSTSRGSC3.4
RGSC_v3.44119,387,849 - 119,387,972UniSTSRGSC3.4
Celera4106,676,622 - 106,676,745UniSTS
Celera4106,656,007 - 106,656,130UniSTS
RH 3.4 Map4688.8UniSTS
Cytogenetic Map4q34UniSTS


Related Rat Strains
The following Strains have been annotated to Spr


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000020749   ⟹   ENSRNOP00000020749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)Ensembl
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109585   ⟹   ENSRNOP00000081024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)Ensembl
RefSeq Acc Id: NM_019181   ⟹   NP_062054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,229,447 - 119,233,179 (-)NCBI
mRatBN7.24117,671,948 - 117,675,680 (-)NCBI
Rnor_6.04116,912,343 - 116,916,073 (-)NCBI
Rnor_5.04181,492,882 - 181,496,612 (-)NCBI
RGSC_v3.44119,365,578 - 119,369,308 (-)RGD
Celera4106,655,853 - 106,659,586 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107200   ⟹   XP_038963128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,229,473 - 119,233,201 (-)NCBI
mRatBN7.24117,671,948 - 117,675,684 (-)NCBI
RefSeq Acc Id: XM_039107201   ⟹   XP_038963129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84119,229,473 - 119,233,320 (-)NCBI
mRatBN7.24117,671,948 - 117,676,292 (-)NCBI
RefSeq Acc Id: NP_062054   ⟸   NM_019181
- UniProtKB: P18297 (UniProtKB/Swiss-Prot),   B2RYK3 (UniProtKB/TrEMBL),   A0A8I5ZU80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020749   ⟸   ENSRNOT00000020749
RefSeq Acc Id: XP_038963129   ⟸   XM_039107201
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963128   ⟸   XM_039107200
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081024   ⟸   ENSRNOT00000109585

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18297-F1-model_v2 AlphaFold P18297 1-262 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693192
Promoter ID:EPDNEW_R3717
Type:multiple initiation site
Name:Spr_1
Description:sepiapterin reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04116,916,075 - 116,916,135EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3753 AgrOrtholog
BioCyc Gene G2FUF-43954 BioCyc
Ensembl Genes ENSRNOG00000015455 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012862 UniProtKB/Swiss-Prot
  ENSRNOG00060024409 UniProtKB/Swiss-Prot
  ENSRNOG00065016616 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020749.7 UniProtKB/Swiss-Prot
  ENSRNOT00000109585.1 UniProtKB/TrEMBL
  ENSRNOT00055022005 UniProtKB/Swiss-Prot
  ENSRNOT00060042333 UniProtKB/Swiss-Prot
  ENSRNOT00065027685 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8373837 IMAGE-MGC_LOAD
InterPro Biopterin_syn/organic_redct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sepiapterin_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29270 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188618 IMAGE-MGC_LOAD
NCBI Gene 29270 ENTREZGENE
PANTHER SEPIAPTERIN REDUCTASE UniProtKB/Swiss-Prot
  SEPIAPTERIN REDUCTASE UniProtKB/Swiss-Prot
  SEPIAPTERIN REDUCTASE UniProtKB/TrEMBL
  SEPIAPTERIN REDUCTASE UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spr PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015455 RatGTEx
  ENSRNOG00055012862 RatGTEx
  ENSRNOG00060024409 RatGTEx
  ENSRNOG00065016616 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204785
UniProt A0A8I5ZU80 ENTREZGENE, UniProtKB/TrEMBL
  B2RYK3 ENTREZGENE, UniProtKB/TrEMBL
  P18297 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Spr  sepiapterin reductase  Spr  sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Spr  sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)  Spr  sepiapterin reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Spr  sepiapterin reductase      Name updated 70584 APPROVED