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Gene: Spr (sepiapterin reductase) Rattus norvegicus
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Symbol: Spr
Name: sepiapterin reductase
Description: Exhibits sepiapterin reductase activity. Involved in response to organic substance and tetrahydrobiopterin biosynthetic process. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
Orthologs:
Homo sapiens (human) : SPR (sepiapterin reductase)  HGNC  Alliance
Mus musculus (house mouse) : Spr (sepiapterin reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spr (sepiapterin reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : SPR (sepiapterin reductase)
Canis lupus familiaris (dog) : SPR (sepiapterin reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spr (sepiapterin reductase)
Sus scrofa (pig) : SPR (sepiapterin reductase)
more info ...
Is Marker For: Strains:   DA.PVG.1AV1-(D4Rat155-Spr)   BB.SHR-(D4Mit6-Spr)/K  
QTLs:   Bw22   Bp135   Scl4   Bw40  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Spr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3753
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.