Mgll (monoglyceride lipase) - Rat Genome Database

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Gene: Mgll (monoglyceride lipase) Rattus norvegicus
Analyze
Symbol: Mgll
Name: monoglyceride lipase
RGD ID: 71039
Description: Enables acylglycerol lipase activity. Involved in monoacylglycerol catabolic process and positive regulation of vasoconstriction. Located in synapse. Orthologous to human MGLL (monoglyceride lipase); PARTICIPATES IN glycerolipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAGL; MGC124942; MGL; monoacylglycerol lipase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24121,192,187 - 121,294,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4121,192,195 - 121,294,179 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4126,663,831 - 126,765,859 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04122,438,590 - 122,540,610 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04121,062,826 - 121,164,848 (+)NCBIRnor_WKY
Rnor_6.04120,671,436 - 120,773,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,671,489 - 120,771,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,912,102 - 186,014,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,822,493 - 122,922,892 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14123,068,176 - 123,167,195 (+)NCBI
Celera4110,145,418 - 110,245,006 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-3,5-dihydroxyphenylglycine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (EXP,ISO)
2-oleoylglycerol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxyphenylethyleneglycol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chaetocin  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
Forsythiaside  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
glafenine  (EXP)
glycerol  (EXP)
graphite  (EXP)
hexadecanoic acid  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
mifepristone  (EXP)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
oleic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
PCB138  (EXP)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (ISO)
cytosol  (ISO,ISS)
extrinsic component of membrane  (ISO,ISS)
lipid droplet  (TAS)
membrane  (IBA,IEA)
nucleoplasm  (ISO)
synapse  (IDA,ISO)
varicosity  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Brain monoglyceride lipase participating in endocannabinoid inactivation. Dinh TP, etal., Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10819-10824.
2. Brain monoglyceride lipase participating in endocannabinoid inactivation. Dinh TP, etal., Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10819-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
6. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Ho WS and Randall MD, Br J Pharmacol. 2007 Mar;150(5):641-51. Epub 2007 Jan 22.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Vila A, etal., Biochemistry. 2007 Aug 21;46(33):9578-85. doi: 10.1021/bi7005898. Epub 2007 Jul 25.
Additional References at PubMed
PMID:9341166   PMID:12477932   PMID:15489334   PMID:17700715   PMID:18096503   PMID:18948437   PMID:19957260   PMID:20554061   PMID:20599824   PMID:20657592   PMID:20729846   PMID:20962221  
PMID:22821058   PMID:22969151   PMID:23319656   PMID:25041240   PMID:25912803   PMID:25921063   PMID:26166819   PMID:26867016   PMID:29292159   PMID:34185425  


Genomics

Comparative Map Data
Mgll
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24121,192,187 - 121,294,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4121,192,195 - 121,294,179 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4126,663,831 - 126,765,859 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04122,438,590 - 122,540,610 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04121,062,826 - 121,164,848 (+)NCBIRnor_WKY
Rnor_6.04120,671,436 - 120,773,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4120,671,489 - 120,771,088 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04185,912,102 - 186,014,066 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,822,493 - 122,922,892 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14123,068,176 - 123,167,195 (+)NCBI
Celera4110,145,418 - 110,245,006 (+)NCBICelera
Cytogenetic Map4q34NCBI
MGLL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383127,689,066 - 127,823,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3127,689,062 - 128,052,190 (-)EnsemblGRCh38hg38GRCh38
GRCh373127,407,909 - 127,542,028 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363128,890,599 - 129,024,741 (-)NCBINCBI36Build 36hg18NCBI36
Build 343128,890,608 - 129,024,399NCBI
Celera3125,834,761 - 125,969,898 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3124,788,663 - 124,922,449 (-)NCBIHuRef
CHM1_13127,371,222 - 127,505,366 (-)NCBICHM1_1
T2T-CHM13v2.03130,423,721 - 130,557,760 (-)NCBIT2T-CHM13v2.0
Mgll
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,701,381 - 88,805,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl688,701,394 - 88,805,342 (+)EnsemblGRCm39 Ensembl
GRCm38688,724,412 - 88,828,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,724,412 - 88,828,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,674,406 - 88,778,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36688,690,469 - 88,793,998 (+)NCBIMGSCv36mm8
Celera690,660,468 - 90,766,558 (+)NCBICelera
Cytogenetic Map6D1NCBI
Mgll
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,759,540 - 15,960,835 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,760,159 - 15,960,774 (+)NCBIChiLan1.0ChiLan1.0
MGLL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,040,430 - 132,171,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,040,430 - 132,171,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03124,733,770 - 124,865,302 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MGLL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1201,765,650 - 1,880,710 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl201,766,216 - 1,943,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha201,803,361 - 1,918,069 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0201,787,245 - 1,901,999 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl201,788,085 - 1,901,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1201,508,582 - 1,623,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0201,835,979 - 1,950,579 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0201,795,784 - 1,910,369 (-)NCBIUU_Cfam_GSD_1.0
Mgll
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494220,639,895 - 20,679,987 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936798681,380 - 724,463 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936798681,549 - 721,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGLL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,480,174 - 72,568,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,480,395 - 72,568,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,998,289 - 80,086,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGLL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12253,092,970 - 53,354,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2253,218,672 - 53,354,448 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041113,000,703 - 113,137,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgll
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462497487,600 - 170,228 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462497485,513 - 169,904 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mgll
285 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:236
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000029125
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat

Markers in Region
AU049228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24121,283,967 - 121,284,135 (+)MAPPERmRatBN7.2
Rnor_6.04120,763,239 - 120,763,406NCBIRnor6.0
Rnor_5.04186,003,847 - 186,004,014UniSTSRnor5.0
RGSC_v3.44122,915,063 - 122,915,230UniSTSRGSC3.4
Celera4110,237,177 - 110,237,344UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 39 23 19 23 8 11 46 31 23 11 8
Low 12 18 18 18 28 4 18
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029125   ⟹   ENSRNOP00000030271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4121,192,195 - 121,294,179 (+)Ensembl
Rnor_6.0 Ensembl4120,671,489 - 120,771,066 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077231   ⟹   ENSRNOP00000070667
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4121,192,201 - 121,293,246 (+)Ensembl
Rnor_6.0 Ensembl4120,672,152 - 120,771,088 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110964   ⟹   ENSRNOP00000080270
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4121,192,195 - 121,294,179 (+)Ensembl
RefSeq Acc Id: NM_138502   ⟹   NP_612511
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24121,192,220 - 121,291,797 (+)NCBI
Rnor_6.04120,671,489 - 120,771,068 (+)NCBI
Rnor_5.04185,912,102 - 186,014,066 (+)NCBI
RGSC_v3.44122,822,493 - 122,922,892 (+)RGD
Celera4110,145,418 - 110,245,006 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763053   ⟹   XP_008761275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24121,192,187 - 121,294,187 (+)NCBI
Rnor_6.04120,671,436 - 120,773,458 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_612511   ⟸   NM_138502
- UniProtKB: Q32PZ2 (UniProtKB/Swiss-Prot),   Q8R431 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761275   ⟸   XM_008763053
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070667   ⟸   ENSRNOT00000077231
RefSeq Acc Id: ENSRNOP00000030271   ⟸   ENSRNOT00000029125
RefSeq Acc Id: ENSRNOP00000080270   ⟸   ENSRNOT00000110964
Protein Domains
Hydrolase_4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R431-F1-model_v2 AlphaFold Q8R431 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693235
Promoter ID:EPDNEW_R3759
Type:multiple initiation site
Name:Mgll_1
Description:monoglyceride lipase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04120,671,484 - 120,671,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71039 AgrOrtholog
BioCyc Gene G2FUF-43808 BioCyc
BioCyc Pathway LIPAS-PWY [triacylglycerol degradation] BioCyc
  PWY-7420 [monoacylglycerol metabolism (yeast)] BioCyc
Ensembl Genes ENSRNOG00000014508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030271 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070667.1 UniProtKB/TrEMBL
  ENSRNOP00000080270 ENTREZGENE
  ENSRNOP00000080270.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029125 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077231.2 UniProtKB/TrEMBL
  ENSRNOT00000110964 ENTREZGENE
  ENSRNOT00000110964.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446100 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29254 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124942 IMAGE-MGC_LOAD
NCBI Gene 29254 ENTREZGENE
Pfam Hydrolase_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mgll PhenoGen
PRINTS ABHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYI5_RAT UniProtKB/TrEMBL
  A0A8I5ZPF3_RAT UniProtKB/TrEMBL
  MGLL_RAT UniProtKB/Swiss-Prot
  Q32PZ2 ENTREZGENE
  Q8R431 ENTREZGENE
UniProt Secondary Q32PZ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mgll  monoglyceride lipase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 633224
gene_expression expression is increased 2.3 fold in SHR compared with WKY rats 1357414
gene_protein 303 amino acids; 33.4 kDa 633224