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Gene: Ptn (pleiotrophin) Rattus norvegicus
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Symbol: Ptn
Name: pleiotrophin
Description: Exhibits several functions, including glycosaminoglycan binding activity; growth factor activity; and syndecan binding activity. Involved in several processes, including negative regulation of cell population proliferation; nervous system development; and regulation of neuromuscular junction development. Localizes to several cellular components, including the cell surface; neuromuscular junction; and perinuclear region of cytoplasm. Used to study Parkinson's disease. Biomarker of brain disease (multiple); extrahepatic cholestasis; liver cirrhosis; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HARP; HB-GAM; HBBM; HBGF-8; Hbnf; heparin affine regulatory peptide; heparin binding factor; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurotrophic factor; heparin-binding neutrophic factor; OSF-1; osteoblast-specific factor 1; Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)
Orthologs:
Homo sapiens (human) : PTN (pleiotrophin)  HGNC  Alliance
Mus musculus (house mouse) : Ptn (pleiotrophin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptn (pleiotrophin)
Pan paniscus (bonobo/pygmy chimpanzee) : PTN (pleiotrophin)
Canis lupus familiaris (dog) : PTN (pleiotrophin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptn (pleiotrophin)
Sus scrofa (pig) : PTN (pleiotrophin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0464,239,156 - 64,330,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0464,063,952 - 64,156,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,078,755 - 64,160,135 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1464,354,886 - 64,436,265 (-)NCBI
Celera460,333,929 - 60,415,522 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ptn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3444
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.