Ptn Rat 1,2-dimethylhydrazine increases expression ISO RGD:11190 6480464 1,2-Dimethylhydrazine results in increased expression of PTN mRNA CTD PMID:22206623 Ptn Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of PTN mRNA CTD PMID:25380136 Ptn Rat 1-nitropyrene decreases expression ISO RGD:736479 6480464 1-nitropyrene results in decreased expression of PTN mRNA CTD PMID:19041380 Ptn Rat 17alpha-ethynylestradiol decreases expression ISO RGD:11190 6480464 Ethinyl Estradiol results in decreased expression of PTN mRNA CTD PMID:17555576 Ptn Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of PTN mRNA CTD PMID:15834898|PMID:17557909 Ptn Rat 17alpha-ethynylestradiol multiple interactions ISO RGD:11190 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PTN mRNA CTD PMID:17942748 Ptn Rat 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of PTN mRNA CTD PMID:26496021 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736479 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PTN mRNA CTD PMID:19684285 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PTN mRNA CTD PMID:34747641 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTN mRNA CTD PMID:32109520 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PTN mRNA CTD PMID:20959002|PMID:21215274 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11190 6480464 Tetrachlorodibenzodioxin affects the expression of PTN mRNA CTD PMID:21570461 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11190 6480464 Tetrachlorodibenzodioxin results in increased expression of PTN mRNA CTD PMID:17942748 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11190 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PTN mRNA CTD PMID:17942748 Ptn Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736479 6480464 Tetrachlorodibenzodioxin results in increased expression of PTN mRNA CTD PMID:19684285 Ptn Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression ISO RGD:736479 6480464 2,2',4,4',5-brominated diphenyl ether results in decreased expression of PTN mRNA CTD PMID:26705709 Ptn Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO RGD:11190 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of PTN mRNA CTD PMID:38648751 Ptn Rat 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of PTN mRNA CTD PMID:12057922 Ptn Rat 2-amino-2-deoxy-D-galactopyranose increases expression EXP 6480464 Galactosamine results in increased expression of PTN mRNA; Galactosamine results in increased expression of PTN more ... CTD PMID:12057922 Ptn Rat 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PTN mRNA CTD PMID:23196670 Ptn Rat 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTN mRNA CTD PMID:32119087 Ptn Rat 3-methylcholanthrene decreases expression ISO RGD:11190 6480464 Methylcholanthrene results in decreased expression of PTN mRNA CTD PMID:20713471 Ptn Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of PTN mRNA CTD PMID:25380136 Ptn Rat 4,4'-sulfonyldiphenol multiple interactions ISO RGD:736479 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of PTN gene CTD PMID:31601247 Ptn Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of PTN mRNA CTD PMID:24780913|PMID:30047161 Ptn Rat 7,12-dimethyltetraphene decreases expression ISO RGD:11190 6480464 9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PTN mRNA CTD PMID:32553695 Ptn Rat acrylamide decreases expression ISO RGD:736479 6480464 Acrylamide results in decreased expression of PTN mRNA CTD PMID:32763439 Ptn Rat aflatoxin B1 affects expression ISO RGD:736479 6480464 Aflatoxin B1 affects the expression of PTN protein CTD PMID:20106945 Ptn Rat all-trans-retinoic acid decreases expression ISO RGD:736479 6480464 Tretinoin results in decreased expression of PTN mRNA CTD PMID:21934132 Ptn Rat all-trans-retinoic acid increases expression ISO RGD:736479 6480464 Tretinoin results in increased expression of PTN mRNA CTD PMID:23724009 Ptn Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of PTN mRNA CTD PMID:38685447 Ptn Rat amitrole increases expression EXP 6480464 Amitrole results in increased expression of PTN mRNA CTD PMID:30047161 Ptn Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PTN mRNA CTD PMID:16483693 Ptn Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of PTN mRNA CTD PMID:15862925 Ptn Rat amphetamine decreases response to substance ISO RGD:11190 6480464 PTN gene mutant form results in decreased susceptibility to Amphetamine; PTN protein results in decreased more ... CTD PMID:20192945|PMID:23459167 Ptn Rat amphetamine multiple interactions EXP 6480464 Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA] CTD PMID:15862925 Ptn Rat amphetamine multiple interactions ISO RGD:11190 6480464 [PTN gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression more ... CTD PMID:20620199|PMID:23459167 Ptn Rat arsane decreases expression ISO RGD:11190 6480464 Arsenic results in decreased expression of PTN mRNA CTD PMID:24019935 Ptn Rat arsenic atom decreases expression ISO RGD:11190 6480464 Arsenic results in decreased expression of PTN mRNA CTD PMID:24019935 Ptn Rat atrazine increases expression EXP 6480464 Atrazine results in increased expression of PTN mRNA CTD PMID:36841081 Ptn Rat benzo[a]pyrene decreases expression ISO RGD:11190 6480464 Benzo(a)pyrene metabolite results in decreased expression of PTN mRNA; Benzo(a)pyrene results in decreased expression of more ... CTD PMID:20713471|PMID:22228805|PMID:32553695 Ptn Rat benzo[a]pyrene decreases methylation ISO RGD:736479 6480464 Benzo(a)pyrene results in decreased methylation of PTN 5' UTR CTD PMID:27901495 Ptn Rat benzo[a]pyrene decreases methylation ISO RGD:11190 6480464 Benzo(a)pyrene results in decreased methylation of PTN exon; Benzo(a)pyrene results in decreased methylation of PTN more ... CTD PMID:27901495 Ptn Rat benzo[a]pyrene affects methylation ISO RGD:736479 6480464 Benzo(a)pyrene affects the methylation of PTN promoter CTD PMID:27901495 Ptn Rat benzo[a]pyrene diol epoxide I increases expression ISO RGD:736479 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PTN mRNA CTD PMID:20382639 Ptn Rat beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTN mRNA CTD PMID:18164116 Ptn Rat bis(2-ethylhexyl) phthalate decreases expression ISO RGD:736479 6480464 Diethylhexyl Phthalate results in decreased expression of PTN protein CTD PMID:31163220 Ptn Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:736479 6480464 Diethylhexyl Phthalate results in increased expression of PTN mRNA CTD PMID:31163220 Ptn Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of PTN mRNA CTD PMID:26496021 Ptn Rat bisphenol A increases expression ISO RGD:11190 6480464 bisphenol A results in increased expression of PTN mRNA CTD PMID:37105096 Ptn Rat bisphenol A decreases methylation ISO RGD:736479 6480464 bisphenol A results in decreased methylation of PTN gene CTD PMID:31601247 Ptn Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PTN mRNA CTD PMID:32145629|PMID:33296240 Ptn Rat bisphenol A increases expression ISO RGD:736479 6480464 bisphenol A results in increased expression of PTN mRNA CTD PMID:27685785 Ptn Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PTN mRNA CTD PMID:25181051 Ptn Rat butanal increases expression ISO RGD:736479 6480464 butyraldehyde results in increased expression of PTN mRNA CTD PMID:26079696 Ptn Rat cadmium dichloride multiple interactions ISO RGD:11190 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PTN mRNA CTD PMID:19840844 Ptn Rat cadmium dichloride decreases expression ISO RGD:736479 6480464 Cadmium Chloride results in decreased expression of PTN mRNA CTD PMID:12160620 Ptn Rat calcitriol decreases expression ISO RGD:11190 6480464 Calcitriol results in decreased expression of PTN mRNA CTD PMID:21153232 Ptn Rat calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of PTN mRNA CTD PMID:21153232 Ptn Rat calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of PTN mRNA CTD PMID:21153232 Ptn Rat cannabidiol decreases expression ISO RGD:736479 6480464 Cannabidiol results in decreased expression of PTN mRNA CTD PMID:27932991 Ptn Rat chondroitin sulfate affects binding ISO RGD:736479 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein; Chondroitin Sulfates analog binds more ... CTD PMID:12221095|PMID:15385557 Ptn Rat cocaine decreases expression ISO RGD:736479 6480464 Cocaine results in decreased expression of PTN mRNA CTD PMID:12629581 Ptn Rat cocaine multiple interactions ISO RGD:11190 6480464 Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form] CTD PMID:24096156 Ptn Rat copper atom increases expression EXP 6480464 Copper results in increased expression of PTN mRNA CTD PMID:30556269 Ptn Rat copper(0) increases expression EXP 6480464 Copper results in increased expression of PTN mRNA CTD PMID:30556269 Ptn Rat cycloheximide increases expression ISO RGD:736479 6480464 Cycloheximide results in increased expression of PTN mRNA CTD PMID:19684285 Ptn Rat cycloheximide multiple interactions ISO RGD:736479 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PTN mRNA CTD PMID:19684285 Ptn Rat cyclosporin A decreases expression ISO RGD:736479 6480464 Cyclosporine results in decreased expression of PTN mRNA CTD PMID:20106945 Ptn Rat dermatan sulfate affects binding ISO RGD:736479 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:15385557 Ptn Rat dextran sulfate decreases expression ISO RGD:11190 6480464 Dextran Sulfate results in decreased expression of PTN mRNA CTD PMID:35093514 Ptn Rat diazinon affects expression EXP 6480464 Diazinon affects the expression of PTN mRNA CTD PMID:22546817 Ptn Rat dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of PTN mRNA CTD PMID:18636392 Ptn Rat dichlorine increases expression EXP 6480464 Chlorine results in increased expression of PTN mRNA CTD PMID:18636392 Ptn Rat dieldrin affects expression EXP 6480464 Dieldrin affects the expression of PTN mRNA CTD PMID:22546817 Ptn Rat diethylstilbestrol decreases expression ISO RGD:11190 6480464 Diethylstilbestrol results in decreased expression of PTN mRNA CTD PMID:15591538 Ptn Rat dizocilpine maleate multiple interactions EXP 6480464 Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA] CTD PMID:15862925 Ptn Rat dorsomorphin multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Ptn Rat doxorubicin decreases expression ISO RGD:736479 6480464 Doxorubicin results in decreased expression of PTN mRNA CTD PMID:29803840 Ptn Rat ellagic acid decreases expression ISO RGD:736479 6480464 Ellagic Acid results in decreased expression of PTN mRNA CTD PMID:12002526 Ptn Rat ellagic acid increases expression ISO RGD:736479 6480464 Ellagic Acid results in increased expression of PTN mRNA CTD PMID:12002526 Ptn Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of PTN mRNA CTD PMID:29391264 Ptn Rat ethanol multiple interactions ISO RGD:11190 6480464 Ethanol affects the expression of and affects the splicing of PTN mRNA CTD PMID:30319688 Ptn Rat ethanol increases expression ISO RGD:11190 6480464 Ethanol results in increased expression of PTN mRNA CTD PMID:30319688 Ptn Rat folic acid decreases expression ISO RGD:11190 6480464 Folic Acid results in decreased expression of PTN mRNA CTD PMID:25629700 Ptn Rat fulvestrant multiple interactions ISO RGD:736479 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of PTN gene CTD PMID:31601247 Ptn Rat furan increases expression EXP 6480464 furan results in increased expression of PTN mRNA CTD PMID:27387713 Ptn Rat furosemide affects expression EXP 6480464 Furosemide affects the expression of PTN mRNA CTD PMID:16526316 Ptn Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of PTN mRNA CTD PMID:33387578 Ptn Rat glyphosate decreases expression ISO RGD:11190 6480464 Glyphosate results in decreased expression of PTN mRNA CTD PMID:35897073 Ptn Rat L-ascorbic acid increases expression ISO RGD:11190 6480464 Ascorbic Acid results in increased expression of PTN mRNA CTD PMID:15305145 Ptn Rat methimazole increases expression EXP 6480464 Methimazole results in increased expression of PTN mRNA CTD PMID:30047161 Ptn Rat methylmercury chloride increases expression ISO RGD:736479 6480464 methylmercuric chloride results in increased expression of PTN mRNA CTD PMID:34089799 Ptn Rat miconazole increases expression ISO RGD:11190 6480464 Miconazole results in increased expression of PTN mRNA CTD PMID:27462272 Ptn Rat N-methyl-4-phenylpyridinium decreases expression ISO RGD:736479 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PTN mRNA CTD PMID:24810058 Ptn Rat N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:11190 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PTN mRNA; [Methylnitronitrosoguanidine co-treated with more ... CTD PMID:19840844 Ptn Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTN mRNA CTD PMID:18164116 Ptn Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of PTN mRNA CTD PMID:25380136 Ptn Rat nickel atom decreases expression ISO RGD:736479 6480464 Nickel results in decreased expression of PTN mRNA CTD PMID:24768652|PMID:25583101 Ptn Rat okadaic acid multiple interactions ISO RGD:11190 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PTN mRNA CTD PMID:19840844 Ptn Rat oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of PTN mRNA CTD PMID:25729387 Ptn Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PTN mRNA CTD PMID:25729387 Ptn Rat ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of PTN mRNA CTD PMID:18636392 Ptn Rat p-chloromercuribenzoic acid decreases expression ISO RGD:736479 6480464 p-Chloromercuribenzoic Acid results in decreased expression of PTN mRNA CTD PMID:26272509 Ptn Rat p-chloromercuribenzoic acid multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Ptn Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of PTN mRNA CTD PMID:33387578 Ptn Rat paraquat increases expression ISO RGD:11190 6480464 Paraquat results in increased expression of PTN mRNA CTD PMID:26345256 Ptn Rat pentachlorophenol increases expression ISO RGD:11190 6480464 Pentachlorophenol results in increased expression of PTN mRNA CTD PMID:23892564 Ptn Rat perfluorohexanesulfonic acid increases expression ISO RGD:11190 6480464 perfluorohexanesulfonic acid results in increased expression of PTN mRNA CTD PMID:37995155 Ptn Rat perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of PTN mRNA CTD PMID:19162173 Ptn Rat phenylmercury acetate multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Ptn Rat phorbol 13-acetate 12-myristate multiple interactions ISO RGD:11190 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTN mRNA CTD PMID:19840844 Ptn Rat progesterone decreases expression ISO RGD:736479 6480464 Progesterone results in decreased expression of PTN mRNA CTD PMID:20864642 Ptn Rat Rutecarpine decreases expression ISO RGD:736479 6480464 rutecarpine results in decreased expression of PTN mRNA CTD PMID:34955744 Ptn Rat SB 431542 multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Ptn Rat silver atom decreases expression ISO RGD:11190 6480464 Silver results in decreased expression of PTN mRNA CTD PMID:27131904 Ptn Rat silver(0) decreases expression ISO RGD:11190 6480464 Silver results in decreased expression of PTN mRNA CTD PMID:27131904 Ptn Rat sodium arsenite affects methylation ISO RGD:736479 6480464 sodium arsenite affects the methylation of PTN gene CTD PMID:28589171 Ptn Rat sodium arsenite decreases expression ISO RGD:736479 6480464 sodium arsenite results in decreased expression of PTN mRNA CTD PMID:35954277 Ptn Rat sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of PTN mRNA CTD PMID:30047161 Ptn Rat sunitinib decreases expression ISO RGD:736479 6480464 Sunitinib results in decreased expression of PTN mRNA CTD PMID:31533062 Ptn Rat tamoxifen affects expression ISO RGD:736479 6480464 Tamoxifen affects the expression of PTN mRNA CTD PMID:14699072 Ptn Rat tamoxifen affects expression ISO RGD:11190 6480464 Tamoxifen affects the expression of PTN mRNA CTD PMID:17555576 Ptn Rat testosterone enanthate affects expression ISO RGD:736479 6480464 testosterone enanthate affects the expression of PTN mRNA CTD PMID:17440010 Ptn Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PTN mRNA CTD PMID:11999218|PMID:18381592 Ptn Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of PTN mRNA CTD PMID:34492290 Ptn Rat topotecan increases expression EXP 6480464 Topotecan results in increased expression of PTN mRNA CTD PMID:25729387 Ptn Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of PTN mRNA CTD PMID:25729387 Ptn Rat Tributyltin oxide decreases expression ISO RGD:11190 6480464 bis(tri-n-butyltin)oxide results in decreased expression of PTN mRNA CTD PMID:18958704 Ptn Rat trichostatin A increases expression ISO RGD:736479 6480464 trichostatin A results in increased expression of PTN mRNA CTD PMID:24935251|PMID:26272509 Ptn Rat trichostatin A multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Ptn Rat trimellitic anhydride decreases expression ISO RGD:11190 6480464 trimellitic anhydride results in decreased expression of PTN mRNA CTD PMID:19042947 Ptn Rat valproic acid increases expression ISO RGD:736479 6480464 Valproic Acid results in increased expression of PTN mRNA CTD PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369|PMID:29154799 Ptn Rat valproic acid decreases expression ISO RGD:736479 6480464 Valproic Acid results in decreased expression of PTN mRNA CTD PMID:28001369 Ptn Rat valproic acid multiple interactions ISO RGD:736479 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Ptn Rat vorinostat increases expression ISO RGD:736479 6480464 vorinostat results in increased expression of PTN mRNA CTD PMID:26272509