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Gene: Ptn (pleiotrophin) Rattus norvegicus
Symbol: Ptn
Name: pleiotrophin
Description: Exhibits several functions, including glycosaminoglycan binding activity; growth factor activity; and syndecan binding activity. Involved in several processes, including nervous system development; regulation of epithelial cell proliferation; and regulation of neuromuscular junction development. Localizes to several cellular components, including cell surface; neuromuscular junction; and perinuclear region of cytoplasm. Used to study Parkinson's disease. Biomarker of several diseases, including extrahepatic cholestasis; liver cirrhosis; sciatic neuropathy; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Also known as: HARP; HB-GAM; HBBM; HBGF-8; Hbnf; heparin affine regulatory peptide; heparin binding factor; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurotrophic factor; heparin-binding neutrophic factor; OSF-1; osteoblast-specific factor 1; Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)
Homo sapiens (human) : PTN (pleiotrophin)  HGNC  Alliance
Mus musculus (house mouse) : Ptn (pleiotrophin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptn (pleiotrophin)
Pan paniscus (bonobo/pygmy chimpanzee) : PTN (pleiotrophin)
Canis lupus familiaris (dog) : PTN (pleiotrophin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptn (pleiotrophin)
Sus scrofa (pig) : PTN (pleiotrophin)
Chlorocebus sabaeus (African green monkey) : PTN (pleiotrophin)
Heterocephalus glaber (naked mole-rat) : Ptn (pleiotrophin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0464,239,156 - 64,330,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,239,158 - 64,330,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,063,952 - 64,156,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,078,755 - 64,160,135 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1464,354,886 - 64,436,265 (-)NCBI
Celera460,333,929 - 60,415,522 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ptn
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3444
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.