Ptprz1 (protein tyrosine phosphatase, receptor type Z1) - Rat Genome Database

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Gene: Ptprz1 (protein tyrosine phosphatase, receptor type Z1) Rattus norvegicus
Symbol: Ptprz1
Name: protein tyrosine phosphatase, receptor type Z1 (Ensembl:protein tyrosine phosphatase, receptor type Z, polypeptide 1)
RGD ID: 3455
Description: Enables fibroblast growth factor binding activity and protein tyrosine phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including perineuronal net; postsynaptic membrane; and ruffle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; temporal lobe epilepsy; and visual epilepsy. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1); INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; 6B4 proteoglycan; phosphacan; Protein tyrosine phosphatase receptor-type zeta polypeptide; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; Protein tyrosine phosphatase, receptor-type, zeta polypeptide; PTP zeta; Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S; R-PTP-zeta; receptor-type tyrosine-protein phosphatase zeta; RPTPbeta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2451,397,316 - 51,595,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl451,397,601 - 51,595,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx456,378,267 - 56,560,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0452,299,317 - 52,481,722 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0450,726,932 - 50,924,348 (+)NCBIRnor_WKY
Rnor_6.0449,941,046 - 50,140,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,941,304 - 50,140,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,730,302 - 49,927,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,267,521 - 49,468,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1449,498,094 - 49,699,266 (+)NCBI
Celera446,598,237 - 46,787,500 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP)
cytarabine  (ISO)
dimethylarsinous acid  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
iron(III) nitrilotriacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
manganese(II) chloride  (EXP)
methyl beta-cyclodextrin  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Carmichael ST, etal., Exp Neurol. 2005 Jun;193(2):291-311.
2. Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Davies JE, etal., Eur J Neurosci. 2004 Mar;19(5):1226-42.
3. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa SS, etal., J Biol Chem. 2006 Jun 30;281(26):17789-800. Epub 2006 Apr 27.
4. Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan. Engel M, etal., J Comp Neurol 1996 Feb 26;366(1):34-43.
5. Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS. Forostyak S, etal., Stem Cells. 2014 Aug 11. doi: 10.1002/stem.1812.
6. Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z. Fujikawa A, etal., J Biochem. 2007 Sep;142(3):343-50. Epub 2007 Jul 23.
7. Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. Fujikawa A, etal., J Biol Chem. 2011 Oct 28;286(43):37137-46. doi: 10.1074/jbc.M111.270140. Epub 2011 Sep 2.
8. Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization. Fukada M, etal., FEBS Lett. 2006 Jul 24;580(17):4051-6. Epub 2006 Jun 27.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue. Grumet M, etal., J Biol Chem 1994 Apr 22;269(16):12142-6.
12. Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats. Hayashi N, etal., Brain Res. 2005 Jul 19;1050(1-2):163-9.
13. Chondroitin sulfate proteoglycan phosphacan associates with parallel fibers and modulates axonal extension and fasciculation of cerebellar granule cells. Hayashi N, etal., Mol Cell Neurosci. 2005 Nov;30(3):364-77. Epub 2005 Sep 16.
14. Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan. Hayashi N, etal., Neuroscience. 2005;131(2):331-48.
15. Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. Inatani M, etal., Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1930-8.
16. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Jones LL, etal., Exp Neurol. 2003 Aug;182(2):399-411.
17. Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo. Katoh-Semba R, etal., Neurosci Res. 1998 Aug;31(4):273-82.
18. Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system. Kawachi H, etal., Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6593-8. Epub 2001 May 29.
19. Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats. Kurazono S, etal., Brain Res. 2001 Apr 13;898(1):36-48.
20. Recombinant core protein fragment of phosphacan, a brain specific chondroitin sulfate proteoglycan, promote excitotoxic cell death of cultured rat hippocampal neurons. Kurazono S, etal., Neurosci Lett. 2001 May 25;304(3):169-72.
21. Regulated expression during development and following sciatic nerve injury of mRNAs encoding the receptor tyrosine phosphatase HPTPzeta/RPTPbeta. Li J, etal., Brain Res Mol Brain Res. 1998 Sep 18;60(1):77-88.
22. 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons. Maeda N and Noda M, Development. 1996 Feb;122(2):647-58.
23. Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. Maeda N and Noda M, J Cell Biol. 1998 Jul 13;142(1):203-16.
24. 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). Maeda N, etal., J Biol Chem. 1996 Aug 30;271(35):21446-52.
25. A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. Maeda N, etal., J Biol Chem. 1999 Apr 30;274(18):12474-9.
26. Changes in the amounts of chondroitin sulfate proteoglycans in rat brain after neonatal hypoxia-ischemia. Matsui F, etal., J Neurosci Res. 2005 Sep 15;81(6):837-45.
27. Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision. Matsui F, etal., Neuroscience 2002;112(4):773-81.
28. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Maurel P, etal., Proc Natl Acad Sci U S A 1994 Mar 29;91(7):2512-6.
29. Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan. Meyer-Puttlitz B, etal., J Comp Neurol 1996 Feb 26;366(1):44-54.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin. Milev P, etal., J Biol Chem 1995 Oct 20;270(42):24650-3.
32. The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity. Milev P, etal., J Biol Chem. 1998 Aug 21;273(34):21439-42.
33. Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. Milev P, etal., J Cell Biol 1994 Dec;127(6 Pt 1):1703-15.
34. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. Muramatsu H, etal., J Cell Sci. 2004 Oct 15;117(Pt 22):5405-15. doi: 10.1242/jcs.01423. Epub 2004 Oct 5.
35. Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. Naffah-Mazzacoratti MG, etal., Brain Res Bull. 1999 Nov 1;50(4):229-39.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Characterization and developmental regulation of proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta isoforms. Nishiwaki T, etal., J Biochem. 1998 Mar;123(3):458-67.
38. Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus. Okamoto M, etal., Cell Tissue Res. 2001 Nov;306(2):217-29.
39. Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures. Okamoto M, etal., Exp Neurol. 2003 Nov;184(1):179-95.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase. Qi M, etal., J Biol Chem. 2001 May 11;276(19):15868-75.
42. Regulation of tyrosine phosphorylation and protein tyrosine phosphatases during oligodendrocyte differentiation. Ranjan M and Hudson LD, Mol Cell Neurosci. 1996 May;7(5):404-18.
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Hippocampal gene expression profiling in spatial discrimination learning. Robles Y, etal., Neurobiol Learn Mem. 2003 Jul;80(1):80-95.
46. Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro. Sango K, etal., Exp Neurol. 2003 Jul;182(1):1-11.
47. A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum. Tanaka M, etal., J Neurosci. 2003 Apr 1;23(7):2804-14.
48. The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Tanga N, etal., Glia. 2019 May;67(5):967-984. doi: 10.1002/glia.23583. Epub 2019 Jan 22.
49. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
50. Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells. Thomaidou D, etal., J Neurochem. 2001 Aug;78(4):767-78.
51. Chronic erythropoietin-mediated effects on the expression of astrocyte markers in a rat model of contusive spinal cord injury. Vitellaro-Zuccarello L, etal., Neuroscience. 2008 Jan 24;151(2):452-66. Epub 2007 Nov 7.
52. Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation. Wilson MT and Snow DM, J Comp Neurol. 2000 Aug 28;424(3):532-46.
Additional References at PubMed
PMID:7579589   PMID:7628014   PMID:8889548   PMID:9118959   PMID:9182584   PMID:10234020   PMID:10706604   PMID:10769382   PMID:10793198   PMID:12573468   PMID:12700241   PMID:12840014  
PMID:16452087   PMID:16513268   PMID:17368428   PMID:18055543   PMID:18713734   PMID:19141078   PMID:19141530   PMID:19751804   PMID:21969550   PMID:24029230   PMID:25519047   PMID:26615567  
PMID:26857455   PMID:27374750   PMID:27445335   PMID:28717188  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2451,397,316 - 51,595,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl451,397,601 - 51,595,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx456,378,267 - 56,560,689 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0452,299,317 - 52,481,722 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0450,726,932 - 50,924,348 (+)NCBIRnor_WKY
Rnor_6.0449,941,046 - 50,140,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,941,304 - 50,140,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,730,302 - 49,927,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,267,521 - 49,468,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1449,498,094 - 49,699,266 (+)NCBI
Celera446,598,237 - 46,787,500 (+)NCBICelera
Cytogenetic Map4q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387121,873,161 - 122,062,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7121,873,089 - 122,062,036 (+)EnsemblGRCh38hg38GRCh38
GRCh377121,513,215 - 121,702,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367121,300,395 - 121,489,326 (+)NCBINCBI36Build 36hg18NCBI36
Build 347121,107,357 - 121,296,039NCBI
Celera7116,322,385 - 116,511,311 (+)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7115,876,018 - 116,065,533 (+)NCBIHuRef
CHM1_17121,446,481 - 121,635,390 (+)NCBICHM1_1
T2T-CHM13v2.07123,189,006 - 123,377,936 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27120,907,807 - 121,096,757 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39622,875,302 - 23,052,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl622,875,501 - 23,052,915 (+)EnsemblGRCm39 Ensembl
GRCm38622,875,315 - 23,052,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl622,875,502 - 23,052,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37622,825,502 - 23,002,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36622,825,503 - 23,002,917 (+)NCBIMGSCv36mm8
Celera622,923,288 - 23,100,277 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554793,624,993 - 3,733,183 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554793,611,658 - 3,734,225 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17126,569,630 - 126,758,155 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7126,569,630 - 126,758,155 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07113,882,557 - 114,073,283 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11459,769,553 - 59,944,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,827,650 - 59,943,315 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,203,408 - 59,361,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,825,102 - 59,979,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,863,616 - 59,979,379 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11459,916,795 - 60,071,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,543,462 - 59,698,673 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01459,919,950 - 60,076,006 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511848,835,842 - 49,007,255 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,196,548 - 3,368,175 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366053,195,893 - 3,368,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1825,045,742 - 25,168,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11825,046,027 - 25,228,276 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21826,650,579 - 26,832,837 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12190,686,091 - 90,877,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2190,686,167 - 90,877,649 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604212,666,623 - 12,858,179 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478313,912,332 - 14,105,292 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478313,911,525 - 14,105,403 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptprz1
1219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:300
Count of miRNA genes:198
Interacting mature miRNAs:227
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2451,397,796 - 51,397,896 (+)MAPPERmRatBN7.2
Rnor_6.0449,941,500 - 49,941,599NCBIRnor6.0
Rnor_5.0449,730,748 - 49,730,847UniSTSRnor5.0
RGSC_v3.4449,267,717 - 49,267,816UniSTSRGSC3.4
Celera446,598,433 - 46,598,532UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2451,542,199 - 51,542,361 (+)MAPPERmRatBN7.2
Rnor_6.0450,087,617 - 50,087,778NCBIRnor6.0
Rnor_5.0449,874,248 - 49,874,409UniSTSRnor5.0
RGSC_v3.4449,415,743 - 49,415,904UniSTSRGSC3.4
Celera446,734,344 - 46,734,505UniSTS
RH 3.4 Map4300.0UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2451,546,075 - 51,546,250 (+)MAPPERmRatBN7.2
Rnor_6.0450,091,493 - 50,091,667NCBIRnor6.0
Rnor_5.0449,878,124 - 49,878,298UniSTSRnor5.0
RGSC_v3.4449,419,619 - 49,419,793UniSTSRGSC3.4
Celera446,738,220 - 46,738,394UniSTS
RH 3.4 Map4296.3UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2451,594,899 - 51,595,084 (+)MAPPERmRatBN7.2
Rnor_6.0450,140,444 - 50,140,628NCBIRnor6.0
Rnor_5.0449,927,008 - 49,927,192UniSTSRnor5.0
RGSC_v3.4449,468,377 - 49,468,561UniSTSRGSC3.4
Celera446,787,180 - 46,787,364UniSTS
RH 3.4 Map4299.7UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2451,594,309 - 51,594,380 (+)MAPPERmRatBN7.2
Rnor_6.0450,139,854 - 50,139,924NCBIRnor6.0
Rnor_5.0449,926,418 - 49,926,488UniSTSRnor5.0
RGSC_v3.4449,467,787 - 49,467,857UniSTSRGSC3.4
Celera446,786,590 - 46,786,660UniSTS
Cytogenetic Map4q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 74
Low 2 6 32 16 8 16 3 3 23 33 11 3
Below cutoff 1 37 20 20 11 20 5 7 12 6 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008719   ⟹   ENSRNOP00000008719
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl451,397,601 - 51,595,218 (+)Ensembl
Rnor_6.0 Ensembl449,941,304 - 50,140,762 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116498   ⟹   ENSRNOP00000097069
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl451,397,601 - 51,595,218 (+)Ensembl
RefSeq Acc Id: NM_001170685   ⟹   NP_001164156
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2451,397,601 - 51,545,567 (+)NCBI
Rnor_6.0449,941,304 - 50,090,984 (+)NCBI
Rnor_5.0449,730,302 - 49,927,328 (+)NCBI
Celera446,598,237 - 46,737,711 (+)NCBI
RefSeq Acc Id: NM_013080   ⟹   NP_037212
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2451,397,601 - 51,595,220 (+)NCBI
Rnor_6.0449,941,304 - 50,140,764 (+)NCBI
Rnor_5.0449,730,302 - 49,927,328 (+)NCBI
RGSC_v3.4449,267,521 - 49,468,692 (+)RGD
Celera446,598,237 - 46,787,500 (+)NCBI
RefSeq Acc Id: XM_006236137   ⟹   XP_006236199
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2451,397,316 - 51,595,220 (+)NCBI
Rnor_6.0449,941,046 - 50,140,764 (+)NCBI
Rnor_5.0449,730,302 - 49,927,328 (+)NCBI
RefSeq Acc Id: XM_006236138   ⟹   XP_006236200
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2451,397,321 - 51,595,220 (+)NCBI
Rnor_6.0449,941,049 - 50,140,764 (+)NCBI
Rnor_5.0449,730,302 - 49,927,328 (+)NCBI
RefSeq Acc Id: XM_006236139   ⟹   XP_006236201
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2451,397,321 - 51,595,220 (+)NCBI
Rnor_6.0449,941,049 - 50,140,764 (+)NCBI
Rnor_5.0449,730,302 - 49,927,328 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037212   ⟸   NM_013080
- Peptide Label: isoform 1 precursor
- UniProtKB: Q62656 (UniProtKB/Swiss-Prot),   F1LMY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164156   ⟸   NM_001170685
- Peptide Label: isoform 2 precursor
- UniProtKB: Q62656 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236200   ⟸   XM_006236138
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006236201   ⟸   XM_006236139
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006236199   ⟸   XM_006236137
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ATT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008719   ⟸   ENSRNOT00000008719
RefSeq Acc Id: ENSRNOP00000097069   ⟸   ENSRNOT00000116498
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62656-F1-model_v2 AlphaFold Q62656 1-2316 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3455 AgrOrtholog
BioCyc Gene G2FUF-45501 BioCyc
Ensembl Genes ENSRNOG00000006030 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008719 ENTREZGENE
  ENSRNOP00000008719.6 UniProtKB/TrEMBL
  ENSRNOP00000097069.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008719 ENTREZGENE
  ENSRNOT00000008719.6 UniProtKB/TrEMBL
  ENSRNOT00000116498.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro alpha_CARP_receptor-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprz1 PhenoGen
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218471
UniProt Secondary Q62621 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Ptprz1  protein tyrosine phosphatase, receptor type Z1  Ptprz1  protein tyrosine phosphatase, receptor-type, Z polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ptprz1  protein tyrosine phosphatase, receptor-type, Z polypeptide 1    Protein tyrosine phosphatase, receptor-type, zeta polypeptide  Name updated 629478 APPROVED
2002-06-10 Ptprz1  Protein tyrosine phosphatase, receptor-type, zeta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction alternative splicing product phosphocan binds neural cell adhesion molecules, binding is mediated by phosphocan asparagine-linnked oligosaccharides 729925
gene_transcript phosphocan is a product of alternative splicing that contains the Ptprz1 extracellular domain 729925