RGD Reference Report - Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.

General

Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.
Authors:	Ezquerra, L Alguacil, LF Nguyen, T Deuel, TF Silos-Santiago, I Herradon, G
Citation:	Ezquerra L, etal., Growth Factors. 2008 Feb;26(1):44-8. doi: 10.1080/08977190801987711.
RGD ID:	9831453
Pubmed:	PMID:18365878 (View Abstract at PubMed)
DOI:	DOI:10.1080/08977190801987711 (Journal Full-text)
Pleiotrophin (PTN) and midkine (MK) are two growth factors highly redundant in function that exhibit neurotrophic actions and are upregulated at sites of nerve injury, both properties being compatible with a potential involvement in the pathophysiological events that follow nerve damage (i.e. neuropathic pain). We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their behavioural responses to chronic constriction injury (CCI) of the sciatic nerve: Lewis, Fischer 344 (F344) and Sprague-Dawley (SD). Real time RT-PCR revealed minimal changes in PTN/MK gene expression in the spinal cord after CCI despite the strain considered, but marked changes were detected in DRG. A significant upregulation of PTN gene expression occurred in injured DRG of the F344 strain, the only strain that recovers from CCI-induced mechanical allodynia 28 days after surgery. In contrast, PTN was found to be downregulated in injured DRG of SD rats, the most sensitive strain in behavioural studies. These changes in PTN were not paralleled by concomitant modifications of MK gene expression. The results demonstrate previously unidentified differences between PTN and MK patterns of expression. Furthermore, the data suggest that upregulation of PTN, but not MK, could play an important role in the recovery from CCI.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
sciatic neuropathy		ISO	Ptn (Rattus norvegicus)	9831453; 9831453	mRNA:altered expression:dorsal root ganglia (rat)	RGD
sciatic neuropathy		IEP		9831453	mRNA:altered expression:dorsal root ganglia (rat)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ptn (pleiotrophin)

Genes (Mus musculus)

Ptn (pleiotrophin)

Genes (Homo sapiens)

PTN (pleiotrophin)

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Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.