PTN (pleiotrophin) - Rat Genome Database

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Pathways
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Gene: PTN (pleiotrophin) Pan paniscus
Analyze
Symbol: PTN
Name: pleiotrophin
RGD ID: 11853124
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); chondroitin sulfate proteoglycan binding (ortholog); glycosaminoglycan binding (ortholog); INVOLVED IN bone mineralization (ortholog); cellular response to hypoxia (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH adrenal carcinoma (ortholog); Animal Mammary Neoplasms (ortholog); Body Weight (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,039,263 - 174,155,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,049,516 - 26,165,561 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07129,184,786 - 129,300,815 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17141,678,056 - 141,794,565 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,701,430 - 141,705,623 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone mineralization  (IEA,ISO)
cellular response to hypoxia  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to UV  (ISO)
cellular response to vitamin D  (ISO)
cerebellum development  (ISO)
decidualization  (IEA)
dendrite arborization  (IEA)
dendrite regeneration  (ISO)
endothelial cell differentiation  (ISO)
estrous cycle  (IEA,ISO)
heart development  (ISO)
hindbrain development  (ISO)
integrin-mediated signaling pathway  (IEA)
learning  (IEA,ISO)
leukocyte chemotaxis involved in inflammatory response  (IEA)
liver development  (ISO)
long-term synaptic potentiation  (ISO)
lung development  (ISO)
memory  (IEA)
modulation of chemical synaptic transmission  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of membrane potential  (ISO)
negative regulation of mesenchymal cell proliferation  (ISO)
negative regulation of neuroblast proliferation  (IEA)
negative regulation of neuromuscular junction development  (ISO)
oogenesis  (IEA)
ossification  (IEA,ISO)
ossification involved in bone remodeling  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of cell differentiation  (IEA)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of dendrite development  (IEA)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of leukocyte chemotaxis  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA)
positive regulation of ossification  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of stem cell differentiation  (IEA)
receptor clustering  (IEA)
regulation of cell shape  (ISO)
regulation of hemopoiesis  (IEA)
regulation of myelination  (IEA)
regulation of stem cell population maintenance  (IEA)
regulation of synaptic plasticity  (IEA)
response to activity  (ISO)
response to auditory stimulus  (IEA)
response to ciliary neurotrophic factor  (ISO)
response to estradiol  (ISO)
response to kainic acid  (ISO)
response to nerve growth factor  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
retinal rod cell differentiation  (ISO)
rod bipolar cell differentiation  (ISO)
spinal cord development  (ISO)
thalamus development  (ISO)
tissue regeneration  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,039,263 - 174,155,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,049,516 - 26,165,561 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07129,184,786 - 129,300,815 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17141,678,056 - 141,794,565 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,701,430 - 141,705,623 (-)Ensemblpanpan1.1panPan2
PTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387137,227,341 - 137,343,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7137,227,341 - 137,343,774 (-)EnsemblGRCh38hg38GRCh38
GRCh377136,912,088 - 137,028,479 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,562,628 - 136,679,086 (-)NCBINCBI36Build 36hg18NCBI36
Build 347136,369,349 - 136,485,801NCBI
Celera7131,651,010 - 131,767,463 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7131,217,379 - 131,333,760 (-)NCBIHuRef
CHM1_17136,845,103 - 136,961,863 (-)NCBICHM1_1
T2T-CHM13v2.07138,536,475 - 138,652,884 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27136,256,123 - 136,372,579 (-)NCBI
Ptn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39636,691,863 - 36,787,114 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl636,691,864 - 36,787,155 (-)EnsemblGRCm39 Ensembl
GRCm38636,714,924 - 36,810,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl636,714,929 - 36,810,220 (-)EnsemblGRCm38mm10GRCm38
MGSCv37636,665,663 - 36,761,361 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36636,645,815 - 36,741,513 (-)NCBIMGSCv36mm8
Celera636,692,206 - 36,788,072 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map615.48NCBI
Ptn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8466,260,764 - 66,342,614 (-)NCBIGRCr8
mRatBN7.2465,293,731 - 65,375,572 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,293,734 - 65,375,456 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx470,249,455 - 70,330,998 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0466,170,411 - 66,252,058 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,567,580 - 64,649,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,239,156 - 64,330,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,239,158 - 64,330,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,063,952 - 64,156,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,078,755 - 64,160,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,354,886 - 64,436,265 (-)NCBI
Celera460,333,929 - 60,415,522 (-)NCBICelera
Cytogenetic Map4q22NCBI
Ptn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,580,422 - 5,684,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,580,264 - 5,681,848 (+)NCBIChiLan1.0ChiLan1.0
PTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11611,283,078 - 11,382,820 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1611,283,077 - 11,382,814 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1612,295,731 - 12,396,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01611,248,309 - 11,349,640 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1611,247,988 - 11,349,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,708,020 - 11,809,056 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01610,807,935 - 10,909,300 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01610,950,643 - 11,051,479 (+)NCBIUU_Cfam_GSD_1.0
Ptn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511817,455,142 - 17,512,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365921,707,693 - 1,730,617 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365921,706,979 - 1,806,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1812,219,787 - 12,309,044 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11812,219,708 - 12,309,045 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,892,250 - 12,981,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121105,911,171 - 106,027,108 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21105,911,120 - 106,027,215 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660722,777,500 - 2,887,026 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476517,522,916 - 17,548,184 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476517,523,086 - 17,625,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000042841   ⟹   ENSPPAP00000020056
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7141,701,430 - 141,705,623 (-)Ensembl
RefSeq Acc Id: XM_003813429   ⟹   XP_003813477
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26174,039,263 - 174,155,443 (-)NCBI
NHGRI_mPanPan1726,049,516 - 26,165,556 (-)NCBI
Mhudiblu_PPA_v07129,184,786 - 129,300,815 (-)NCBI
PanPan1.17141,678,056 - 141,794,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965987   ⟹   XP_008964235
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26174,039,263 - 174,155,345 (-)NCBI
NHGRI_mPanPan1726,049,516 - 26,165,561 (-)NCBI
Mhudiblu_PPA_v07129,184,786 - 129,300,781 (-)NCBI
PanPan1.17141,678,056 - 141,794,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063606391   ⟹   XP_063462461
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26174,039,263 - 174,155,305 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003813477 (Get FASTA)   NCBI Sequence Viewer  
  XP_008964235 (Get FASTA)   NCBI Sequence Viewer  
  XP_063462461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000020056.1
Reference Protein Sequences
RefSeq Acc Id: XP_008964235   ⟸   XM_008965987
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ART8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003813477   ⟸   XM_003813429
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ART8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000020056   ⟸   ENSPPAT00000042841
RefSeq Acc Id: XP_063462461   ⟸   XM_063606391
- Peptide Label: isoform X1
Protein Domains
Pleiotrophin/Midkine C-terminal   Pleiotrophin/Midkine N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033237 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042841.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.60.10 UniProtKB/TrEMBL
InterPro Midkine_heparin-bd_GF UniProtKB/TrEMBL
  PTN/MK_C_dom UniProtKB/TrEMBL
  PTN/MK_C_dom_sf UniProtKB/TrEMBL
  PTN/MK_diS_sf UniProtKB/TrEMBL
  PTN/MK_N_dom UniProtKB/TrEMBL
  PTN/MK_N_dom_sf UniProtKB/TrEMBL
  PTN_MK_heparin-bd_GF_CS UniProtKB/TrEMBL
NCBI Gene PTN ENTREZGENE
PANTHER PLEIOTROPHIN UniProtKB/TrEMBL
  PTHR13850 UniProtKB/TrEMBL
Pfam PTN_MK_C UniProtKB/TrEMBL
  PTN_MK_N UniProtKB/TrEMBL
PRINTS PTNMIDKINE UniProtKB/TrEMBL
PROSITE PTN_MK_1 UniProtKB/TrEMBL
  PTN_MK_2 UniProtKB/TrEMBL
SMART PTN UniProtKB/TrEMBL
Superfamily-SCOP SSF57288 UniProtKB/TrEMBL
UniProt A0A2R9ART8 ENTREZGENE, UniProtKB/TrEMBL