Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:heparan sulfate
go back to main search page
Accession:CHEBI:28815 term browser browse the term
Definition:A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.
Synonyms:related_synonym: Formula=(C12H19NO20S3)n;   Heparan N-sulfate;   Heparan sulphate;   Heparatan sulfate;   Heparin monosulfate;   Heparin sulfate;   Heparitin monosulfate;   Heparitin sulfate;   N-Acetylheparan sulfate
 alt_id: CHEBI:24502;   CHEBI:24507;   CHEBI:5661
 xref: Beilstein:8186767;   CAS:9050-30-0;   KEGG:C00925;   KEGG:D08536
 xref_mesh: MESH:D006497
 xref: PMID:8713797
 cyclic_relationship: is_conjugate_acid_of CHEBI:157750


show annotations for term's descendants           Sort by:
heparan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of [CCL5 protein binds to CCL5 protein]]; Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of CCL5 protein] CTD PMID:21963154 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate] CTD PMID:12549928 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Fgf1 fibroblast growth factor 1 affects binding ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein CTD PMID:12604602 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects activity ISO Heparitin Sulfate affects the activity of FGF10 protein CTD PMID:12781692 PMID:12818887 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
affects binding
increases activity		 ISO Heparitin Sulfate binds to and affects the activity of FGF2 protein
Heparitin Sulfate binds to FGF2 protein
Heparitin Sulfate analog results in increased activity of FGF2 protein		 CTD PMID:12460940 PMID:15464572 PMID:15958608 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf4 fibroblast growth factor 4 affects binding ISO Heparitin Sulfate binds to FGF4 protein CTD PMID:15769253 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466 		JBrowse link
G Fgf7 fibroblast growth factor 7 affects binding ISO Heparitin Sulfate binds to FGF7 protein CTD PMID:15769253 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgf8 fibroblast growth factor 8 affects binding
increases activity		 ISO Heparitin Sulfate binds to FGF8 protein alternative form
Heparitin Sulfate analog results in increased activity of FGF8 protein		 CTD PMID:12460940 PMID:15769253 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects binding
increases activity		 ISO FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein
Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative form		 CTD PMID:12460940 PMID:12604602 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO Heparitin Sulfate analog results in decreased activity of FGFR2 protein mutant form CTD PMID:16373332 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases activity ISO Heparitin Sulfate analog results in increased activity of FGFR3 protein alternative form CTD PMID:12460940 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects binding ISO Heparitin Sulfate analog binds to FGFR4 protein CTD PMID:11278860 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Heparitin Sulfate CTD PMID:3391615 NCBI chr 7:56,889,139...56,923,170
Ensembl chr 7:56,889,232...56,923,151 		JBrowse link
G Gpc1 glypican 1 affects binding
multiple interactions		 ISO GPC1 protein binds to Heparitin Sulfate
GPC1 protein modified form results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]; nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]; Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]		 CTD PMID:12732622 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047 		JBrowse link
G Hpse heparanase multiple interactions
decreases abundance
affects abundance		 ISO
EXP		 [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate; [phosphomannopentaose sulfate results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate
HPSE protein results in decreased abundance of Heparitin Sulfate
HPSE protein affects the abundance of Heparitin Sulfate		 CTD PMID:16899518 PMID:17121850 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein] CTD PMID:19937756 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 multiple interactions ISO Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein] CTD PMID:19937756 NCBI chr15:3,563,358...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
G Prnp prion protein affects binding ISO PRNP protein modified form binds to Heparitin Sulfate metabolite CTD PMID:18717736 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein CTD PMID:23109338 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] CTD PMID:20067761 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            eukaryotic metabolite 19284
              animal metabolite 19138
                mammalian metabolite 19137
                  mouse metabolite 18827
                    heparan sulfate 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            heteroorganic entity 19453
                              organochalcogen compound 19240
                                organooxygen compound 19152
                                  carbohydrates and carbohydrate derivatives 14950
                                    carbohydrate 14950
                                      polysaccharide 8187
                                        polysaccharide derivative 5090
                                          aminoglycan 399
                                            glycosaminoglycan 373
                                              heparan 24
                                                heparan sulfates 24
                                                  heparan sulfate 24
paths to the root