RGD Reference Report - CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury. - Rat Genome Database

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CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury.

Authors: Yu, Y  Gao, Y  Qin, J  Kuang, CY  Song, MB  Yu, SY  Cui, B  Chen, JF  Huang, L 
Citation: Yu Y, etal., Basic Res Cardiol. 2010 Nov;105(6):713-24. doi: 10.1007/s00395-010-0117-0. Epub 2010 Sep 10.
RGD ID: 9686141
Pubmed: PMID:20830586   (View Abstract at PubMed)
DOI: DOI:10.1007/s00395-010-0117-0   (Journal Full-text)

Endothelial progenitor cells (EPCs) contribute to the process of reendothelialization and prevent neointimal formation after vascular injury. The present study was designed to investigate whether the cysteine-rich 61 (CYR61, CCN1), an important matricellular component of local vascular microenvironment, has effect on EPCs differentiation and reendothelialization in response to vascular injury in rat. Following balloon injury, CCN1 was rapidly induced and dynamically changed at vascular lesions. Overexpression of CCN1 by adenovirus (Ad-CCN1) accelerated reendothelialization and inhibited neointimal formation in the early phase (day 14) after vascular injury (p < 0.05), while no effect was shown on day 21. Ad-CCN1 treatment increased the adhering EPCs on the surface of injured vessels on day 7, and the ratio of GFP- and vWF-positive area to the total luminal length on day 14 was 2.3-fold higher in the Ad-CCN1-EPC-transplanted group than in controls. Consistent with these findings, CCN1-stimulated EPC differentiation in vitro and 20 genes were found differentially expressed during CCN1-induced EPC differentiation, including Id1, Vegf-b, Vegf-c, Kdr, Igf-1, Ereg, Tgf, Mdk, Ptn, Timp2, etc. Among them, negative transcriptional regulator Id1 was associated with CCN1 effect on EPC differentiation. Our data suggest that CCN1, from the microenvironment of injured vessels, enhances reendothelialization via a direct action on EPC differentiation, revealing a possible new mechanism underlying the process of vascular repair.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PtnRatendothelial cell differentiation  IEP  RGD 
Id1Ratnegative regulation of endothelial cell differentiation  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Id1  (inhibitor of DNA binding 1)
Ptn  (pleiotrophin)


Additional Information