(+)-pilocarpine multiple interactions ISO RGD:736260 6480464 Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein] CTD PMID:16492139 (+)-pilocarpine increases activity ISO RGD:736260 6480464 Pilocarpine results in increased activity of EIF2AK3 protein CTD PMID:16492139 (S)-nicotine multiple interactions EXP 6480464 Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein], ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 (S)-nicotine increases phosphorylation EXP 6480464 Nicotine results in increased phosphorylation of EIF2AK3 protein CTD PMID:26803847 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of EIF2AK3 protein CTD PMID:17337753 1,2-dichloroethane increases expression ISO RGD:736260 6480464 ethylene dichloride results in increased expression of EIF2AK3 mRNA CTD PMID:28973639 1,2-dimethylhydrazine multiple interactions EXP 6480464 p-coumaric acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased phosphorylation of EIF2AK3 protein] CTD PMID:29879413 1,2-dimethylhydrazine decreases expression ISO RGD:736260 6480464 1, 2-Dimethylhydrazine results in decreased expression of EIF2AK3 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases phosphorylation EXP 6480464 1, 2-Dimethylhydrazine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:29879413 1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:12486162 1,4-dithiothreitol increases phosphorylation ISO RGD:1354090 6480464 Dithiothreitol results in increased phosphorylation of EIF2AK3 protein CTD PMID:25321315 17beta-estradiol increases expression ISO RGD:1354090 6480464 Estradiol results in increased expression of EIF2AK3 mRNA CTD PMID:20106945 17beta-estradiol decreases expression ISO RGD:1354090 6480464 Estradiol results in decreased expression of EIF2AK3 mRNA CTD PMID:19167446 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1354090 6480464 Dihydrotestosterone results in increased expression of EIF2AK3 mRNA CTD PMID:29581250 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:1354090 6480464 2 more ... CTD PMID:19095052 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:736260 6480464 2 more ... CTD PMID:30294300 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions ISO RGD:736260 6480464 epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2 more ... CTD PMID:25639565 2,2',4,4'-Tetrabromodiphenyl ether increases phosphorylation ISO RGD:736260 6480464 2 more ... CTD PMID:25639565 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736260 6480464 Tetrachlorodibenzodioxin results in decreased expression of EIF2AK3 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of EIF2AK3 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of EIF2AK3 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736260 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of EIF2AK3 mRNA CTD PMID:25975270 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2AK3 protein CTD PMID:24932542 2,3-dimethoxynaphthalene-1,4-dione increases phosphorylation ISO RGD:1354090 6480464 2 more ... CTD PMID:21703327 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 EIF2AK3 gene mutant form inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:16324875 2-amino-2-deoxy-D-glucopyranose increases expression ISO RGD:1354090 6480464 Glucosamine results in increased expression of EIF2AK3 protein CTD PMID:33812996 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:1354090 6480464 NUS1 protein inhibits the reaction [Glucosamine results in increased expression of EIF2AK3 protein] CTD PMID:33812996 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:736260 6480464 EIF2AK3 protein affects the reaction [Glucosamine results in increased expression of ATF4 mRNA] more ... CTD PMID:30602124 2-amino-2-deoxy-D-glucopyranose increases phosphorylation ISO RGD:1354090 6480464 Glucosamine results in increased phosphorylation of EIF2AK3 protein CTD PMID:19383982 2-hydroxypropanoic acid increases expression ISO RGD:1354090 6480464 Lactic Acid results in increased expression of EIF2AK3 mRNA CTD PMID:30851411 2-methyl-6-(phenylethynyl)pyridine multiple interactions EXP 6480464 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] CTD PMID:17303341 2-tert-butylhydroquinone multiple interactions ISO RGD:1354090 6480464 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 3-acetyldeoxynivalenol increases expression ISO RGD:736260 6480464 3-acetyldeoxynivalenol results in increased expression of EIF2AK3 mRNA CTD PMID:35413383 3-chloropropane-1,2-diol multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein], alpha-Chlorohydrin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:33651226 3-methyladenine multiple interactions ISO RGD:1354090 6480464 [3-methyladenine co-treated with Potassium Dichromate] results in increased expression of EIF2AK3 protein modified form CTD PMID:32569804 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of EIF2AK3 mRNA CTD PMID:19162173 3H-1,2-dithiole-3-thione multiple interactions ISO RGD:736260 6480464 1 more ... CTD PMID:22959925 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid multiple interactions ISO RGD:736260 6480464 4 more ... CTD PMID:27638049 4-hydroxynon-2-enal increases phosphorylation ISO RGD:736260 6480464 4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 4-hydroxyphenyl retinamide multiple interactions ISO RGD:1354090 6480464 EIF2AK3 mutant form inhibits the reaction [Fenretinide results in increased phosphorylation of EIF2S1 protein] CTD PMID:20022965 4-hydroxyphenyl retinamide decreases response to substance ISO RGD:1354090 6480464 EIF2AK3 results in decreased susceptibility to Fenretinide CTD PMID:20022965 4-phenylbutyric acid decreases expression EXP 6480464 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form CTD PMID:27484784 4-phenylbutyric acid multiple interactions ISO RGD:736260 6480464 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein], 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34175825 , PMID:35533795 4-phenylbutyric acid decreases expression ISO RGD:1354090 6480464 4-phenylbutyric acid results in decreased expression of EIF2AK3 protein CTD PMID:30796460 4-phenylbutyric acid multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:27470132 more ... 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [6-chloro-2 more ... CTD PMID:27484784 more ... 5-fluorouracil increases expression ISO RGD:1354090 6480464 Fluorouracil results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 5-fluorouracil increases phosphorylation ISO RGD:1354090 6480464 Fluorouracil results in increased phosphorylation of EIF2AK3 protein CTD PMID:29879413 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [6-chloro-2 more ... CTD PMID:29653943 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide increases acetylation EXP 6480464 6-chloro-2 more ... CTD PMID:29653943 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide increases phosphorylation EXP 6480464 6-chloro-2 more ... CTD PMID:29653943 abamectin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA] CTD PMID:34748272 abamectin increases expression EXP 6480464 abamectin results in increased expression of EIF2AK3 mRNA CTD PMID:34748272 acrolein increases phosphorylation ISO RGD:736260 6480464 Acrolein results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 , PMID:34813903 acrolein multiple interactions ISO RGD:736260 6480464 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2 more ... CTD PMID:34813903 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of EIF2AK3 mRNA CTD PMID:28959563 acrylamide increases phosphorylation EXP 6480464 Acrylamide results in increased phosphorylation of EIF2AK3 protein CTD PMID:33421551 aflatoxin B1 increases methylation ISO RGD:1354090 6480464 Aflatoxin B1 results in increased methylation of EIF2AK3 intron CTD PMID:30157460 agomelatine multiple interactions EXP 6480464 agomelatine inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein], agomelatine inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34081941 , PMID:34673010 aldehydo-D-glucosamine multiple interactions EXP 6480464 EIF2AK3 gene mutant form inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:16324875 aldehydo-D-glucosamine increases expression ISO RGD:1354090 6480464 Glucosamine results in increased expression of EIF2AK3 protein CTD PMID:33812996 aldehydo-D-glucosamine multiple interactions ISO RGD:1354090 6480464 NUS1 protein inhibits the reaction [Glucosamine results in increased expression of EIF2AK3 protein] CTD PMID:33812996 aldehydo-D-glucosamine multiple interactions ISO RGD:736260 6480464 EIF2AK3 protein affects the reaction [Glucosamine results in increased expression of ATF4 mRNA] more ... CTD PMID:30602124 aldehydo-D-glucosamine increases phosphorylation ISO RGD:1354090 6480464 Glucosamine results in increased phosphorylation of EIF2AK3 protein CTD PMID:19383982 aldehydo-D-glucose multiple interactions ISO RGD:1354090 6480464 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31022492 aldehydo-D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of EIF2AK3 protein CTD PMID:34801538 aldehydo-D-glucose multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein], Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 aldehydo-D-glucose increases phosphorylation ISO RGD:1354090 6480464 Glucose deficiency results in increased phosphorylation of EIF2AK3 protein CTD PMID:31022492 all-trans-retinoic acid increases expression ISO RGD:736260 6480464 Tretinoin results in increased expression of EIF2AK3 mRNA, Tretinoin results in increased expression of EIF2AK3 protein CTD PMID:22498432 alpha-D-galactose multiple interactions EXP 6480464 agomelatine inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein], Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34673010 alpha-D-galactose increases phosphorylation EXP 6480464 Galactose results in increased phosphorylation of EIF2AK3 protein CTD PMID:34673010 amiodarone increases expression ISO RGD:1354090 6480464 Amiodarone results in increased expression of EIF2AK3 mRNA CTD PMID:19774075 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EIF2AK3 mRNA CTD PMID:16483693 apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA], acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:23270704 aristolochic acid A decreases expression ISO RGD:1354090 6480464 aristolochic acid I results in decreased expression of EIF2AK3 mRNA CTD PMID:33212167 arsane affects methylation ISO RGD:1354090 6480464 Arsenic affects the methylation of EIF2AK3 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1354090 6480464 Arsenic affects the methylation of EIF2AK3 gene CTD PMID:25304211 arsenite(3-) multiple interactions ISO RGD:736260 6480464 CALR protein affects the reaction [arsenite results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32443253 arsenite(3-) increases phosphorylation ISO RGD:736260 6480464 arsenite results in increased phosphorylation of EIF2AK3 protein CTD PMID:32443253 arsenous acid increases expression ISO RGD:736260 6480464 Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form CTD PMID:27638049 arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK3 protein CTD PMID:29111283 arsenous acid multiple interactions ISO RGD:1354090 6480464 sulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form] CTD PMID:22922937 arsenous acid increases phosphorylation ISO RGD:736260 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK3 protein CTD PMID:29111283 arsenous acid increases expression ISO RGD:1354090 6480464 Arsenic Trioxide results in increased expression of EIF2AK3 mRNA, Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form CTD PMID:17963750 , PMID:22922937 arsenous acid multiple interactions ISO RGD:736260 6480464 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form] more ... CTD PMID:27638049 atorvastatin calcium multiple interactions ISO RGD:1354090 6480464 EIF2AK3 mutant form inhibits the reaction [Atorvastatin results in increased phosphorylation of EIF2S1 protein] CTD PMID:20876807 atorvastatin calcium increases response to substance ISO RGD:1354090 6480464 EIF2AK3 results in increased susceptibility to Atorvastatin CTD PMID:20876807 Aurin increases phosphorylation ISO RGD:1354090 6480464 aurin results in increased phosphorylation of EIF2AK3 protein CTD PMID:25477506 Azaspiracid increases expression ISO RGD:1354090 6480464 azaspiracid results in increased expression of EIF2AK3 mRNA CTD PMID:28939011 BAPTA multiple interactions ISO RGD:1354090 6480464 [fisetin co-treated with 1 more ... CTD PMID:28181380 BAPTA increases expression ISO RGD:1354090 6480464 1 more ... CTD PMID:28181380 benomyl increases expression ISO RGD:1354090 6480464 Benomyl results in increased expression of EIF2AK3 protein CTD PMID:27784618 benomyl multiple interactions ISO RGD:1354090 6480464 Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein], MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein] CTD PMID:27784618 benzo[a]pyrene increases methylation ISO RGD:736260 6480464 Benzo(a)pyrene results in increased methylation of EIF2AK3 exon, Benzo(a)pyrene results in increased methylation of EIF2AK3 intron CTD PMID:27901495 benzo[a]pyrene diol epoxide I affects expression ISO RGD:1354090 6480464 7 more ... CTD PMID:20382639 benzo[a]pyrene diol epoxide I increases phosphorylation ISO RGD:1354090 6480464 7 more ... CTD PMID:35297523 Benzo[ghi]perylene multiple interactions ISO RGD:1354090 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1 more ... CTD PMID:35182551 Benzo[ghi]perylene increases expression ISO RGD:1354090 6480464 1, 12-benzoperylene results in increased expression of EIF2AK3 mRNA CTD PMID:35182551 beta-D-glucosamine multiple interactions EXP 6480464 EIF2AK3 gene mutant form inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:16324875 beta-D-glucosamine increases expression ISO RGD:1354090 6480464 Glucosamine results in increased expression of EIF2AK3 protein CTD PMID:33812996 beta-D-glucosamine multiple interactions ISO RGD:1354090 6480464 NUS1 protein inhibits the reaction [Glucosamine results in increased expression of EIF2AK3 protein] CTD PMID:33812996 beta-D-glucosamine multiple interactions ISO RGD:736260 6480464 EIF2AK3 protein affects the reaction [Glucosamine results in increased expression of ATF4 mRNA] more ... CTD PMID:30602124 beta-D-glucosamine increases phosphorylation ISO RGD:1354090 6480464 Glucosamine results in increased phosphorylation of EIF2AK3 protein CTD PMID:19383982 bilirubin IXalpha multiple interactions ISO RGD:1354090 6480464 Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein, EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA] CTD PMID:20196124 , PMID:27578021 bis(2-chloroethyl) sulfide increases expression ISO RGD:736260 6480464 Mustard Gas results in increased expression of EIF2AK3 mRNA CTD PMID:15674844 bisphenol A affects expression ISO RGD:1354090 6480464 bisphenol A affects the expression of EIF2AK3 mRNA CTD PMID:22574217 bisphenol A multiple interactions EXP 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA] CTD PMID:35699857 bisphenol A decreases methylation ISO RGD:1354090 6480464 bisphenol A results in decreased methylation of EIF2AK3 gene CTD PMID:31601247 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EIF2AK3 mRNA CTD PMID:18180321 more ... bisphenol A decreases expression ISO RGD:736260 6480464 bisphenol A results in decreased expression of EIF2AK3 mRNA CTD PMID:26063408 boric acid multiple interactions ISO RGD:736260 6480464 EIF2AK3 protein affects the reaction [boric acid affects the localization of NFE2L2 protein] more ... CTD PMID:30196486 bortezomib increases phosphorylation ISO RGD:1354090 6480464 Bortezomib results in increased phosphorylation of EIF2AK3 protein CTD PMID:15509775 more ... bortezomib increases phosphorylation ISO RGD:736260 6480464 Bortezomib results in increased phosphorylation of EIF2AK3 protein CTD PMID:15509775 bortezomib multiple interactions ISO RGD:736260 6480464 Bortezomib inhibits the reaction [1, 2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]] CTD PMID:22959925 bortezomib multiple interactions ISO RGD:1354090 6480464 Bortezomib promotes the reaction [ricolinostat results in increased phosphorylation of EIF2AK3 protein], EIF2AK3 mutant form inhibits the reaction [Bortezomib results in increased phosphorylation of EIF2S1 protein] CTD PMID:20022965 , PMID:22262760 bortezomib decreases response to substance ISO RGD:1354090 6480464 EIF2AK3 results in decreased susceptibility to Bortezomib CTD PMID:20022965 brefeldin A increases expression ISO RGD:1354090 6480464 Brefeldin A results in increased expression of EIF2AK3 protein CTD PMID:24865413 bufalin decreases phosphorylation ISO RGD:1354090 6480464 bufalin results in decreased phosphorylation of EIF2AK3 protein CTD PMID:23949904 busulfan increases phosphorylation ISO RGD:736260 6480464 Busulfan results in increased phosphorylation of EIF2AK3 protein CTD PMID:35533795 busulfan multiple interactions ISO RGD:736260 6480464 4-phenylbutyric acid inhibits the reaction [Busulfan results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35533795 C.I. Natural Red 20 multiple interactions EXP 6480464 [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]] more ... CTD PMID:35028790 cadmium atom increases phosphorylation ISO RGD:1354090 6480464 Cadmium results in increased phosphorylation of EIF2AK3 protein CTD PMID:20600546 cadmium atom decreases phosphorylation EXP 6480464 Cadmium results in decreased phosphorylation of EIF2AK3 protein CTD PMID:27658547 cadmium dichloride increases expression ISO RGD:736260 6480464 Cadmium Chloride results in increased expression of EIF2AK3 protein modified form CTD PMID:21325019 cadmium dichloride increases phosphorylation ISO RGD:1354090 6480464 Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:33127495 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:33127495 cadmium dichloride multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of EIF2AK3 protein] CTD PMID:30796460 cadmium dichloride increases expression ISO RGD:1354090 6480464 Cadmium Chloride results in increased expression of EIF2AK3 protein CTD PMID:30796460 caffeine increases phosphorylation ISO RGD:1354090 6480464 Caffeine results in increased phosphorylation of EIF2AK3 protein CTD PMID:35688186 calcitriol multiple interactions ISO RGD:1354090 6480464 [salinomycin co-treated with Calcitriol] results in increased expression of EIF2AK3 mRNA CTD PMID:35914560 calcium atom multiple interactions ISO RGD:1354090 6480464 Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26609140 calcium(0) multiple interactions ISO RGD:1354090 6480464 Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26609140 camptothecin multiple interactions ISO RGD:1354090 6480464 Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein], MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:30266318 camptothecin increases phosphorylation ISO RGD:1354090 6480464 Camptothecin results in increased phosphorylation of EIF2AK3 protein CTD PMID:30266318 cannabidiol decreases expression ISO RGD:736260 6480464 Cannabidiol results in decreased expression of EIF2AK3 mRNA CTD PMID:33019509 cannabidiol increases phosphorylation ISO RGD:1354090 6480464 Cannabidiol results in increased phosphorylation of EIF2AK3 protein CTD PMID:31699976 cannabigerol decreases expression ISO RGD:736260 6480464 cannabigerol results in decreased expression of EIF2AK3 mRNA CTD PMID:33019509 cantharidin increases expression ISO RGD:1354090 6480464 Cantharidin results in increased expression of EIF2AK3 mRNA, Cantharidin results in increased expression of EIF2AK3 protein CTD PMID:27113412 , PMID:35398186 carbamazepine increases activity ISO RGD:1354090 6480464 Carbamazepine results in increased activity of EIF2AK3 protein CTD PMID:24752500 carbamazepine affects expression ISO RGD:1354090 6480464 Carbamazepine affects the expression of EIF2AK3 mRNA CTD PMID:24752500 CGP 52608 multiple interactions ISO RGD:1354090 6480464 CGP 52608 promotes the reaction [RORA protein binds to EIF2AK3 gene] CTD PMID:28238834 chenodeoxycholic acid multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 chloroacetic acid multiple interactions ISO RGD:736260 6480464 Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25451595 chloroacetic acid increases phosphorylation ISO RGD:736260 6480464 chloroacetic acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:25451595 chlorogenic acid multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein], Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 choline multiple interactions ISO RGD:736260 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene CTD PMID:20938992 chromium(6+) increases phosphorylation ISO RGD:1354090 6480464 chromium hexavalent ion results in increased phosphorylation of EIF2AK3 protein CTD PMID:30416085 chrysophanol multiple interactions ISO RGD:1354090 6480464 Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:30300626 chrysophanol increases phosphorylation ISO RGD:1354090 6480464 chrysophanic acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:30300626 ciglitazone multiple interactions ISO RGD:1354090 6480464 ciglitazone promotes the reaction [Niflumic Acid results in increased phosphorylation of EIF2AK3 protein], Niflumic Acid promotes the reaction [ciglitazone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:21067863 ciglitazone increases phosphorylation ISO RGD:1354090 6480464 ciglitazone results in increased phosphorylation of EIF2AK3 protein CTD PMID:21067863 cisplatin multiple interactions ISO RGD:1354090 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of EIF2AK3 mRNA CTD PMID:30871063 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of EIF2AK3 mRNA CTD PMID:17602206 cocaine increases expression EXP 6480464 Cocaine results in increased expression of EIF2AK3 protein CTD PMID:17303341 cocaine multiple interactions EXP 6480464 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] more ... CTD PMID:17303341 copper atom multiple interactions ISO RGD:1354090 6480464 [Chelating Agents binds to Copper] which affects the expression of EIF2AK3 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:1354090 6480464 [Chelating Agents binds to Copper] which affects the expression of EIF2AK3 mRNA CTD PMID:30911355 copper(II) sulfate decreases expression ISO RGD:1354090 6480464 Copper Sulfate results in decreased expression of EIF2AK3 mRNA CTD PMID:19549813 coumarin increases phosphorylation ISO RGD:1354090 6480464 coumarin results in increased phosphorylation of EIF2AK3 protein CTD PMID:35688186 coumestrol decreases expression ISO RGD:1354090 6480464 Coumestrol results in decreased expression of EIF2AK3 mRNA CTD PMID:19167446 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:22425709 cycloheximide multiple interactions ISO RGD:1354090 6480464 Cycloheximide inhibits the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1, 12-benzoperylene results in increased expression of EIF2AK3 mRNA]] CTD PMID:35182551 cyclophosphamide multiple interactions EXP 6480464 sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein], Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 cyclophosphamide increases phosphorylation EXP 6480464 Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein CTD PMID:32197949 cyclosporin A increases expression ISO RGD:1354090 6480464 Cyclosporine results in increased expression of EIF2AK3 mRNA CTD PMID:20106945 more ... cyclosporin A multiple interactions ISO RGD:1354090 6480464 EIF2AK3 protein affects the reaction [Cyclosporine results in increased expression of DDIT3 protein] CTD PMID:35033536 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA CTD PMID:29038839 D-glucose multiple interactions ISO RGD:1354090 6480464 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31022492 D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of EIF2AK3 protein CTD PMID:34801538 D-glucose multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein], Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 D-glucose increases phosphorylation ISO RGD:1354090 6480464 Glucose deficiency results in increased phosphorylation of EIF2AK3 protein CTD PMID:31022492 D-penicillamine multiple interactions ISO RGD:1354090 6480464 Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:22843330 dantrolene decreases phosphorylation EXP 6480464 Dantrolene results in decreased phosphorylation of EIF2AK3 protein CTD PMID:15921666 deguelin increases phosphorylation ISO RGD:1354090 6480464 deguelin results in increased phosphorylation of EIF2AK3 protein CTD PMID:25322282 demethoxycurcumin multiple interactions ISO RGD:1354090 6480464 demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26264395 deoxycholic acid multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 diarsenic trioxide multiple interactions ISO RGD:1354090 6480464 sulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form] CTD PMID:22922937 diarsenic trioxide increases phosphorylation ISO RGD:736260 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK3 protein CTD PMID:29111283 diarsenic trioxide multiple interactions ISO RGD:736260 6480464 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form] more ... CTD PMID:27638049 diarsenic trioxide increases expression ISO RGD:1354090 6480464 Arsenic Trioxide results in increased expression of EIF2AK3 mRNA, Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form CTD PMID:17963750 , PMID:22922937 diarsenic trioxide increases expression ISO RGD:736260 6480464 Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form CTD PMID:27638049 diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of EIF2AK3 protein CTD PMID:29111283 dibutyl phthalate increases expression ISO RGD:736260 6480464 Dibutyl Phthalate results in increased expression of EIF2AK3 mRNA CTD PMID:21266533 dibutyl phthalate increases phosphorylation ISO RGD:736260 6480464 Dibutyl Phthalate results in increased phosphorylation of EIF2AK3 protein CTD PMID:30910607 dibutyl phthalate increases phosphorylation EXP 6480464 Dibutyl Phthalate results in increased phosphorylation of EIF2AK3 protein CTD PMID:30910607 dibutyl phthalate multiple interactions ISO RGD:736260 6480464 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2 more ... CTD PMID:30910607 diclofenac increases phosphorylation ISO RGD:1354090 6480464 Diclofenac results in increased phosphorylation of EIF2AK3 protein CTD PMID:26609140 diclofenac increases expression ISO RGD:736260 6480464 Diclofenac results in increased expression of EIF2AK3 mRNA CTD PMID:26934552 diclofenac increases activity ISO RGD:1354090 6480464 Diclofenac results in increased activity of EIF2AK3 protein CTD PMID:24752500 diclofenac affects expression ISO RGD:1354090 6480464 Diclofenac affects the expression of EIF2AK3 mRNA CTD PMID:24752500 diclofenac multiple interactions ISO RGD:1354090 6480464 1 more ... CTD PMID:26609140 dimethylarsinous acid multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:22425709 dimethylarsinous acid increases phosphorylation EXP 6480464 dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:22425709 dioxygen increases phosphorylation ISO RGD:736260 6480464 Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 dioxygen multiple interactions ISO RGD:736260 6480464 1-(4-(6-bromobenzo(1 more ... CTD PMID:32996202 dioxygen increases expression ISO RGD:736260 6480464 Oxygen results in increased expression of EIF2AK3 protein CTD PMID:32996202 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of EIF2AK3 mRNA, Oxygen deficiency results in increased expression of EIF2AK3 protein CTD PMID:22226148 , PMID:23270704 dioxygen multiple interactions EXP 6480464 4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA] more ... CTD PMID:19041636 more ... diquat increases expression ISO RGD:736260 6480464 Diquat results in increased expression of EIF2AK3 mRNA CTD PMID:32536062 disodium selenite decreases expression ISO RGD:1354090 6480464 Sodium Selenite results in decreased expression of EIF2AK3 protein CTD PMID:34520753 dizocilpine maleate multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] CTD PMID:17303341 dorsomorphin multiple interactions EXP 6480464 dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein]], dorsomorphin promotes the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:33137417 dorsomorphin multiple interactions ISO RGD:1354090 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:736260 6480464 Doxorubicin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:20656019 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of EIF2AK3 protein CTD PMID:35152301 doxorubicin multiple interactions EXP 6480464 sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Doxorubicin results in increased expression of EIF2AK3 protein] CTD PMID:35152301 efavirenz increases expression ISO RGD:1354090 6480464 efavirenz results in increased expression of EIF2AK3 protein modified form CTD PMID:28940366 empagliflozin multiple interactions EXP 6480464 empagliflozin inhibits the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35654124 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of EIF2AK3 mRNA CTD PMID:29391264 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of EIF2AK3 mRNA CTD PMID:29038839 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA CTD PMID:29038839 epoxomicin multiple interactions ISO RGD:736260 6480464 epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2 more ... CTD PMID:25639565 ethanol increases phosphorylation ISO RGD:736260 6480464 Ethanol results in increased phosphorylation of EIF2AK3 protein CTD PMID:28119953 ethanol increases expression ISO RGD:1354090 6480464 Ethanol results in increased expression of EIF2AK3 protein modified form CTD PMID:24224909 ethanol multiple interactions ISO RGD:1354090 6480464 resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2AK3 protein modified form] CTD PMID:24224909 ethanol increases phosphorylation EXP 6480464 Ethanol results in increased phosphorylation of EIF2AK3 protein CTD PMID:26747958 ethanol multiple interactions EXP 6480464 [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein more ... CTD PMID:26747958 EUK-134 multiple interactions ISO RGD:1354090 6480464 EUK-134 inhibits the reaction [evodiamine results in decreased expression of EIF2AK3 protein] CTD PMID:34808100 Evodiamine decreases expression ISO RGD:1354090 6480464 evodiamine results in decreased expression of EIF2AK3 protein CTD PMID:34808100 Evodiamine multiple interactions ISO RGD:1354090 6480464 EUK-134 inhibits the reaction [evodiamine results in decreased expression of EIF2AK3 protein] CTD PMID:34808100 fisetin multiple interactions ISO RGD:1354090 6480464 [fisetin co-treated with 1 more ... CTD PMID:28181380 flavokawain B increases phosphorylation ISO RGD:1354090 6480464 flavokawain B results in increased phosphorylation of EIF2AK3 protein CTD PMID:30025493 fluoranthene multiple interactions ISO RGD:736260 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of EIF2AK3 mRNA CTD PMID:28329830 folic acid multiple interactions ISO RGD:736260 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene CTD PMID:20938992 formaldehyde decreases expression ISO RGD:1354090 6480464 Formaldehyde results in decreased expression of EIF2AK3 mRNA CTD PMID:20655997 formaldehyde increases phosphorylation ISO RGD:1354090 6480464 Formaldehyde results in increased phosphorylation of EIF2AK3 protein CTD PMID:24140967 fructose increases phosphorylation ISO RGD:736260 6480464 Fructose results in increased phosphorylation of EIF2AK3 protein CTD PMID:22698815 fructose multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein more ... CTD PMID:34801538 fructose multiple interactions ISO RGD:736260 6480464 Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:22698815 fumonisin B1 increases expression ISO RGD:1354090 6480464 fumonisin B1 results in increased expression of EIF2AK3 protein CTD PMID:31891755 fumonisin B1 multiple interactions ISO RGD:1354090 6480464 EIF2AK3 protein affects the reaction [fumonisin B1 results in increased expression of ATF4 protein], EIF2AK3 protein affects the reaction [fumonisin B1 results in increased expression of DDIT3 protein] CTD PMID:31891755 gadolinium trichloride increases expression EXP 6480464 gadolinium chloride results in increased expression of EIF2AK3 protein CTD PMID:21198628 galactose multiple interactions EXP 6480464 agomelatine inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein], Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34673010 galactose increases phosphorylation EXP 6480464 Galactose results in increased phosphorylation of EIF2AK3 protein CTD PMID:34673010 geraniol multiple interactions ISO RGD:1354090 6480464 geraniol inhibits the reaction [Rotenone results in increased expression of EIF2AK3 protein] CTD PMID:30141137 glucose increases phosphorylation ISO RGD:1354090 6480464 Glucose deficiency results in increased phosphorylation of EIF2AK3 protein CTD PMID:31022492 glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of EIF2AK3 protein CTD PMID:34801538 glucose multiple interactions EXP 6480464 Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein], Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 glucose multiple interactions ISO RGD:1354090 6480464 4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31022492 glutathione multiple interactions ISO RGD:1354090 6480464 Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein], Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] CTD PMID:24515801 , PMID:30266318 glycochenodeoxycholic acid multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 glycocholic acid multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 glycodeoxycholic acid multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA, [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 glycyrrhetinate multiple interactions EXP 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA] CTD PMID:35699857 glycyrrhetinic acid multiple interactions EXP 6480464 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA] CTD PMID:35699857 gold atom increases phosphorylation ISO RGD:1354090 6480464 Gold analog results in increased phosphorylation of EIF2AK3 protein CTD PMID:26551149 gold(0) increases phosphorylation ISO RGD:1354090 6480464 Gold analog results in increased phosphorylation of EIF2AK3 protein CTD PMID:26551149 GSK2656157 multiple interactions EXP 6480464 GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:35028790 GSK2656157 decreases activity EXP 6480464 GSK2656157 results in decreased activity of EIF2AK3 protein CTD PMID:35028790 hemin multiple interactions EXP 6480464 Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein], Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA], Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA] CTD PMID:34748272 , PMID:35413380 hexadecanoic acid multiple interactions ISO RGD:1354090 6480464 3-N-1(spermine)-7 more ... CTD PMID:30547786 , PMID:32369900 hexadecanoic acid increases expression ISO RGD:736260 6480464 Palmitic Acid results in increased expression of EIF2AK3 mRNA, Palmitic Acid results in increased expression of EIF2AK3 protein CTD PMID:36030031 homocysteine decreases phosphorylation ISO RGD:1354090 6480464 Homocysteine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:22964297 hydrogen peroxide affects expression ISO RGD:1354090 6480464 Hydrogen Peroxide affects the expression of EIF2AK3 mRNA CTD PMID:20044591 hydroquinone increases phosphorylation ISO RGD:1354090 6480464 hydroquinone results in increased phosphorylation of EIF2AK3 protein CTD PMID:24053669 Ibutilide multiple interactions EXP 6480464 ibutilide inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 protein] CTD PMID:28399139 indinavir increases expression ISO RGD:1354090 6480464 Indinavir results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 indometacin increases expression ISO RGD:1354090 6480464 Indomethacin results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 isoprenaline increases expression ISO RGD:736260 6480464 Isoproterenol results in increased expression of EIF2AK3 mRNA CTD PMID:21335049 kainic acid multiple interactions ISO RGD:736260 6480464 [cyanoginosin LR co-treated with Kainic Acid] results in increased phosphorylation of EIF2AK3 protein CTD PMID:34352349 ketoconazole multiple interactions ISO RGD:736260 6480464 Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:16330322 L-1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:12486162 L-1,4-dithiothreitol increases phosphorylation ISO RGD:1354090 6480464 Dithiothreitol results in increased phosphorylation of EIF2AK3 protein CTD PMID:25321315 L-glutamic acid multiple interactions EXP 6480464 [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]] more ... CTD PMID:35028790 L-glutamic acid increases phosphorylation EXP 6480464 Glutamic Acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:35028790 L-methionine multiple interactions ISO RGD:736260 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene CTD PMID:20938992 lead diacetate increases phosphorylation EXP 6480464 lead acetate results in increased phosphorylation of EIF2AK3 protein CTD PMID:25088297 lead diacetate multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25088297 Licochalcone B decreases expression ISO RGD:1354090 6480464 licochalcone B results in decreased expression of EIF2AK3 protein CTD PMID:35948134 linsidomine increases phosphorylation ISO RGD:1354090 6480464 linsidomine results in increased phosphorylation of EIF2AK3 protein CTD PMID:21703327 lipopolysaccharide increases phosphorylation ISO RGD:1354090 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein CTD PMID:19675143 , PMID:28245985 lipopolysaccharide multiple interactions ISO RGD:736260 6480464 salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31654708 lipopolysaccharide increases phosphorylation ISO RGD:736260 6480464 Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein CTD PMID:31654708 lipopolysaccharide multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28245985 lycopene multiple interactions EXP 6480464 Lycopene inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA] CTD PMID:32544411 manganese atom multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 manganese(0) multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 manganese(II) chloride increases phosphorylation EXP 6480464 manganese chloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:23948121 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of EIF2AK3 protein CTD PMID:25732873 manganese(II) chloride multiple interactions EXP 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein more ... CTD PMID:23934647 more ... Mecamylamine multiple interactions EXP 6480464 Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 meglumine amidotrizoate increases phosphorylation EXP 6480464 Diatrizoate Meglumine results in increased phosphorylation of EIF2AK3 protein CTD PMID:20071420 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Galactose results in increased phosphorylation of EIF2AK3 protein], Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 , PMID:34673010 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein], Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 methamphetamine multiple interactions ISO RGD:1354090 6480464 CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:27323860 , PMID:29705343 methamphetamine increases phosphorylation EXP 6480464 Methamphetamine results in increased phosphorylation of EIF2AK3 protein CTD PMID:29705343 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of EIF2AK3 protein modified form CTD PMID:28070110 methamphetamine multiple interactions EXP 6480464 CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein], Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 , PMID:29705343 methamphetamine increases expression ISO RGD:736260 6480464 Methamphetamine results in increased expression of EIF2AK3 protein CTD PMID:27323860 methamphetamine increases phosphorylation ISO RGD:1354090 6480464 Methamphetamine results in increased phosphorylation of EIF2AK3 protein CTD PMID:27323860 , PMID:29705343 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of EIF2AK3 mRNA CTD PMID:30467583 methylmercury chloride multiple interactions ISO RGD:736260 6480464 Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein], AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31330229 methylmercury chloride increases phosphorylation ISO RGD:736260 6480464 methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:31330229 methylmercury chloride increases expression ISO RGD:1354090 6480464 methylmercuric chloride results in increased expression of EIF2AK3 mRNA CTD PMID:28001369 methylseleninic acid multiple interactions ISO RGD:1354090 6480464 HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein], methylselenic acid results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:16204082 , PMID:16205645 mevastatin increases phosphorylation ISO RGD:736260 6480464 mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 microcystin-LR multiple interactions ISO RGD:736260 6480464 4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein], [cyanoginosin LR co-treated with Kainic Acid] results in increased phosphorylation of EIF2AK3 protein CTD PMID:34175825 , PMID:34352349 microcystin-LR increases phosphorylation ISO RGD:736260 6480464 cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein CTD PMID:34175825 minocycline increases phosphorylation EXP 6480464 Minocycline results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 N,N-dimethylformamide multiple interactions EXP 6480464 [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified form CTD PMID:20097184 N-acetyl-L-cysteine multiple interactions ISO RGD:1354090 6480464 Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein] more ... CTD PMID:19722195 more ... N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form] CTD PMID:27484784 N-acetyl-L-cysteine decreases expression EXP 6480464 Acetylcysteine results in decreased expression of EIF2AK3 protein modified form CTD PMID:27484784 N-acetyl-L-cysteine multiple interactions ISO RGD:736260 6480464 Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein], Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25451595 , PMID:31330229 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:736260 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1, 2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]] CTD PMID:22959925 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27638906 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases phosphorylation ISO RGD:1354090 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein CTD PMID:27638906 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:12486162 naltrexone multiple interactions ISO RGD:1354090 6480464 Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 niclosamide increases expression ISO RGD:1354090 6480464 Niclosamide results in increased expression of EIF2AK3 mRNA CTD PMID:26917416 niclosamide multiple interactions ISO RGD:1354090 6480464 ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA], Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:26917416 nicotine multiple interactions EXP 6480464 Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein], ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 nicotine increases phosphorylation EXP 6480464 Nicotine results in increased phosphorylation of EIF2AK3 protein CTD PMID:26803847 nifedipine multiple interactions EXP 6480464 Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA], Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:22226148 Niflumic acid multiple interactions ISO RGD:1354090 6480464 ciglitazone promotes the reaction [Niflumic Acid results in increased phosphorylation of EIF2AK3 protein], Niflumic Acid promotes the reaction [ciglitazone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:21067863 Niflumic acid increases phosphorylation ISO RGD:1354090 6480464 Niflumic Acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:21067863 Norbinaltorphimine multiple interactions ISO RGD:1354090 6480464 norbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 ochratoxin A increases phosphorylation ISO RGD:1354090 6480464 ochratoxin A results in increased phosphorylation of EIF2AK3 protein CTD PMID:33465424 , PMID:36587836 ochratoxin A increases expression ISO RGD:1354090 6480464 ochratoxin A results in increased expression of EIF2AK3 protein CTD PMID:36058351 ochratoxin A multiple interactions ISO RGD:1354090 6480464 ursolic acid inhibits the reaction [ochratoxin A results in increased phosphorylation of EIF2AK3 protein] CTD PMID:36587836 ochratoxin A decreases expression ISO RGD:1354090 6480464 ochratoxin A results in decreased expression of EIF2AK3 mRNA CTD PMID:30763683 oleic acid multiple interactions ISO RGD:1354090 6480464 3-N-1(spermine)-7 more ... CTD PMID:30547786 , PMID:32369900 orlistat increases response to substance ISO RGD:736260 6480464 EIF2AK3 gene mutant form results in increased susceptibility to orlistat CTD PMID:17283163 orlistat multiple interactions ISO RGD:736260 6480464 orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein] CTD PMID:17283163 ouabain multiple interactions ISO RGD:1354090 6480464 Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 oxaliplatin multiple interactions EXP 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of EIF2AK3 mRNA, Lycopene inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA] CTD PMID:25729387 , PMID:32544411 oxaliplatin increases expression EXP 6480464 Oxaliplatin results in increased expression of EIF2AK3 mRNA CTD PMID:32544411 oxidopamine affects response to substance ISO RGD:736260 6480464 EIF2AK3 protein affects the susceptibility to Oxidopamine CTD PMID:12486162 oxidopamine multiple interactions EXP 6480464 Oxidopamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:12486162 paclitaxel affects response to substance ISO RGD:1354090 6480464 EIF2AK3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 paracetamol affects expression ISO RGD:736260 6480464 Acetaminophen affects the expression of EIF2AK3 mRNA CTD PMID:17562736 paraquat increases phosphorylation EXP 6480464 Paraquat results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 paraquat increases phosphorylation ISO RGD:1354090 6480464 Paraquat results in increased phosphorylation of EIF2AK3 protein CTD PMID:28986289 paraquat increases expression ISO RGD:1354090 6480464 Paraquat results in increased expression of EIF2AK3 mRNA, Paraquat results in increased expression of EIF2AK3 protein modified form CTD PMID:28986289 , PMID:34097952 paraquat increases expression ISO RGD:736260 6480464 Paraquat results in increased expression of EIF2AK3 protein modified form CTD PMID:27442881 Pendulone multiple interactions ISO RGD:1354090 6480464 Acetylcysteine inhibits the reaction [pendulone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:35288263 Pendulone increases phosphorylation ISO RGD:1354090 6480464 pendulone results in increased phosphorylation of EIF2AK3 protein CTD PMID:35288263 perhexiline multiple interactions ISO RGD:1354090 6480464 [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA, CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA] CTD PMID:36083301 pirinixic acid multiple interactions ISO RGD:736260 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EIF2AK3 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:736260 6480464 pirinixic acid results in decreased expression of EIF2AK3 mRNA CTD PMID:17426115 platycodin D increases phosphorylation ISO RGD:1354090 6480464 platycodin D results in increased phosphorylation of EIF2AK3 protein CTD PMID:22784044 potassium dichromate increases expression ISO RGD:1354090 6480464 Potassium Dichromate results in increased expression of EIF2AK3 protein modified form CTD PMID:32569804 potassium dichromate increases expression ISO RGD:736260 6480464 Potassium Dichromate results in increased expression of EIF2AK3 protein CTD PMID:36473502 potassium dichromate multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [Potassium Dichromate results in increased expression of EIF2AK3 protein modified form], [3-methyladenine co-treated with Potassium Dichromate] results in increased expression of EIF2AK3 protein modified form CTD PMID:32569804 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25088297 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA CTD PMID:29038839 propiconazole increases expression ISO RGD:736260 6480464 propiconazole results in increased expression of EIF2AK3 mRNA CTD PMID:21278054 pterostilbene increases phosphorylation ISO RGD:1354090 6480464 pterostilbene results in increased phosphorylation of EIF2AK3 protein CTD PMID:25341683 pterostilbene multiple interactions ISO RGD:1354090 6480464 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:25341683 pyrazinecarboxamide increases phosphorylation ISO RGD:1354090 6480464 Pyrazinamide results in increased phosphorylation of EIF2AK3 protein CTD PMID:28063906 pyrazinecarboxamide multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28063906 pyrazinecarboxamide increases phosphorylation EXP 6480464 Pyrazinamide results in increased phosphorylation of EIF2AK3 protein CTD PMID:28063906 pyrazinecarboxamide multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28063906 quercetin increases phosphorylation ISO RGD:1354090 6480464 Quercetin results in increased phosphorylation of EIF2AK3 protein CTD PMID:24368982 , PMID:24612139 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Vincristine results in increased expression of EIF2AK3 mRNA] CTD PMID:33038355 rac-lactic acid increases expression ISO RGD:1354090 6480464 Lactic Acid results in increased expression of EIF2AK3 mRNA CTD PMID:30851411 resveratrol increases phosphorylation ISO RGD:1354090 6480464 resveratrol results in increased phosphorylation of EIF2AK3 protein CTD PMID:24264887 resveratrol multiple interactions ISO RGD:736260 6480464 Resveratrol inhibits the reaction [Acrolein results in increased phosphorylation of EIF2AK3 protein], Resveratrol inhibits the reaction [titanium dioxide results in increased expression of EIF2AK3 mRNA] CTD PMID:31298478 , PMID:34813903 resveratrol multiple interactions ISO RGD:1354090 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of EIF2AK3 mRNA, Resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2AK3 protein modified form] CTD PMID:23557933 , PMID:24224909 resveratrol multiple interactions EXP 6480464 [resveratrol co-treated with Dietary Fats] results in decreased phosphorylation of EIF2AK3 protein CTD PMID:26055348 rifampicin increases phosphorylation EXP 6480464 Rifampin results in increased phosphorylation of EIF2AK3 protein CTD PMID:24638036 rifampicin multiple interactions ISO RGD:1354090 6480464 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA], 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein] CTD PMID:27470132 rifampicin increases expression ISO RGD:1354090 6480464 Rifampin results in increased expression of EIF2AK3 mRNA, Rifampin results in increased expression of EIF2AK3 protein CTD PMID:27470132 rotenone increases phosphorylation ISO RGD:1354090 6480464 Rotenone results in increased phosphorylation of EIF2AK3 protein CTD PMID:19233273 , PMID:28359145 rotenone increases expression ISO RGD:1354090 6480464 Rotenone results in increased expression of EIF2AK3 protein CTD PMID:30141137 rotenone multiple interactions ISO RGD:1354090 6480464 geraniol inhibits the reaction [Rotenone results in increased expression of EIF2AK3 protein], PTPN1 protein affects the reaction [Rotenone results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28359145 , PMID:30141137 rotenone increases phosphorylation EXP 6480464 Rotenone results in increased phosphorylation of EIF2AK3 protein CTD PMID:33137417 , PMID:35654124 rotenone multiple interactions EXP 6480464 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2 more ... CTD PMID:12486162 more ... S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:1354090 6480464 Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 Salinomycin multiple interactions ISO RGD:1354090 6480464 [salinomycin co-treated with Calcitriol] results in increased expression of EIF2AK3 mRNA CTD PMID:35914560 Salinomycin increases expression ISO RGD:1354090 6480464 salinomycin results in increased expression of EIF2AK3 mRNA CTD PMID:35914560 Salvianolic acid A multiple interactions ISO RGD:736260 6480464 salvianolic acid A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31654708 SB 431542 multiple interactions ISO RGD:1354090 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA CTD PMID:27188386 SCH 23390 multiple interactions EXP 6480464 SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] CTD PMID:17303341 sertraline multiple interactions ISO RGD:1354090 6480464 MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein], Sertraline results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:24865413 sertraline increases expression ISO RGD:1354090 6480464 Sertraline results in increased expression of EIF2AK3 mRNA CTD PMID:24865413 Shikonin multiple interactions EXP 6480464 [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]] more ... CTD PMID:35028790 silicon dioxide increases expression ISO RGD:736260 6480464 Silicon Dioxide results in increased expression of EIF2AK3 mRNA CTD PMID:23221170 sodium arsenite increases phosphorylation ISO RGD:1354090 6480464 sodium arsenite results in increased phosphorylation of EIF2AK3 protein CTD PMID:28973481 , PMID:32506763 sodium arsenite increases expression ISO RGD:736260 6480464 sodium arsenite results in increased expression of EIF2AK3 mRNA CTD PMID:36209798 sodium arsenite decreases expression ISO RGD:1354090 6480464 sodium arsenite results in decreased expression of EIF2AK3 mRNA, sodium arsenite results in decreased expression of EIF2AK3 protein CTD PMID:34032870 sodium arsenite multiple interactions ISO RGD:1354090 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32506763 sodium arsenite increases phosphorylation ISO RGD:736260 6480464 sodium arsenite results in increased phosphorylation of EIF2AK3 protein CTD PMID:21911445 sodium dichromate decreases expression ISO RGD:736260 6480464 sodium bichromate results in decreased expression of EIF2AK3 mRNA CTD PMID:22155349 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of EIF2AK3 mRNA CTD PMID:25132241 , PMID:35413380 sodium fluoride multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA] CTD PMID:35413380 Sodium iodate increases phosphorylation ISO RGD:1354090 6480464 sodium iodate results in increased phosphorylation of EIF2AK3 protein CTD PMID:24053669 sorafenib multiple interactions ISO RGD:1354090 6480464 [sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to EIF2AK3 protein] more ... CTD PMID:18787411 sorafenib increases phosphorylation ISO RGD:1354090 6480464 sorafenib results in increased phosphorylation of EIF2AK3 protein CTD PMID:17548474 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein more ... CTD PMID:34801538 streptozocin multiple interactions ISO RGD:736260 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of EIF2AK3 protein, NUS1 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of EIF2AK3 protein] CTD PMID:33812996 sulforaphane multiple interactions ISO RGD:1354090 6480464 sulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form] CTD PMID:22922937 sulforaphane increases expression ISO RGD:1354090 6480464 sulforaphane results in increased expression of EIF2AK3 protein modified form CTD PMID:22922937 sulindac increases expression ISO RGD:1354090 6480464 Sulindac results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 sunitinib decreases expression ISO RGD:1354090 6480464 Sunitinib results in decreased expression of EIF2AK3 mRNA CTD PMID:31533062 Sunset Yellow FCF multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 T-2 toxin decreases expression ISO RGD:1354090 6480464 T-2 Toxin results in decreased expression of EIF2AK3 mRNA CTD PMID:31863870 T-2 toxin increases phosphorylation ISO RGD:1354090 6480464 T-2 Toxin results in increased phosphorylation of EIF2AK3 protein CTD PMID:34673134 tartrazine multiple interactions ISO RGD:1354090 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in increased expression of EIF2AK3 mRNA CTD PMID:33819548 tauroursodeoxycholic acid multiple interactions EXP 6480464 ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:26803847 , PMID:35028790 testosterone decreases expression ISO RGD:736260 6480464 Testosterone deficiency results in decreased expression of EIF2AK3 mRNA CTD PMID:33848595 tetrachloromethane multiple interactions EXP 6480464 [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified form CTD PMID:20097184 tetrachloromethane increases expression ISO RGD:736260 6480464 Carbon Tetrachloride results in increased expression of EIF2AK3 mRNA CTD PMID:31919559 tetrachloromethane increases phosphorylation ISO RGD:736260 6480464 Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein CTD PMID:25827057 tetrachloromethane multiple interactions ISO RGD:736260 6480464 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25827057 thapsigargin multiple interactions ISO RGD:1354090 6480464 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:20022965 more ... thapsigargin increases phosphorylation EXP 6480464 Thapsigargin results in increased phosphorylation of EIF2AK3 protein CTD PMID:29653943 , PMID:35028790 thapsigargin increases acetylation EXP 6480464 Thapsigargin results in increased acetylation of EIF2AK3 protein CTD PMID:29653943 thapsigargin increases phosphorylation ISO RGD:1354090 6480464 Thapsigargin results in increased phosphorylation of EIF2AK3 protein CTD PMID:23576437 more ... thapsigargin increases expression ISO RGD:1354090 6480464 Thapsigargin results in increased expression of EIF2AK3 mRNA more ... CTD PMID:17963750 more ... thapsigargin increases phosphorylation ISO RGD:736260 6480464 Thapsigargin results in increased phosphorylation of EIF2AK3 protein CTD PMID:23576437 , PMID:24150608 thapsigargin multiple interactions EXP 6480464 EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein], shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:16324875 , PMID:35028790 thapsigargin multiple interactions ISO RGD:736260 6480464 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] more ... CTD PMID:17283163 more ... thapsigargin increases response to substance ISO RGD:736260 6480464 EIF2AK3 gene mutant form results in increased susceptibility to Thapsigargin CTD PMID:17283163 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of EIF2AK3 mRNA CTD PMID:34492290 thymoquinone increases expression ISO RGD:1354090 6480464 thymoquinone results in increased expression of EIF2AK3 protein CTD PMID:29981725 titanium dioxide decreases expression ISO RGD:736260 6480464 titanium dioxide results in decreased expression of EIF2AK3 mRNA CTD PMID:29264374 titanium dioxide affects expression ISO RGD:1354090 6480464 titanium dioxide affects the expression of EIF2AK3 protein CTD PMID:30273564 titanium dioxide increases expression ISO RGD:736260 6480464 titanium dioxide results in increased expression of EIF2AK3 mRNA CTD PMID:31298478 , PMID:31769605 titanium dioxide multiple interactions ISO RGD:736260 6480464 Resveratrol inhibits the reaction [titanium dioxide results in increased expression of EIF2AK3 mRNA] CTD PMID:31298478 titanium dioxide increases phosphorylation ISO RGD:1354090 6480464 titanium dioxide results in increased phosphorylation of EIF2AK3 protein CTD PMID:30273564 titanium dioxide increases expression ISO RGD:1354090 6480464 titanium dioxide results in increased expression of EIF2AK3 mRNA CTD PMID:30273564 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EIF2AK3 mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:1354090 6480464 trichostatin A results in increased expression of EIF2AK3 mRNA CTD PMID:24935251 triclocarban increases expression ISO RGD:1354090 6480464 triclocarban results in increased expression of EIF2AK3 protein modified form CTD PMID:30592132 troglitazone increases expression ISO RGD:1354090 6480464 Troglitazone results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 tunicamycin multiple interactions ISO RGD:736260 6480464 1 more ... CTD PMID:16330322 more ... tunicamycin increases expression EXP 6480464 Tunicamycin results in increased expression of EIF2AK3 protein CTD PMID:28399139 tunicamycin increases phosphorylation ISO RGD:1354090 6480464 Tunicamycin results in increased phosphorylation of EIF2AK3 protein CTD PMID:23741617 tunicamycin multiple interactions ISO RGD:1354090 6480464 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide promotes the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein], Tunicamycin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:23741617 , PMID:26551149 tunicamycin increases expression ISO RGD:1354090 6480464 Tunicamycin results in increased expression of EIF2AK3 mRNA, Tunicamycin results in increased expression of EIF2AK3 protein modified form CTD PMID:22378314 more ... tunicamycin increases phosphorylation EXP 6480464 Tunicamycin results in increased phosphorylation of EIF2AK3 protein CTD PMID:32740777 tunicamycin increases phosphorylation ISO RGD:736260 6480464 Tunicamycin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 more ... tunicamycin multiple interactions EXP 6480464 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2 more ... CTD PMID:28399139 , PMID:32740777 tunicamycin increases expression ISO RGD:736260 6480464 Tunicamycin results in increased expression of EIF2AK3 mRNA, Tunicamycin results in increased expression of EIF2AK3 protein CTD PMID:22959925 , PMID:36030031 tunicamycin increases response to substance ISO RGD:736260 6480464 EIF2AK3 gene mutant form results in increased susceptibility to Tunicamycin CTD PMID:24648495 urethane increases expression ISO RGD:1354090 6480464 Urethane results in increased expression of EIF2AK3 mRNA CTD PMID:28818685 ursolic acid multiple interactions ISO RGD:1354090 6480464 EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein] more ... CTD PMID:24802810 , PMID:36587836 ursolic acid increases phosphorylation ISO RGD:1354090 6480464 ursolic acid results in increased phosphorylation of EIF2AK3 protein CTD PMID:24802810 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of EIF2AK3 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:736260 6480464 Valproic Acid affects the expression of EIF2AK3 mRNA CTD PMID:17963808 valproic acid multiple interactions ISO RGD:1354090 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1354090 6480464 Valproic Acid results in increased expression of EIF2AK3 mRNA CTD PMID:26272509 , PMID:28001369 valproic acid increases expression ISO RGD:736260 6480464 Valproic Acid results in increased expression of EIF2AK3 mRNA CTD PMID:19136453 , PMID:21427059 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 vildagliptin multiple interactions EXP 6480464 Vildagliptin inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34081941 vincristine increases expression EXP 6480464 Vincristine results in increased expression of EIF2AK3 mRNA CTD PMID:33038355 vincristine multiple interactions EXP 6480464 Quercetin inhibits the reaction [Vincristine results in increased expression of EIF2AK3 mRNA] CTD PMID:33038355 vorinostat multiple interactions ISO RGD:1354090 6480464 [sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to EIF2AK3 protein] more ... CTD PMID:18787411 vorinostat increases phosphorylation ISO RGD:1354090 6480464 vorinostat results in increased phosphorylation of EIF2AK3 protein CTD PMID:20962572 zinc atom multiple interactions ISO RGD:1354090 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of EIF2AK3 mRNA CTD PMID:18593933 zinc oxide increases phosphorylation ISO RGD:736260 6480464 Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein CTD PMID:25680694 zinc protoporphyrin multiple interactions EXP 6480464 zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein], zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 zinc(0) multiple interactions ISO RGD:1354090 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of EIF2AK3 mRNA CTD PMID:18593933
