Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Rattus norvegicus
Analyze
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
RGD ID: 70884
Description: Enables Hsp90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PEK; PRKR-like endoplasmic reticulum kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,363,838 - 104,425,271 (+)NCBIGRCr8
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,196,337 - 108,257,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,971,422 - 104,032,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,575,411 - 102,636,807 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Celera491,981,676 - 92,042,995 (+)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-tert-butylhydroquinone  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
abamectin  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
Azaspiracid  (ISO)
BAPTA  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
bufalin  (ISO)
busulfan  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (EXP)
dapagliflozin  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
empagliflozin  (EXP)
endosulfan  (EXP)
epoxiconazole  (EXP)
epoxomicin  (ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
ferrostatin-1  (ISO)
fisetin  (ISO)
flavokawain B  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GSK2656157  (EXP)
hemin  (EXP)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Ibutilide  (EXP)
indinavir  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
Leonurine  (ISO)
Licochalcone B  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
Mecamylamine  (EXP)
meglumine amidotrizoate  (EXP)
melatonin  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naltrexone  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nifedipine  (EXP)
Niflumic acid  (ISO)
Norbinaltorphimine  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
Pendulone  (ISO)
perfluorohexanesulfonic acid  (ISO)
perhexiline  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
proanthocyanidin  (EXP)
prochloraz  (EXP)
procymidone  (ISO)
propiconazole  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Sodium iodate  (ISO)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclocarban  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
uranium atom  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (ISO)
vildagliptin  (EXP)
vincristine  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
bone mineralization  (ISO)
calcium-mediated signaling  (ISO)
cellular response to amino acid starvation  (ISO,ISS)
cellular response to cold  (ISO,ISS)
cellular response to glucose starvation  (ISO)
chondrocyte development  (ISO)
endocrine pancreas development  (ISO,ISS)
endoplasmic reticulum organization  (ISO)
endoplasmic reticulum unfolded protein response  (ISO,ISS)
ER overload response  (ISO,ISS)
ERAD pathway  (ISO)
fat cell differentiation  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of myelination  (ISO)
negative regulation of translation  (ISO)
negative regulation of translation in response to endoplasmic reticulum stress  (ISO)
negative regulation of translation in response to stress  (IDA)
ossification  (ISO,ISS)
pancreas development  (ISO)
PERK-mediated unfolded protein response  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glutathione biosynthetic process  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of transcription by RNA polymerase I  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IDA)
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO,ISS)
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of translational initiation  (ISO)
response to endoplasmic reticulum stress  (ISO,ISS)
response to manganese-induced endoplasmic reticulum stress  (IEP)
skeletal system development  (ISO)
SREBP signaling pathway  (ISO)
translation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The EIF2AK3 gene region and type I diabetes in subjects from South India. Allotey RA, etal., Genes Immun. 2004 Dec;5(8):648-52.
2. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Delepine M, etal., Nat Genet 2000 Aug;25(4):406-9.
3. Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner. Fernandez J, etal., J Biol Chem 2002 Apr 5;277(14):11780-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
7. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
8. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. Marcu MG, etal., Mol Cell Biol. 2002 Dec;22(24):8506-13.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
12. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Shi Y, etal., Mol Cell Biol 1998 Dec;18(12):7499-509.
21. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
22. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
23. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
Additional References at PubMed
PMID:9930704   PMID:10026192   PMID:10677345   PMID:10854322   PMID:10882126   PMID:11106749   PMID:11430819   PMID:11747369   PMID:11907036   PMID:11997520   PMID:12086964   PMID:12388085  
PMID:12610133   PMID:12865332   PMID:14517290   PMID:14676213   PMID:14729979   PMID:14978030   PMID:15542627   PMID:15911877   PMID:16176978   PMID:16352659   PMID:16973740   PMID:18550523  
PMID:18852460   PMID:19061639   PMID:19732428   PMID:19875812   PMID:19946888   PMID:21059295   PMID:21193559   PMID:21525936   PMID:21767604   PMID:22169477   PMID:22240901   PMID:22915762  
PMID:23000344   PMID:23103912   PMID:23152784   PMID:23787763   PMID:24114838   PMID:24180212   PMID:24223705   PMID:24636620   PMID:25012492   PMID:25132241   PMID:25329545   PMID:27785700  
PMID:28178380   PMID:28641278   PMID:29653943   PMID:30005895   PMID:32304741   PMID:33635524   PMID:35315506  


Genomics

Comparative Map Data
Eif2ak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,363,838 - 104,425,271 (+)NCBIGRCr8
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,196,337 - 108,257,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,971,422 - 104,032,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,575,411 - 102,636,807 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Celera491,981,676 - 92,042,995 (+)NCBICelera
Cytogenetic Map4q32NCBI
EIF2AK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,556,741 - 88,628,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,556,741 - 88,691,518 (-)EnsemblGRCh38hg38GRCh38
GRCh37288,856,259 - 88,926,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,637,374 - 88,708,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34288,695,522 - 88,766,221NCBI
Celera287,859,255 - 87,930,028 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,778,073 - 87,848,926 (-)NCBIHuRef
CHM1_1288,785,816 - 88,856,644 (-)NCBICHM1_1
T2T-CHM13v2.0288,568,747 - 88,640,715 (-)NCBIT2T-CHM13v2.0
Eif2ak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,821,468 - 70,882,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl670,821,499 - 70,882,229 (+)EnsemblGRCm39 Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBIMGSCv36mm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.09NCBI
Eif2ak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21238,675,784 - 38,746,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A38,678,745 - 38,749,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,688,732 - 87,759,580 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,596,833 - 89,667,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,596,833 - 89,667,468 (-)Ensemblpanpan1.1panPan2
EIF2AK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,886,397 - 37,950,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,886,601 - 37,949,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,569,354 - 37,633,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,616,654 - 38,681,115 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,616,628 - 38,681,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,783,596 - 37,848,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,820,035 - 37,884,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,169,639 - 38,234,208 (+)NCBIUU_Cfam_GSD_1.0
Eif2ak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,404,001 - 80,450,064 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712414,446 - 454,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712413,602 - 454,443 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,423,943 - 57,506,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,423,894 - 57,506,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,029,999 - 60,114,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,135,973 - 18,209,471 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,136,291 - 18,209,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,565,866 - 1,639,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474915,869,569 - 15,950,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474915,867,444 - 15,950,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2ak3
159 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:276
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000008451
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
8662350Eae35Experimental allergic encephalomyelitis QTL 356.2blood tumor necrosis factor amount (VT:0008552)inflammatory exudate tumor necrosis factor level (CMO:0001435)4100834579103761084Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 21 13 19 13 72 35 33 11
Low 35 36 28 28 8 11 2 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000008451   ⟹   ENSRNOP00000008451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)Ensembl
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094657   ⟹   ENSRNOP00000090000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4102,805,510 - 102,824,666 (+)Ensembl
RefSeq Acc Id: NM_031599   ⟹   NP_113787
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,363,872 - 104,425,271 (+)NCBI
mRatBN7.24102,805,510 - 102,866,914 (+)NCBI
Rnor_6.0498,648,545 - 98,709,695 (+)NCBI
Rnor_5.04163,428,182 - 163,488,914 (+)NCBI
RGSC_v3.44104,016,940 - 104,078,261 (+)RGD
Celera491,981,676 - 92,042,995 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236624   ⟹   XP_006236686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,363,838 - 104,416,649 (+)NCBI
mRatBN7.24102,805,495 - 102,858,283 (+)NCBI
Rnor_6.0498,648,513 - 98,701,045 (+)NCBI
Rnor_5.04163,428,182 - 163,488,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762977   ⟹   XP_008761199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,377,254 - 104,425,271 (+)NCBI
mRatBN7.24102,818,888 - 102,866,914 (+)NCBI
Rnor_6.0498,663,549 - 98,709,695 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113787   ⟸   NM_031599
- Peptide Label: precursor
- UniProtKB: Q9Z1Z1 (UniProtKB/Swiss-Prot),   A6IA60 (UniProtKB/TrEMBL),   A6IA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236686   ⟸   XM_006236624
- Peptide Label: isoform X2
- UniProtKB: A6IA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761199   ⟸   XM_008762977
- Peptide Label: isoform X1
- UniProtKB: A6IA61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008451   ⟸   ENSRNOT00000008451
RefSeq Acc Id: ENSRNOP00000090000   ⟸   ENSRNOT00000094657
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Z1-F1-model_v2 AlphaFold Q9Z1Z1 1-1108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693106
Promoter ID:EPDNEW_R3631
Type:initiation region
Name:Eif2ak3_1
Description:eukaryotic translation initiation factor 2 alpha kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0498,648,586 - 98,648,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70884 AgrOrtholog
BioCyc Gene G2FUF-44201 BioCyc
Ensembl Genes ENSRNOG00000006069 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019871 UniProtKB/Swiss-Prot
  ENSRNOG00060016036 UniProtKB/Swiss-Prot
  ENSRNOG00065005152 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008451 ENTREZGENE
  ENSRNOT00000008451.6 UniProtKB/Swiss-Prot
  ENSRNOT00000094657.1 UniProtKB/TrEMBL
  ENSRNOT00055033992 UniProtKB/Swiss-Prot
  ENSRNOT00060027487 UniProtKB/Swiss-Prot
  ENSRNOT00065007558 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YVTN repeat-like/Quinoprotein amine dehydrogenase UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29702 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29702 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak3 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006069 RatGTEx
  ENSRNOG00055019871 RatGTEx
  ENSRNOG00060016036 RatGTEx
  ENSRNOG00065005152 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
  Quinoprotein alcohol dehydrogenase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6AAY3_RAT UniProtKB/TrEMBL
  A6IA60 ENTREZGENE, UniProtKB/TrEMBL
  A6IA61 ENTREZGENE, UniProtKB/TrEMBL
  E2AK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Eif2ak3  eukaryotic translation initiation factor 2 alpha kinase 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation autophosphorylated on both serine and threonine residues 70729