Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) - Rat Genome Database

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Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Chinchilla lanigera
Analyze
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
RGD ID: 8757531
Description: ENCODES a protein that exhibits enzyme binding (ortholog); eukaryotic translation initiation factor 2alpha kinase activity (ortholog); Hsp90 protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); bone mineralization (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Chronic Hepatitis B (ortholog); connective tissue disease (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eukaryotic translation initiation factor 2-alpha kinase 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
bone mineralization  (ISO)
calcium-mediated signaling  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to cold  (ISO)
cellular response to glucose starvation  (ISO)
chondrocyte development  (ISO)
eiF2alpha phosphorylation in response to endoplasmic reticulum stress  (ISO)
endocrine pancreas development  (ISO)
endoplasmic reticulum organization  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
ER overload response  (ISO)
ERAD pathway  (ISO)
fat cell differentiation  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of myelination  (ISO)
negative regulation of translation  (ISO)
negative regulation of translation in response to endoplasmic reticulum stress  (ISO)
negative regulation of translation in response to stress  (ISO)
ossification  (ISO)
pancreas development  (ISO)
peptidyl-serine phosphorylation  (ISO)
PERK-mediated unfolded protein response  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glutathione biosynthetic process  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of transcription by RNA polymerase I  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of translational initiation  (ISO)
regulation of translational initiation by eIF2 alpha phosphorylation  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to manganese-induced endoplasmic reticulum stress  (ISO)
skeletal system development  (ISO)
SREBP signaling pathway  (ISO)
translation  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eif2ak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,556,741 - 88,628,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,556,741 - 88,691,518 (-)EnsemblGRCh38hg38GRCh38
GRCh37288,856,259 - 88,926,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,637,374 - 88,708,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34288,695,522 - 88,766,221NCBI
Celera287,859,255 - 87,930,028 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,778,073 - 87,848,926 (-)NCBIHuRef
CHM1_1288,785,816 - 88,856,644 (-)NCBICHM1_1
T2T-CHM13v2.0288,568,747 - 88,640,715 (-)NCBIT2T-CHM13v2.0
Eif2ak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,821,468 - 70,882,225 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl670,821,499 - 70,882,229 (+)EnsemblGRCm39 Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBIMGSCv36mm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.09NCBI
Eif2ak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,363,838 - 104,425,271 (+)NCBIGRCr8
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,196,337 - 108,257,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,971,422 - 104,032,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,575,411 - 102,636,807 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Celera491,981,676 - 92,042,995 (+)NCBICelera
Cytogenetic Map4q32NCBI
EIF2AK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21238,675,784 - 38,746,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A38,678,745 - 38,749,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,688,732 - 87,759,580 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,596,833 - 89,667,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,596,833 - 89,667,468 (-)Ensemblpanpan1.1panPan2
EIF2AK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,886,397 - 37,950,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,886,601 - 37,949,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,569,354 - 37,633,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,616,654 - 38,681,115 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,616,628 - 38,681,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,783,596 - 37,848,117 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,820,035 - 37,884,543 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,169,639 - 38,234,208 (+)NCBIUU_Cfam_GSD_1.0
Eif2ak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,404,001 - 80,450,064 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712414,446 - 454,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712413,602 - 454,443 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,423,943 - 57,506,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,423,894 - 57,506,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,029,999 - 60,114,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,135,973 - 18,209,471 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,136,291 - 18,209,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,565,866 - 1,639,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474915,869,569 - 15,950,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474915,867,444 - 15,950,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000011222   ⟹   ENSCLAP00000011087
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)Ensembl
RefSeq Acc Id: XM_013514710   ⟹   XP_013370164
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370164 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000011087
  ENSCLAP00000011087.1
RefSeq Acc Id: XP_013370164   ⟸   XM_013514710
- UniProtKB: A0A8C2V706 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000011087   ⟸   ENSCLAT00000011222
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007656 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000011222 ENTREZGENE
  ENSCLAT00000011222.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CC_SR_Kinase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Eif2ak3 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2V706 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Eif2ak3  eukaryotic translation initiation factor 2 alpha kinase 3    eukaryotic translation initiation factor 2-alpha kinase 3  Symbol and/or name change 5135510 APPROVED