Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) - Rat Genome Database

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Gene: Eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3) Mus musculus
Analyze
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
RGD ID: 736260
MGI Page MGI
Description: Enables eukaryotic translation initiation factor 2alpha kinase activity and identical protein binding activity. Involved in several processes, including PERK-mediated unfolded protein response; protein phosphorylation; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including animal organ development; intracellular signal transduction; and regulation of apoptotic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is expressed in several structures, including eye; heart; liver; pancreas tip epithelium; and tooth. Used to study Wolcott-Rallison syndrome. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI427929; eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PE; Pek; Perk; PRKR-like endoplasmic reticulum kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,821,468 - 70,882,225 (+)NCBIGRCm39mm39
GRCm39 Ensembl670,821,499 - 70,882,229 (+)Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBImm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-tert-butylhydroquinone  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
Azaspiracid  (ISO)
BAPTA  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
boric acid  (EXP)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP)
cannabigerol  (EXP)
cantharidin  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetic acid  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysophanol  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
efavirenz  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
epoxomicin  (EXP)
ethanol  (EXP,ISO)
fisetin  (ISO)
flavokawain B  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
gadolinium trichloride  (ISO)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hemin  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
Ibutilide  (ISO)
indinavir  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (ISO)
meglumine amidotrizoate  (ISO)
melatonin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
mevastatin  (EXP)
minocycline  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naltrexone  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
Niflumic acid  (ISO)
Norbinaltorphimine  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
orlistat  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium dichromate  (ISO)
proanthocyanidin  (ISO)
prochloraz  (ISO)
propiconazole  (EXP)
pterostilbene  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salvianolic acid A  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
sertraline  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
angiogenesis  (ISO)
bone mineralization  (IMP)
calcium-mediated signaling  (IMP)
cellular response to amino acid starvation  (ISO)
cellular response to cold  (ISO)
cellular response to glucose starvation  (IMP,ISO)
chondrocyte development  (IMP)
eiF2alpha phosphorylation in response to endoplasmic reticulum stress  (IMP,ISO)
endocrine pancreas development  (ISO)
endoplasmic reticulum organization  (IMP)
endoplasmic reticulum unfolded protein response  (IDA,IMP,ISO,TAS)
ER overload response  (ISO)
fat cell differentiation  (IDA)
insulin-like growth factor receptor signaling pathway  (IMP)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
lactation  (IMP)
negative regulation of apoptotic process  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of myelination  (IMP)
negative regulation of translation  (IDA,IGI,IMP)
negative regulation of translation in response to endoplasmic reticulum stress  (IDA)
negative regulation of translation in response to stress  (ISO)
ossification  (ISO)
pancreas development  (IMP)
peptidyl-serine phosphorylation  (IDA)
PERK-mediated unfolded protein response  (IMP)
phosphorylation  (IEA)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IGI)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glutathione biosynthetic process  (IMP)
positive regulation of protein binding  (IMP)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of signal transduction  (IDA)
positive regulation of transcription by RNA polymerase I  (IMP,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IMP)
positive regulation of vascular endothelial growth factor production  (IMP,ISO)
protein autophosphorylation  (IDA,IMP,ISO)
protein phosphorylation  (IBA,IDA,IMP,ISO)
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (IMP)
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
regulation of fatty acid metabolic process  (IMP)
regulation of translation  (IEA)
regulation of translational initiation by eIF2 alpha phosphorylation  (IDA,IMP)
response to endoplasmic reticulum stress  (IDA,IMP,ISO)
response to manganese-induced endoplasmic reticulum stress  (ISO)
response to unfolded protein  (IEA)
skeletal system development  (IMP)
SREBP signaling pathway  (IDA)
translation  (IDA)
ubiquitin-dependent ERAD pathway  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal myelination  (IAGP)
abnormal oligodendrocyte apoptosis  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic alpha cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal spinal cord white matter morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral body morphology  (IAGP)
absent pancreatic alpha cells  (IAGP)
absent pancreatic beta cells  (IAGP)
acute pancreas inflammation  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineralization  (IAGP)
decreased circulating insulin level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased prostate gland tumor incidence  (IAGP)
exocrine pancreas atrophy  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
hunched posture  (IAGP)
hyperglycemia  (IAGP)
hypoactivity  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating amylase level  (IAGP)
increased liver glycogen level  (IAGP)
increased osteoblast apoptosis  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased spinal cord apoptosis  (IAGP)
osteoporosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
small pancreas  (IAGP)
small pancreatic islets  (IAGP)
steatorrhea  (IAGP)
tonic seizures  (IAGP)
tremors  (IAGP)
References

Additional References at PubMed
PMID:9930704   PMID:10349636   PMID:10854322   PMID:10882126   PMID:11035797   PMID:11042159   PMID:11076861   PMID:11106749   PMID:11389192   PMID:11430819   PMID:11747369   PMID:11781318  
PMID:11997520   PMID:12388085   PMID:12446838   PMID:12477932   PMID:12520002   PMID:12610133   PMID:12667446   PMID:12865332   PMID:12904583   PMID:14517290   PMID:14610273   PMID:14676213  
PMID:14729979   PMID:14978030   PMID:15314157   PMID:15542627   PMID:15747579   PMID:15782199   PMID:15911877   PMID:16000157   PMID:16124869   PMID:16141072   PMID:16141073   PMID:16176978  
PMID:16288713   PMID:16352659   PMID:16418533   PMID:16923392   PMID:16973740   PMID:17090218   PMID:17141632   PMID:17229688   PMID:17273557   PMID:17325203   PMID:17475769   PMID:17540781  
PMID:17707796   PMID:17727724   PMID:17765679   PMID:17785458   PMID:17822768   PMID:17998206   PMID:18049481   PMID:18052927   PMID:18297134   PMID:18426796   PMID:18437163   PMID:18550523  
PMID:18554416   PMID:18677106   PMID:18683826   PMID:18768473   PMID:18852460   PMID:19029953   PMID:19139267   PMID:19509078   PMID:19586904   PMID:19633360   PMID:19732428   PMID:19783659  
PMID:19805353   PMID:19858219   PMID:19875812   PMID:19898960   PMID:19911006   PMID:19956728   PMID:20034494   PMID:20072654   PMID:20221394   PMID:20453876   PMID:20530744   PMID:20660158  
PMID:20661282   PMID:20700529   PMID:20798685   PMID:20924113   PMID:21044701   PMID:21135100   PMID:21193559   PMID:21285438   PMID:21385877   PMID:21419175   PMID:21543844   PMID:21638082  
PMID:21677750   PMID:21688289   PMID:21709020   PMID:21737679   PMID:21873635   PMID:21917591   PMID:22240901   PMID:22253692   PMID:22431749   PMID:22493067   PMID:22509299   PMID:22705852  
PMID:22739985   PMID:22773666   PMID:22813743   PMID:22915762   PMID:22961085   PMID:23000413   PMID:23022383   PMID:23042294   PMID:23068609   PMID:23071091   PMID:23143306   PMID:23144714  
PMID:23152784   PMID:23160380   PMID:23193662   PMID:23524851   PMID:23554479   PMID:23667408   PMID:23921556   PMID:23933749   PMID:24114838   PMID:24161835   PMID:24269558   PMID:24481666  
PMID:24741110   PMID:24746698   PMID:24889041   PMID:24915520   PMID:24958502   PMID:25113558   PMID:25132241   PMID:25183803   PMID:25203443   PMID:25329545   PMID:25925385   PMID:25956028  
PMID:25986605   PMID:26039714   PMID:26106220   PMID:26173459   PMID:26410627   PMID:26434994   PMID:26446798   PMID:26449458   PMID:26450683   PMID:26483256   PMID:26627716   PMID:26651292  
PMID:26674075   PMID:26753564   PMID:26960794   PMID:26982722   PMID:27052593   PMID:27095827   PMID:27103515   PMID:27106802   PMID:27141928   PMID:27181404   PMID:27226638   PMID:27334877  
PMID:27416896   PMID:27627766   PMID:27633668   PMID:27698114   PMID:27716400   PMID:27802424   PMID:27807175   PMID:27977682   PMID:27993242   PMID:28292936   PMID:28304100   PMID:28332979  
PMID:28378742   PMID:28440222   PMID:28498443   PMID:28522733   PMID:28594573   PMID:28688763   PMID:28724791   PMID:28869608   PMID:28888981   PMID:28948615   PMID:28981072   PMID:29036441  
PMID:29056340   PMID:29076578   PMID:29196323   PMID:29230015   PMID:29273589   PMID:29295856   PMID:29335505   PMID:29337352   PMID:29449374   PMID:29653943   PMID:29717162   PMID:29718201  
PMID:29720449   PMID:30036391   PMID:30118681   PMID:30137327   PMID:30204503   PMID:30553965   PMID:30594305   PMID:30615948   PMID:30635284   PMID:30655546   PMID:30674717   PMID:30773986  
PMID:30842412   PMID:30880003   PMID:30894532   PMID:30902831   PMID:30923003   PMID:30963569   PMID:31138784   PMID:31189710   PMID:31320508   PMID:31421261   PMID:31436800   PMID:31543404  
PMID:32029570   PMID:32053121   PMID:32212900   PMID:32294407   PMID:32309436   PMID:32329716   PMID:32479530   PMID:32617517   PMID:32758541   PMID:32768667   PMID:32788341   PMID:33051453  
PMID:33208886   PMID:33361822   PMID:33592173   PMID:33879538   PMID:33951764   PMID:34058476   PMID:34124052   PMID:34168130  


Genomics

Comparative Map Data
Eif2ak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,821,468 - 70,882,225 (+)NCBIGRCm39mm39
GRCm39 Ensembl670,821,499 - 70,882,229 (+)Ensembl
GRCm38670,844,484 - 70,905,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37670,794,521 - 70,855,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv36670,774,114 - 70,834,817 (+)NCBImm8
Celera672,929,631 - 72,983,380 (+)NCBICelera
Cytogenetic Map6C1NCBI
EIF2AK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl288,556,741 - 88,691,518 (-)EnsemblGRCh38hg38GRCh38
GRCh38288,556,741 - 88,627,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37288,856,259 - 88,926,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,637,374 - 88,708,109 (-)NCBINCBI36hg18NCBI36
Build 34288,695,522 - 88,766,221NCBI
Celera287,859,255 - 87,930,028 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef287,778,073 - 87,848,926 (-)NCBIHuRef
CHM1_1288,785,816 - 88,856,644 (-)NCBICHM1_1
Eif2ak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24102,805,495 - 102,866,914 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4102,805,510 - 102,866,911 (+)Ensembl
Rnor_6.0498,648,513 - 98,709,695 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,648,545 - 98,709,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,428,182 - 163,488,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,016,940 - 104,078,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14104,261,420 - 104,322,741 (+)NCBI
Celera491,981,676 - 92,042,995 (+)NCBICelera
Cytogenetic Map4q31NCBI
Eif2ak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424226,038 - 280,593 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424210,867 - 279,267 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A89,596,833 - 89,667,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,596,833 - 89,667,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A87,688,732 - 87,759,580 (-)NCBIMhudiblu_PPA_v0panPan3
EIF2AK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,886,397 - 37,950,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,886,601 - 37,949,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,569,354 - 37,633,691 (+)NCBI
ROS_Cfam_1.01738,616,654 - 38,681,115 (+)NCBI
UMICH_Zoey_3.11737,783,596 - 37,848,117 (+)NCBI
UNSW_CanFamBas_1.01737,820,035 - 37,884,543 (+)NCBI
UU_Cfam_GSD_1.01738,169,639 - 38,234,208 (+)NCBI
Eif2ak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,404,001 - 80,450,064 (-)NCBI
SpeTri2.0NW_004936712413,602 - 454,443 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,423,875 - 57,506,247 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,423,894 - 57,506,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,029,999 - 60,114,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,135,973 - 18,209,471 (+)NCBIChlSab1.1chlSab2
ChlSab1.11418,135,973 - 18,209,471 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,136,291 - 18,209,457 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660801,565,866 - 1,639,604 (-)NCBIVero_WHO_p1.0
Eif2ak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474915,867,444 - 15,950,757 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Z72375  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38670,842,964 - 70,843,065UniSTSGRCm38
MGSCv37670,792,958 - 70,793,059UniSTSGRCm37
Celera672,928,068 - 72,928,169UniSTS
Cytogenetic Map6C1UniSTS
AI427929  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38670,905,030 - 70,905,183UniSTSGRCm38
MGSCv37670,855,024 - 70,855,177UniSTSGRCm37
Celera672,983,170 - 72,983,323UniSTS
Cytogenetic Map6C1UniSTS
Whitehead/MRC_RH6704.77UniSTS
Eif2ak3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C1UniSTS
cM Map6 UniSTS
PMC262586P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38670,889,549 - 70,890,101UniSTSGRCm38
MGSCv37670,839,543 - 70,840,095UniSTSGRCm37
Celera672,974,647 - 72,975,199UniSTS
Cytogenetic Map6C1UniSTS
RH91182  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38670,905,029 - 70,905,159UniSTSGRCm38
MGSCv37670,855,023 - 70,855,153UniSTSGRCm37
Celera672,983,169 - 72,983,299UniSTS
Cytogenetic Map6C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
14746995Manh60_mmandible shape 60 (mouse)63722567771225677Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64089129671379171Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64446587171119467Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:562
Count of miRNA genes:433
Interacting mature miRNAs:497
Transcripts:ENSMUST00000034093, ENSMUST00000159401, ENSMUST00000161316, ENSMUST00000162950
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF076681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP762515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA316032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034093   ⟹   ENSMUSP00000034093
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl670,821,499 - 70,882,229 (+)Ensembl
GRCm38.p6 Ensembl670,844,515 - 70,905,245 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159401
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl670,855,545 - 70,870,420 (+)Ensembl
GRCm38.p6 Ensembl670,878,561 - 70,893,436 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161316
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl670,873,748 - 70,877,242 (+)Ensembl
GRCm38.p6 Ensembl670,896,764 - 70,900,258 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162950   ⟹   ENSMUSP00000123759
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl670,821,537 - 70,841,809 (+)Ensembl
GRCm38.p6 Ensembl670,844,553 - 70,864,825 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl670,821,540 - 70,822,603 (+)Ensembl
GRCm38.p6 Ensembl670,844,556 - 70,845,619 (+)Ensembl
RefSeq Acc Id: NM_001313918   ⟹   NP_001300847
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39670,821,499 - 70,841,809 (+)NCBI
GRCm38670,844,515 - 70,864,825 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010121   ⟹   NP_034251
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39670,821,499 - 70,882,225 (+)NCBI
GRCm38670,844,515 - 70,905,241 (+)NCBI
MGSCv37670,794,521 - 70,855,234 (+)RGD
Celera672,929,631 - 72,983,380 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505501   ⟹   XP_006505564
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39670,821,468 - 70,882,224 (+)NCBI
GRCm38670,844,484 - 70,905,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011241202   ⟹   XP_011239504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39670,821,468 - 70,882,224 (+)NCBI
GRCm38670,844,484 - 70,905,240 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034251   ⟸   NM_010121
- Peptide Label: isoform 1 precursor
- UniProtKB: E9QQ30 (UniProtKB/TrEMBL),   Q7TQC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505564   ⟸   XM_006505501
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011239504   ⟸   XM_011241202
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001300847   ⟸   NM_001313918
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9Z2B5 (UniProtKB/Swiss-Prot),   A0A0R4J1Y1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034093   ⟸   ENSMUST00000034093
RefSeq Acc Id: ENSMUSP00000123759   ⟸   ENSMUST00000162950
Protein Domains
Protein kinase

Promoters
RGD ID:6839219
Promoter ID:MM_KWN:46403
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000077032,   UC009CGA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36670,793,661 - 70,794,592 (+)MPROMDB
RGD ID:6889942
Promoter ID:EPDNEW_M8422
Type:initiation region
Name:Eif2ak3_1
Description:Mus musculus eukaryotic translation initiation factor 2 alphakinase 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38670,844,556 - 70,844,616EPDNEW
RGD ID:6839221
Promoter ID:MM_KWN:46406
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000077035
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36670,845,876 - 70,846,376 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341830 AgrOrtholog
Ensembl Genes ENSMUSG00000031668 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034093 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000123759 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034093 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000162950 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13666 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1341830 ENTREZGENE
NCBI Gene 13666 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak3 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1Y1 ENTREZGENE, UniProtKB/TrEMBL
  E2AK3_MOUSE UniProtKB/Swiss-Prot
  E9QQ30 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQC8 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z2B5 ENTREZGENE
UniProt Secondary Q9CTK8 UniProtKB/Swiss-Prot
  Q9CWT5 UniProtKB/Swiss-Prot