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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3decreases response to substanceISOEIF2AK3 (Homo sapiens)6480464CTDEIF2AK3 results in decreased susceptibility to BortezomibPMID:20022965
Eif2ak3increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464CTDBortezomib results in increased phosphorylation of EIF2AK3 proteinPMID:15509775 PMID:16928686 PMID:22262760
Eif2ak3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDBortezomib results in increased phosphorylation of EIF2AK3 proteinPMID:15509775
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTDBortezomib promotes the reaction [ricolinostat results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 mutant form inhibits the reaction [Bortezomib results in increased phosphorylation of EIF2S1 protein]PMID:20022965 PMID:22262760
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTDBortezomib inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]PMID:22959925
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