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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDcyanoginosin LR results in increased phosphorylation of EIF2AK3 proteinPMID:34175825
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of EIF2AK3 protein]; [cyanoginosin LR co-treated with Kainic Acid] results in increased phosphorylation of EIF2AK3 proteinPMID:34175825 PMID:34352349
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