Eae35 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

QTL: Eae35 (Experimental allergic encephalomyelitis QTL 35) Rattus norvegicus

Symbol: Eae35
Name: Experimental allergic encephalomyelitis QTL 35
RGD ID: 8662350
Trait: blood tumor necrosis factor amount   (VT:0008552)    
Measurement Type: inflammatory exudate tumor necrosis factor level   (CMO:0001435)    
LOD Score: 6.2
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24100,834,579 - 103,761,084RGD_MAPPER_PIPELINE
Rnor_6.0498,500,164 - 99,633,958RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04163,276,554 - 164,411,864RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44101,974,044 - 104,998,251RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: DA/ZtmKini PVG.1AV1/Kini 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Kdm3a is a candidate Gene for Eae35

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
11493642LOC108350715uncharacterized LOC10835071549851412798518772Rat
9399880LOC103692154uncharacterized LOC10369215449852484198556660Rat
1311377Rpiaribose 5-phosphate isomerase A49856802898593664Rat
7583063LOC102549525uncharacterized LOC10254952549864582898648396Rat
70884Eif2ak3eukaryotic translation initiation factor 2 alpha kinase 349864851398709695Rat
1560163RGD1560163similar to SPCS2 protein49871142198713892Rat
1562720Tex37testis expressed 3749872810998735346Rat
1561816Foxi3forkhead box I349877590898780082Rat
1309144Thnsl2threonine synthase-like 249897655998997187Rat
2590Fabp1fatty acid binding protein 149906318199066957Rat
1305105Smyd1SET and MYND domain containing 149907112299125143Rat
7727476LOC102549052low molecular weight phosphotyrosine protein phosphatase-like49911976399121314Rat
1306495Krcc1lysine-rich coiled-coil 149913373599148236Rat
7647571LOC102552663uncharacterized LOC10255266349916139899169504Rat
11434940LOC108350716uncharacterized LOC10835071649916942399186027Rat
2317Cd8bCD8b molecule49918596099201887Rat
1587245LOC500198similar to Tubulin alpha-3 chain (Alpha-tubulin 3)49920286799215408Rat
11365136LOC108350717uncharacterized LOC10835071749921543199217458Rat
2316Cd8aCD8a molecule49921764099243352Rat
1309766Rmnd5arequired for meiotic nuclear division 5 homolog A49924915999305805Rat
6500636LOC100909974uncharacterized LOC10090997449930604399399123Rat
620586Rnf103ring finger protein 10349939847999415193Rat
708556Chmp3charged multivesicular body protein 349944921399496156Rat
708351Kdm3alysine demethylase 3A49950316099547315Rat
1305230Reep1receptor accessory protein 149961862299735329Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10560D4Mit1217949906697299067150Ratregion
10561D4Wox2014449906696599067108Ratregion
10562D4Arb2128049906682399067102Ratregion
10782D4Mit810349854200398542106Ratregion
35673D4Rat3915449882452098824678Ratregion
42708D4Rat23220049963375999633958Ratregion
5038648AU0243489149925203499252124Ratregion
5039316RH12763619549852307198523265Ratregion
5027315AW1462378049941504799415126Ratregion
5025822RH12981921449856818798568400Ratregion
5055907RH14407114049899500898995147Ratregion
5052983RH14238620049924946199249660Ratregion
5044860RH13084520549897668198976885Ratregion
5046108RH13156318849914778399147970Ratregion
5044934RH13088718249949581299495993Ratregion
5042326RH12937019149924919699249386Ratregion
5080354RH14153120949951054699510754Ratregion
5070594RH13459219449941473699414929Ratregion
5073086RH13722815949925298699253144Ratregion
5069342AU04656015549950755099507701Ratregion
5062360BI28877925049905640699056655Ratregion
5090389AU04972221749861176598611981Ratregion
5088759AU04876019449889390898894095Ratregion
5090161AU04958721849921771699217933Ratregion
5090215AU04961927349950750599507774Ratregion
5504408PMC196178P124849853230498532551Ratregion
5502030MARC_24177-24178:1033563974:165949941406799414725Ratregion
5502766RPIA10349857602798576774Ratregion
Position Markers

Flank 1: (D4Got215)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24100,834,579 - 100,834,710 (-)MAPPER
Rnor_6.0318,311,029 - 18,311,159NCBI
Rnor_5.0323,580,878 - 23,581,008UniSTS
RGSC_v3.44101,974,044 - 101,974,174UniSTS
Celera317,354,479 - 17,354,609UniSTS
Cytogenetic Map4 RGD
Peak: (D4Mit12)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24103,194,805 - 103,194,984 (+)MAPPER
Rnor_6.0499,066,972 - 99,067,150NCBI
Rnor_5.04163,844,120 - 163,844,298UniSTS
RGSC_v3.44104,415,992 - 104,416,171RGD
RGSC_v3.44104,415,993 - 104,416,171UniSTS
RGSC_v3.14104,660,473 - 104,660,652RGD
Celera492,370,739 - 92,370,917UniSTS
SHRSP x BN Map448.75UniSTS
SHRSP x BN Map448.75RGD
FHH x ACI Map460.18RGD
Cytogenetic Map4q32UniSTS
Flank 2: (D4Rat232)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24103,760,884 - 103,761,084 (+)MAPPER
Rnor_6.0499,633,759 - 99,633,958NCBI
Rnor_5.04164,411,665 - 164,411,864UniSTS
RGSC_v3.44104,998,051 - 104,998,251RGD
RGSC_v3.44104,998,052 - 104,998,251UniSTS
RGSC_v3.14105,242,532 - 105,242,732RGD
Celera492,917,864 - 92,918,063UniSTS
SHRSP x BN Map448.75UniSTS
SHRSP x BN Map448.75RGD
Cytogenetic Map4q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)456092756101092756Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)456092756101092756Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458166424103166424Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)46043912799066957Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)460439127113416139Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)461038901127777403Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)461708341113100992Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)461708341113100992Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)461975371106975371Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)462947687125671711Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)463812687108812687Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)463938412108938412Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470773471132455556Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)471476518116476518Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)471476518116476518Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473786419132455556Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)475258970120258970Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)475258970120258970Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)476567036121567036Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)477307388116916073Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)479555067124555067Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)479557856116916073Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47956245198542106Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481874073119546974Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)481959983152055009Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)485794049129615056Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486312589146942261Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486312589147702403Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486532519131532519Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487136446132136446Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487136446132136446Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)48977755299067150Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)494414208139414208Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
8662350Eae35Experimental allergic encephalomyelitis QTL 356.2blood tumor necrosis factor amount (VT:0008552)inflammatory exudate tumor necrosis factor level (CMO:0001435)49850016499633958Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)499066823144066823Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)499066972110635449Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_disease region regulates several inflammatory diseases like experimental autoimmune encephalomyelitis, experimental arthritis, experimental autoimmune neuritis and central inflammatory molecules 8662331
qtl_general inducing agent: lipopolysaccharide (LPS) 8662331
qtl_general measurement method: air pouches were made in 8-10 wks old rats by injecting sterile filtered air at the dorsal midline, after 72 hrs more air was injected followed by LPS on day 4 to induce cytokine production, after 1 hr rats were sacrificed and EDTA injected into the pouch; collected and examined for inflammatory exudate 8662331
qtl_general number of animals used: 463 rats; 239 males and 224 females from the 12th generation of advanced intercross lines 8662331
qtl_general spans 3 Mb 8662331
qtl_general region confirmed by DA.PVG.1AV1-(D4Got60-D4Kini1)/Kini had lower levels of Tnf and DA.PVG.1AV1-(D4Rat103-D4Mit12)/Kini had similar levels of Tnf as compared to DA/Kini 8662331