Hk2 (hexokinase 2) - Rat Genome Database

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Gene: Hk2 (hexokinase 2) Rattus norvegicus
Analyze
Symbol: Hk2
Name: hexokinase 2
RGD ID: 2797
Description: Enables ATP binding activity; glucose binding activity; and hexokinase activity. Involved in several processes, including carbohydrate phosphorylation; lactation; and response to ischemia. Located in several cellular components, including cytosol; mitochondrion; and sarcoplasmic reticulum. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hexokinase type II; hexokinase-2; hexokinase-B; HK II; type II hexokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,234,509 - 115,283,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,703,515 - 120,752,497 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04116,478,737 - 116,527,715 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04115,100,199 - 115,149,197 (-)NCBIRnor_WKY
Rnor_6.04113,559,396 - 113,609,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,237,866 - 178,288,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,925,725 - 116,975,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,170,205 - 117,219,692 (-)NCBI
Celera4104,230,959 - 104,279,831 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4-chlorobiphenyl  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
AP20187  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
betulinic acid  (ISO)
bicalutamide  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clotrimazole  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mercury dichloride  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mirex  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
promethazine  (EXP)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
roxadustat  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
ATP binding  (IDA,IEA)
fructokinase activity  (IBA,IDA)
glucokinase activity  (IBA,IDA,ISO)
glucose binding  (IDA,IEA)
hexokinase activity  (IDA,IEA,ISO)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Reduced expression of hexokinase II in insulin-resistant diabetes. Braithwaite SS, etal., Diabetes. 1995 Jan;44(1):43-8.
2. Evolution and regulatory role of the hexokinases. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
3. Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes. Cusi KJ, etal., Metabolism. 2001 May;50(5):602-6.
4. Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62.
5. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
6. Initial rate and isotope exchange studies of rat skeletal muscle hexokinase. Ganson NJ and Fromm HJ, J Biol Chem. 1985 Oct 5;260(22):12099-105.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver. González C, etal., Biochem Biophys Res Commun. 1964 Jul 1;16(4):347-52. doi: 10.1016/0006-291x(64)90038-5.
10. Isotope-exchange evidence that glucose 6-phosphate inhibits rat-muscle hexokinase II at an allosteric site. Gregoriou M, etal., Eur J Biochem. 1983 Aug 1;134(2):283-8.
11. Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene. Ichihara J, etal., Biochim Biophys Acta 1995 Feb 21;1260(3):365-8.
12. Expression of hexokinase 1 and hexokinase 2 in mammary tissue of nonlactating and lactating rats: evaluation by RT-PCR. Kaselonis GL, etal., Mol Genet Metab. 1999 Nov;68(3):371-4.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Majewski N, etal., Mol Cell 2004 Dec 3;16(5):819-30.
15. Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. Mathupala SP, etal., J Biol Chem 1995 Jul 14;270(28):16918-25.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
19. The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia. Pasdois P, etal., Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Hexokinase II mRNA and gene structure, regulation by insulin, and evolution. Printz RL, etal., J Biol Chem 1993 Mar 5;268(7):5209-19.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor. Thelen AP and Wilson JE, Arch Biochem Biophys 1991 May 1;286(2):645-51.
28. Functional organization of mammalian hexokinases: both N- and C-terminal halves of the rat type II isozyme possess catalytic sites. Tsai HJ and Wilson JE, Arch Biochem Biophys. 1996 May 1;329(1):17-23.
29. Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium. Waskova-Arnostova P, etal., Cell Physiol Biochem. 2014;33(2):310-20. doi: 10.1159/000356671. Epub 2014 Jan 31.
Additional References at PubMed
PMID:10428828   PMID:11068878   PMID:12566445   PMID:14701745   PMID:16551620   PMID:16951044   PMID:17516843   PMID:17639019   PMID:18165236   PMID:18350175   PMID:18614015   PMID:19228992  
PMID:19681047   PMID:19946888   PMID:20439489   PMID:21049555   PMID:21408025   PMID:22517678   PMID:22627259   PMID:23525412   PMID:23962723   PMID:24462113   PMID:25801897   PMID:26316108  
PMID:26985301   PMID:28258543   PMID:28290047   PMID:28522551   PMID:29205357   PMID:29298880   PMID:30391711   PMID:31573845   PMID:32415544   PMID:32495363   PMID:32579577  


Genomics

Comparative Map Data
Hk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,234,509 - 115,283,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,703,515 - 120,752,497 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04116,478,737 - 116,527,715 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04115,100,199 - 115,149,197 (-)NCBIRnor_WKY
Rnor_6.04113,559,396 - 113,609,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,237,866 - 178,288,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,925,725 - 116,975,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,170,205 - 117,219,692 (-)NCBI
Celera4104,230,959 - 104,279,831 (-)NCBICelera
Cytogenetic Map4q34NCBI
HK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,834,127 - 74,893,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl274,834,127 - 74,893,359 (+)EnsemblGRCh38hg38GRCh38
GRCh37275,061,254 - 75,120,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,913,290 - 74,973,989 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,971,436 - 75,032,134NCBI
Celera274,890,867 - 74,951,557 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef274,796,877 - 74,857,297 (+)NCBIHuRef
CHM1_1274,989,111 - 75,049,797 (+)NCBICHM1_1
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBIT2T-CHM13v2.0
Hk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,702,004 - 82,751,435 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,702,006 - 82,751,435 (-)EnsemblGRCm39 Ensembl
GRCm38682,725,025 - 82,774,454 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,725,025 - 82,774,454 (-)EnsemblGRCm38mm10GRCm38
MGSCv37682,675,019 - 82,724,448 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,690,705 - 82,740,117 (-)NCBIMGSCv36mm8
Celera684,700,692 - 84,750,369 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Hk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,897,485 - 10,966,025 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,897,528 - 10,966,025 (-)NCBIChiLan1.0ChiLan1.0
HK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,400,240 - 76,460,881 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,400,240 - 76,460,874 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,897,914 - 74,957,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,287,367 - 48,329,470 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,289,272 - 48,348,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,929,800 - 47,991,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,149,327 - 49,211,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,149,338 - 49,211,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,164,479 - 48,226,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,228,923 - 48,290,663 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,791,741 - 48,853,532 (-)NCBIUU_Cfam_GSD_1.0
Hk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,624,471 - 9,683,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,054,021 - 1,113,450 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365561,054,143 - 1,113,425 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,153,835 - 68,231,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,155,656 - 68,231,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,331,772 - 71,407,448 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,385,237 - 32,443,864 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,385,249 - 32,442,403 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,732,113 - 79,789,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,618,030 - 28,689,794 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,618,146 - 28,718,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hk2
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:505
Count of miRNA genes:251
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000008813
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 16 6 9 6 8 11 22 12 33 1 8
Low 2 41 35 10 35 52 23 8 10
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008813   ⟹   ENSRNOP00000008813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)Ensembl
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109070   ⟹   ENSRNOP00000090099
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)Ensembl
RefSeq Acc Id: NM_012735   ⟹   NP_036867
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,234,509 - 115,283,530 (-)NCBI
Rnor_6.04113,560,880 - 113,609,897 (-)NCBI
Rnor_5.04178,237,866 - 178,288,251 (-)NCBI
RGSC_v3.44116,925,725 - 116,975,211 (-)RGD
Celera4104,230,959 - 104,279,831 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036867   ⟸   NM_012735
- UniProtKB: Q9QWR1 (UniProtKB/Swiss-Prot),   P27881 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008813   ⟸   ENSRNOT00000008813
RefSeq Acc Id: ENSRNOP00000090099   ⟸   ENSRNOT00000109070
Protein Domains
Hexokinase   Hexokinase_1   Hexokinase_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27881-F1-model_v2 AlphaFold P27881 1-917 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693160
Promoter ID:EPDNEW_R3685
Type:initiation region
Name:Hk2_1
Description:hexokinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04113,610,185 - 113,610,245EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2797 AgrOrtholog
BioCyc Gene G2FUF-44043 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-3861 [mannitol degradation II] BioCyc
  PWY-5941 [glycogen degradation II] BioCyc
  PWY3O-1743 [D-mannose degradation II] BioCyc
  UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II] BioCyc
Ensembl Genes ENSRNOG00000006116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008813 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000090099.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008813 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000109070.1 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25059 UniProtKB/Swiss-Prot
NCBI Gene 25059 ENTREZGENE
PANTHER PTHR19443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hk2 PhenoGen
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GIL6_RAT UniProtKB/TrEMBL
  HXK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QWR1 ENTREZGENE
UniProt Secondary Q9QWR1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hk2  Hexokinase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein a protein of 103 kDa 632919
gene_regulation mRNA expression is induced by insulin 632919