Tgfa (transforming growth factor alpha) - Rat Genome Database

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Gene: Tgfa (transforming growth factor alpha) Rattus norvegicus
Analyze
Symbol: Tgfa
Name: transforming growth factor alpha
RGD ID: 3849
Description: Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protransforming growth factor alpha; RATTGFAA; TGFAA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar2 Hcar8 Ept5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,175,549 - 120,258,342 (+)NCBIGRCr8
mRatBN7.24118,618,043 - 118,700,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,090,369 - 124,173,637 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,865,117 - 119,948,389 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,489,559 - 118,572,638 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
Celera4107,591,450 - 107,673,528 (+)NCBICelera
RH 3.4 Map4688.3RGD
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acteoside  (ISO)
adenosine  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
auranofin  (ISO)
batimastat  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (EXP)
carvacrol  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
crizotinib  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dextromethorphan  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dizocilpine maleate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
ferric oxide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
hexachlorobenzene  (ISO)
hydrogen chloride  (EXP)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
kaempferol  (ISO)
KN-93  (ISO)
lansoprazole  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
limonene  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
marimastat  (ISO)
melatonin  (ISO)
melittin  (ISO)
mercury dichloride  (EXP)
metamizole sodium  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nitrofurazone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
PD 168393  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
PHA-665752  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
pifithrin-?  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
poly(propylene imine) macromolecule  (ISO)
probenecid  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rottlerin  (ISO)
Ruscogenin  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (EXP)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sulpyrine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Facilitation of survival in a rat fulminant hepatic failure model by combination therapy using recombinant G-CSF and tacrolimus. Aihaiti X, etal., J Interferon Cytokine Res. 2006 Apr;26(4):226-34.
2. Distribution patterns of TGF-alpha, laminin and fibronectin and their relationship with folliculogenesis in rat ovary. Akkoyunlu G, etal., Acta Histochem. 2003;105(4):295-301.
3. Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Appleton CT, etal., Arthritis Rheum. 2007 Nov;56(11):3693-705.
4. Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis. Baughman RP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):57-61.
5. Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences. Blasband AJ, etal., Mol Cell Biol 1990 May;10(5):2111-21.
6. The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein. Borrell-Pagès M, etal., Mol Biol Cell. 2000 Dec;11(12):4217-25.
7. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Buck M, etal., Mol Cell. 1999 Dec;4(6):1087-92.
8. A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. Dell KM, etal., Kidney Int. 2001 Oct;60(4):1240-8.
9. Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats. Dombrowski F, etal., Am J Pathol. 1997 Mar;150(3):1071-87.
10. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Franklin JL, etal., Exp Cell Res. 2005 Feb 15;303(2):457-70.
11. Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Garrett TP, etal., Cell. 2002 Sep 20;110(6):763-73.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells. Gentry LE, etal., Mol Cell Biol. 1987 May;7(5):1585-91.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. Grasl-Kraupp B, etal., Hepatology 2002 Jun;35(6):1372-80.
16. Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model. Guerra-Crespo M, etal., Neuroscience. 2009 May 5;160(2):470-83. Epub 2009 Feb 25.
17. Immunolocalization of transforming growth factor alpha and epidermal growth factor receptor in lungs of patients with cystic fibrosis. Hardie WD, etal., Pediatr Dev Pathol. 1999 Sep-Oct;2(5):415-23.
18. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
19. Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states. Jiang D, etal., J Biol Chem. 1998 Nov 20;273(47):31471-9.
20. Wound epithelialization deficits in the transforming growth factor-alpha knockout mouse. Kim I, etal., Wound Repair Regen. 2001 Sep-Oct;9(5):386-90.
21. IP receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-alpha. Kimura M, etal., J Pharmacol Sci. 2009 Apr;109(4):618-29. Epub 2009 Apr 4.
22. Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis. Kitano M, etal., Cancer Sci. 2006 Jun;97(6):478-83.
23. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha. Korc M, etal., J Clin Invest. 1992 Oct;90(4):1352-60.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood. Le Cras TD, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L718-29. Epub 2004 Apr 16.
26. Transforming growth factor alpha immunoreactivity in human gallbladder and extrahepatic biliary tract tumours. Lee CS Eur J Surg Oncol. 1998 Feb;24(1):38-42.
27. Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha. Lee DC, etal., Nature 1985 Feb 7-13;313(6002):489-91.
28. Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor. Luetteke NC and Lee DC, Semin Cancer Biol. 1990 Aug;1(4):265-75.
29. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Luetteke NC, etal., Cell. 1993 Apr 23;73(2):263-78.
30. Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Madtes DK, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):424-30.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Cyclooxygenase 2, pS2, inducible nitric oxide synthase and transforming growth factor alpha in gastric adaptation to stress. Nie SN, etal., World J Gastroenterol. 2004 Dec 1;10(23):3537-41.
34. Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFalpha overexpression. Nomura S, etal., Gastroenterology. 2005 May;128(5):1292-305.
35. Molecular genetics of malignant insulinoma. Pavelic K, etal., Anticancer Res. 1996 Jul-Aug;16(4A):1707-17.
36. Transforming growth factor-alpha attenuates N-methyl-D-aspartic acid toxicity in cortical cultures by preventing protein synthesis inhibition through an Erk1/2-dependent mechanism. Petegnief V, etal., J Biol Chem 2003 Aug 8;278(32):29552-9. Epub 2003 May 27.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. Rosen K, etal., J Biol Chem 2001 Oct 5;276(40):37273-9.
43. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
44. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Siveke JT, etal., Cancer Cell. 2007 Sep;12(3):266-79.
45. Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. Sukhotnik I, etal., Pediatr Surg Int. 2008 Dec;24(12):1303-11.
46. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
47. Immunohistochemical localization of EGF, TGF-alpha, TGF-beta, and their receptors in rat corneas during healing of excimer laser ablation. Tuli SS, etal., Curr Eye Res. 2006 Sep;31(9):709-19.
48. Involvement of transforming growth factor alpha in the regulation of rat ovarian X-linked inhibitor of apoptosis protein expression and follicular growth by follicle-stimulating hormone. Wang Y, etal., Biol Reprod 2002 Jun;66(6):1672-80.
49. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
Additional References at PubMed
PMID:6320373   PMID:6605968   PMID:8702723   PMID:10331984   PMID:11278323   PMID:12743035   PMID:14998491   PMID:15064403   PMID:15353178   PMID:17031671   PMID:17553928   PMID:19237431  
PMID:24595367   PMID:26804134   PMID:34968668  


Genomics

Comparative Map Data
Tgfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,175,549 - 120,258,342 (+)NCBIGRCr8
mRatBN7.24118,618,043 - 118,700,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,090,369 - 124,173,637 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,865,117 - 119,948,389 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,489,559 - 118,572,638 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
Celera4107,591,450 - 107,673,528 (+)NCBICelera
RH 3.4 Map4688.3RGD
Cytogenetic Map4q34NCBI
TGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38270,447,284 - 70,553,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl270,447,284 - 70,554,193 (-)EnsemblGRCh38hg38GRCh38
GRCh37270,674,416 - 70,780,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,527,924 - 70,634,613 (-)NCBINCBI36Build 36hg18NCBI36
Build 34270,586,073 - 70,692,585NCBI
Celera270,525,095 - 70,631,786 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef270,410,567 - 70,517,904 (-)NCBIHuRef
CHM1_1270,602,969 - 70,710,469 (-)NCBICHM1_1
T2T-CHM13v2.0270,458,007 - 70,564,581 (-)NCBIT2T-CHM13v2.0
Tgfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,172,020 - 86,252,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,172,205 - 86,252,701 (+)EnsemblGRCm39 Ensembl
GRCm38686,195,038 - 86,275,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,195,223 - 86,275,719 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,145,245 - 86,225,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36686,161,050 - 86,240,791 (+)NCBIMGSCv36mm8
Celera688,129,264 - 88,209,219 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.62NCBI
Tgfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,616,259 - 14,710,183 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,616,390 - 14,709,723 (+)NCBIChiLan1.0ChiLan1.0
TGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21255,834,831 - 55,941,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A55,838,772 - 55,945,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A70,510,727 - 70,617,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A71,625,196 - 71,731,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,625,196 - 71,731,461 (-)Ensemblpanpan1.1panPan2
TGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,915,671 - 68,957,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,799,798 - 68,879,353 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01069,935,210 - 70,012,287 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11069,652,504 - 69,732,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,914,727 - 69,994,269 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01070,213,444 - 70,290,872 (-)NCBIUU_Cfam_GSD_1.0
Tgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629213,812,443 - 13,910,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649114,657,100 - 14,758,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649114,659,089 - 14,758,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,948,137 - 72,050,474 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,948,232 - 72,054,257 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,409,715 - 75,437,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,545,641 - 36,654,213 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1436,545,875 - 36,648,237 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604575,360,438 - 75,475,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247622,832,078 - 2,937,318 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247622,832,073 - 2,941,150 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfa
623 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1086
Count of miRNA genes:339
Interacting mature miRNAs:471
Transcripts:ENSRNOT00000057441
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat

Markers in Region
D4Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,699,850 - 118,699,963 (+)MAPPERmRatBN7.2
Rnor_6.04118,044,882 - 118,044,994NCBIRnor6.0
Rnor_5.04182,615,672 - 182,615,784UniSTSRnor5.0
RGSC_v3.44120,436,732 - 120,436,845RGDRGSC3.4
RGSC_v3.44120,436,733 - 120,436,845UniSTSRGSC3.4
RGSC_v3.14120,681,213 - 120,681,326RGD
Celera4107,672,487 - 107,672,599UniSTS
RH 3.4 Map4694.3RGD
RH 3.4 Map4694.3UniSTS
Cytogenetic Map4q34UniSTS
D4Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,699,819 - 118,700,066 (+)MAPPERmRatBN7.2
Rnor_6.04118,044,851 - 118,045,097NCBIRnor6.0
Rnor_5.04182,615,641 - 182,615,887UniSTSRnor5.0
RGSC_v3.44120,436,701 - 120,436,948RGDRGSC3.4
RGSC_v3.44120,436,702 - 120,436,948UniSTSRGSC3.4
RGSC_v3.14120,681,182 - 120,681,429RGD
Celera4107,672,456 - 107,672,702UniSTS
Cytogenetic Map4q34UniSTS
D4Got90  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,664,949 - 118,665,239 (+)MAPPERmRatBN7.2
Rnor_6.04118,010,289 - 118,010,578NCBIRnor6.0
Rnor_5.04182,580,930 - 182,581,219UniSTSRnor5.0
RGSC_v3.44120,402,230 - 120,402,519UniSTSRGSC3.4
RGSC_v3.44120,402,229 - 120,402,519RGDRGSC3.4
RGSC_v3.14120,646,710 - 120,647,000RGD
RH 3.4 Map4688.9UniSTS
RH 3.4 Map4688.9RGD
Cytogenetic Map4q34UniSTS
D4Cebr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,686,099 - 118,686,310 (+)MAPPERmRatBN7.2
Rnor_6.04118,031,131 - 118,031,341NCBIRnor6.0
Rnor_5.04182,601,921 - 182,602,131UniSTSRnor5.0
RGSC_v3.44120,422,982 - 120,423,192UniSTSRGSC3.4
Celera4107,658,736 - 107,658,946UniSTS
Cytogenetic Map4q34UniSTS
AU047195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,623,940 - 118,624,221 (+)MAPPERmRatBN7.2
Rnor_6.04117,969,355 - 117,969,635NCBIRnor6.0
Rnor_5.04182,540,023 - 182,540,303UniSTSRnor5.0
RGSC_v3.44120,361,353 - 120,361,633UniSTSRGSC3.4
Celera4107,597,112 - 107,597,392UniSTS
Cytogenetic Map4q34UniSTS
RH94516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,698,966 - 118,699,136 (+)MAPPERmRatBN7.2
Rnor_6.04118,043,998 - 118,044,167NCBIRnor6.0
Rnor_5.04182,614,788 - 182,614,957UniSTSRnor5.0
RGSC_v3.44120,435,849 - 120,436,018UniSTSRGSC3.4
Celera4107,671,603 - 107,671,772UniSTS
RH 3.4 Map4688.3UniSTS
Cytogenetic Map4q34UniSTS
ABA004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,696,898 - 118,697,652 (+)MAPPERmRatBN7.2
mRatBN7.24118,696,913 - 118,697,652 (+)MAPPERmRatBN7.2
Rnor_6.04118,041,930 - 118,042,683NCBIRnor6.0
Rnor_6.04118,041,945 - 118,042,683NCBIRnor6.0
Rnor_5.04182,612,735 - 182,613,473UniSTSRnor5.0
Rnor_5.04182,612,720 - 182,613,473UniSTSRnor5.0
Celera4107,669,550 - 107,670,288UniSTS
Celera4107,669,535 - 107,670,288UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000057441   ⟹   ENSRNOP00000054248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)Ensembl
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108625   ⟹   ENSRNOP00000082421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,687,365 - 118,697,294 (+)Ensembl
RefSeq Acc Id: NM_012671   ⟹   NP_036803
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,175,719 - 120,258,337 (+)NCBI
mRatBN7.24118,618,269 - 118,700,892 (+)NCBI
Rnor_6.04117,962,178 - 118,045,923 (+)NCBI
Rnor_5.04182,534,161 - 182,616,713 (+)NCBI
RGSC_v3.44120,355,649 - 120,437,772 (+)RGD
Celera4107,591,450 - 107,673,528 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236822   ⟹   XP_006236884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,175,563 - 120,254,252 (+)NCBI
mRatBN7.24118,618,052 - 118,696,807 (+)NCBI
Rnor_6.04117,961,877 - 118,041,838 (+)NCBI
Rnor_5.04182,534,161 - 182,616,713 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107070   ⟹   XP_038962998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,175,549 - 120,254,252 (+)NCBI
mRatBN7.24118,618,043 - 118,696,807 (+)NCBI
RefSeq Acc Id: XM_039107071   ⟹   XP_038962999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,175,567 - 120,258,342 (+)NCBI
mRatBN7.24118,618,061 - 118,700,897 (+)NCBI
RefSeq Acc Id: NP_036803   ⟸   NM_012671
- Peptide Label: preproprotein
- UniProtKB: Q63749 (UniProtKB/Swiss-Prot),   P01134 (UniProtKB/Swiss-Prot),   A6IAV5 (UniProtKB/TrEMBL),   A6IAV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236884   ⟸   XM_006236822
- Peptide Label: isoform X3
- UniProtKB: U5LKN7 (UniProtKB/TrEMBL),   A6IAV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054248   ⟸   ENSRNOT00000057441
RefSeq Acc Id: XP_038962998   ⟸   XM_039107070
- Peptide Label: isoform X1
- UniProtKB: A6IAV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962999   ⟸   XM_039107071
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QQQ8 (UniProtKB/TrEMBL),   A6IAV6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082421   ⟸   ENSRNOT00000108625
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01134-F1-model_v2 AlphaFold P01134 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693204
Promoter ID:EPDNEW_R3729
Type:multiple initiation site
Name:Tgfa_1
Description:transforming growth factor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,962,266 - 117,962,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3849 AgrOrtholog
BioCyc Gene G2FUF-43908 BioCyc
Ensembl Genes ENSRNOG00000016182 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057441.5 UniProtKB/TrEMBL
  ENSRNOT00000108625.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24827 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24827 ENTREZGENE
PANTHER PROTRANSFORMING GROWTH FACTOR ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfa PhenoGen
PRINTS EGFTGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016182 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC224838
UniProt A0A8I5ZX55_RAT UniProtKB/TrEMBL
  A0A8L2QQQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6IAV5 ENTREZGENE, UniProtKB/TrEMBL
  A6IAV6 ENTREZGENE, UniProtKB/TrEMBL
  P01134 ENTREZGENE
  Q63749 ENTREZGENE
  TGFA_RAT UniProtKB/Swiss-Prot
  U5LKN7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63749 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tgfa  Transforming growth factor, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in oocyte nuclei, as well as granulosa and interstitial thecal cells of developing ovarian follicles 1578551
gene_function increases in androgen production in immature Leydig cells 1578561
gene_regulation inhibition of apoptosis is c-Src-dependent 730227
gene_regulation upregulates its own mRNA and protein expression as well as EGF receptor protein expression in immature Leydig cells 1578561
gene_regulation expression in gastric mucosa increases in response to water immersion and restraint stress (WRS), and continues to increase during the period of adaptation in response to repeated WRS 1578552