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Gene: Tgfa (transforming growth factor alpha) Rattus norvegicus
Symbol: Tgfa
Name: transforming growth factor alpha
Description: Exhibits epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and wound healing. Localizes to extracellular space and nucleus. Colocalizes with plasma membrane. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; INTERACTS WITH (+)-alpha-tocopherol; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: protransforming growth factor alpha; RATTGFAA; TGFAA
Homo sapiens (human) : TGFA (transforming growth factor alpha)  HGNC  Alliance
Mus musculus (house mouse) : Tgfa (transforming growth factor alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfa (transforming growth factor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFA (transforming growth factor alpha)
Canis lupus familiaris (dog) : TGFA (transforming growth factor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfa (transforming growth factor alpha)
Sus scrofa (pig) : TGFA (transforming growth factor alpha)
Chlorocebus sabaeus (African green monkey) : TGFA (transforming growth factor alpha)
Heterocephalus glaber (naked mole-rat) : Tgfa (transforming growth factor alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
Celera4107,591,450 - 107,673,528 (+)NCBICelera
Cytogenetic Map4q34NCBI
RH 3.4 Map4688.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tgfa
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3849
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.