Tgfa (transforming growth factor alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tgfa (transforming growth factor alpha) Rattus norvegicus
Analyze
Symbol: Tgfa
Name: transforming growth factor alpha
RGD ID: 3849
Description: Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and wound healing. Located in extracellular space and nucleus. Colocalizes with plasma membrane. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protransforming growth factor alpha; RATTGFAA; TGFAA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,618,043 - 118,700,897 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)Ensembl
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
Celera4107,591,450 - 107,673,528 (+)NCBICelera
RH 3.4 Map4688.3RGD
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acteoside  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromocriptine  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (EXP)
carvacrol  (ISO)
celecoxib  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dextromethorphan  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dizocilpine maleate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
hexachlorobenzene  (ISO)
hydrogen chloride  (EXP)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
kaempferol  (ISO)
KN-93  (ISO)
lansoprazole  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
limonene  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
marimastat  (ISO)
melittin  (ISO)
mercury dichloride  (EXP)
metamizole sodium  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
mifepristone  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nitrofurazone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
PD 168393  (ISO)
permethrin  (EXP)
PHA-665752  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
poly(propylene imine) macromolecule  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rottlerin  (ISO)
rutin  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sulpyrine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
trans-piceid  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Aihaiti X, etal., J Interferon Cytokine Res. 2006 Apr;26(4):226-34.
2. Akkoyunlu G, etal., Acta Histochem. 2003;105(4):295-301.
3. Appleton CT, etal., Arthritis Rheum. 2007 Nov;56(11):3693-705.
4. Baughman RP, etal., Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):57-61.
5. Blasband AJ, etal., Mol Cell Biol 1990 May;10(5):2111-21.
6. Borrell-Pag├Ęs M, etal., Mol Biol Cell. 2000 Dec;11(12):4217-25.
7. Buck M, etal., Mol Cell. 1999 Dec;4(6):1087-92.
8. Dell KM, etal., Kidney Int. 2001 Oct;60(4):1240-8.
9. Dombrowski F, etal., Am J Pathol. 1997 Mar;150(3):1071-87.
10. Franklin JL, etal., Exp Cell Res. 2005 Feb 15;303(2):457-70.
11. Garrett TP, etal., Cell. 2002 Sep 20;110(6):763-73.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gentry LE, etal., Mol Cell Biol. 1987 May;7(5):1585-91.
14. GOA data from the GO Consortium
15. Grasl-Kraupp B, etal., Hepatology 2002 Jun;35(6):1372-80.
16. Guerra-Crespo M, etal., Neuroscience. 2009 May 5;160(2):470-83. Epub 2009 Feb 25.
17. Hardie WD, etal., Pediatr Dev Pathol. 1999 Sep-Oct;2(5):415-23.
18. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
19. Jiang D, etal., J Biol Chem. 1998 Nov 20;273(47):31471-9.
20. Kim I, etal., Wound Repair Regen. 2001 Sep-Oct;9(5):386-90.
21. Kimura M, etal., J Pharmacol Sci. 2009 Apr;109(4):618-29. Epub 2009 Apr 4.
22. Kitano M, etal., Cancer Sci. 2006 Jun;97(6):478-83.
23. Korc M, etal., J Clin Invest. 1992 Oct;90(4):1352-60.
24. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Le Cras TD, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L718-29. Epub 2004 Apr 16.
26. Lee CS Eur J Surg Oncol. 1998 Feb;24(1):38-42.
27. Lee DC, etal., Nature 1985 Feb 7-13;313(6002):489-91.
28. Luetteke NC and Lee DC, Semin Cancer Biol. 1990 Aug;1(4):265-75.
29. Luetteke NC, etal., Cell. 1993 Apr 23;73(2):263-78.
30. Madtes DK, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):424-30.
31. MGD data from the GO Consortium
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Nie SN, etal., World J Gastroenterol. 2004 Dec 1;10(23):3537-41.
34. Nomura S, etal., Gastroenterology. 2005 May;128(5):1292-305.
35. Pavelic K, etal., Anticancer Res. 1996 Jul-Aug;16(4A):1707-17.
36. Petegnief V, etal., J Biol Chem 2003 Aug 8;278(32):29552-9. Epub 2003 May 27.
37. Pipeline to import KEGG annotations from KEGG into RGD
38. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. RGD automated data pipeline
40. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. RGD automated import pipeline for gene-chemical interactions
42. Rosen K, etal., J Biol Chem 2001 Oct 5;276(40):37273-9.
43. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
44. Siveke JT, etal., Cancer Cell. 2007 Sep;12(3):266-79.
45. Sukhotnik I, etal., Pediatr Surg Int. 2008 Dec;24(12):1303-11.
46. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
47. Tuli SS, etal., Curr Eye Res. 2006 Sep;31(9):709-19.
48. Wang Y, etal., Biol Reprod 2002 Jun;66(6):1672-80.
49. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
Additional References at PubMed
PMID:6320373   PMID:6605968   PMID:8702723   PMID:10331984   PMID:11278323   PMID:12743035   PMID:14998491   PMID:15064403   PMID:15353178   PMID:17031671   PMID:17553928   PMID:19237431  
PMID:24595367   PMID:26804134   PMID:34968668  


Genomics

Candidate Gene Status
Tgfa is a candidate Gene for QTL Hcar2
Tgfa is a candidate Gene for QTL Hcar8
Tgfa is a candidate Gene for QTL Ept5
Comparative Map Data
Tgfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,618,043 - 118,700,897 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)Ensembl
Rnor_6.04117,961,877 - 118,045,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,534,161 - 182,616,713 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,355,649 - 120,437,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,600,129 - 120,682,257 (+)NCBI
Celera4107,591,450 - 107,673,528 (+)NCBICelera
RH 3.4 Map4688.3RGD
Cytogenetic Map4q34NCBI
TGFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38270,447,284 - 70,553,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl270,447,284 - 70,554,193 (-)EnsemblGRCh38hg38GRCh38
GRCh37270,674,416 - 70,780,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,527,924 - 70,634,613 (-)NCBINCBI36hg18NCBI36
Build 34270,586,073 - 70,692,585NCBI
Celera270,525,095 - 70,631,786 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,410,567 - 70,517,904 (-)NCBIHuRef
CHM1_1270,602,969 - 70,710,469 (-)NCBICHM1_1
T2T-CHM13v2.0270,458,007 - 70,564,581 (-)NCBI
Tgfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,172,020 - 86,252,726 (+)NCBIGRCm39mm39
GRCm39 Ensembl686,172,205 - 86,252,701 (+)Ensembl
GRCm38686,195,038 - 86,275,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,195,223 - 86,275,719 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,145,245 - 86,225,443 (+)NCBIGRCm37mm9NCBIm37
MGSCv36686,161,050 - 86,240,791 (+)NCBImm8
Celera688,129,264 - 88,209,219 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.62NCBI
Tgfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,616,259 - 14,710,183 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,616,390 - 14,709,723 (+)NCBIChiLan1.0ChiLan1.0
TGFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A71,625,196 - 71,731,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A71,625,196 - 71,731,461 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,510,727 - 70,617,628 (-)NCBIMhudiblu_PPA_v0panPan3
TGFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,915,671 - 68,957,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,799,798 - 68,879,353 (-)NCBI
ROS_Cfam_1.01069,935,210 - 70,012,287 (-)NCBI
UMICH_Zoey_3.11069,652,504 - 69,732,094 (-)NCBI
UNSW_CanFamBas_1.01069,914,727 - 69,994,269 (-)NCBI
UU_Cfam_GSD_1.01070,213,444 - 70,290,872 (-)NCBI
Tgfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629213,812,443 - 13,910,943 (+)NCBI
SpeTri2.0NW_00493649114,659,089 - 14,758,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,948,137 - 72,050,488 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,948,232 - 72,054,257 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2375,409,715 - 75,437,890 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,545,641 - 36,654,213 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1436,545,875 - 36,648,237 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604575,360,438 - 75,475,321 (-)NCBIVero_WHO_p1.0
Tgfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247622,832,078 - 2,937,318 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247622,832,073 - 2,941,150 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D4Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,699,850 - 118,699,963 (+)MAPPERmRatBN7.2
Rnor_6.04118,044,882 - 118,044,994NCBIRnor6.0
Rnor_5.04182,615,672 - 182,615,784UniSTSRnor5.0
RGSC_v3.44120,436,732 - 120,436,845RGDRGSC3.4
RGSC_v3.44120,436,733 - 120,436,845UniSTSRGSC3.4
RGSC_v3.14120,681,213 - 120,681,326RGD
Celera4107,672,487 - 107,672,599UniSTS
RH 3.4 Map4694.3RGD
RH 3.4 Map4694.3UniSTS
Cytogenetic Map4q34UniSTS
D4Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,699,819 - 118,700,066 (+)MAPPERmRatBN7.2
Rnor_6.04118,044,851 - 118,045,097NCBIRnor6.0
Rnor_5.04182,615,641 - 182,615,887UniSTSRnor5.0
RGSC_v3.44120,436,701 - 120,436,948RGDRGSC3.4
RGSC_v3.44120,436,702 - 120,436,948UniSTSRGSC3.4
RGSC_v3.14120,681,182 - 120,681,429RGD
Celera4107,672,456 - 107,672,702UniSTS
Cytogenetic Map4q34UniSTS
D4Got90  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,664,949 - 118,665,239 (+)MAPPERmRatBN7.2
Rnor_6.04118,010,289 - 118,010,578NCBIRnor6.0
Rnor_5.04182,580,930 - 182,581,219UniSTSRnor5.0
RGSC_v3.44120,402,230 - 120,402,519UniSTSRGSC3.4
RGSC_v3.44120,402,229 - 120,402,519RGDRGSC3.4
RGSC_v3.14120,646,710 - 120,647,000RGD
RH 3.4 Map4688.9UniSTS
RH 3.4 Map4688.9RGD
Cytogenetic Map4q34UniSTS
D4Cebr4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,686,099 - 118,686,310 (+)MAPPERmRatBN7.2
Rnor_6.04118,031,131 - 118,031,341NCBIRnor6.0
Rnor_5.04182,601,921 - 182,602,131UniSTSRnor5.0
RGSC_v3.44120,422,982 - 120,423,192UniSTSRGSC3.4
Celera4107,658,736 - 107,658,946UniSTS
Cytogenetic Map4q34UniSTS
AU047195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,623,940 - 118,624,221 (+)MAPPERmRatBN7.2
Rnor_6.04117,969,355 - 117,969,635NCBIRnor6.0
Rnor_5.04182,540,023 - 182,540,303UniSTSRnor5.0
RGSC_v3.44120,361,353 - 120,361,633UniSTSRGSC3.4
Celera4107,597,112 - 107,597,392UniSTS
Cytogenetic Map4q34UniSTS
RH94516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,698,966 - 118,699,136 (+)MAPPERmRatBN7.2
Rnor_6.04118,043,998 - 118,044,167NCBIRnor6.0
Rnor_5.04182,614,788 - 182,614,957UniSTSRnor5.0
RGSC_v3.44120,435,849 - 120,436,018UniSTSRGSC3.4
Celera4107,671,603 - 107,671,772UniSTS
RH 3.4 Map4688.3UniSTS
Cytogenetic Map4q34UniSTS
ABA004  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24118,696,898 - 118,697,652 (+)MAPPERmRatBN7.2
mRatBN7.24118,696,913 - 118,697,652 (+)MAPPERmRatBN7.2
Rnor_6.04118,041,930 - 118,042,683NCBIRnor6.0
Rnor_6.04118,041,945 - 118,042,683NCBIRnor6.0
Rnor_5.04182,612,735 - 182,613,473UniSTSRnor5.0
Rnor_5.04182,612,720 - 182,613,473UniSTSRnor5.0
Celera4107,669,550 - 107,670,288UniSTS
Celera4107,669,535 - 107,670,288UniSTS
Cytogenetic Map4q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1086
Count of miRNA genes:339
Interacting mature miRNAs:471
Transcripts:ENSRNOT00000057441
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 38 11
Low 2 29 56 41 18 41 2 2 36 35 30 11 2
Below cutoff 14 1 1 6 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057441   ⟹   ENSRNOP00000054248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,618,269 - 118,700,894 (+)Ensembl
Rnor_6.0 Ensembl4117,962,319 - 118,046,344 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108625   ⟹   ENSRNOP00000082421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4118,687,365 - 118,697,294 (+)Ensembl
RefSeq Acc Id: NM_012671   ⟹   NP_036803
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,618,269 - 118,700,892 (+)NCBI
Rnor_6.04117,962,178 - 118,045,923 (+)NCBI
Rnor_5.04182,534,161 - 182,616,713 (+)NCBI
RGSC_v3.44120,355,649 - 120,437,772 (+)RGD
Celera4107,591,450 - 107,673,528 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236822   ⟹   XP_006236884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,618,052 - 118,696,807 (+)NCBI
Rnor_6.04117,961,877 - 118,041,838 (+)NCBI
Rnor_5.04182,534,161 - 182,616,713 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107070   ⟹   XP_038962998
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,618,043 - 118,696,807 (+)NCBI
RefSeq Acc Id: XM_039107071   ⟹   XP_038962999
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24118,618,061 - 118,700,897 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036803   ⟸   NM_012671
- Peptide Label: preproprotein
- UniProtKB: P01134 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236884   ⟸   XM_006236822
- Peptide Label: isoform X3
- UniProtKB: U5LKN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054248   ⟸   ENSRNOT00000057441
RefSeq Acc Id: XP_038962998   ⟸   XM_039107070
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962999   ⟸   XM_039107071
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000082421   ⟸   ENSRNOT00000108625
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01134-F1-model_v2 AlphaFold P01134 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693204
Promoter ID:EPDNEW_R3729
Type:multiple initiation site
Name:Tgfa_1
Description:transforming growth factor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04117,962,266 - 117,962,326EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3849 AgrOrtholog
BioCyc Gene G2FUF-43908 BioCyc
Ensembl Genes ENSRNOG00000016182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000054248 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057441 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_rcpt_ligand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24827 UniProtKB/Swiss-Prot
NCBI Gene 24827 ENTREZGENE
PANTHER PTHR10740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfa PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC224838
UniProt P01134 ENTREZGENE, UniProtKB/Swiss-Prot
  U5LKN7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63749 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tgfa  Transforming growth factor, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in oocyte nuclei, as well as granulosa and interstitial thecal cells of developing ovarian follicles 1578551
gene_function increases in androgen production in immature Leydig cells 1578561
gene_regulation inhibition of apoptosis is c-Src-dependent 730227
gene_regulation upregulates its own mRNA and protein expression as well as EGF receptor protein expression in immature Leydig cells 1578561
gene_regulation expression in gastric mucosa increases in response to water immersion and restraint stress (WRS), and continues to increase during the period of adaptation in response to repeated WRS 1578552