Exhibits epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and wound healing. Localizes to the extracellular space and nucleus. Colocalizes with the plasma membrane. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha); PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; pancreatic cancer pathway; INTERACTS WITH (+)-alpha-tocopherol; 1,3-dinitrobenzene; 17beta-estradiol.
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[ADAM17 protein co-treated with ADAM10 protein] affects the reaction [bisphenol A results in increased secretion of TGFA protein], GW280264X inhibits the reaction [bisphenol A results in increased secretion of TGFA protein]
[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of TGFA mRNA
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[[Gasoline co-treated with Ethanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of TGFA mRNA
Fulvestrant inhibits the reaction [4-hydroxy-equilenin results in increased expression of TGFA mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of TGFA mRNA]
[Genistein co-treated with vinclozolin] affects the expression of TGFA mRNA, [Genistein co-treated with vinclozolin] results in decreased expression of TGFA mRNA
[Glucose co-treated with Glucosamine] results in increased expression of TGFA protein, Glucosamine promotes the reaction [Glucose results in increased expression of TGFA mRNA]
[Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein, [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein
[[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of TGFA mRNA
Dextromethorphan inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA], Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]
Estradiol inhibits the reaction [manganese chloride results in decreased expression of TGFA protein], Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of TGFA protein]
[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate, TGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]
PD168393 inhibits the reaction [TGFA protein affects the localization of EGFR protein modified form], PD168393 inhibits the reaction [TGFA protein affects the localization of EGFR protein]
rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein], rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein], N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Silicon Dioxide analog results in increased secretion of TGFA protein]
sodium arsenite results in increased expression of and results in increased stability of TGFA mRNA, TGFA protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]
[Genistein co-treated with vinclozolin] affects the expression of TGFA mRNA, [Genistein co-treated with vinclozolin] results in decreased expression of TGFA mRNA
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
Target capture sequencing of exons and conserved non-coding sequences. Provided by: Dr. Mikita Suyama (Kyushu University) and Dr. Takashi Kuramoto (Kyoto University)
Publications:
Yoshihara M, etal., Genom Data. 2016 Nov 14;10:155-157. eCollection 2016 Dec.
expression in gastric mucosa increases in response to water immersion and restraint stress (WRS), and continues to increase during the period of adaptation in response to repeated WRS
Gene-Chemical Interaction Annotations
