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Gene: Ggcx (gamma-glutamyl carboxylase) Rattus norvegicus
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Symbol: Ggcx
Name: gamma-glutamyl carboxylase
Description: Exhibits gamma-glutamyl carboxylase activity and vitamin binding activity. Involved in several processes, including peptidyl-glutamic acid carboxylation; response to dexamethasone; and response to vitamin. Localizes to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in coagulation protein disease and inherited blood coagulation disease. Orthologous to human GGCX (gamma-glutamyl carboxylase); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; vitamin K-dependent gamma-glutamyl carboxylase
Orthologs:
Homo sapiens (human) : GGCX (gamma-glutamyl carboxylase)  HGNC  Alliance
Mus musculus (house mouse) : Ggcx (gamma-glutamyl carboxylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ggcx (gamma-glutamyl carboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : GGCX (gamma-glutamyl carboxylase)
Canis lupus familiaris (dog) : GGCX (gamma-glutamyl carboxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ggcx (gamma-glutamyl carboxylase)
Sus scrofa (pig) : GGCX (gamma-glutamyl carboxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04100,277,345 - 100,293,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04165,047,672 - 165,063,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,719,323 - 105,735,037 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14105,963,803 - 105,979,517 (+)NCBI
Celera493,622,596 - 93,638,331 (+)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ggcx
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68383
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.