Gng12 (G protein subunit gamma 12) - Rat Genome Database

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Gene: Gng12 (G protein subunit gamma 12) Rattus norvegicus
Analyze
Symbol: Gng12
Name: G protein subunit gamma 12
RGD ID: 621516
Description: Enables phosphate ion binding activity. Involved in cerebral cortex development and response to lipopolysaccharide. Located in actin filament. Orthologous to human GNG12 (G protein subunit gamma 12); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; follicle-stimulating hormone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanine nucleotide binding protein (G protein), gamma 12; guanine nucleotide binding protein 12; guanine nucleotide binding protein gamma 12 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; heterotrimeric guanine nucleotide-binding protein 3a; Hg3a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gng12Tn(sb-T2/Bart3)2.320Mcwi  
Genetic Models: F344-Gng12Tn(sb-T2/Bart3)2.320Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,340,830 - 97,464,422 (+)NCBIGRCr8
mRatBN7.2496,011,118 - 96,134,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,010,952 - 96,134,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,285,782 - 101,380,771 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,060,751 - 97,155,744 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,485,792 - 95,580,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,634,925 - 97,763,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,657,671 - 97,760,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,420,268 - 162,549,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,622,363 - 96,624,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,866,867 - 96,868,580 (+)NCBI
Celera490,733,078 - 90,828,214 (+)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
Clofop  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenamidone  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
GW 7647  (EXP,ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
metronidazole  (EXP)
neomycin  (EXP)
paracetamol  (ISO)
pentane  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo. Asano T, etal., Eur J Biochem. 1998 Jan 15;251(1-2):314-9.
2. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, etal., Neuroscience 1998 Jul;85(2):475-86.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2. Larson KC, etal., Inflamm Res. 2009 Jul 1.
5. Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. Morishita R, etal., J Neurochem. 1997 Feb;68(2):820-7.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:19056867   PMID:23209302   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Gng12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,340,830 - 97,464,422 (+)NCBIGRCr8
mRatBN7.2496,011,118 - 96,134,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,010,952 - 96,134,712 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,285,782 - 101,380,771 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,060,751 - 97,155,744 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,485,792 - 95,580,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0497,634,925 - 97,763,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl497,657,671 - 97,760,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,420,268 - 162,549,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,622,363 - 96,624,479 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1496,866,867 - 96,868,580 (+)NCBI
Celera490,733,078 - 90,828,214 (+)NCBICelera
Cytogenetic Map4q31NCBI
GNG12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,701,475 - 67,833,467 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,701,475 - 67,833,467 (-)EnsemblGRCh38hg38GRCh38
GRCh37168,167,158 - 68,299,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,939,737 - 68,071,730 (-)NCBINCBI36Build 36hg18NCBI36
Build 34167,879,242 - 68,011,129NCBI
Celera166,458,012 - 66,589,844 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef166,277,405 - 66,409,293 (-)NCBIHuRef
CHM1_1168,281,656 - 68,413,579 (-)NCBICHM1_1
T2T-CHM13v2.0167,578,994 - 67,710,912 (-)NCBIT2T-CHM13v2.0
Gng12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39666,873,381 - 66,998,345 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl666,873,381 - 66,998,334 (+)EnsemblGRCm39 Ensembl
GRCm38666,896,397 - 67,021,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl666,896,397 - 67,021,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv37666,846,391 - 66,971,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36666,826,034 - 66,950,872 (+)NCBIMGSCv36mm8
Celera669,009,110 - 69,142,819 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.68NCBI
Gng12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,634,402 - 23,644,600 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,576,515 - 23,644,600 (+)NCBIChiLan1.0ChiLan1.0
GNG12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,037,990 - 159,167,844 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,197,602 - 158,327,585 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,941,315 - 67,071,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,897,289 - 69,025,742 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,901,264 - 68,903,487 (-)Ensemblpanpan1.1panPan2
GNG12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1677,316,649 - 77,378,356 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl677,338,685 - 77,374,937 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha679,907,731 - 79,987,868 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0677,972,445 - 77,978,233 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1677,452,925 - 77,558,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0677,346,730 - 77,427,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0677,832,739 - 77,913,898 (+)NCBIUU_Cfam_GSD_1.0
Gng12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,506,244 - 80,674,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365913,977,507 - 3,980,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365913,860,668 - 3,983,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNG12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6144,782,503 - 144,918,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16144,782,478 - 144,918,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28115,141,133 - 115,141,412 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNG12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,280,816 - 65,409,685 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,403,471 - 65,405,699 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603352,202,558 - 52,331,733 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gng12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,700,538 - 27,718,555 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,652,114 - 27,721,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gng12
252 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000075400
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
D4Rat41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2496,130,123 - 96,130,297 (+)MAPPERmRatBN7.2
Rnor_6.0497,758,884 - 97,759,057NCBIRnor6.0
Rnor_5.04162,544,759 - 162,544,932UniSTSRnor5.0
RGSC_v3.4496,623,259 - 96,623,433RGDRGSC3.4
RGSC_v3.4496,623,260 - 96,623,433UniSTSRGSC3.4
RGSC_v3.1496,867,740 - 96,867,914RGD
Celera490,826,995 - 90,827,168UniSTS
SHRSP x BN Map448.75RGD
SHRSP x BN Map448.75UniSTS
Cytogenetic Map4q31UniSTS
BM384455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2496,080,323 - 96,080,506 (+)MAPPERmRatBN7.2
Rnor_6.0497,701,161 - 97,701,343NCBIRnor6.0
Rnor_5.04162,486,856 - 162,487,038UniSTSRnor5.0
RGSC_v3.4496,571,682 - 96,571,864UniSTSRGSC3.4
Celera490,777,599 - 90,777,781UniSTS
RH 3.4 Map4588.6UniSTS
Cytogenetic Map4q31UniSTS
AI842738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2496,131,377 - 96,131,478 (+)MAPPERmRatBN7.2
Rnor_6.0497,760,138 - 97,760,238NCBIRnor6.0
Rnor_5.04162,546,013 - 162,546,113UniSTSRnor5.0
RGSC_v3.4496,624,514 - 96,624,614UniSTSRGSC3.4
Celera490,828,249 - 90,828,349UniSTS
Cytogenetic Map4q31UniSTS


Genetic Models
This gene Gng12 is modified in the following models/strains:
F344-Gng12Tn(sb-T2/Bart3)2.320Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF022091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG378509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM031435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OU667103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000075400   ⟹   ENSRNOP00000067190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl496,011,154 - 96,131,341 (+)Ensembl
Rnor_6.0 Ensembl497,657,671 - 97,760,102 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109450   ⟹   ENSRNOP00000084739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl496,010,952 - 96,134,712 (+)Ensembl
RefSeq Acc Id: NM_053661   ⟹   NP_446113
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,365,961 - 97,461,053 (+)NCBI
mRatBN7.2496,036,246 - 96,131,343 (+)NCBI
Rnor_6.0497,657,671 - 97,760,103 (+)NCBI
Rnor_5.04162,420,268 - 162,549,350 (+)NCBI
Celera490,733,078 - 90,828,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106904   ⟹   XP_038962832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,340,838 - 97,464,422 (+)NCBI
mRatBN7.2496,011,118 - 96,134,718 (+)NCBI
RefSeq Acc Id: XM_063285384   ⟹   XP_063141454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,340,830 - 97,464,422 (+)NCBI
RefSeq Acc Id: XM_063285385   ⟹   XP_063141455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,340,859 - 97,464,422 (+)NCBI
RefSeq Acc Id: XM_063285386   ⟹   XP_063141456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,456,109 - 97,464,422 (+)NCBI
RefSeq Acc Id: XM_063285387   ⟹   XP_063141457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,341,332 - 97,464,422 (+)NCBI
RefSeq Acc Id: NP_446113   ⟸   NM_053661
- UniProtKB: G3V6P8 (UniProtKB/TrEMBL),   A6KF41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067190   ⟸   ENSRNOT00000075400
RefSeq Acc Id: XP_038962832   ⟸   XM_039106904
- Peptide Label: isoform X1
- UniProtKB: G3V6P8 (UniProtKB/TrEMBL),   A6KF41 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084739   ⟸   ENSRNOT00000109450
RefSeq Acc Id: XP_063141454   ⟸   XM_063285384
- Peptide Label: isoform X1
- UniProtKB: A6KF41 (UniProtKB/TrEMBL),   G3V6P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141455   ⟸   XM_063285385
- Peptide Label: isoform X1
- UniProtKB: A6KF41 (UniProtKB/TrEMBL),   G3V6P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141457   ⟸   XM_063285387
- Peptide Label: isoform X1
- UniProtKB: A6KF41 (UniProtKB/TrEMBL),   G3V6P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141456   ⟸   XM_063285386
- Peptide Label: isoform X1
- UniProtKB: A6KF41 (UniProtKB/TrEMBL),   G3V6P8 (UniProtKB/TrEMBL)
Protein Domains
G protein gamma

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6P8-F1-model_v2 AlphaFold G3V6P8 1-72 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621516 AgrOrtholog
BioCyc Gene G2FUF-44581 BioCyc
Ensembl Genes ENSRNOG00000050231 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075400.3 UniProtKB/TrEMBL
  ENSRNOT00000109450.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.10 UniProtKB/TrEMBL
InterPro G-protein_gamma-like_dom UniProtKB/TrEMBL
  GGL_sf UniProtKB/TrEMBL
  Gprotein-gamma UniProtKB/TrEMBL
KEGG Report rno:114120 UniProtKB/TrEMBL
NCBI Gene 114120 ENTREZGENE
PANTHER PTHR13809 UniProtKB/TrEMBL
Pfam G-gamma UniProtKB/TrEMBL
PhenoGen Gng12 PhenoGen
PRINTS GPROTEING UniProtKB/TrEMBL
PROSITE G_PROTEIN_GAMMA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050231 RatGTEx
SMART G_gamma UniProtKB/TrEMBL
  GGL UniProtKB/TrEMBL
Superfamily-SCOP G-protein_gamma-like UniProtKB/TrEMBL
UniProt A0A8I6GAY3_RAT UniProtKB/TrEMBL
  A6KF41 ENTREZGENE, UniProtKB/TrEMBL
  G3V6P8 ENTREZGENE, UniProtKB/TrEMBL
  Q45QK0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gng12  guanine nucleotide binding protein (G protein), gamma 12    guanine nucleotide binding protein 12  Name updated 1299863 APPROVED
2002-08-07 Gng12  guanine nucleotide binding protein 12      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null expressed in white matter pathways