Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GNG12 mRNA | CTD | PMID:36331819 | (R)-adrenaline | multiple interactions | EXP | | 6480464 | Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] | CTD | PMID:30737458 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of GNG12 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GNG12 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of GNG12 mRNA | CTD | PMID:17557909 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of GNG12 mRNA | CTD | PMID:19484750 | 17beta-estradiol | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of GNG12 mRNA | CTD | PMID:26496021 | 2,2,2-tetramine | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Trientine results in increased expression of GNG12 protein | CTD | PMID:19634143 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GNG12 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GNG12 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GNG12 mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | affects expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane affects the expression of GNG12 mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of GNG12 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of GNG12 mRNA | CTD | PMID:24780913 | 7,12-dimethyltetraphene | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | 9 more ... | CTD | PMID:19480007 | aflatoxin B1 | affects expression | ISO | GNG12 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of GNG12 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | GNG12 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of GNG12 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of GNG12 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of GNG12 mRNA | CTD | PMID:16483693 | ampicillin | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein | CTD | PMID:30545405 | aristolochic acid A | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of GNG12 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of GNG12 mRNA] | CTD | PMID:15034205 | benzo[a]pyrene | affects methylation | ISO | GNG12 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of GNG12 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GNG12 mRNA | CTD | PMID:15034205 and PMID:19770486 | benzo[e]pyrene | increases methylation | ISO | GNG12 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of GNG12 intron | CTD | PMID:30157460 | bisphenol A | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of GNG12 mRNA | CTD | PMID:26496021 | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of GNG12 promoter | CTD | PMID:27334623 | bisphenol A | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of GNG12 mRNA | CTD | PMID:25181051 | butyric acid | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Butyric Acid results in increased expression of GNG12 mRNA | CTD | PMID:34581912 | cadmium dichloride | affects expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Cadmium Chloride affects the expression of GNG12 mRNA | CTD | PMID:22110744 | carbamazepine | affects expression | ISO | GNG12 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of GNG12 mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Chlorpyrifos results in decreased expression of GNG12 mRNA | CTD | PMID:17452286 | cisplatin | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of GNG12 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of GNG12 mRNA | CTD | PMID:27392435 | Clofop | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [fenofibric acid binds to PPARA protein] which results in increased expression of GNG12 mRNA | CTD | PMID:16197558 | cobalt dichloride | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of GNG12 mRNA | CTD | PMID:19320972 | cocaine | affects expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Cocaine affects the expression of GNG12 mRNA | CTD | PMID:20187946 | copper atom | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of GNG12 mRNA | CTD | PMID:30911355 | copper(0) | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in increased expression of GNG12 mRNA | CTD | PMID:30911355 | Cuprizon | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of GNG12 mRNA | CTD | PMID:27523638 | cyclophosphamide | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Cyclophosphamide results in increased expression of GNG12 mRNA | CTD | PMID:17403535 | diazinon | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Diazinon results in decreased expression of GNG12 mRNA | CTD | PMID:17452286 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of GNG12 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in increased expression of GNG12 mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of GNG12 mRNA | CTD | PMID:33729688 | dorsomorphin | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA | CTD | PMID:27188386 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of GNG12 mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol affects the expression of and affects the splicing of GNG12 mRNA | CTD | PMID:30319688 | fenamidone | increases expression | EXP | | 6480464 | fenamidone results in increased expression of GNG12 mRNA | CTD | PMID:27029645 | finasteride | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of GNG12 mRNA | CTD | PMID:24136188 | fipronil | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of GNG12 mRNA | CTD | PMID:34044035 | flutamide | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of GNG12 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GNG12 mRNA | CTD | PMID:22206623 | FR900359 | increases phosphorylation | ISO | GNG12 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of GNG12 protein | CTD | PMID:37730182 | geldanamycin | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of GNG12 mRNA | CTD | PMID:26705709 | gentamycin | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein | CTD | PMID:30545405 | GW 7647 | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | GW 7647 results in increased expression of GNG12 mRNA | CTD | PMID:31628012 | GW 7647 | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | GW 7647 results in decreased expression of GNG12 mRNA | CTD | PMID:31628012 | ivermectin | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of GNG12 protein | CTD | PMID:32959892 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of GNG12 mRNA | CTD | PMID:22613225 | lead(0) | affects expression | ISO | GNG12 (Homo sapiens) | 6480464 | Lead affects the expression of GNG12 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | leflunomide results in increased expression of GNG12 mRNA | CTD | PMID:24136188 | methapyrilene | increases methylation | ISO | GNG12 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of GNG12 intron | CTD | PMID:30157460 | metronidazole | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein | CTD | PMID:30545405 | neomycin | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein | CTD | PMID:30545405 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of GNG12 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of GNG12 mRNA | CTD | PMID:21420995 and PMID:26690555 | pentane | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | pentane results in decreased expression of GNG12 mRNA | CTD | PMID:33064461 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GNG12 mRNA | CTD | PMID:36331819 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of GNG12 mRNA | CTD | PMID:17251523 | SB 431542 | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA | CTD | PMID:27188386 | sodium fluoride | increases expression | EXP | | 6480464 | Sodium Fluoride results in increased expression of GNG12 protein | CTD | PMID:28918527 | Soman | increases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Soman results in increased expression of GNG12 mRNA | CTD | PMID:19281266 | sunitinib | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of GNG12 mRNA | CTD | PMID:31533062 | tetrachloromethane | decreases expression | ISO | Gng12 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of GNG12 mRNA | CTD | PMID:33387578 | thapsigargin | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Thapsigargin results in decreased expression of GNG12 mRNA | CTD | PMID:29453283 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of GNG12 mRNA | CTD | PMID:27760801 | torcetrapib | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | torcetrapib results in increased expression of GNG12 mRNA | CTD | PMID:23228038 | trichostatin A | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of GNG12 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | GNG12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA | CTD | PMID:27188386 | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of GNG12 mRNA | CTD | PMID:33045310 | tunicamycin | decreases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of GNG12 mRNA | CTD | PMID:29453283 | valproic acid | increases expression | ISO | GNG12 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GNG12 mRNA | CTD | PMID:19101580 more ... | vancomycin | multiple interactions | ISO | Gng12 (Rattus norvegicus) | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein | CTD | PMID:30545405 | | 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Mammalian Phenotype
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 5. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 6. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 8. | Database resources of the National Center for Biotechnology Information. | Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6. |
Additional References at PubMed
| PMID:8889548 | PMID:10191100 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:14610273 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16602821 |
| PMID:18287559 | PMID:18799693 | PMID:19568691 | PMID:20697350 | PMID:21267068 | PMID:21677750 | PMID:21862448 | PMID:21873635 | PMID:23209302 | PMID:24599258 | PMID:25044020 | PMID:26816005 |
| PMID:27113764 | PMID:29518331 | PMID:30254276 | PMID:30550785 | PMID:32325033 | PMID:34932372 |
Genomics
Comparative Map Data
| Gng12 (Mus musculus - house mouse) |
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| GNG12 (Homo sapiens - human) |
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| Gng12 (Rattus norvegicus - Norway rat) |
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| Gng12 (Chinchilla lanigera - long-tailed chinchilla) |
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| GNG12 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| GNG12 (Canis lupus familiaris - dog) |
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| Gng12 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| GNG12 (Sus scrofa - pig) |
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| GNG12 (Chlorocebus sabaeus - green monkey) |
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| Gng12 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Gng12
3688 total Variants 
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