Impdh1 (inosine monophosphate dehydrogenase 1)

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Gene: Impdh1 (inosine monophosphate dehydrogenase 1) Rattus norvegicus

Analyze

Symbol:

Impdh1

Name:

inosine monophosphate dehydrogenase 1

RGD ID:

1311108

Description:

Predicted to enable DNA binding activity; IMP dehydrogenase activity; and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMPD 1; IMPDH 1; inosine 5'-phosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1; LOC362329

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IMPDH1 (inosine monophosphate dehydrogenase 1)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Impdh1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Impdh1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IMPDH1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IMPDH1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Impdh1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IMPDH1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IMPDH1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Impdh1 (inosine monophosphate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	IMPDH1 (inosine monophosphate dehydrogenase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Impdh1 (inosine monophosphate dehydrogenase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	impdh1b (IMP (inosine 5'-monophosphate) dehydrogenase 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	impdh1a (IMP (inosine 5'-monophosphate) dehydrogenase 1a)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T22D1.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ras	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IMD4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	impdh1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	57,801,842 - 57,817,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	57,801,831 - 57,819,076 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	62,784,631 - 62,800,160 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	58,700,781 - 58,716,310 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	57,102,678 - 57,118,207 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	56,478,383 - 56,493,987 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	56,478,384 - 56,493,923 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	56,245,545 - 56,261,238 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	56,075,236 - 56,090,775 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	56,328,720 - 56,344,413 (-)	NCBI
Celera	4	52,909,914 - 52,925,453 (-)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fundus dystrophy (ISO)

genetic disease (ISO)

Leber congenital amaurosis (ISO)

Leber congenital amaurosis 11 (ISO)

pleomorphic xanthoastrocytoma (ISO)

retinal degeneration (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 10 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

Cuprizon (EXP,ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

furan (EXP)

gallic acid (ISO)

haloperidol (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (EXP)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

quercetin (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' XMP biosynthetic process (ISO)

GMP biosynthetic process (IEA,ISO)

GTP biosynthetic process (IBA)

lymphocyte proliferation (ISO)

purine nucleotide biosynthetic process (ISO)

retina development in camera-type eye (IEP)

Cellular Component

cytoplasm (IBA,IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

identical protein binding (ISO)

IMP dehydrogenase activity (IBA,IEA,ISO)

metal ion binding (IEA)

nucleic acid binding (ISO)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

de novo purine biosynthetic pathway (TAS)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

mercaptopurine pharmacokinetics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

mycophenolic acid pharmacokinetics pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.	Aherne A, etal., Hum Mol Genet. 2004 Mar 15;13(6):641-50.
2.	Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.	Bowne SJ, etal., Hum Mol Genet. 2002 Mar 1;11(5):559-68.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.	Gunter JH, etal., Int J Biochem Cell Biol. 2008;40(9):1716-28. Epub 2008 Jan 18.
6.	Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.	Kennan A, etal., Hum Mol Genet. 2002 Mar 1;11(5):547-57.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).	Tam LC, etal., Hum Mol Genet. 2008 Jul 15;17(14):2084-100. Epub 2008 Apr 1.
16.	Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals.	Watanabe M, etal., Biochim Biophys Acta. 2008 Jan;1777(1):104-12. Epub 2007 Nov 6.

Additional References at PubMed

PMID:7763314	PMID:12944494	PMID:14766016

Genomics

Comparative Map Data

Impdh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	57,801,842 - 57,817,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	57,801,831 - 57,819,076 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	62,784,631 - 62,800,160 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	58,700,781 - 58,716,310 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	57,102,678 - 57,118,207 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	56,478,383 - 56,493,987 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	56,478,384 - 56,493,923 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	56,245,545 - 56,261,238 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	56,075,236 - 56,090,775 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	56,328,720 - 56,344,413 (-)	NCBI
Celera	4	52,909,914 - 52,925,453 (-)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

IMPDH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	128,392,277 - 128,409,982 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	128,392,277 - 128,409,986 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	128,032,331 - 128,050,036 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	127,819,567 - 127,837,272 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	127,626,282 - 127,643,992	NCBI
Celera	7	122,835,429 - 122,853,135 (-)	NCBI		Celera
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	122,393,708 - 122,411,003 (-)	NCBI		HuRef
CHM1_1	7	127,965,901 - 127,983,582 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	129,704,030 - 129,721,735 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	127,415,442 - 127,433,147 (-)	NCBI

Impdh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	29,200,435 - 29,216,363 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	29,200,433 - 29,216,363 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	29,200,436 - 29,216,364 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	29,200,434 - 29,216,364 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	29,150,440 - 29,162,271 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	29,150,450 - 29,162,281 (-)	NCBI		MGSCv36	mm8
Celera	6	29,206,299 - 29,218,129 (-)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	12.36	NCBI

Impdh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	9,388,108 - 9,406,764 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	9,388,241 - 9,406,717 (-)	NCBI	ChiLan1.0	ChiLan1.0

IMPDH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	7	17,256,310 - 17,274,047 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	120,382,719 - 120,400,417 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	133,036,328 - 133,053,496 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	133,036,328 - 133,053,580 (-)	Ensembl	panpan1.1		panPan2

IMPDH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	8,001,575 - 8,013,181 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	7,996,717 - 8,012,467 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	7,683,371 - 7,699,655 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	7,763,475 - 7,779,761 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	7,763,396 - 7,779,755 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	7,968,180 - 7,984,460 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	7,709,322 - 7,725,599 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	7,855,531 - 7,872,037 (+)	NCBI		UU_Cfam_GSD_1.0

Impdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	54,399,577 - 54,416,526 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	15,523,037 - 15,540,173 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936479	15,523,342 - 15,540,229 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IMPDH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	19,979,983 - 19,996,429 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	19,979,983 - 19,996,432 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	21,049,179 - 21,065,545 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IMPDH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	97,188,835 - 97,231,871 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	97,189,481 - 97,206,726 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	6,199,094 - 6,217,528 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Impdh1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	7,574,093 - 7,590,909 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	7,574,025 - 7,590,920 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Impdh1
53 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	461
Count of miRNA genes:	224
Interacting mature miRNAs:	260
Transcripts:	ENSRNOT00000027173
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	39505275	73892441	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	39524264	74726312	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	81266970	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	34	18	19	18	1	2	74	22	34	11	1
Low		8	23	23		23	7	9		13	7		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001398857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027173 ⟹ ENSRNOP00000027173

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	57,801,844 - 57,817,422 (-)	Ensembl
Rnor_6.0 Ensembl	4	56,478,384 - 56,493,923 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094463 ⟹ ENSRNOP00000089156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	57,801,831 - 57,819,076 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098302 ⟹ ENSRNOP00000092649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	57,801,843 - 57,817,353 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110384 ⟹ ENSRNOP00000095077

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	57,801,843 - 57,819,076 (-)	Ensembl

RefSeq Acc Id:

NM_001108619 ⟹ NP_001102089

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	57,801,843 - 57,817,389 (-)	NCBI
Rnor_6.0	4	56,478,384 - 56,493,923 (-)	NCBI
Rnor_5.0	4	56,245,545 - 56,261,238 (-)	NCBI
RGSC_v3.4	4	56,075,236 - 56,090,775 (-)	RGD
Celera	4	52,909,914 - 52,925,453 (-)	RGD

Sequence:

show sequence

GGCTCCCGCCGCCCAGAGCTGCGGCCTCCGCATGGCATGGAGGAACCGCTCTCACCCCCACCGG
AGTCCGGGCTACTCTCGCCGCTGCTGCAGGGAGGCGGAGCCGCTGCTGCTCCAGAGCCCGGAGC
CCGGCAACACCCGGGACATGAGACCGCGGCGCAGCGGTACAGCGCCCGCCTGCTGCAGGCCGGC
TACGAGCCGGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTTCCCGAGGATG
GGCTCACCGCGCAGCAGCTCTTCGCCAACGCGGATGGCCTCACCTACAACGATTTCCTGATCCT
CCCAGGATTCATAGACTTCATAGCTGATGAAGTGGACCTGACATCAGCCCTGACCCGGAAGATC
ACACTGAAGACACCACTGATCTCGTCTCCCATGGATACCGTGACAGAGGCTGACATGGCCATTG
CAATGGCTCTCATGGGAGGAATTGGTTTCATTCACCACAACTGTACCCCAGAGTTCCAGGCCAA
TGAGGTGCGGAAGGTCAAGAAGTTTGAGCAAGGCTTCATCACAGACCCTGTGGTCCTGAGCCCT
TCACATACCGTGGGTGATGTTCTGGAGGCCAAGATACAGCATGGCTTCTCTGGTATCCCTATCA
CCGCAACGGGCACCATGGGGAGCAAGCTGGTGATGACGCCGAGGATCGAGCTGGTGGTGGCTCC
AGCAGGTGTGACATTGAAAGAGGCAAATGAGATTTTGCAGCGCAGCAAGAAAGGGAAGCTGCCC
ATAGTCAACGATCAAGACGAGCTGGTAGCCATTATTGCACGCACAGACCTGAAGAAGAACAGAG
ACTACCCTCTGGCCTCCAAAGACTCCCACAAACAGCTGTTGTGTGGGGCAGCTGTGGGCACCCG
TGAGGATGACAAATACCGTCTGGATTTGCTCACTCAGGCCGGTGCTGACGTCATAGTACTAGAT
TCATCCCAGGGGAACTCAGTATATCAGATCGCCATGGTGCACTATATCAAGCAGAAGTACCCCC
ACCTCCAGGTGATTGGGGGAAACGTGGTGACAGCGGCCCAGGCCAAGAACTTGATCGATGCCGG
TGTGGATGGGCTTCGTGTGGGCATGGGCTGTGGCTCCATCTGCATCACTCAGGAAGTGATGGCC
TGTGGCCGACCCCAGGGCACTGCTGTCTACAAGGTGGCTGAGTATGCCCGGCGCTTTGGGGTGC
CGGTAATAGCTGATGGTGGTATCCAGACTGTGGGCCATGTGGTCAAAGCCCTGGCGCTCGGAGC
CTCTACAGTGATGATGGGCTCCTTGCTGGCTGCTACCACGGAGGCCCCTGGTGAATACTTCTTC
TCAGACGGGGTGAGGCTTAAGAAGTACCGAGGCATGGGTTCCCTGGACGCCATGGAGAAGAGCA
GCAGCAGCCAGAAGCGATACTTCAGTGAGGGGGACAAAGTGAAGATCGCACAGGGTGTCTCGGG
CTCCATCCAGGATAAAGGCTCCATTCAGAAGTTTGTGCCCTACCTCATAGCAGGGATCCAGCAT
GGCTGTCAGGATATTGGGGCCCAAAGCCTGTCTGTCCTGCGATCCATGATGTACTCAGGAGAGC
TCAAGTTTGAGAAGCGGACCATGTCAGCCCAGATAGAGGGCGGTGTGCACGGCCTACACTCTTA
CGAGAAGCGGCTGTACTGAGGACAGCGGCGGCGGCGGCCAAGGCAGTGGAGGGGGAGAACCCCG
GGGTTCCACTCCGGGAACAGCTCCCCTCCATAACTGAGTGGTCCATAGATTTGCACTACGGGTT
CCCCAGCTCCTTTCCAGGGAGAGGAGTGGAGTCCCTGAGGGGACTGTGGCCCCTCTCTGGGCAA
CTCCACAGAGTCAGGTAGCCCCCTGTGCCAGGCTGCCCCGTGAGATCTTCTGGGTTCCCCCTTC
CTCAGCCCCCTGAGCCCAGTCAGCCTTGGTTCTCAGGCCCTGTGCCTGCCTCAGGTCTTTCTTG
CTGCAGCCTGCTCTGGCCCAGTATCCAACTCTGACCCCTGGGGAAGGTAGCCCCTCCTGGCTTC
TCCTATAGGGCACCTCTCTCTCGCTGCCCCCTTCCTCCCAGGAAATGGTGCTCTCCTGACCCTG
CCTCTGACCCATCCTTGGAGTGCTGTCCTCTCAGCCATGTGGCACTGTGGGTTCTGACCCTAGG
CCAGGGGGAGGTCTCTGCCCCCTTCCTCTGGCTTGAGGCTCCCATGGGGCCTGCTCCTCAGCCT
AGTTCCCCGTCTCTGAGCCCAGGGAGGGCCTGATGATGACCGCCTGCCCTTCATTCCTGACTCA
CCATTGTCCCCAGGTGTACCGTCCCTGCCCTCTCTTCTCAGCTGCAGCTGAAGGCTTTAACTTT
GCACACTTTGGGGTCACAATCGTGTCATTATATATTAAATAATCTGAATAAATCAAGCAGTTAT
CAATGC

hide sequence

RefSeq Acc Id:

NM_001398857 ⟹ NP_001385786

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	57,801,842 - 57,813,412 (-)	NCBI

RefSeq Acc Id:

XM_006236210 ⟹ XP_006236272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	57,801,842 - 57,817,433 (-)	NCBI
Rnor_6.0	4	56,478,383 - 56,493,980 (-)	NCBI
Rnor_5.0	4	56,245,545 - 56,261,238 (-)	NCBI

Sequence:

show sequence

CCGGAGTGGACTGGGGCTCTTATTGCCTTCCCTGGTCCGGGAGCCTCCACGCGGAGAGGCTCCC
GCCGCCCAGAGCTGCGGCCTCCGCATGGCATGGAGGAACCGCTCTCACCCCCACCGGAGTCCGG
GCTACTCTCGCCGCTGCTGCAGGGAGGCGGAGCCGCTGCTGCTCCAGAGCCCGGAGCCCGGCAA
CACCCGGGACATGAGACCGCGGCGCAGCGGTACAGCGCCCGCCTGCTGCAGGCCGGCTACGAGC
CGGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTTCCCGAGGATGGGCTCAC
CGCGCAGCAGCTCTTCGCCAACGCGGATGGCCTCACCTACAACGATTTCCTGATCCTCCCAGGA
TTCATAGACTTCATAGCTGATGAAGTGGACCTGACATCAGCCCTGACCCGGAAGATCACACTGA
AGACACCACTGATCTCGTCTCCCATGGATACCGTGACAGAGGCTGACATGGCCATTGCAATGGC
TCTCATGGGAGGAATTGGTTTCATTCACCACAACTGTACCCCAGAGTTCCAGGCCAATGAGGTG
CGGAAGGTCAAGAAGTTTGAGCAAGGCTTCATCACAGACCCTGTGGTCCTGAGCCCTTCACATA
CCGTGGGTGATGTTCTGGAGGCCAAGATACAGCATGGCTTCTCTGGTATCCCTATCACCGCAAC
GGGCACCATGGGGAGCAAGCTGGTGGGCATCGTTACCTCCCGAGACATCGACTTCCTCGCTGAG
AAGGACCACACCACCCTCCTCAGTGAGGTGATGACGCCGAGGATCGAGCTGGTGGTGGCTCCAG
CAGGTGTGACATTGAAAGAGGCAAATGAGATTTTGCAGCGCAGCAAGAAAGGGAAGCTGCCCAT
AGTCAACGATCAAGACGAGCTGGTAGCCATTATTGCACGCACAGACCTGAAGAAGAACAGAGAC
TACCCTCTGGCCTCCAAAGACTCCCACAAACAGCTGTTGTGTGGGGCAGCTGTGGGCACCCGTG
AGGATGACAAATACCGTCTGGATTTGCTCACTCAGGCCGGTGCTGACGTCATAGTACTAGATTC
ATCCCAGGGGAACTCAGTATATCAGATCGCCATGGTGCACTATATCAAGCAGAAGTACCCCCAC
CTCCAGGTGATTGGGGGAAACGTGGTGACAGCGGCCCAGGCCAAGAACTTGATCGATGCCGGTG
TGGATGGGCTTCGTGTGGGCATGGGCTGTGGCTCCATCTGCATCACTCAGGAAGTGATGGCCTG
TGGCCGACCCCAGGGCACTGCTGTCTACAAGGTGGCTGAGTATGCCCGGCGCTTTGGGGTGCCG
GTAATAGCTGATGGTGGTATCCAGACTGTGGGCCATGTGGTCAAAGCCCTGGCGCTCGGAGCCT
CTACAGTGATGATGGGCTCCTTGCTGGCTGCTACCACGGAGGCCCCTGGTGAATACTTCTTCTC
AGACGGGGTGAGGCTTAAGAAGTACCGAGGCATGGGTTCCCTGGACGCCATGGAGAAGAGCAGC
AGCAGCCAGAAGCGATACTTCAGTGAGGGGGACAAAGTGAAGATCGCACAGGGTGTCTCGGGCT
CCATCCAGGATAAAGGCTCCATTCAGAAGTTTGTGCCCTACCTCATAGCAGGGATCCAGCATGG
CTGTCAGGATATTGGGGCCCAAAGCCTGTCTGTCCTGCGATCCATGATGTACTCAGGAGAGCTC
AAGTTTGAGAAGCGGACCATGTCAGCCCAGATAGAGGGCGGTGTGCACGGCCTACACTCTTACG
AGAAGCGGCTGTACTGAGGACAGCGGCGGCGGCGGCCAAGGCAGTGGAGGGGGAGAACCCCGGG
GTTCCACTCCGGGAACAGCTCCCCTCCATAACTGAGTGGTCCATAGATTTGCACTACGGGTTCC
CCAGCTCCTTTCCAGGGAGAGGAGTGGAGTCCCTGAGGGGACTGTGGCCCCTCTCTGGGCAACT
CCACAGAGTCAGGTAGCCCCCTGTGCCAGGCTGCCCCGTGAGATCTTCTGGGTTCCCCCTTCCT
CAGCCCCCTGAGCCCAGTCAGCCTTGGTTCTCAGGCCCTGTGCCTGCCTCAGGTCTTTCTTGCT
GCAGCCTGCTCTGGCCCAGTATCCAACTCTGACCCCTGGGGAAGGTAGCCCCTCCTGGCTTCTC
CTATAGGGCACCTCTCTCTCGCTGCCCCCTTCCTCCCAGGAAATGGTGCTCTCCTGACCCTGCC
TCTGACCCATCCTTGGAGTGCTGTCCTCTCAGCCATGTGGCACTGTGGGTTCTGACCCTAGGCC
AGGGGGAGGTCTCTGCCCCCTTCCTCTGGCTTGAGGCTCCCATGGGGCCTGCTCCTCAGCCTAG
TTCCCCGTCTCTGAGCCCAGGGAGGGCCTGATGATGACCGCCTGCCCTTCATTCCTGACTCACC
ATTGTCCCCAGGTGTACCGTCCCTGCCCTCTCTTCTCAGCTGCAGCTGAAGGCTTTAACTTTGC
ACACTTTGGGGTCACAATCGTGTCATTATATATTAAATAATCTGAATAAATCAAGCAGTTATCA
ATGCC

hide sequence

RefSeq Acc Id:

XM_039107773 ⟹ XP_038963701

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	57,801,842 - 57,817,434 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102089	(Get FASTA)	NCBI Sequence Viewer
	NP_001385786	(Get FASTA)	NCBI Sequence Viewer
	XP_006236272	(Get FASTA)	NCBI Sequence Viewer
	XP_038963701	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZLZ7	(Get FASTA)	NCBI Sequence Viewer
	EDM15207	(Get FASTA)	NCBI Sequence Viewer
	EDM15208	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001102089 ⟸ NM_001108619
- Peptide Label:	isoform 1
- UniProtKB:	A0A0A0MXZ8 (UniProtKB/TrEMBL), A6IEC0 (UniProtKB/TrEMBL), A0A8I6AI29 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEEPLSPPPESGLLSPLLQGGGAAAAPEPGARQHPGHETAAQRYSARLLQAGYEPESMADYLIS GGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMD TVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKI QHGFSGIPITATGTMGSKLVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAII ARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAM VHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKV AEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGM GSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQSLSV LRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY hide sequence

RefSeq Acc Id:	XP_006236272 ⟸ XM_006236210
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AI29 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEEPLSPPPESGLLSPLLQGGGAAAAPEPGARQHPGHETAAQRYSARLLQAGYEPESMADYLIS GGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMD TVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKI QHGFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANE ILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLL TQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGC GSICITQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLA ATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQK FVPYLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY hide sequence

RefSeq Acc Id:

ENSRNOP00000027173 ⟸ ENSRNOT00000027173

RefSeq Acc Id:	XP_038963701 ⟸ XM_039107773
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6AI29 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000095077 ⟸ ENSRNOT00000110384

RefSeq Acc Id:

ENSRNOP00000089156 ⟸ ENSRNOT00000094463

RefSeq Acc Id:

ENSRNOP00000092649 ⟸ ENSRNOT00000098302

RefSeq Acc Id:	NP_001385786 ⟸ NM_001398857
- Peptide Label:	isoform 2
- UniProtKB:	D3ZLZ7 (UniProtKB/Swiss-Prot), A0A0A0MXZ8 (UniProtKB/TrEMBL)

Protein Domains

CBS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZLZ7-F1-model_v2	AlphaFold	D3ZLZ7	1-514	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311108	AgrOrtholog
BioCyc Gene	G2FUF-45405	BioCyc
BioCyc Pathway	PWY-5695 [inosine 5'-phosphate degradation]	BioCyc
	PWY-7221 [guanosine ribonucleotides de novo biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000020032	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000027173	ENTREZGENE
	ENSRNOP00000027173.7	UniProtKB/TrEMBL
	ENSRNOP00000089156.1	UniProtKB/TrEMBL
	ENSRNOP00000092649.1	UniProtKB/TrEMBL
	ENSRNOP00000095077	ENTREZGENE
	ENSRNOP00000095077.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027173	ENTREZGENE
	ENSRNOT00000027173.7	UniProtKB/TrEMBL
	ENSRNOT00000094463.1	UniProtKB/TrEMBL
	ENSRNOT00000098302.1	UniProtKB/TrEMBL
	ENSRNOT00000110384	ENTREZGENE
	ENSRNOT00000110384.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CBS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH/GMP_Rdtase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH_GMPRt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362329	UniProtKB/TrEMBL
NCBI Gene	362329	ENTREZGENE
PANTHER	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11911	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	IMPDH1	RGD
PhenoGen	Impdh1	PhenoGen
PIRSF	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMP_DH_GMP_RED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CBS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IMPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Inosine monophosphate dehydrogenase (IMPDH)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0A0MXZ8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AC45_RAT	UniProtKB/TrEMBL
	A0A8I6AI29	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6APP1_RAT	UniProtKB/TrEMBL
	A6IEC0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZLZ7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-29	Impdh1	inosine monophosphate dehydrogenase 1	Impdh1	IMP (inosine 5'-monophosphate) dehydrogenase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Impdh1	IMP (inosine 5'-monophosphate) dehydrogenase 1	Impdh1	IMP (inosine monophosphate) dehydrogenase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-06	Impdh1	IMP (inosine monophosphate) dehydrogenase 1	Impdh1	inosine 5'-phosphate dehydrogenase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Impdh1	inosine 5'-phosphate dehydrogenase 1	Impdh1_predicted	IMP (inosine monophosphate) dehydrogenase 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Impdh1_predicted	IMP (inosine monophosphate) dehydrogenase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)