Impdh1 (inosine monophosphate dehydrogenase 1) - Rat Genome Database

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Gene: Impdh1 (inosine monophosphate dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Impdh1
Name: inosine monophosphate dehydrogenase 1
RGD ID: 1311108
Description: Predicted to enable DNA binding activity; IMP dehydrogenase activity; and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMPD 1; IMPDH 1; inosine 5'-phosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1; LOC362329
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,767,230 - 58,782,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,767,230 - 58,783,124 (-)EnsemblGRCr8
mRatBN7.2457,801,842 - 57,817,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,801,831 - 57,819,076 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx462,784,631 - 62,800,160 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,700,781 - 58,716,310 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,102,678 - 57,118,207 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,478,383 - 56,493,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,478,384 - 56,493,923 (-)Ensemblrn6Rnor6.0
Rnor_5.0456,245,545 - 56,261,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,075,236 - 56,090,775 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera452,909,914 - 52,925,453 (-)NCBICelera
RGSC_v3.1456,328,720 - 56,344,413 (-)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Aherne A, etal., Hum Mol Genet. 2004 Mar 15;13(6):641-50.
2. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Bowne SJ, etal., Hum Mol Genet. 2002 Mar 1;11(5):559-68.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms. Gunter JH, etal., Int J Biochem Cell Biol. 2008;40(9):1716-28. Epub 2008 Jan 18.
6. Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice. Kennan A, etal., Hum Mol Genet. 2002 Mar 1;11(5):547-57.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10). Tam LC, etal., Hum Mol Genet. 2008 Jul 15;17(14):2084-100. Epub 2008 Apr 1.
16. Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals. Watanabe M, etal., Biochim Biophys Acta. 2008 Jan;1777(1):104-12. Epub 2007 Nov 6.
Additional References at PubMed
PMID:7763314   PMID:12944494   PMID:14766016  


Genomics

Comparative Map Data
Impdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,767,230 - 58,782,825 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,767,230 - 58,783,124 (-)EnsemblGRCr8
mRatBN7.2457,801,842 - 57,817,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,801,831 - 57,819,076 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx462,784,631 - 62,800,160 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,700,781 - 58,716,310 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,102,678 - 57,118,207 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,478,383 - 56,493,987 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,478,384 - 56,493,923 (-)Ensemblrn6Rnor6.0
Rnor_5.0456,245,545 - 56,261,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,075,236 - 56,090,775 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera452,909,914 - 52,925,453 (-)NCBICelera
RGSC_v3.1456,328,720 - 56,344,413 (-)NCBI
Cytogenetic Map4q22NCBI
IMPDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,392,277 - 128,409,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,392,277 - 128,409,986 (-)Ensemblhg38GRCh38
GRCh377128,032,331 - 128,050,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,819,567 - 127,837,272 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347127,626,282 - 127,643,992NCBI
Celera7122,835,429 - 122,853,135 (-)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,393,708 - 122,411,003 (-)NCBIHuRef
CHM1_17127,965,901 - 127,983,582 (-)NCBICHM1_1
T2T-CHM13v2.07129,704,030 - 129,721,735 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,415,442 - 127,433,147 (-)NCBI
Impdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,200,435 - 29,216,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,200,433 - 29,216,363 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38629,200,436 - 29,216,364 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,200,434 - 29,216,364 (-)Ensemblmm10GRCm38
MGSCv37629,150,440 - 29,162,271 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36629,150,450 - 29,162,281 (-)NCBIMGSCv36mm8
Celera629,206,299 - 29,218,129 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Impdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,388,108 - 9,406,764 (-)Ensembl
ChiLan1.0NW_0049554799,388,241 - 9,406,717 (-)NCBIChiLan1.0ChiLan1.0
IMPDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,246,060 - 165,263,800 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,256,310 - 17,274,047 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,382,719 - 120,400,417 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,036,328 - 133,053,496 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,036,328 - 133,053,580 (-)EnsemblpanPan2panpan1.1
IMPDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,001,575 - 8,013,181 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,996,717 - 8,012,467 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha147,683,371 - 7,699,655 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0147,763,475 - 7,779,761 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,763,396 - 7,779,755 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,968,180 - 7,984,460 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,709,322 - 7,725,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,855,531 - 7,872,037 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Impdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,399,577 - 54,416,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,523,037 - 15,540,173 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,523,342 - 15,540,229 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,979,983 - 19,996,429 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11819,979,983 - 19,996,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,049,179 - 21,065,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IMPDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,188,835 - 97,231,871 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,189,481 - 97,206,726 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660426,199,094 - 6,217,528 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Impdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,574,093 - 7,590,909 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247837,574,025 - 7,590,920 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Impdh1
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:461
Count of miRNA genes:224
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000027173
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027173   ⟹   ENSRNOP00000027173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,767,231 - 58,782,772 (-)Ensembl
mRatBN7.2 Ensembl457,801,844 - 57,817,422 (-)Ensembl
Rnor_6.0 Ensembl456,478,384 - 56,493,923 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094463   ⟹   ENSRNOP00000089156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl457,801,831 - 57,819,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098302   ⟹   ENSRNOP00000092649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,767,230 - 58,782,736 (-)Ensembl
mRatBN7.2 Ensembl457,801,843 - 57,817,353 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110384   ⟹   ENSRNOP00000095077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,767,230 - 58,783,124 (-)Ensembl
mRatBN7.2 Ensembl457,801,843 - 57,819,076 (-)Ensembl
RefSeq Acc Id: NM_001108619   ⟹   NP_001102089
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,231 - 58,782,772 (-)NCBI
mRatBN7.2457,801,843 - 57,817,389 (-)NCBI
Rnor_6.0456,478,384 - 56,493,923 (-)NCBI
Rnor_5.0456,245,545 - 56,261,238 (-)NCBI
RGSC_v3.4456,075,236 - 56,090,775 (-)RGD
Celera452,909,914 - 52,925,453 (-)RGD
Sequence:
RefSeq Acc Id: NM_001398857   ⟹   NP_001385786
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,778,795 (-)NCBI
mRatBN7.2457,801,842 - 57,813,412 (-)NCBI
RefSeq Acc Id: XM_006236210   ⟹   XP_006236272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,782,822 (-)NCBI
mRatBN7.2457,801,842 - 57,817,433 (-)NCBI
Rnor_6.0456,478,383 - 56,493,980 (-)NCBI
Rnor_5.0456,245,545 - 56,261,238 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107773   ⟹   XP_038963701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,782,823 (-)NCBI
mRatBN7.2457,801,842 - 57,817,434 (-)NCBI
RefSeq Acc Id: XM_063286237   ⟹   XP_063142307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,782,824 (-)NCBI
RefSeq Acc Id: XM_063286238   ⟹   XP_063142308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,779,931 (-)NCBI
RefSeq Acc Id: XM_063286239   ⟹   XP_063142309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,782,825 (-)NCBI
RefSeq Acc Id: XM_063286240   ⟹   XP_063142310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,767,230 - 58,779,931 (-)NCBI
RefSeq Acc Id: NP_001102089   ⟸   NM_001108619
- Peptide Label: isoform 1
- UniProtKB: A6IEC0 (UniProtKB/TrEMBL),   A0A8I6AI29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236272   ⟸   XM_006236210
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AI29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027173   ⟸   ENSRNOT00000027173
RefSeq Acc Id: XP_038963701   ⟸   XM_039107773
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AI29 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095077   ⟸   ENSRNOT00000110384
Ensembl Acc Id: ENSRNOP00000089156   ⟸   ENSRNOT00000094463
Ensembl Acc Id: ENSRNOP00000092649   ⟸   ENSRNOT00000098302
RefSeq Acc Id: NP_001385786   ⟸   NM_001398857
- Peptide Label: isoform 2
- UniProtKB: D3ZLZ7 (UniProtKB/Swiss-Prot),   A0A0A0MXZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142309   ⟸   XM_063286239
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AC45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142307   ⟸   XM_063286237
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AC45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142310   ⟸   XM_063286240
- Peptide Label: isoform X6
- UniProtKB: A0A0A0MXZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142308   ⟸   XM_063286238
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AC45 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLZ7-F1-model_v2 AlphaFold D3ZLZ7 1-514 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692918
Promoter ID:EPDNEW_R3443
Type:initiation region
Name:Impdh1_1
Description:inosine monophosphate dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0456,493,932 - 56,493,992EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311108 AgrOrtholog
BioCyc Gene G2FUF-45405 BioCyc
BioCyc Pathway PWY-5695 [inosine 5'-phosphate degradation] BioCyc
  PWY-7221 [guanosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-5695 BioCyc
  PWY-7221 BioCyc
Ensembl Genes ENSRNOG00000020032 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027173 ENTREZGENE
  ENSRNOT00000110384 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  CBS_dom UniProtKB/Swiss-Prot
  IMP_DH UniProtKB/Swiss-Prot
  IMP_DH/GMP_Rdtase_CS UniProtKB/Swiss-Prot
  IMP_DH_GMPRt UniProtKB/Swiss-Prot
NCBI Gene 362329 ENTREZGENE
PANTHER INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 UniProtKB/Swiss-Prot
  PTHR11911 UniProtKB/Swiss-Prot
Pfam CBS UniProtKB/Swiss-Prot
  IMPDH UniProtKB/Swiss-Prot
PharmGKB IMPDH1 RGD
PhenoGen Impdh1 PhenoGen
PIRSF IMPDH UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
  IMP_DH_GMP_RED UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020032 RatGTEx
SMART CBS UniProtKB/Swiss-Prot
  IMPDH UniProtKB/Swiss-Prot
Superfamily-SCOP Inosine monophosphate dehydrogenase (IMPDH) UniProtKB/Swiss-Prot
UniProt A0A0A0MXZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AC45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AI29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APP1_RAT UniProtKB/TrEMBL
  A6IEC0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLZ7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Impdh1  inosine monophosphate dehydrogenase 1  Impdh1  IMP (inosine 5'-monophosphate) dehydrogenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Impdh1  IMP (inosine 5'-monophosphate) dehydrogenase 1  Impdh1  IMP (inosine monophosphate) dehydrogenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Impdh1  IMP (inosine monophosphate) dehydrogenase 1  Impdh1  inosine 5'-phosphate dehydrogenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Impdh1  inosine 5'-phosphate dehydrogenase 1  Impdh1_predicted  IMP (inosine monophosphate) dehydrogenase 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Impdh1_predicted  IMP (inosine monophosphate) dehydrogenase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED