Setd5 (SET domain containing 5) - Rat Genome Database

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Gene: Setd5 (SET domain containing 5) Rattus norvegicus
Analyze
Symbol: Setd5
Name: SET domain containing 5
RGD ID: 1310433
Description: Predicted to enable methylated histone binding activity; protein-lysine N-methyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including regulation of DNA-templated transcription; regulation of chromatin organization; and regulation of synapse assembly. Predicted to be located in nucleoplasm. Predicted to be part of Rpd3L-Expanded complex; Set3 complex; and euchromatin. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 23. Orthologous to human SETD5 (SET domain containing 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase SETD5; LOC297514; RGD1310433; SET domain-containing protein 5; similar to mKIAA1757 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,772,955 - 147,850,669 (+)NCBIGRCr8
mRatBN7.24146,217,172 - 146,294,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,217,180 - 146,294,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,601,552 - 151,679,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,382,364 - 147,459,988 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,003,773 - 146,081,375 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,017,549 - 145,095,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,017,608 - 145,095,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,315,923 - 208,393,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,949,819 - 149,027,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,194,804 - 149,272,302 (+)NCBI
Celera4134,776,438 - 134,854,033 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Setd5 is required in cardiopharyngeal mesoderm for heart development and its haploinsufficiency is associated with outflow tract defects in mouse. Cheung MY, etal., Genesis. 2021 Aug;59(7-8):e23421. doi: 10.1002/dvg.23421. Epub 2021 May 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice. Moore SM, etal., Transl Psychiatry. 2019 Jan 17;9(1):24. doi: 10.1038/s41398-018-0344-y.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. SET domain-containing 5 is a potential prognostic biomarker that promotes esophageal squamous cell carcinoma stemness. Piao L, etal., Exp Cell Res. 2020 Apr 1;389(1):111861. doi: 10.1016/j.yexcr.2020.111861. Epub 2020 Jan 22.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth. Yang Z, etal., Am J Pathol. 2022 Apr;192(4):712-721. doi: 10.1016/j.ajpath.2021.12.006. Epub 2022 Jan 19.
10. Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer. Zhang Y, etal.
Additional References at PubMed
PMID:22939622   PMID:27864380   PMID:30455454   PMID:31515109  


Genomics

Comparative Map Data
Setd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,772,955 - 147,850,669 (+)NCBIGRCr8
mRatBN7.24146,217,172 - 146,294,896 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,217,180 - 146,294,894 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,601,552 - 151,679,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,382,364 - 147,459,988 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,003,773 - 146,081,375 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,017,549 - 145,095,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,017,608 - 145,095,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,315,923 - 208,393,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,949,819 - 149,027,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,194,804 - 149,272,302 (+)NCBI
Celera4134,776,438 - 134,854,033 (+)NCBICelera
Cytogenetic Map4q42NCBI
SETD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3839,397,615 - 9,478,154 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl39,397,615 - 9,479,240 (+)EnsemblGRCh38hg38GRCh38
GRCh3739,439,299 - 9,519,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,414,403 - 9,494,838 (+)NCBINCBI36Build 36hg18NCBI36
Celera39,374,104 - 9,454,540 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef39,376,157 - 9,456,594 (+)NCBIHuRef
CHM1_139,389,634 - 9,470,072 (+)NCBICHM1_1
T2T-CHM13v2.039,389,553 - 9,470,070 (+)NCBIT2T-CHM13v2.0
Setd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,054,326 - 113,130,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,054,326 - 113,130,396 (+)EnsemblGRCm39 Ensembl
GRCm386113,077,262 - 113,153,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,077,365 - 113,153,435 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,027,633 - 113,103,418 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,043,416 - 113,119,201 (+)NCBIMGSCv36mm8
Celera6114,906,553 - 114,982,234 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.73NCBI
Setd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561968,814 - 1,042,691 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955561968,814 - 1,091,687 (+)NCBIChiLan1.0ChiLan1.0
SETD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v229,409,409 - 9,498,076 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan139,414,169 - 9,495,101 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v039,350,026 - 9,430,760 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,592,517 - 9,672,306 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,592,517 - 9,672,306 (+)Ensemblpanpan1.1panPan2
SETD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,681,714 - 8,766,013 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,683,738 - 8,732,674 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,714,249 - 8,798,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,711,279 - 8,795,473 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,713,184 - 8,795,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,433,002 - 8,517,373 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,778,660 - 8,862,780 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,751,943 - 8,836,101 (-)NCBIUU_Cfam_GSD_1.0
Setd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,255,510 - 15,330,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,577,525 - 3,654,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,577,543 - 3,654,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SETD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,759,987 - 65,850,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,759,973 - 65,851,747 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,888,860 - 72,927,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SETD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,391,871 - 45,475,183 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2245,430,660 - 45,475,217 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,083,848 - 121,167,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Setd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247314,098,091 - 4,172,555 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247314,098,137 - 4,170,889 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Setd5
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:529
Count of miRNA genes:265
Interacting mature miRNAs:328
Transcripts:ENSRNOT00000066723
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat

Markers in Region
RH12737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,293,134 - 146,293,266 (+)MAPPERmRatBN7.2
Rnor_6.04145,093,486 - 145,093,617NCBIRnor6.0
Rnor_5.04208,391,843 - 208,391,974UniSTSRnor5.0
RGSC_v3.44149,025,700 - 149,025,831UniSTSRGSC3.4
Celera4134,852,274 - 134,852,405UniSTS
Cytogenetic Map4q42UniSTS
BI278082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,239,996 - 146,240,152 (+)MAPPERmRatBN7.2
Rnor_6.04145,040,358 - 145,040,513NCBIRnor6.0
Rnor_5.04208,338,715 - 208,338,870UniSTSRnor5.0
RGSC_v3.44148,972,570 - 148,972,725UniSTSRGSC3.4
Celera4134,799,191 - 134,799,346UniSTS
RH 3.4 Map4936.7UniSTS
Cytogenetic Map4q42UniSTS
RH142085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,263,612 - 146,263,802 (+)MAPPERmRatBN7.2
Rnor_6.04145,063,970 - 145,064,159NCBIRnor6.0
Rnor_5.04208,362,327 - 208,362,516UniSTSRnor5.0
RGSC_v3.44148,996,184 - 148,996,373UniSTSRGSC3.4
Celera4134,822,758 - 134,822,947UniSTS
RH 3.4 Map4937.1UniSTS
Cytogenetic Map4q42UniSTS
G66214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,254,556 - 146,254,634 (+)MAPPERmRatBN7.2
Rnor_6.04145,054,914 - 145,054,991NCBIRnor6.0
Rnor_5.04208,353,271 - 208,353,348UniSTSRnor5.0
RGSC_v3.44148,987,128 - 148,987,205UniSTSRGSC3.4
Celera4134,813,704 - 134,813,781UniSTS
Cytogenetic Map4q42UniSTS
BI278082  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,239,996 - 146,240,173 (+)MAPPERmRatBN7.2
Rnor_6.04145,040,358 - 145,040,534NCBIRnor6.0
Rnor_5.04208,338,715 - 208,338,891UniSTSRnor5.0
RGSC_v3.44148,972,570 - 148,972,746UniSTSRGSC3.4
Celera4134,799,191 - 134,799,367UniSTS
RH 3.4 Map4936.7UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 55 39 19 39 7 7 74 34 39 11 7
Low 2 2 2 2 1 4 1 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000066723   ⟹   ENSRNOP00000059211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,217,246 - 146,294,894 (+)Ensembl
Rnor_6.0 Ensembl4145,017,608 - 145,095,245 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110888   ⟹   ENSRNOP00000083274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,217,180 - 146,294,894 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115284   ⟹   ENSRNOP00000085738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,217,411 - 146,294,894 (+)Ensembl
RefSeq Acc Id: NM_001106614   ⟹   NP_001100084
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,773,028 - 147,850,667 (+)NCBI
mRatBN7.24146,217,246 - 146,294,894 (+)NCBI
Rnor_6.04145,017,608 - 145,095,245 (+)NCBI
Rnor_5.04208,315,923 - 208,393,604 (+)NCBI
RGSC_v3.44148,949,819 - 149,027,459 (+)RGD
Celera4134,776,438 - 134,854,033 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237012   ⟹   XP_006237074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,772,955 - 147,850,669 (+)NCBI
mRatBN7.24146,217,172 - 146,294,896 (+)NCBI
Rnor_6.04145,017,549 - 145,095,247 (+)NCBI
Rnor_5.04208,315,923 - 208,393,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237015   ⟹   XP_006237077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,809,379 - 147,850,669 (+)NCBI
mRatBN7.24146,249,144 - 146,294,896 (+)NCBI
Rnor_6.04145,049,538 - 145,095,247 (+)NCBI
Rnor_5.04208,315,923 - 208,393,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237016   ⟹   XP_006237078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,772,955 - 147,850,669 (+)NCBI
mRatBN7.24146,217,173 - 146,294,896 (+)NCBI
Rnor_6.04145,017,550 - 145,095,247 (+)NCBI
Rnor_5.04208,315,923 - 208,393,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237018   ⟹   XP_006237080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,772,955 - 147,850,669 (+)NCBI
mRatBN7.24146,217,174 - 146,294,896 (+)NCBI
Rnor_6.04145,017,551 - 145,095,247 (+)NCBI
Rnor_5.04208,315,923 - 208,393,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592570   ⟹   XP_017448059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,804,938 - 147,850,669 (+)NCBI
mRatBN7.24146,249,143 - 146,294,896 (+)NCBI
Rnor_6.04145,049,538 - 145,095,247 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107397   ⟹   XP_038963325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,772,955 - 147,850,669 (+)NCBI
mRatBN7.24146,217,173 - 146,294,896 (+)NCBI
RefSeq Acc Id: XM_039107398   ⟹   XP_038963326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,805,849 - 147,850,669 (+)NCBI
mRatBN7.24146,249,130 - 146,294,896 (+)NCBI
RefSeq Acc Id: XM_039107401   ⟹   XP_038963329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,809,379 - 147,837,795 (+)NCBI
mRatBN7.24146,249,130 - 146,282,059 (+)NCBI
RefSeq Acc Id: XM_063285864   ⟹   XP_063141934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,805,849 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285865   ⟹   XP_063141935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,805,849 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285866   ⟹   XP_063141936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,809,379 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285867   ⟹   XP_063141937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,810,341 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285868   ⟹   XP_063141938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,805,849 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285869   ⟹   XP_063141939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,805,849 - 147,850,669 (+)NCBI
RefSeq Acc Id: XM_063285870   ⟹   XP_063141940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,809,379 - 147,836,181 (+)NCBI
RefSeq Acc Id: NP_001100084   ⟸   NM_001106614
- UniProtKB: A6IBP2 (UniProtKB/TrEMBL),   A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237074   ⟸   XM_006237012
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237078   ⟸   XM_006237016
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237080   ⟸   XM_006237018
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237077   ⟸   XM_006237015
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448059   ⟸   XM_017592570
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059211   ⟸   ENSRNOT00000066723
RefSeq Acc Id: XP_038963325   ⟸   XM_039107397
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963326   ⟸   XM_039107398
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZVR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963329   ⟸   XM_039107401
- Peptide Label: isoform X12
RefSeq Acc Id: ENSRNOP00000085738   ⟸   ENSRNOT00000115284
RefSeq Acc Id: ENSRNOP00000083274   ⟸   ENSRNOT00000110888
RefSeq Acc Id: XP_063141934   ⟸   XM_063285864
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141935   ⟸   XM_063285865
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141938   ⟸   XM_063285868
- Peptide Label: isoform X10
- UniProtKB: A6IBP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141939   ⟸   XM_063285869
- Peptide Label: isoform X10
- UniProtKB: A6IBP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141936   ⟸   XM_063285866
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A251 (UniProtKB/TrEMBL),   D4A2W7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141940   ⟸   XM_063285870
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063141937   ⟸   XM_063285867
- Peptide Label: isoform X9
- UniProtKB: A6IBP3 (UniProtKB/TrEMBL)
Protein Domains
SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2W7-F1-model_v2 AlphaFold D4A2W7 1-1446 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693292
Promoter ID:EPDNEW_R3815
Type:initiation region
Name:Setd5_2
Description:SET domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3816  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,017,545 - 145,017,605EPDNEW
RGD ID:13693291
Promoter ID:EPDNEW_R3816
Type:initiation region
Name:Setd5_1
Description:SET domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3815  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,017,773 - 145,017,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310433 AgrOrtholog
BioCyc Gene G2FUF-43402 BioCyc
Ensembl Genes ENSRNOG00000007472 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066723.3 UniProtKB/TrEMBL
  ENSRNOT00000110888.1 UniProtKB/TrEMBL
  ENSRNOT00000115284.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
InterPro SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SETD5_SET UniProtKB/TrEMBL
KEGG Report rno:297514 UniProtKB/TrEMBL
NCBI Gene 297514 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE SETD5 UniProtKB/TrEMBL
  UPSET, ISOFORM A UniProtKB/TrEMBL
Pfam SET UniProtKB/TrEMBL
PhenoGen Setd5 PhenoGen
PROSITE SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007472 RatGTEx
SMART SET UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/TrEMBL
UniProt A0A8I5ZVR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A251 ENTREZGENE, UniProtKB/TrEMBL
  A6IBP2 ENTREZGENE, UniProtKB/TrEMBL
  A6IBP3 ENTREZGENE, UniProtKB/TrEMBL
  D4A2W7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Setd5  SET domain containing 5  RGD1310433_predicted  similar to mKIAA1757 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310433_predicted  similar to mKIAA1757 protein (predicted)  LOC297514_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC297514_predicted  similar to mKIAA1757 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL