Exoc4 (exocyst complex component 4) - Rat Genome Database

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Gene: Exoc4 (exocyst complex component 4) Rattus norvegicus
Symbol: Exoc4
Name: exocyst complex component 4
RGD ID: 621791
Description: Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including Golgi to transport vesicle transport; oligodendrocyte differentiation; and positive regulation of calcium-mediated signaling. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse; postsynaptic density, intracellular component; and synaptic vesicle. Colocalizes with endosome. Orthologous to human EXOC4 (exocyst complex component 4); PARTICIPATES IN E-cadherin signaling pathway; insulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALR; augmenter of liver regeneration (ALR) pseudogene; exocyst complex component Sec8; rSec8; Sec8; SEC8-like 1; SEC8-like 1 (S. cerevisiae); Sec8l1; secretory protein SEC8
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Exoc4Tn(sb-T2/Bart3)2.317Mcwi  
Genetic Models: F344-Exoc4Tn(sb-T2/Bart3)2.317Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8462,774,896 - 63,551,541 (+)NCBIGRCr8
mRatBN7.2461,807,706 - 62,584,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl461,807,761 - 62,585,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx466,761,366 - 67,530,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0462,677,087 - 63,445,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0461,079,497 - 61,848,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0460,549,128 - 61,358,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl460,549,197 - 61,355,994 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0460,287,465 - 60,839,820 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0460,913,238 - 61,081,401 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4460,406,942 - 61,284,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1460,683,071 - 61,559,840 (+)NCBI
Celera456,882,713 - 57,637,636 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
etoposide  (ISO)
formaldehyde  (ISO)
glyphosate  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. A role for Sec8 in oligodendrocyte morphological differentiation. Anitei M, etal., J Cell Sci. 2006 Mar 1;119(Pt 5):807-18. Epub 2006 Feb 14.
2. The glycine transporter GLYT1 interacts with Sec3, a component of the exocyst complex. Cubelos B, etal., Neuropharmacology. 2005 Nov;49(6):935-44. doi: 10.1016/j.neuropharm.2005.07.021. Epub 2005 Sep 21.
3. Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. Gainey MA, etal., Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3590-9. doi: 10.1073/pnas.1510754112. Epub 2015 Jun 24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. Gerges NZ, etal., EMBO J. 2006 Apr 19;25(8):1623-34. Epub 2006 Apr 6.
6. MyRIP anchors protein kinase A to the exocyst complex. Goehring AS, etal., J Biol Chem. 2007 Nov 9;282(45):33155-67. Epub 2007 Sep 7.
7. RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC. Lalli G J Cell Sci. 2009 May 15;122(Pt 10):1499-506. Epub 2009 Apr 21.
8. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Mao L, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43. doi: 10.1073/pnas.1013494107. Epub 2010 Oct 18.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Parrini MC, etal., Mol Cell. 2011 Jun 10;42(5):650-61. doi: 10.1016/j.molcel.2011.03.032.
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). Riefler GM, etal., Biochem J. 2003 Jul 1;373(Pt 1):49-55.
16. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
17. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
18. Arl13b and the exocyst interact synergistically in ciliogenesis. Seixas C, etal., Mol Biol Cell. 2016 Jan 15;27(2):308-20. doi: 10.1091/mbc.E15-02-0061. Epub 2015 Nov 18.
19. The mammalian Sec6/8 complex interacts with Ca(2+) signaling complexes and regulates their activity. Shin DM, etal., J Cell Biol. 2000 Sep 4;150(5):1101-12.
20. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
21. rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion. Ting AE, etal., Proc Natl Acad Sci U S A 1995 Oct 10;92(21):9613-7.
Additional References at PubMed
PMID:9441674   PMID:11406615   PMID:17086175   PMID:18480549   PMID:19587293   PMID:19946888   PMID:20237282   PMID:21389209   PMID:24056301   PMID:30053369  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8462,774,896 - 63,551,541 (+)NCBIGRCr8
mRatBN7.2461,807,706 - 62,584,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl461,807,761 - 62,585,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx466,761,366 - 67,530,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0462,677,087 - 63,445,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0461,079,497 - 61,848,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0460,549,128 - 61,358,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl460,549,197 - 61,355,994 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0460,287,465 - 60,839,820 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0460,913,238 - 61,081,401 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4460,406,942 - 61,284,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1460,683,071 - 61,559,840 (+)NCBI
Celera456,882,713 - 57,637,636 (+)NCBICelera
Cytogenetic Map4q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387133,253,078 - 134,100,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7133,253,073 - 134,066,589 (+)EnsemblGRCh38hg38GRCh38
GRCh377132,937,834 - 133,750,514 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367132,588,363 - 133,401,054 (+)NCBINCBI36Build 36hg18NCBI36
Build 347132,395,083 - 133,207,766NCBI
Celera7127,689,360 - 128,501,714 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7127,253,094 - 128,065,500 (+)NCBIHuRef
CHM1_17132,872,749 - 133,685,075 (+)NCBICHM1_1
T2T-CHM13v2.07134,574,528 - 135,422,862 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27132,277,237 - 133,089,663 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39633,226,025 - 33,950,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl633,226,020 - 33,950,914 (+)EnsemblGRCm39 Ensembl
GRCm38633,249,090 - 33,973,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl633,249,085 - 33,973,979 (+)EnsemblGRCm38mm10GRCm38
MGSCv37633,199,150 - 33,922,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36633,179,308 - 33,903,101 (+)NCBIMGSCv36mm8
Celera633,234,875 - 33,967,226 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map614.59NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541033,935,320 - 34,673,764 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,937,825 - 34,672,790 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v26170,083,599 - 170,888,092 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1722,093,854 - 22,898,347 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07125,226,107 - 126,030,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17137,734,349 - 138,537,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7137,734,400 - 138,536,214 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1143,334,286 - 4,077,478 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,334,220 - 4,077,411 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,990,436 - 3,736,256 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0143,063,572 - 3,812,726 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl143,063,572 - 3,812,695 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,267,885 - 4,015,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0143,012,296 - 3,761,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0143,158,194 - 3,902,305 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1815,105,138 - 15,906,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11815,105,152 - 15,906,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21816,661,831 - 16,935,462 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.121101,885,192 - 102,694,892 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666042666,279 - 1,487,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247832,316,300 - 3,165,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247832,315,128 - 3,165,343 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Exoc4
3554 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1525
Count of miRNA genes:303
Interacting mature miRNAs:402
Transcripts:ENSRNOT00000071249, ENSRNOT00000075621
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,277,855 - 62,278,020 (+)MAPPERmRatBN7.2
Rnor_6.0461,038,901 - 61,039,065NCBIRnor6.0
Rnor_5.0460,769,721 - 60,769,885UniSTSRnor5.0
RGSC_v3.4460,974,346 - 60,974,511RGDRGSC3.4
RGSC_v3.4460,974,347 - 60,974,511UniSTSRGSC3.4
RGSC_v3.1461,250,477 - 61,250,641RGD
Celera457,345,999 - 57,346,163UniSTS
RH 3.4 Map4372.0RGD
RH 3.4 Map4372.0UniSTS
RH 2.0 Map4420.2RGD
SHRSP x BN Map432.92RGD
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,040,245 - 62,040,395 (+)MAPPERmRatBN7.2
Rnor_6.0460,782,539 - 60,782,688NCBIRnor6.0
Rnor_5.0460,523,379 - 60,523,528UniSTSRnor5.0
RGSC_v3.4460,645,105 - 60,645,254UniSTSRGSC3.4
Celera457,111,999 - 57,112,148UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2461,830,729 - 61,830,911 (+)MAPPERmRatBN7.2
mRatBN7.21071,323,979 - 71,324,161 (+)MAPPERmRatBN7.2
Rnor_6.01073,821,382 - 73,821,563NCBIRnor6.0
Rnor_6.0460,572,121 - 60,572,302NCBIRnor6.0
Rnor_5.01076,278,016 - 76,278,197UniSTSRnor5.0
Rnor_5.0460,310,219 - 60,310,400UniSTSRnor5.0
RGSC_v3.4460,430,567 - 60,430,748UniSTSRGSC3.4
RGSC_v3.41076,654,206 - 76,654,387UniSTSRGSC3.4
Celera1070,245,705 - 70,245,886UniSTS
Celera456,905,674 - 56,905,855UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,178,051 - 62,178,247 (+)MAPPERmRatBN7.2
Rnor_6.0460,922,688 - 60,922,883NCBIRnor6.0
Rnor_5.0460,657,937 - 60,658,132UniSTSRnor5.0
RGSC_v3.4460,784,776 - 60,784,971UniSTSRGSC3.4
Celera457,249,959 - 57,250,154UniSTS
RH 3.4 Map4372.0UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2461,820,740 - 61,820,848 (+)MAPPERmRatBN7.2
Rnor_6.0460,562,160 - 60,562,267NCBIRnor6.0
Rnor_5.0460,300,428 - 60,300,535UniSTSRnor5.0
RGSC_v3.4460,419,905 - 60,420,012UniSTSRGSC3.4
Celera456,895,674 - 56,895,781UniSTS
RH 3.4 Map4368.3UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2461,904,692 - 61,904,856 (+)MAPPERmRatBN7.2
Rnor_6.0460,641,308 - 60,641,471NCBIRnor6.0
Rnor_5.0460,384,009 - 60,384,172UniSTSRnor5.0
RGSC_v3.4460,507,690 - 60,507,853UniSTSRGSC3.4
Celera456,978,290 - 56,978,453UniSTS
RH 3.4 Map4397.7UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,275,150 - 62,275,293 (+)MAPPERmRatBN7.2
Rnor_6.0461,036,196 - 61,036,338NCBIRnor6.0
Rnor_5.0460,767,016 - 60,767,158UniSTSRnor5.0
RGSC_v3.4460,971,642 - 60,971,784UniSTSRGSC3.4
Celera457,343,294 - 57,343,436UniSTS
RH 3.4 Map4372.0UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,158,210 - 62,158,383 (+)MAPPERmRatBN7.2
Rnor_6.0460,897,303 - 60,897,475NCBIRnor6.0
Rnor_5.0460,638,022 - 60,638,194UniSTSRnor5.0
RGSC_v3.4460,764,601 - 60,764,773UniSTSRGSC3.4
Celera457,229,593 - 57,229,759UniSTS
Cytogenetic Map4q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2462,585,477 - 62,585,598 (+)MAPPERmRatBN7.2
Rnor_6.0461,357,154 - 61,357,274NCBIRnor6.0
Rnor_5.0461,082,561 - 61,082,681UniSTSRnor5.0
RGSC_v3.4461,285,454 - 61,285,574UniSTSRGSC3.4
Celera457,638,796 - 57,638,916UniSTS
RH 3.4 Map4370.4UniSTS
Cytogenetic Map4q22UniSTS

Genetic Models
This gene Exoc4 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 39 33 17 19 17 8 10 74 35 38 11 8
Low 2 4 24 24 24 1 3
Below cutoff


RefSeq Acc Id: ENSRNOT00000071249   ⟹   ENSRNOP00000064888
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl461,807,761 - 62,054,122 (+)Ensembl
Rnor_6.0 Ensembl460,549,197 - 61,355,410 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075621   ⟹   ENSRNOP00000066892
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl461,807,774 - 62,585,723 (+)Ensembl
Rnor_6.0 Ensembl460,549,197 - 61,355,994 (+)Ensembl
RefSeq Acc Id: NM_053875   ⟹   NP_446327
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8462,774,967 - 63,551,541 (+)NCBI
mRatBN7.2461,807,778 - 62,584,316 (+)NCBI
Rnor_6.0460,549,197 - 61,355,994 (+)NCBI
Rnor_5.0460,287,465 - 60,839,820 (+)NCBI
Rnor_5.0460,913,238 - 61,081,401 (+)NCBI
RGSC_v3.4460,406,942 - 61,284,294 (+)RGD
Celera456,882,713 - 57,637,636 (+)RGD
RefSeq Acc Id: XM_039106942   ⟹   XP_038962870
Rat AssemblyChrPosition (strand)Source
GRCr8462,774,896 - 63,145,482 (+)NCBI
mRatBN7.2461,807,706 - 62,178,302 (+)NCBI
RefSeq Acc Id: XM_039106944   ⟹   XP_038962872
Rat AssemblyChrPosition (strand)Source
GRCr8462,774,896 - 63,224,931 (+)NCBI
mRatBN7.2461,807,706 - 62,229,432 (+)NCBI
RefSeq Acc Id: NP_446327   ⟸   NM_053875
- UniProtKB: Q62824 (UniProtKB/Swiss-Prot),   M0RBF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066892   ⟸   ENSRNOT00000075621
RefSeq Acc Id: ENSRNOP00000064888   ⟸   ENSRNOT00000071249
RefSeq Acc Id: XP_038962872   ⟸   XM_039106944
- Peptide Label: isoform X2
- UniProtKB: M0R649 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962870   ⟸   XM_039106942
- Peptide Label: isoform X1
- UniProtKB: M0R649 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62824-F1-model_v2 AlphaFold Q62824 1-975 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692952
Promoter ID:EPDNEW_R3473
Type:multiple initiation site
Description:exocyst complex component 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0460,549,183 - 60,549,243EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621791 AgrOrtholog
BioCyc Gene G2FUF-45285 BioCyc
Ensembl Genes ENSRNOG00000046023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071249.4 UniProtKB/TrEMBL
  ENSRNOT00000075621.3 UniProtKB/TrEMBL
InterPro Sec8/EXOC4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec8_exocyst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec8_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116654 UniProtKB/Swiss-Prot
  PTHR14146 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sec8_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec8_exocyst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Exoc4 PhenoGen
RatGTEx ENSRNOG00000046023 RatGTEx
  EXOC4_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Exoc4  exocyst complex component 4  Sec8l1  SEC8-like 1 (S. cerevisiae)  Symbol and Name updated 1299863 APPROVED
2004-09-10 Sec8l1  SEC8-like 1 (S. cerevisiae)  Sec8  secretory protein SEC8  Symbol and Name updated 1299863 APPROVED
2002-08-07 Sec8  secretory protein SEC8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 20% identity to yeast Sec8p 633933
gene_protein 110-kDa protein 633933