 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
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 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
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InterViewer (Protein-Protein Interactions) |
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 Gene Annotator (Annotation Comparison) unavailable |
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Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Anitei M, etal., J Cell Sci. 2006 Mar 1;119(Pt 5):807-18. Epub 2006 Feb 14. |
| 2. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 3. | Gerges NZ, etal., EMBO J. 2006 Apr 19;25(8):1623-34. Epub 2006 Apr 6. |
| 4. | Goehring AS, etal., J Biol Chem. 2007 Nov 9;282(45):33155-67. Epub 2007 Sep 7. |
| 5. | Lalli G J Cell Sci. 2009 May 15;122(Pt 10):1499-506. Epub 2009 Apr 21. |
| 6. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. | Parrini MC, etal., Mol Cell. 2011 Jun 10;42(5):650-61. doi: 10.1016/j.molcel.2011.03.032. |
| 8. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. | RGD automated data pipeline |
| 10. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 11. | RGD automated import pipeline for gene-chemical interactions |
| 12. | Riefler GM, etal., Biochem J. 2003 Jul 1;373(Pt 1):49-55. |
| 13. | Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3. |
| 14. | Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30. |
| 15. | Shin DM, etal., J Cell Biol. 2000 Sep 4;150(5):1101-12. |
| 16. | Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46. |
| 17. | Ting AE, etal., Proc Natl Acad Sci U S A 1995 Oct 10;92(21):9613-7. |
References - uncuratedGenomics
Comparative Map Data| Exoc4 (Rattus norvegicus - Norway rat) |
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| EXOC4 (Homo sapiens - human) |
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| Exoc4 (Mus musculus - house mouse) |
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| Exoc4 (Chinchilla lanigera - long-tailed chinchilla) |
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| EXOC4 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| EXOC4 (Canis lupus familiaris - dog) |
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| EXOC4 (Sus scrofa - pig) |
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| EXOC4 (Chlorocebus sabaeus - African green monkey) |
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| Exoc4 (Heterocephalus glaber - naked mole-rat) |
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Position Markers| D4Rat22 |
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| WI-14795 |
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| RH131294 |
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| RH131455 |
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| RH143015 |
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| BE110230 |
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| BF396724 |
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| AU047597 |
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| RH136778 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Genetic ModelsmiRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 1 | 39 | 33 | 17 | 19 | 17 | 8 | 10 | 74 | 35 | 38 | 11 | 8 |
| Low | 2 | 4 | 24 | 24 | 24 | 1 | 3 | ||||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_053875 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_017592394 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07060165 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07060166 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060167 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060168 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060169 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060170 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060171 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060172 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060173 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060174 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060175 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060176 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060177 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060178 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060179 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060180 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060181 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060182 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060183 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060184 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07060185 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029402 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029403 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029404 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029405 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029406 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029407 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029408 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029409 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029410 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029411 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029412 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029413 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029414 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029415 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029416 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029417 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029418 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029419 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029420 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029421 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029422 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029423 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029424 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029425 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029426 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029427 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029428 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029429 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029430 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029431 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029432 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029433 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029434 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029435 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029436 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029437 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029438 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029439 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029440 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01029441 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF190019 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473959 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FM107548 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U32498 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000071249 ⟹ ENSRNOP00000064888 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000075621 ⟹ ENSRNOP00000066892 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_053875 ⟹ NP_446327 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
ATGGCGGCAGAAGCAGCTGGTGGGAAATACAGGAGCACAGTCAGCAAAAGCAAAGACCCCTCGGhide sequence |
| RefSeq Acc Id: | XM_017592394 ⟹ XP_017447883 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
TCCGGGTCAGCCGCGGCGTTTACACTTTCCCGGTCCTGTCAAGCACCTGGCTCTCGCTCCCGTAhide sequence |
Protein Sequences| Protein RefSeqs | NP_446327 | (Get FASTA) | NCBI Sequence Viewer |
| XP_017447883 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAC52265 | (Get FASTA) | NCBI Sequence Viewer |
| EDM15293 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM15294 | (Get FASTA) | NCBI Sequence Viewer | |
| Q62824 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_446327 ⟸ NM_053875 |
| - UniProtKB: | Q62824 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQhide sequence |
| RefSeq Acc Id: | XP_017447883 ⟸ XM_017592394 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQhide sequence |
| RefSeq Acc Id: | ENSRNOP00000066892 ⟸ ENSRNOT00000075621 |
| RefSeq Acc Id: | ENSRNOP00000064888 ⟸ ENSRNOT00000071249 |
Protein Domains
Sec8_exocyst
TranscriptomePromoters| RGD ID: | 13692952 | ||||||||
| Promoter ID: | EPDNEW_R3473 | ||||||||
| Type: | multiple initiation site | ||||||||
| Name: | Exoc4_1 | ||||||||
| Description: | exocyst complex component 4 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:621791 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000046023 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000064888 | UniProtKB/TrEMBL |
| ENSRNOP00000066892 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000071249 | UniProtKB/TrEMBL |
| ENSRNOT00000075621 | ENTREZGENE, UniProtKB/TrEMBL | |
| InterPro | Sec8/EXOC4 | UniProtKB/Swiss-Prot |
| Sec8_exocyst | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:116654 | UniProtKB/Swiss-Prot |
| NCBI Gene | 116654 | ENTREZGENE |
| PANTHER | PTHR14146 | UniProtKB/Swiss-Prot |
| Pfam | Sec8_exocyst | UniProtKB/Swiss-Prot |
| PhenoGen | Exoc4 | PhenoGen |
| Transposagen | Exoc4 |
Transposagen |
| UniGene | Rn.51841 | ENTREZGENE |
| UniProt | EXOC4_RAT | UniProtKB/Swiss-Prot |
| M0R649_RAT | UniProtKB/TrEMBL | |
| M0RBF8_RAT | UniProtKB/TrEMBL | |
| Q62824 | ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Exoc4 | exocyst complex component 4 | Sec8l1 | SEC8-like 1 (S. cerevisiae) | Symbol and Name updated | 1299863 | APPROVED |
| 2004-09-10 | Sec8l1 | SEC8-like 1 (S. cerevisiae) | Sec8 | secretory protein SEC8 | Symbol and Name updated | 1299863 | APPROVED |
| 2002-08-07 | Sec8 | secretory protein SEC8 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_homology | shows 20% identity to yeast Sec8p | 633933 |
| gene_protein | 110-kDa protein | 633933 |
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| More on Exoc4 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 621791 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-06-09 |
| Status: | ACTIVE |
