Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EXOC4 mRNA | CTD | PMID:22079256 | 1,2-dichloroethane | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of EXOC4 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of EXOC4 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EXOC4 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EXOC4 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Exoc4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EXOC4 mRNA | CTD | PMID:21570461 | 2,4,6-tribromophenol | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2-acetamidofluorene | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | 2-Acetylaminofluorene results in increased expression of EXOC4 mRNA | CTD | PMID:21607683 | 2-methylcholine | affects expression | ISO | EXOC4 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of EXOC4 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of EXOC4 protein | CTD | PMID:31675489 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of EXOC4 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | affects expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of EXOC4 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EXOC4 mRNA | CTD | PMID:33354967 | aflatoxin B1 | increases methylation | ISO | EXOC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of EXOC4 gene and Aflatoxin B1 results in increased methylation of EXOC4 intron | CTD | PMID:27153756 and PMID:30157460 | aflatoxin B1 | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of EXOC4 mRNA | CTD | PMID:21641981 and PMID:22100608 | alpha-pinene | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EXOC4 mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of EXOC4 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EXOC4 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of EXOC4 mRNA | CTD | PMID:23650126 | arsane | affects methylation | ISO | EXOC4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EXOC4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | EXOC4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EXOC4 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to EXOC4 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of EXOC4 mRNA | CTD | PMID:19770486 and PMID:22610609 | benzo[a]pyrene | multiple interactions | ISO | Exoc4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EXOC4 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of EXOC4 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene diol epoxide I | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[b]fluoranthene | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of EXOC4 mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | ISO | Exoc4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EXOC4 mRNA | CTD | PMID:27858113 | bis(2-chloroethyl) sulfide | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of EXOC4 mRNA | CTD | PMID:15674844 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of EXOC4 gene | CTD | PMID:28505145 | bisphenol A | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EXOC4 protein | CTD | PMID:31675489 | bisphenol A | increases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of EXOC4 mRNA | CTD | PMID:29275510 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EXOC4 mRNA | CTD | PMID:25181051 and PMID:34947998 | Bisphenol B | increases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of EXOC4 protein | CTD | PMID:34186270 | cadmium dichloride | increases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of EXOC4 mRNA | CTD | PMID:26472689 | caffeine | affects phosphorylation | ISO | EXOC4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of EXOC4 protein | CTD | PMID:35688186 | chlorpyrifos | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of EXOC4 mRNA | CTD | PMID:37019170 | chrysene | multiple interactions | ISO | Exoc4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EXOC4 mRNA | CTD | PMID:27858113 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of EXOC4 mRNA | CTD | PMID:22023808 | cisplatin | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of EXOC4 mRNA | CTD | PMID:27392435 and PMID:27594783 | cisplatin | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of EXOC4 mRNA | CTD | PMID:27392435 | clothianidin | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | clothianidin results in decreased expression of EXOC4 mRNA | CTD | PMID:31626844 | copper(II) sulfate | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of EXOC4 mRNA | CTD | PMID:19549813 | decabromodiphenyl ether | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of EXOC4 protein | CTD | PMID:31675489 | dibenz[a,h]anthracene | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of EXOC4 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXOC4 mRNA | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of EXOC4 mRNA | CTD | PMID:19277126 | doxorubicin | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of EXOC4 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of EXOC4 mRNA | CTD | PMID:29391264 | etoposide | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Etoposide results in increased expression of EXOC4 mRNA | CTD | PMID:25270620 | formaldehyde | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of EXOC4 mRNA | CTD | PMID:23649840 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of EXOC4 gene | CTD | PMID:35440735 | irinotecan | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of EXOC4 mRNA | CTD | PMID:18927307 | ivermectin | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EXOC4 protein | CTD | PMID:32959892 | methoxychlor | increases methylation | EXP | | 6480464 | Methoxychlor results in increased methylation of EXOC4 gene | CTD | PMID:23303685 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of EXOC4 gene | CTD | PMID:35440735 | methylmercury chloride | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of EXOC4 mRNA | CTD | PMID:28001369 | mitomycin C | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Mitomycin results in increased expression of EXOC4 mRNA | CTD | PMID:25270620 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of EXOC4 gene | CTD | PMID:33148267 | N-nitrosodiethylamine | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of EXOC4 mRNA | CTD | PMID:21607683 | N-Nitrosopyrrolidine | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of EXOC4 mRNA | CTD | PMID:32234424 | O-methyleugenol | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of EXOC4 mRNA | CTD | PMID:32234424 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of EXOC4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EXOC4 mRNA more ... | CTD | PMID:32699268 more ... | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of EXOC4 mRNA | CTD | PMID:33387578 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of EXOC4 gene | CTD | PMID:33148267 | pirinixic acid | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of EXOC4 mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of EXOC4 mRNA | CTD | PMID:23811191 | potassium chromate | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EXOC4 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of EXOC4 mRNA | CTD | PMID:22079256 | quercetin | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of EXOC4 mRNA | CTD | PMID:21632981 | quercetin | decreases phosphorylation | ISO | EXOC4 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of EXOC4 protein | CTD | PMID:35688186 | SB 431542 | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | sodium arsenite | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of EXOC4 mRNA | CTD | PMID:25270620 | sodium arsenite | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of EXOC4 protein | CTD | PMID:30528433 | sodium dichromate | affects expression | EXP | | 6480464 | sodium bichromate affects the expression of EXOC4 mRNA | CTD | PMID:22110744 | temozolomide | decreases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of EXOC4 mRNA | CTD | PMID:31758290 | tetrachloromethane | affects expression | ISO | Exoc4 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of EXOC4 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of EXOC4 mRNA | CTD | PMID:31150632 | tetraphene | multiple interactions | ISO | Exoc4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EXOC4 mRNA | CTD | PMID:27858113 | thapsigargin | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | Thapsigargin results in increased expression of EXOC4 protein | CTD | PMID:24648495 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of EXOC4 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of EXOC4 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | EXOC4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of EXOC4 mRNA | CTD | PMID:24935251 | Triptolide | increases expression | ISO | Exoc4 (Mus musculus) | 6480464 | triptolide results in increased expression of EXOC4 mRNA | CTD | PMID:32835833 | troglitazone | decreases expression | ISO | Exoc4 (Mus musculus) | 6480464 | troglitazone results in decreased expression of EXOC4 mRNA | CTD | PMID:28973697 | valproic acid | multiple interactions | ISO | EXOC4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EXOC4 mRNA | CTD | PMID:27188386 | |