Doxl1 (diamine oxidase-like protein 1) - Rat Genome Database

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Gene: Doxl1 (diamine oxidase-like protein 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Doxl1
Name: diamine oxidase-like protein 1
RGD ID: 735023
Description: Predicted to enable copper ion binding activity; diamine oxidase activity; and primary methylamine oxidase activity. Predicted to be involved in putrescine metabolic process. Predicted to be active in plasma membrane. Orthologous to human AOC1 (amine oxidase copper containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,210,298 - 79,213,914 (+)NCBIGRCr8
mRatBN7.2477,879,428 - 77,883,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,879,410 - 77,883,044 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,086,881 - 83,090,497 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,862,350 - 78,865,966 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,302,668 - 77,306,284 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,563,625 - 78,567,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,563,625 - 78,567,241 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,250,914 - 143,254,530 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4477,025,230 - 77,028,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,301,359 - 77,304,976 (+)NCBI
Celera472,815,916 - 72,819,532 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doxl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DOXL1 mRNACTDPMID:34747641
Doxl1Ratbisphenol A decreases methylationEXP 6480464bisphenol A results in decreased methylation of DOXL1 geneCTDPMID:28505145


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doxl1Ratamine metabolic process involved_inIEAInterPro:IPR000269 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Doxl1Ratamine metabolic process involved_inIEAUniRule:UR0000003261600115GO_REF:0000104UniProtGO_REF:0000104
Doxl1Ratputrescine metabolic process involved_inIBAPANTHER:PTN002578729 and UniProtKB:P198011600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doxl1Ratplasma membrane is_active_inIBAPANTHER:PTN000067340 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Doxl1Ratcopper ion binding enablesIBAPANTHER:PTN000067313 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Doxl1Ratcopper ion binding enablesIEAInterPro:IPR000269 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Doxl1Ratdiamine oxidase activity enablesIBAPANTHER:PTN002578729 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Doxl1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Doxl1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Doxl1Ratprimary methylamine oxidase activity enablesIBAPANTHER:PTN000067313 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Doxl1Ratprimary methylamine oxidase activity enablesIEAInterPro:IPR000269 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Doxl1Ratquinone binding enablesIEAInterPro:IPR000269 more ...1600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12930721  



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Variants in Doxl1
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000032300
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 58 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat

1 to 10 of 58 rows
UniSTS:234646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,882,805 - 77,883,013 (+)MAPPERmRatBN7.2
Rnor_6.0478,567,003 - 78,567,210NCBIRnor6.0
Rnor_5.04143,254,292 - 143,254,499UniSTSRnor5.0
RGSC_v3.4477,028,608 - 77,028,815UniSTSRGSC3.4
Celera472,819,294 - 72,819,501UniSTS
Cytogenetic Map4q24UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 1 28 17 22 6 11 6 2 29 16 23 2 15 16



Ensembl Acc Id: ENSRNOT00000032300   ⟹   ENSRNOP00000033821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,879,410 - 77,883,044 (+)Ensembl
Rnor_6.0 Ensembl478,563,625 - 78,567,241 (+)Ensembl
RefSeq Acc Id: NM_199233   ⟹   NP_954703
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,210,298 - 79,213,914 (+)NCBI
mRatBN7.2477,879,428 - 77,883,044 (+)NCBI
Rnor_6.0478,563,625 - 78,567,241 (+)NCBI
Rnor_5.04143,250,914 - 143,254,530 (+)NCBI
RGSC_v3.4477,025,230 - 77,028,846 (+)RGD
Celera472,815,916 - 72,819,532 (+)RGD
Sequence:
Protein RefSeqs NP_954703 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02038 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033821
  ENSRNOP00000033821.3
RefSeq Acc Id: NP_954703   ⟸   NM_199233
- Peptide Label: precursor
- UniProtKB: Q6IMK6 (UniProtKB/TrEMBL),   F7FN84 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033821   ⟸   ENSRNOT00000032300
Copper amine oxidase catalytic   Copper amine oxidase N2-terminal   Copper amine oxidase N3-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMK6-F1-model_v2 AlphaFold Q6IMK6 1-700 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-44932 BioCyc
Ensembl Genes ENSRNOG00000023612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032300 ENTREZGENE
  ENSRNOT00000032300.3 UniProtKB/TrEMBL
Gene3D-CATH 2.70.98.20 UniProtKB/TrEMBL
  3.10.450.40 UniProtKB/TrEMBL
InterPro Cu_amine_oxidase UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/TrEMBL
  Cu_amine_oxidase_N3 UniProtKB/TrEMBL
KEGG Report rno:312316 UniProtKB/TrEMBL
NCBI Gene 312316 ENTREZGENE
PANTHER AMINE OXIDASE UniProtKB/TrEMBL
  CuNH_oxidase UniProtKB/TrEMBL
Pfam Cu_amine_oxid UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/TrEMBL
  Cu_amine_oxidN3 UniProtKB/TrEMBL
PhenoGen Doxl1 PhenoGen
PRINTS CUDAOXIDASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023612 RatGTEx
Superfamily-SCOP Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  CuNH_oxidase UniProtKB/TrEMBL
UniProt F7FN84 ENTREZGENE, UniProtKB/TrEMBL
  Q6IMK6 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Doxl1  diamine oxidase-like protein 1  DOXL1    Symbol updated 1299863 APPROVED