Reg3a (regenerating islet-derived 3 alpha) - Rat Genome Database

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Gene: Reg3a (regenerating islet-derived 3 alpha) Rattus norvegicus
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Symbol: Reg3a
Name: regenerating islet-derived 3 alpha
RGD ID: 621401
Description: Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of keratinocyte differentiation; and positive regulation of keratinocyte proliferation. Predicted to be active in extracellular space. Used to study acute pancreatitis. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; Pap2; PapII; REG 3; reg III-alpha; REG-3-alpha; regenerating islet-derived protein 3 alpha; regenerating islet-derived protein 3-alpha; regenerating islet-derived protein III-alpha; regIII
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84112,430,397 - 112,433,163 (+)NCBIGRCr8
mRatBN7.24110,872,398 - 110,875,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,872,425 - 110,875,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,277,957 - 116,280,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04112,053,058 - 112,055,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04110,673,253 - 110,676,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04109,477,893 - 109,480,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,477,920 - 109,480,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,183,721 - 174,186,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,366,001 - 112,368,767 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,610,508 - 112,613,239 (+)NCBI
Celera499,904,353 - 99,907,119 (+)NCBICelera
Cytogenetic Map4q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis. Frigerio JM, etal., Biochemistry 1993 Sep 7;32(35):9236-41.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Structure and expression of a novel rat RegIII gene. Suzuki Y, etal., Gene 1994 Jul 8;144(2):315-6.
8. Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. Viterbo D, etal., JOP. 2009 Jan 8;10(1):15-23.
Additional References at PubMed
PMID:8889548   PMID:15100001   PMID:18437087   PMID:18641332   PMID:18641333   PMID:21926556   PMID:22727489   PMID:23303201   PMID:23370676   PMID:24465846   PMID:28415799  


Genomics

Comparative Map Data
Reg3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84112,430,397 - 112,433,163 (+)NCBIGRCr8
mRatBN7.24110,872,398 - 110,875,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,872,425 - 110,875,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,277,957 - 116,280,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04112,053,058 - 112,055,824 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04110,673,253 - 110,676,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04109,477,893 - 109,480,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,477,920 - 109,480,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,183,721 - 174,186,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,366,001 - 112,368,767 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,610,508 - 112,613,239 (+)NCBI
Celera499,904,353 - 99,907,119 (+)NCBICelera
Cytogenetic Map4q33NCBI
Reg3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,357,692 - 78,360,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl678,357,692 - 78,360,810 (+)EnsemblGRCm39 Ensembl
GRCm38678,380,709 - 78,383,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,380,709 - 78,383,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,330,703 - 78,333,833 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36678,310,218 - 78,313,348 (+)NCBIMGSCv36mm8
Celera680,403,904 - 80,407,034 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.76NCBI

Variants

.
Variants in Reg3a
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:19
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000008468
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 1 22 20 16 5 14 5 22 16 21 10 11

Sequence


Ensembl Acc Id: ENSRNOT00000008468   ⟹   ENSRNOP00000008468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4110,872,425 - 110,875,157 (+)Ensembl
Rnor_6.0 Ensembl4109,477,920 - 109,480,659 (+)Ensembl
RefSeq Acc Id: NM_001145846   ⟹   NP_001139318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84112,430,397 - 112,433,163 (+)NCBI
mRatBN7.24110,872,398 - 110,875,157 (+)NCBI
Rnor_6.04109,477,893 - 109,480,659 (+)NCBI
Rnor_5.04174,183,721 - 174,186,487 (+)NCBI
RGSC_v3.44112,366,001 - 112,368,767 (+)RGD
Celera499,904,353 - 99,907,119 (+)RGD
Sequence:
RefSeq Acc Id: NM_172077   ⟹   NP_742074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84112,430,424 - 112,433,163 (+)NCBI
mRatBN7.24110,872,425 - 110,875,157 (+)NCBI
Rnor_6.04109,477,920 - 109,480,659 (+)NCBI
Rnor_5.04174,183,721 - 174,186,487 (+)NCBI
RGSC_v3.44112,366,001 - 112,368,767 (+)RGD
Celera499,904,380 - 99,907,119 (+)NCBI
Sequence:
RefSeq Acc Id: NP_742074   ⟸   NM_172077
- Peptide Label: precursor
- UniProtKB: P35231 (UniProtKB/Swiss-Prot),   A0A0G2JSI6 (UniProtKB/TrEMBL),   A6IAG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139318   ⟸   NM_001145846
- Peptide Label: precursor
- UniProtKB: P35231 (UniProtKB/Swiss-Prot),   A0A0G2JSI6 (UniProtKB/TrEMBL),   A6IAG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008468   ⟸   ENSRNOT00000008468
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35231-F1-model_v2 AlphaFold P35231 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693154
Promoter ID:EPDNEW_R3678
Type:single initiation site
Name:Reg3a_1
Description:regenerating islet-derived 3 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04109,478,228 - 109,478,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621401 AgrOrtholog
BioCyc Gene G2FUF-44085 BioCyc
Ensembl Genes ENSRNOG00000006360 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008468.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin/snaclec_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171162 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171162 ENTREZGENE
PANTHER MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGENERATING ISLET-DERIVED PROTEIN 3-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg3a PhenoGen
PRINTS PNCREATITSAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006360 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSI6 ENTREZGENE, UniProtKB/TrEMBL
  A6IAG1 ENTREZGENE, UniProtKB/TrEMBL
  P35231 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-15 Reg3a  regenerating islet-derived 3 alpha  Pap2_mapped  pancreatitis-associated protein 2 (mapped)  Data merged from RGD:3255 1643240 APPROVED
2005-11-17 Pap2_mapped  pancreatitis-associated protein 2 (mapped)  Pap2  pancreatitis-associated protein 2  Symbol and Name updated 1556543 APPROVED
2004-09-10 Reg3a  regenerating islet-derived 3 alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Reg3a  regenerating islet-derived 3 alpha      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pap2  Pancreatitis-associated protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in regenerating pancreatic islets, but not in normal islets 633798
gene_transcript promoter region contains two glucocorticoid-response elements and one IL-6-response element 633799