Hyal6 (hyaluronoglucosaminidase 6) - Rat Genome Database

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Gene: Hyal6 (hyaluronoglucosaminidase 6) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hyal6
Name: hyaluronoglucosaminidase 6
RGD ID: 1564219
Description: Predicted to enable hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to be located in extracellular region and membrane. Predicted to be active in cytoplasmic vesicle; PARTICIPATES IN glycosaminoglycan degradation pathway; INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500051; similar to hyaluronoglucosaminidase 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,203,635 - 54,216,332 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,203,627 - 54,216,332 (+)EnsemblGRCr8
mRatBN7.2453,238,118 - 53,250,783 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,237,983 - 53,250,783 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,224,958 - 58,237,623 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0454,132,784 - 54,145,457 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,559,991 - 52,572,664 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0452,129,576 - 52,142,241 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl452,129,556 - 52,142,243 (+)Ensemblrn6Rnor6.0
Rnor_5.0451,898,504 - 51,911,206 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,212,495 - 51,225,160 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,401,639 - 48,414,304 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Hyal6
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:144
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000009435
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 2 2 13 8 6 3 3 3 1 21 7 10 6 30 3

Sequence


Ensembl Acc Id: ENSRNOT00000009435   ⟹   ENSRNOP00000009405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,203,667 - 54,216,332 (+)Ensembl
mRatBN7.2 Ensembl453,238,118 - 53,250,783 (+)Ensembl
Rnor_6.0 Ensembl452,129,556 - 52,142,243 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097887   ⟹   ENSRNOP00000079900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,203,627 - 54,216,332 (+)Ensembl
mRatBN7.2 Ensembl453,237,983 - 53,250,504 (+)Ensembl
RefSeq Acc Id: NM_001024320   ⟹   NP_001019491
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,203,667 - 54,216,332 (+)NCBI
mRatBN7.2453,238,118 - 53,250,783 (+)NCBI
Rnor_6.0452,129,576 - 52,142,241 (+)NCBI
Rnor_5.0451,898,504 - 51,911,206 (+)NCBI
RGSC_v3.4451,212,495 - 51,225,160 (+)RGD
Celera448,401,639 - 48,414,304 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108101   ⟹   XP_038964029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,203,635 - 54,216,332 (+)NCBI
mRatBN7.2453,238,124 - 53,250,712 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001019491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964029 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82016 (Get FASTA)   NCBI Sequence Viewer  
  EDM15177 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009405
  ENSRNOP00000009405.3
  ENSRNOP00000079900
  ENSRNOP00000079900.1
RefSeq Acc Id: NP_001019491   ⟸   NM_001024320
- Peptide Label: precursor
- UniProtKB: Q66H49 (UniProtKB/TrEMBL),   A6IE90 (UniProtKB/TrEMBL),   F7FE88 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009405   ⟸   ENSRNOT00000009435
RefSeq Acc Id: XP_038964029   ⟸   XM_039108101
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPI9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079900   ⟸   ENSRNOT00000097887

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H49-F1-model_v2 AlphaFold Q66H49 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692910
Promoter ID:EPDNEW_R3434
Type:multiple initiation site
Name:Hyal6_1
Description:hyaluronoglucosaminidase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0452,129,588 - 52,129,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564219 AgrOrtholog
BioCyc Gene G2FUF-45475 BioCyc
Ensembl Genes ENSRNOG00000021695 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009435 ENTREZGENE
  ENSRNOT00000009435.6 UniProtKB/TrEMBL
  ENSRNOT00000097887 ENTREZGENE
  ENSRNOT00000097887.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132110 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/TrEMBL
KEGG Report rno:500051 UniProtKB/TrEMBL
MGC_CLONE MGC:94293 IMAGE-MGC_LOAD
NCBI Gene 500051 ENTREZGENE
PANTHER Glyco_hydro_56 UniProtKB/TrEMBL
  HYALURONIDASE UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/TrEMBL
PhenoGen Hyal6 PhenoGen
PIRSF Hyaluronidase UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021695 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
UniProt A0A8I5ZPI9 ENTREZGENE, UniProtKB/TrEMBL
  A6IE90 ENTREZGENE, UniProtKB/TrEMBL
  F7FE88 ENTREZGENE, UniProtKB/TrEMBL
  Q66H49 ENTREZGENE
UniProt Secondary Q66H49 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-19 Hyal6  hyaluronoglucosaminidase 6  LOC500051  similar to hyaluronoglucosaminidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500051  similar to hyaluronoglucosaminidase 2      Symbol and Name status set to provisional 70820 PROVISIONAL