Grm8 (glutamate metabotropic receptor 8) - Rat Genome Database
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Gene: Grm8 (glutamate metabotropic receptor 8) Rattus norvegicus
Analyze
Symbol: Grm8
Name: glutamate metabotropic receptor 8
RGD ID: 619858
Description: Exhibits group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of presynaptic active zone membrane. Used to study epilepsy and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; Glur8; glutamate receptor, metabotropic 8; Gprc1h; metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; mGlur; Mglur8; mGluR8b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WI-Grm8em1Geh  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2455,805,762 - 56,731,690 (-)NCBI
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Corti C, etal., Eur J Neurosci 1998 Dec;10(12):3629-41.
2. Duvoisin RM, etal., Eur J Neurosci. 2005 Jul;22(2):425-36.
3. Elia J, etal., Nat Genet. 2011 Dec 4;44(1):78-84. doi: 10.1038/ng.1013.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Geurts JJ, etal., J Neuroimmunol. 2005 Jan;158(1-2):182-90.
6. Jiang FL, etal., Epilepsia. 2007 Apr;48(4):783-92. Epub 2007 Mar 13.
7. Johnson KA, etal., Neuropharmacology. 2012 Apr 21.
8. Marabese I, etal., Neuropharmacology. 2005;49 Suppl 1:157-66. Epub 2005 Apr 1.
9. Marabese I, etal., Neuropharmacology. 2007 Feb;52(2):253-62. Epub 2006 Nov 17.
10. MGD data from the GO Consortium
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Palazzo E, etal., Neuropharmacology. 2008 Sep;55(4):537-45. Epub 2008 May 16.
13. Pamidimukkala J, etal., Brain Res 2002 Dec 6;957(1):162-73.
14. Panatier A, etal., Neuropharmacology. 2004 Sep;47(3):333-41.
15. Paulose CS, etal., Neurochem Res. 2008 Sep;33(9):1663-71. Epub 2007 Oct 18.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Robbins MJ, etal., Brain Res. 2007 Jun 4;1152:215-27. Epub 2007 Mar 15.
21. Schoepp DD J Pharmacol Exp Ther. 2001 Oct;299(1):12-20.
22. Serajee FJ, etal., J Med Genet 2003 Apr;40(4):e42.
23. Shigemoto R, etal., J Neurosci. 1997 Oct 1;17(19):7503-22.
24. Takaki H, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):6-14.
25. Tong Q and Kirchgessner AL, Am J Physiol Gastrointest Liver Physiol 2003 Nov;285(5):G992-G1003. Epub 2003 Jun 26.
Additional References at PubMed
PMID:7722646   PMID:9016353   PMID:9473604   PMID:11122333   PMID:11166323   PMID:11943148   PMID:16144832   PMID:18255232   PMID:18555800   PMID:20824730   PMID:21288202   PMID:21903594  
PMID:22617702   PMID:24304862   PMID:24495291   PMID:27497709   PMID:29588465   PMID:32016558  


Genomics

Comparative Map Data
Grm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2455,805,762 - 56,731,690 (-)NCBI
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
GRM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7126,438,598 - 127,253,294 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7126,438,598 - 127,253,093 (-)EnsemblGRCh38hg38GRCh38
GRCh387126,438,598 - 127,252,941 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377126,078,652 - 126,892,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367125,865,895 - 126,670,548 (-)NCBINCBI36hg18NCBI36
Build 347125,672,607 - 126,477,261NCBI
Celera7120,880,032 - 121,693,753 (-)NCBI
Cytogenetic Map7q31.33NCBI
HuRef7120,438,961 - 121,253,104 (-)NCBIHuRef
CHM1_17126,006,512 - 126,825,737 (-)NCBICHM1_1
CRA_TCAGchr7v27125,461,722 - 126,275,858 (-)NCBI
Grm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39627,275,120 - 28,135,393 (-)NCBIGRCm39mm39
GRCm39 Ensembl627,275,118 - 28,135,177 (-)Ensembl
GRCm38627,275,121 - 28,135,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl627,275,119 - 28,135,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv37627,225,121 - 28,084,369 (-)NCBIGRCm37mm9NCBIm37
MGSCv36627,225,622 - 28,076,205 (-)NCBImm8
Celera627,279,039 - 28,140,610 (-)NCBICelera
Cytogenetic Map6A3.1- A3.2NCBI
Grm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554797,520,396 - 8,279,755 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554797,520,537 - 8,279,942 (-)NCBIChiLan1.0ChiLan1.0
GRM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17131,117,218 - 131,279,815 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v07118,430,086 - 119,249,147 (-)NCBIMhudiblu_PPA_v0panPan3
GRM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,982,180 - 9,719,813 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,983,802 - 9,719,357 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha148,674,889 - 9,411,322 (+)NCBI
ROS_Cfam_1.0148,755,752 - 9,493,366 (+)NCBI
UMICH_Zoey_3.1148,959,856 - 9,691,012 (+)NCBI
UNSW_CanFamBas_1.0148,694,372 - 9,425,060 (+)NCBI
UU_Cfam_GSD_1.0148,848,168 - 9,585,209 (+)NCBI
Grm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440511852,645,795 - 53,387,066 (-)NCBI
SpeTri2.0NW_00493647913,768,014 - 14,504,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,950,532 - 21,758,170 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,945,049 - 21,756,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21822,609,857 - 23,086,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12195,264,905 - 96,060,822 (-)NCBI
ChlSab1.1 Ensembl2195,264,765 - 96,050,554 (-)Ensembl
Grm8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247838,727,563 - 9,611,933 (+)NCBI

Position Markers
D4Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0455,324,857 - 55,324,953NCBIRnor6.0
Rnor_5.0455,067,578 - 55,067,674UniSTSRnor5.0
RGSC_v3.4454,828,069 - 54,828,166RGDRGSC3.4
RGSC_v3.4454,828,070 - 54,828,166UniSTSRGSC3.4
Celera451,764,933 - 51,765,029UniSTS
RH 3.4 Map4295.8UniSTS
RH 3.4 Map4295.8RGD
Cytogenetic Map4q22UniSTS
D4Mgh15  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0455,375,865 - 55,376,001NCBIRnor6.0
Rnor_5.0455,118,586 - 55,118,722UniSTSRnor5.0
RGSC_v3.4454,879,077 - 54,879,214RGDRGSC3.4
RGSC_v3.4454,879,078 - 54,879,214UniSTSRGSC3.4
RGSC_v3.1455,129,235 - 55,129,371RGD
Celera451,815,819 - 51,815,955UniSTS
RH 3.4 Map4301.72UniSTS
RH 3.4 Map4301.72RGD
Cytogenetic Map4q22UniSTS
D4Got33  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0454,811,204 - 54,811,365NCBIRnor6.0
Rnor_5.0454,564,066 - 54,564,227UniSTSRnor5.0
RGSC_v3.4454,323,273 - 54,323,435RGDRGSC3.4
RGSC_v3.4454,323,274 - 54,323,435UniSTSRGSC3.4
RGSC_v3.1454,556,175 - 54,556,336RGD
Celera451,269,475 - 51,269,636UniSTS
RH 3.4 Map4281.51UniSTS
RH 3.4 Map4281.51RGD
Cytogenetic Map4q22UniSTS
D4Got303  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0454,483,127 - 54,483,271NCBIRnor6.0
Rnor_5.0454,237,536 - 54,237,680UniSTSRnor5.0
RGSC_v3.4453,985,245 - 53,985,389UniSTSRGSC3.4
Celera450,944,747 - 50,944,891UniSTS
Cytogenetic Map4q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4304323179575658Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)43043231145254791Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401755791834Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304401764915903Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4304780755324857Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)4734240492484039Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41263897457638974Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41614994161149941Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)41822218761039065Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42399172176238799Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42399172176238799Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)42463187469631874Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42665474981874227Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)429549895112807890Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43182556083531021Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43182556083531021Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)43363780361708341Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43427793299067150Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)436615599145611886Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43768517573066691Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43770327275345433Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)437703272115372927Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)43920822284208222Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)43920824784208247Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44241577787415777Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)443414792146942075Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)443414792146942075Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)446898276145611886Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44768569455791834Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44768569455791834Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44768569455791834Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)449906054145611886Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45532485779575658Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45532485779575658Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45532485779575658Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45532485779575658Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)455324953148360954Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)455375865125671711Rat


Related Rat Strains
The following Strains have been annotated to Grm8

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000056996
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28
Low 7 8 42 19 25 7
Below cutoff 12 12 4 9 4 1 3 4 16 16 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000031714   ⟹   ENSRNOP00000035953
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000056996   ⟹   ENSRNOP00000053829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl454,474,666 - 55,011,415 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075324   ⟹   ENSRNOP00000067084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl455,398,076 - 55,398,941 (-)Ensembl
RefSeq Acc Id: NM_022202   ⟹   NP_071538
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,806,289 - 56,722,044 (-)NCBI
Rnor_6.0454,474,663 - 55,399,118 (-)NCBI
Rnor_5.0454,226,315 - 55,151,544 (-)NCBI
RGSC_v3.4453,976,781 - 54,902,331 (-)RGD
Celera450,936,284 - 51,838,440 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592855   ⟹   XP_017448344
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,805,762 - 56,731,690 (-)NCBI
Rnor_6.0454,474,344 - 55,409,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592856   ⟹   XP_017448345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,805,762 - 56,730,958 (-)NCBI
Rnor_6.0454,474,344 - 55,408,073 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592857   ⟹   XP_017448346
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,805,762 - 56,721,978 (-)NCBI
Rnor_6.0454,474,344 - 55,409,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592858   ⟹   XP_017448347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0454,474,344 - 55,407,345 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592859   ⟹   XP_017448348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,805,762 - 56,730,308 (-)NCBI
Rnor_6.0454,474,344 - 55,407,365 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108304   ⟹   XP_038964232
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2455,805,762 - 56,412,668 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071538   ⟸   NM_022202
- Peptide Label: precursor
- UniProtKB: P70579 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448346   ⟸   XM_017592857
- Peptide Label: isoform X2
- UniProtKB: F1LRA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448344   ⟸   XM_017592855
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448345   ⟸   XM_017592856
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448348   ⟸   XM_017592859
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448347   ⟸   XM_017592858
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000035953   ⟸   ENSRNOT00000031714
RefSeq Acc Id: ENSRNOP00000067084   ⟸   ENSRNOT00000075324
RefSeq Acc Id: ENSRNOP00000053829   ⟸   ENSRNOT00000056996
RefSeq Acc Id: XP_038964232   ⟸   XM_039108304
- Peptide Label: isoform X3
Protein Domains
ANF_receptor   G_PROTEIN_RECEP_F3_4

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619858 AgrOrtholog
Ensembl Genes ENSRNOG00000021468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000035953 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000053829 UniProtKB/TrEMBL
  ENSRNOP00000067084 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031714 UniProtKB/TrEMBL
  ENSRNOT00000056996 UniProtKB/TrEMBL
  ENSRNOT00000075324 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60590 UniProtKB/Swiss-Prot
NCBI Gene 60590 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm8 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC8R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LRA6 ENTREZGENE, UniProtKB/TrEMBL
  F1LWV8_RAT UniProtKB/TrEMBL
  GRM8_RAT UniProtKB/Swiss-Prot
  M0RBY2_RAT UniProtKB/TrEMBL
  P70579 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Grm8  glutamate metabotropic receptor 8  Grm8  glutamate receptor, metabotropic 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Grm8  glutamate receptor, metabotropic 8    metabotropic glutamate receptor 8  Name updated 1299863 APPROVED
2003-10-06 Grm8  metabotropic glutamate receptor 8  Gprc1h  G protein-coupled receptor, family C, group 1, member H  Data Merged 628472 PROVISIONAL
2002-08-07 Gprc1h  G protein-coupled receptor, family C, group 1, member H      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Grm8  metabotropic glutamate receptor 8      Symbol and Name status set to provisional 70820 PROVISIONAL