Gene: Grm8 (glutamate metabotropic receptor 8) Rattus norvegicus
Symbol: Grm8
Name: glutamate metabotropic receptor 8
Description: Exhibits group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including the GABA-ergic synapse; glutamatergic synapse; and integral component of presynaptic active zone membrane. Used to study epilepsy and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; Glur8; glutamate receptor, metabotropic 8; Gprc1h; metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; mGlur; Mglur8; mGluR8b
Homo sapiens (human) : GRM8 (glutamate metabotropic receptor 8)  HGNC  Alliance
Mus musculus (house mouse) : Grm8 (glutamate receptor, metabotropic 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm8 (glutamate metabotropic receptor 8)
Canis lupus familiaris (dog) : GRM8 (glutamate metabotropic receptor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm8 (glutamate metabotropic receptor 8)
Sus scrofa (pig) : GRM8 (glutamate metabotropic receptor 8)
more info ...
Is Marker For: Strains:   WI-Grm8em1Geh  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Grm8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619858
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.