Grm8 (glutamate metabotropic receptor 8) - Rat Genome Database

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Gene: Grm8 (glutamate metabotropic receptor 8) Rattus norvegicus
Analyze
Symbol: Grm8
Name: glutamate metabotropic receptor 8
RGD ID: 619858
Description: Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and modulation of chemical synaptic transmission. Located in neuronal cell body and presynaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Used to study Parkinsonism; epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; Glur8; glutamate receptor, metabotropic 8; Gprc1h; metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; mGlur; Mglur8; mGluR8b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WI-Grm8em1Geh  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8456,771,247 - 57,696,951 (-)NCBIGRCr8
mRatBN7.2455,805,762 - 56,731,690 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl455,805,955 - 56,730,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx460,819,360 - 61,708,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0456,732,953 - 57,628,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0455,137,420 - 56,026,090 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. Corti C, etal., Eur J Neurosci 1998 Dec;10(12):3629-41.
2. Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. Duvoisin RM, etal., Eur J Neurosci. 2005 Jul;22(2):425-36.
3. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Elia J, etal., Nat Genet. 2011 Dec 4;44(1):78-84. doi: 10.1038/ng.1013.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions. Geurts JJ, etal., J Neuroimmunol. 2005 Jan;158(1-2):182-90.
6. Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. Jiang FL, etal., Epilepsia. 2007 Apr;48(4):783-92. Epub 2007 Mar 13.
7. The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease. Johnson KA, etal., Neuropharmacology. 2012 Apr 21.
8. Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults. Long EC, etal., J Stud Alcohol Drugs. 2015 May;76(3):414-8.
9. Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level. Marabese I, etal., Neuropharmacology. 2005;49 Suppl 1:157-66. Epub 2005 Apr 1.
10. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Marabese I, etal., Neuropharmacology. 2007 Feb;52(2):253-62. Epub 2006 Nov 17.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors. Palazzo E, etal., Neuropharmacology. 2008 Sep;55(4):537-45. Epub 2008 May 16.
14. Expression of metabotropic glutamate receptor 8 in autonomic cell groups of the medulla oblongata of the rat. Pamidimukkala J, etal., Brain Res 2002 Dec 6;957(1):162-73.
15. Regulation of transmitter release by high-affinity group III mGluRs in the supraoptic nucleus of the rat hypothalamus. Panatier A, etal., Neuropharmacology. 2004 Sep;47(3):333-41.
16. Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression. Paulose CS, etal., Neurochem Res. 2008 Sep;33(9):1663-71. Epub 2007 Oct 18.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia. Robbins MJ, etal., Brain Res. 2007 Jun 4;1152:215-27. Epub 2007 Mar 15.
22. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. Schoepp DD J Pharmacol Exp Ther. 2001 Oct;299(1):12-20.
23. The metabotropic glutamate receptor 8 gene at 7q31: partial duplication and possible association with autism. Serajee FJ, etal., J Med Genet 2003 Apr;40(4):e42.
24. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. Shigemoto R, etal., J Neurosci. 1997 Oct 1;17(19):7503-22.
25. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. Takaki H, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):6-14.
26. Localization and function of metabotropic glutamate receptor 8 in the enteric nervous system. Tong Q and Kirchgessner AL, Am J Physiol Gastrointest Liver Physiol 2003 Nov;285(5):G992-G1003. Epub 2003 Jun 26.
Additional References at PubMed
PMID:7722646   PMID:9016353   PMID:9473604   PMID:11122333   PMID:11166323   PMID:11943148   PMID:16144832   PMID:18255232   PMID:18555800   PMID:20824730   PMID:21288202   PMID:21903594  
PMID:22617702   PMID:24304862   PMID:24495291   PMID:27497709   PMID:29588465   PMID:32016558   PMID:38419440  


Genomics

Comparative Map Data
Grm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8456,771,247 - 57,696,951 (-)NCBIGRCr8
mRatBN7.2455,805,762 - 56,731,690 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl455,805,955 - 56,730,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx460,819,360 - 61,708,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0456,732,953 - 57,628,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0455,137,420 - 56,026,090 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
GRM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387126,438,598 - 127,252,941 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7126,438,598 - 127,253,093 (-)EnsemblGRCh38hg38GRCh38
GRCh377126,078,652 - 126,892,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367125,865,895 - 126,670,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 347125,672,607 - 126,477,261NCBI
Celera7120,880,032 - 121,693,753 (-)NCBICelera
Cytogenetic Map7q31.33NCBI
HuRef7120,438,961 - 121,253,104 (-)NCBIHuRef
CHM1_17126,006,512 - 126,825,737 (-)NCBICHM1_1
T2T-CHM13v2.07127,750,296 - 128,564,614 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27125,461,722 - 126,275,858 (-)NCBI
Grm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39627,275,120 - 28,135,094 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl627,275,118 - 28,135,177 (-)EnsemblGRCm39 Ensembl
GRCm38627,275,121 - 28,135,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl627,275,119 - 28,135,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv37627,225,121 - 28,084,369 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36627,225,622 - 28,076,205 (-)NCBIMGSCv36mm8
Celera627,279,039 - 28,140,610 (-)NCBICelera
Cytogenetic Map6A3.1- A3.2NCBI
cM Map611.97NCBI
Grm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554797,520,396 - 8,279,755 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554797,520,537 - 8,279,942 (-)NCBIChiLan1.0ChiLan1.0
GRM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26163,292,442 - 164,111,133 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1715,302,692 - 16,121,384 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07118,430,086 - 119,249,147 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17131,117,218 - 131,279,815 (-)NCBIpanpan1.1PanPan1.1panPan2
GRM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,982,180 - 9,719,813 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,983,802 - 9,719,357 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha148,674,889 - 9,411,322 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,755,752 - 9,493,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,755,412 - 9,493,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,959,856 - 9,691,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,694,372 - 9,425,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,848,168 - 9,585,209 (+)NCBIUU_Cfam_GSD_1.0
Grm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511852,645,795 - 53,387,066 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647913,770,088 - 14,494,569 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647913,768,014 - 14,504,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,951,003 - 21,758,568 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,945,049 - 21,756,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21822,609,857 - 23,086,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12195,264,905 - 96,060,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2195,264,765 - 96,050,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660427,346,560 - 8,165,387 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247838,737,463 - 9,611,475 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247838,727,563 - 9,611,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grm8
4788 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000056996
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat

Markers in Region
D4Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2456,647,776 - 56,647,873 (+)MAPPERmRatBN7.2
Rnor_6.0455,324,857 - 55,324,953NCBIRnor6.0
Rnor_5.0455,067,578 - 55,067,674UniSTSRnor5.0
RGSC_v3.4454,828,069 - 54,828,166RGDRGSC3.4
RGSC_v3.4454,828,070 - 54,828,166UniSTSRGSC3.4
Celera451,764,933 - 51,765,029UniSTS
RH 3.4 Map4295.8RGD
RH 3.4 Map4295.8UniSTS
Cytogenetic Map4q22UniSTS
D4Mgh15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2456,698,790 - 56,698,927 (+)MAPPERmRatBN7.2
Rnor_6.0455,375,865 - 55,376,001NCBIRnor6.0
Rnor_5.0455,118,586 - 55,118,722UniSTSRnor5.0
RGSC_v3.4454,879,077 - 54,879,214RGDRGSC3.4
RGSC_v3.4454,879,078 - 54,879,214UniSTSRGSC3.4
RGSC_v3.1455,129,235 - 55,129,371RGD
Celera451,815,819 - 51,815,955UniSTS
RH 3.4 Map4301.72UniSTS
RH 3.4 Map4301.72RGD
Cytogenetic Map4q22UniSTS
D4Got33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2456,142,861 - 56,143,023 (+)MAPPERmRatBN7.2
Rnor_6.0454,811,204 - 54,811,365NCBIRnor6.0
Rnor_5.0454,564,066 - 54,564,227UniSTSRnor5.0
RGSC_v3.4454,323,273 - 54,323,435RGDRGSC3.4
RGSC_v3.4454,323,274 - 54,323,435UniSTSRGSC3.4
RGSC_v3.1454,556,175 - 54,556,336RGD
Celera451,269,475 - 51,269,636UniSTS
RH 3.4 Map4281.51RGD
RH 3.4 Map4281.51UniSTS
Cytogenetic Map4q22UniSTS
D4Got303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2455,814,752 - 55,814,897 (+)MAPPERmRatBN7.2
Rnor_6.0454,483,127 - 54,483,271NCBIRnor6.0
Rnor_5.0454,237,536 - 54,237,680UniSTSRnor5.0
RGSC_v3.4453,985,245 - 53,985,389UniSTSRGSC3.4
Celera450,944,747 - 50,944,891UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Grm8


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28
Low 7 8 42 19 25 7
Below cutoff 12 12 4 9 4 1 3 4 16 16 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC095281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000031714   ⟹   ENSRNOP00000035953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl455,805,955 - 56,730,831 (-)Ensembl
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000056996   ⟹   ENSRNOP00000053829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl454,474,666 - 55,011,415 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075324   ⟹   ENSRNOP00000067084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl455,398,076 - 55,398,941 (-)Ensembl
RefSeq Acc Id: NM_022202   ⟹   NP_071538
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8456,771,772 - 57,687,506 (-)NCBI
mRatBN7.2455,806,289 - 56,722,044 (-)NCBI
Rnor_6.0454,474,663 - 55,399,118 (-)NCBI
Rnor_5.0454,226,315 - 55,151,544 (-)NCBI
RGSC_v3.4453,976,781 - 54,902,331 (-)RGD
Celera450,936,284 - 51,838,440 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592855   ⟹   XP_017448344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8456,771,247 - 57,696,951 (-)NCBI
mRatBN7.2455,805,762 - 56,731,690 (-)NCBI
Rnor_6.0454,474,344 - 55,409,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592856   ⟹   XP_017448345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8456,771,247 - 57,696,387 (-)NCBI
mRatBN7.2455,805,762 - 56,730,958 (-)NCBI
Rnor_6.0454,474,344 - 55,408,073 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592857   ⟹   XP_017448346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8456,771,247 - 57,696,388 (-)NCBI
mRatBN7.2455,805,762 - 56,721,978 (-)NCBI
Rnor_6.0454,474,344 - 55,409,526 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592859   ⟹   XP_017448348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8456,771,247 - 57,695,775 (-)NCBI
mRatBN7.2455,805,762 - 56,730,308 (-)NCBI
Rnor_6.0454,474,344 - 55,407,365 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071538   ⟸   NM_022202
- Peptide Label: precursor
- UniProtKB: P70579 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448346   ⟸   XM_017592857
- Peptide Label: isoform X2
- UniProtKB: F1LRA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448344   ⟸   XM_017592855
- Peptide Label: isoform X1
- UniProtKB: F1LRA6 (UniProtKB/TrEMBL),   A6IEA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448345   ⟸   XM_017592856
- Peptide Label: isoform X1
- UniProtKB: F1LRA6 (UniProtKB/TrEMBL),   A6IEA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448348   ⟸   XM_017592859
- Peptide Label: isoform X1
- UniProtKB: F1LRA6 (UniProtKB/TrEMBL),   A6IEA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035953   ⟸   ENSRNOT00000031714
RefSeq Acc Id: ENSRNOP00000067084   ⟸   ENSRNOT00000075324
RefSeq Acc Id: ENSRNOP00000053829   ⟸   ENSRNOT00000056996
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70579-F1-model_v2 AlphaFold P70579 1-908 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619858 AgrOrtholog
BioCyc Gene G2FUF-45434 BioCyc
Ensembl Genes ENSRNOG00000021468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031714.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60590 UniProtKB/Swiss-Prot
NCBI Gene 60590 ENTREZGENE
PANTHER METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METABOTROPIC GLUTAMATE RECEPTOR 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm8 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC8R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021468 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IEA2_RAT UniProtKB/TrEMBL
  A6IEA3 ENTREZGENE, UniProtKB/TrEMBL
  F1LRA6 ENTREZGENE, UniProtKB/TrEMBL
  GRM8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Grm8  glutamate metabotropic receptor 8  Grm8  glutamate receptor, metabotropic 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Grm8  glutamate receptor, metabotropic 8    metabotropic glutamate receptor 8  Name updated 1299863 APPROVED
2003-10-06 Grm8  metabotropic glutamate receptor 8  Gprc1h  G protein-coupled receptor, family C, group 1, member H  Data merged from RGD:620508 628472 PROVISIONAL
2002-08-07 Gprc1h  G protein-coupled receptor, family C, group 1, member H      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Grm8  metabotropic glutamate receptor 8      Symbol and Name status set to provisional 70820 PROVISIONAL