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Gene: Mkln1 (muskelin 1) Rattus norvegicus

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Symbol:

Mkln1

Name:

muskelin 1

RGD ID:

620076

Description:

Enables protein homodimerization activity. Involved in regulation of receptor internalization. Located in cytosol. Orthologous to human MKLN1 (muskelin 1); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC103690249; muskelin; muskelin 1, intracellular mediator containing kelch motifs; uncharacterized LOC103690249

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MKLN1 (muskelin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MKLN1 (muskelin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mkln1 (muskelin 1, intracellular mediator containing kelch motifs)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	muskelin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mkln1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mkln1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	60,937,817 - 61,095,210 (+)	Ensembl				GRCr8
mRatBN7.2	4	59,815,912 - 60,124,047 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	60,002,464 - 60,123,993 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	64,972,547 - 65,093,857 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	60,888,753 - 61,009,664 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	59,290,700 - 59,412,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	55,092,934 - 55,213,778 (+)	NCBI		Celera
RGSC_v3.1	4	58,751,831 - 58,876,900 (+)	NCBI
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acrodermatitis (ISO)

Lung Injury (ISO)

pleomorphic xanthoastrocytoma (ISO)

pulmonary fibrosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (ISO)

Bufotalin (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cylindrospermopsin (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

diquat (ISO)

dorsomorphin (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP)

glafenine (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

paraquat (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propanal (ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

torcetrapib (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO,ISS)

cell-matrix adhesion (IEA,ISO,ISS)

neurotransmitter receptor transport postsynaptic membrane to endosome (IEA,ISO)

regulation of cell shape (IEA,ISO,ISS)

regulation of receptor internalization (IMP)

vesicle-mediated transport in synapse (IEA,ISO)

Cellular Component

cell cortex (IEA,ISO,ISS)

cell projection (IEA)

cytoplasm (IBA,IEA,ISO)

cytosol (IDA,IEA,ISO,ISS)

GABA-ergic synapse (IEA,ISO)

nucleoplasm (IEA,ISO)

postsynapse (IEA)

postsynaptic endosome membrane (IEA,ISO)

postsynaptic specialization membrane of symmetric synapse (IEA,ISO)

ruffle (IEA,ISO,ISS)

synapse (IEA)

ubiquitin ligase complex (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH.	Adams JC and Zhang L, Cytogenet Cell Genet 1999;87(1-2):19-21.
2.	The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.	Delto CF, etal., Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9724633	PMID:11006128	PMID:17467196	PMID:18710924	PMID:21586270	PMID:29911972

Genomics

Comparative Map Data

Mkln1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	60,937,817 - 61,095,210 (+)	Ensembl				GRCr8
mRatBN7.2	4	59,815,912 - 60,124,047 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	60,002,464 - 60,123,993 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	64,972,547 - 65,093,857 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	60,888,753 - 61,009,664 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	59,290,700 - 59,412,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	55,092,934 - 55,213,778 (+)	NCBI		Celera
RGSC_v3.1	4	58,751,831 - 58,876,900 (+)	NCBI
Cytogenetic Map	4	q22	NCBI

MKLN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	131,110,094 - 131,496,632 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	131,110,096 - 131,496,632 (+)	Ensembl			hg38	GRCh38
GRCh37	7	130,794,853 - 131,181,391 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	130,663,175 - 130,831,931 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	130,469,892 - 130,638,645	NCBI
Celera	7	125,545,899 - 125,932,352 (+)	NCBI		Celera
Cytogenetic Map	7	q32.3	NCBI
HuRef	7	125,110,633 - 125,497,059 (+)	NCBI		HuRef
CHM1_1	7	130,728,553 - 131,115,275 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	132,427,607 - 132,814,224 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	130,134,571 - 130,521,037 (+)	NCBI

Mkln1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	31,333,833 - 31,493,744 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	31,375,670 - 31,493,746 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	31,398,828 - 31,516,809 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	31,398,735 - 31,516,811 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	31,348,828 - 31,459,482 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	31,329,008 - 31,439,645 (+)	NCBI		MGSCv36	mm8
Celera	6	31,385,689 - 31,497,090 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	12.57	NCBI

Mkln1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	36,251,987 - 36,542,802 (-)	Ensembl
ChiLan1.0	NW_004955410	36,251,987 - 36,568,537 (-)	NCBI	ChiLan1.0	ChiLan1.0

MKLN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	167,930,262 - 168,320,858 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	19,940,570 - 20,331,104 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	123,075,319 - 123,463,509 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	135,806,585 - 135,976,926 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	135,806,585 - 135,968,032 (+)	Ensembl			panPan2	panpan1.1

MKLN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	5,636,148 - 5,799,882 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	5,636,162 - 5,799,833 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	5,298,099 - 5,625,705 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	5,374,406 - 5,699,541 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	5,371,337 - 5,699,433 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	5,577,443 - 5,905,031 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	5,322,616 - 5,650,615 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	5,465,309 - 5,793,416 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mkln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	23,841,621 - 24,179,321 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936579	3,982,296 - 4,150,063 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936579	3,982,296 - 4,150,071 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MKLN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	17,501,857 - 17,832,503 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	17,493,806 - 17,832,519 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	18,593,094 - 18,776,077 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MKLN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	99,952,000 - 100,123,380 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	100,007,890 - 100,123,139 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	3,255,971 - 3,434,499 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mkln1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	4,900,654 - 5,074,740 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624783	4,891,874 - 5,074,769 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Mkln1
1086 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	31
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000016633
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	59753119	104753119	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	57613242	102613242	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	40490442	75726188	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58079875	82597589	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58817672	103817672	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58080146	80212111	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	18900697	63900697	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	59836842	104836842	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	61041057	94638356	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	40471453	75939996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	22288453	63245191	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	18900697	63900697	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	18913151	63913151	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	27862204	62997402	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	51085655	113588029	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58079875	92690793	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	57613242	102613242	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	57613242	102613242	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	59603319	80216952	Rat

Markers in Region

D4Rat23

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	61,041,057 - 61,041,206 (+)	Marker Load Pipeline
Rnor_5.0	4	58,518,430 - 58,518,579	NCBI	Rnor5.0
Rnor_5.0	4	58,518,376 - 58,518,669	NCBI	Rnor5.0
RGSC_v3.4	4	58,550,170 - 58,550,462	RGD	RGSC3.4
RGSC_v3.4	4	58,550,224 - 58,550,372	UniSTS	RGSC3.4
Celera	4	55,163,661 - 55,163,809	UniSTS
RGSC_v3.1	4	58,826,300 - 58,826,592	RGD
RH 3.4 Map	4	354.6	RGD
RH 3.4 Map	4	354.6	UniSTS
RH 2.0 Map	4	381.6	RGD
SHRSP x BN Map	4	32.83	RGD
Cytogenetic Map	4	q22	UniSTS

RH128619

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	60,123,707 - 60,123,926 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	58,817,642 - 58,817,860	NCBI	Rnor6.0
Rnor_5.0	4	58,570,114 - 58,570,332	UniSTS	Rnor5.0
RGSC_v3.4	4	58,600,488 - 58,600,706	UniSTS	RGSC3.4
Celera	4	55,213,496 - 55,213,714	UniSTS
RH 3.4 Map	4	347.93	UniSTS
Cytogenetic Map	4	q22	UniSTS

AU047206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	60,017,354 - 60,017,509 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	58,708,239 - 58,708,393	NCBI	Rnor6.0
Rnor_5.0	4	58,463,008 - 58,463,162	UniSTS	Rnor5.0
RGSC_v3.4	4	58,490,561 - 58,490,715	UniSTS	RGSC3.4
Celera	4	55,107,789 - 55,107,943	UniSTS
Cytogenetic Map	4	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001428641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428642	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB046442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081707 ⟹ ENSRNOP00000075084

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	60,945,875 - 61,095,210 (+)	Ensembl
mRatBN7.2 Ensembl	4	60,002,464 - 60,123,993 (+)	Ensembl
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111994 ⟹ ENSRNOP00000078385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	60,938,243 - 61,095,210 (+)	Ensembl
mRatBN7.2 Ensembl	4	60,002,489 - 60,123,986 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113146 ⟹ ENSRNOP00000077228

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	60,970,110 - 61,091,297 (+)	Ensembl
mRatBN7.2 Ensembl	4	60,002,882 - 60,123,993 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120594 ⟹ ENSRNOP00000098233

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	60,938,243 - 61,095,210 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163527 ⟹ ENSRNOP00000103896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	60,937,817 - 61,095,210 (+)	Ensembl

RefSeq Acc Id:

NM_031359 ⟹ NP_112649

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,969,818 - 61,091,300 (+)	NCBI
mRatBN7.2	4	60,002,498 - 60,123,990 (+)	NCBI
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	RGD
Celera	4	55,092,934 - 55,213,778 (+)	RGD

Sequence:

show sequence

ATGGCGGCTGGCGGGGCTGTTGCTGCGGCGCCCGAGTGCCGGCTTCTGCCCTACGCGCTGCATA
AGTGGAGCTCCTTCTCCTCCACCTACCTTCCCGAGAACATTTTAGTGGATAAACCAAATGATCA
GTCTTCCAGATGGTCTTCAGAGAGCAACTATCCTCCCCAGTACTTGATTCTGAAGCTTGAAAGG
CCTGCTATAGTTCAGAATATTACATTTGGAAAATATGAGAAAACTCATGTCTGCAATTTGAAGA
AATTCAAAGTTTTCGGTGGAATGAATGAAGAAAATATGACAGAGCTGCTGTCCAGCGGCTTGAA
GAATGATTATAACAAAGAGACATTTACCTTGAAACATAAAATTGATGAACAGATGTTCCCTTGT
CGATTCATTAAAATTGTTCCACTTTTGTCCTGGGGGCCCAGCTTTAATTTTAGCATCTGGTATG
TTGAACTCAGTGGCATTGATGATCCTGATATAGTGCAGCCCTGTCTGAACTGGTACAGCAAGTA
CCGCGAACAGGAAGCCATTCGCCTTTGTCTAAAACACTTCAGACAACACAACTATACAGAGGCT
TTTGAATCCCTGCAGAAGAAAACCAAGATTGCACTGGAGCATCCAATGTTGACAGATATGCACG
ACAAATTGGTGTTAAAGGGTGACTTTGATGCTTGCGAGGAGTTGATTGAAAAAGCGGTAAATGA
TGGCTTGTTCAATCAGTATATCAGTCAACAGGAGTATAAGCCACGGTGGAGTCAGATTATTCCT
AAGAGCACCAAAGGTGATGGAGAAGATAACCGTCCAGGAATGAGAGGGGGCCATCAGATGGTCA
TTGATGTTCAGACAGAGACTGTTTATTTGTTTGGTGGCTGGGATGGAACACAAGATCTTGCTGA
CTTCTGGGCATACAGTGTGAAGGAGAACCAGTGGACATGTATTTCTAGAGACACTGAGAAAGAG
AATGGTCCTAGTGCCAGATCATGTCATAAAATGTGCATTGATATTCAGCGGAGACAAATCTACA
CATTGGGCCGTTACTTGGATTCCTCTGTGAGGAACAGCAAATCTCTGAAAAGTGATTTCTACCG
TTACGACATTGACACCAACACCTGGATGTTACTAAGTGAAGACACTGCTGCCGACGGTGGACCA
AAATTGGTGTTTGATCATCAGATGTGTATGGACTCAGAAAAGCATATGATCTATACCTTTGGTG
GTAGGATTTTGACATGTAATGGCAGTGTAGATGACAGCAGAGCCAGTGAACCACAATTCAGTGG
GCTGTTTGCATTCAACTGCCAGTGTCAAACCTGGAAACTTCTTCGAGAGGACTCCTGTAACGCA
GGCCCTGAGGACATCCAGTCTCGGATTGGACACTGCATGCTGTTCCACTCGAAAAACCGTTGTT
TATACGTGTTTGGTGGCCAGAGATCTAAGACCTATTTGAATGATTTTTTTAGTTATGATGTGGA
CTCTGATCATGTAGACATAATTTCAGATGGCACCAAGAAAGACTCTGGAATGGTTCCAATGACC
GGATTCACACAGAGAGCAACTATTGATCCAGAACTGAATGAAATACATGTTTTATCCGGACTTA
GCAAAGACAAAGAAAAGAGGGAAGAGAATGTCAGAAATTCATTCTGGATTTATGACATTGTGAG
GAATAGCTGGTCTTGTGTCTATAAGAATGATCAAGCTGCAAAAGAGAATCTGAGTAAAAGTCTT
CAGGAAGAAGAACCATGTCCAAGGTTTGCCCATCAGCTCGTTTATGATGAATTACACAAGGTTC
ATTATTTATTTGGTGGGAATCCAGGAAAGTCTTGCTCTCCAAAGATGAGACTAGATGACTTCTG
GTCGCTGAAGTTGTGCAGACCTTCGAAGGACTACTTACTGAGGCATTGCAAGTACCTCATCAGG
AAGCACAGGTTTGAAGAAAAGGCCCAGATGGATCCCCTTAGTGCTCTGAAGTATTTACAGAATG
ATCTTTATATAACTGTGGATCATTCGGACCCAGAAGAGACAAAAGAGTTTCAACTCCTAGCCTC
AGCCCTGTTCAAATCTGGCTCAGATTTCACAGCTTTAGGCTTTTCAGACGTGGATCACACCTAT
GCTCAGAGAACTCAGCTCTTTGACACCTTAGTGAATTTCTTTCCTGACAGCATGACTCCTCCTA
AGGGCAACCTGGTAGACCTCATCACACTGTAACTGGGCGTGGATTGAGGAGTTACTGGGCTCAG
AAGTGGAGACAGGAACCGGAGGTTGCTGTTTGTGTGGGCAGAGGTGACGTTGCAGTGACTGAGG
ACTGAGGACTGCATCCGAGTTTTGAAGGATCCTTACTGTCACAAGTTTTAACCCTCTTCCTTCA
TACCTGACCTCAATCCCCTTTTCCTTATATTCCTGCATTAGGCTAATAAAGTGAAATTGATATA
CTTCCCATTAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039108443 ⟹ XP_038964371

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,249 - 61,095,214 (+)	NCBI
mRatBN7.2	4	59,942,800 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108446 ⟹ XP_038964374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,970,374 - 61,095,214 (+)	NCBI
mRatBN7.2	4	60,003,011 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108448 ⟹ XP_038964376

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	61,000,166 - 61,095,214 (+)	NCBI
mRatBN7.2	4	60,002,455 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_063286754 ⟹ XP_063142824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,767 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286755 ⟹ XP_063142825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,767 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286756 ⟹ XP_063142826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286757 ⟹ XP_063142827

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286758 ⟹ XP_063142828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286759 ⟹ XP_063142829

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,241 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XM_063286760 ⟹ XP_063142830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,767 - 61,070,962 (+)	NCBI

RefSeq Acc Id:

XM_063286761 ⟹ XP_063142831

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,239 - 61,095,214 (+)	NCBI

RefSeq Acc Id:

XR_010065709

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	60,939,767 - 61,075,985 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001415570	(Get FASTA)	NCBI Sequence Viewer
	NP_001415571	(Get FASTA)	NCBI Sequence Viewer
	NP_001415572	(Get FASTA)	NCBI Sequence Viewer
	NP_001416227	(Get FASTA)	NCBI Sequence Viewer
	NP_112649	(Get FASTA)	NCBI Sequence Viewer
	XP_038964371	(Get FASTA)	NCBI Sequence Viewer
	XP_038964374	(Get FASTA)	NCBI Sequence Viewer
	XP_038964376	(Get FASTA)	NCBI Sequence Viewer
	XP_063142824	(Get FASTA)	NCBI Sequence Viewer
	XP_063142825	(Get FASTA)	NCBI Sequence Viewer
	XP_063142826	(Get FASTA)	NCBI Sequence Viewer
	XP_063142827	(Get FASTA)	NCBI Sequence Viewer
	XP_063142828	(Get FASTA)	NCBI Sequence Viewer
	XP_063142829	(Get FASTA)	NCBI Sequence Viewer
	XP_063142830	(Get FASTA)	NCBI Sequence Viewer
	XP_063142831	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB21439	(Get FASTA)	NCBI Sequence Viewer
	EDM15280	(Get FASTA)	NCBI Sequence Viewer
	EDM15281	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075084.2
	ENSRNOP00000077228
	ENSRNOP00000078385
	ENSRNOP00000098233
	ENSRNOP00000103896
GenBank Protein	Q99PV3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112649 ⟸ NM_031359

- UniProtKB:

Q99PV3 (UniProtKB/Swiss-Prot), A6IEJ3 (UniProtKB/TrEMBL), A0A0G2K9Q2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLER
PAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPC
RFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA
FESLQKKTKIALEHPMLTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIP
KSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKE
NGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGP
KLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNA
GPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMT
GFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKENLSKSL
QEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIR
KHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTY
AQRTQLFDTLVNFFPDSMTPPKGNLVDLITL

hide sequence

Ensembl Acc Id:

ENSRNOP00000075084 ⟸ ENSRNOT00000081707

RefSeq Acc Id:	XP_038964371 ⟸ XM_039108443
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038964376 ⟸ XM_039108448
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038964374 ⟸ XM_039108446
- Peptide Label:	isoform X8

Ensembl Acc Id:

ENSRNOP00000077228 ⟸ ENSRNOT00000113146

Ensembl Acc Id:

ENSRNOP00000078385 ⟸ ENSRNOT00000111994

RefSeq Acc Id:	XP_063142828 ⟸ XM_063286758
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063142826 ⟸ XM_063286756
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063142827 ⟸ XM_063286757
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063142831 ⟸ XM_063286761
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_063142829 ⟸ XM_063286759
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063142824 ⟸ XM_063286754
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063142825 ⟸ XM_063286755
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063142830 ⟸ XM_063286760
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000098233 ⟸ ENSRNOT00000120594

Ensembl Acc Id:

ENSRNOP00000103896 ⟸ ENSRNOT00000163527

Protein Domains

CTLH LisH Muskelin N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PV3-F1-model_v2	AlphaFold	Q99PV3	1-735	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692943

Promoter ID:

EPDNEW_R3468

Type:

initiation region

Name:

Mkln1_1

Description:

muskelin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	58,693,375 - 58,693,435	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620076	AgrOrtholog
BioCyc Gene	G2FUF-45315	BioCyc
Ensembl Genes	ENSRNOG00000054514	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000081707.2	UniProtKB/Swiss-Prot
	ENSRNOT00000111994	ENTREZGENE
	ENSRNOT00000113146	ENTREZGENE
	ENSRNOT00000120594	ENTREZGENE
	ENSRNOT00000163527	ENTREZGENE
Gene3D-CATH	2.120.10.80	UniProtKB/Swiss-Prot
	Galactose-binding domain-like	UniProtKB/Swiss-Prot
InterPro	Beta-prop_ATRN-MKLN-like	UniProtKB/Swiss-Prot
	CTLH_C	UniProtKB/Swiss-Prot
	CTLH_complex_component	UniProtKB/Swiss-Prot
	Gal_Oxase/kelch_b-propeller	UniProtKB/Swiss-Prot
	Galactose-bd-like_sf	UniProtKB/Swiss-Prot
	Kelch-typ_b-propeller	UniProtKB/Swiss-Prot
	LisH	UniProtKB/Swiss-Prot
	Muskelin_N	UniProtKB/Swiss-Prot
KEGG Report	rno:83536	UniProtKB/Swiss-Prot
NCBI Gene	83536	ENTREZGENE
PANTHER	MUSKELIN	UniProtKB/Swiss-Prot
	MUSKELIN	UniProtKB/Swiss-Prot
Pfam	Beta-prop_ATRN-LZTR1	UniProtKB/Swiss-Prot
	Kelch_3	UniProtKB/Swiss-Prot
	Muskelin_N	UniProtKB/Swiss-Prot
PhenoGen	Mkln1	PhenoGen
PROSITE	CTLH	UniProtKB/Swiss-Prot
	LISH	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000054514	RatGTEx
SMART	LisH	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF117281	UniProtKB/Swiss-Prot
	SSF49785	UniProtKB/Swiss-Prot
	SSF50965	UniProtKB/Swiss-Prot
UniProt	A0A0G2K9Q2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y5I8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G1Q3_RAT	UniProtKB/TrEMBL
	A6IEJ3	ENTREZGENE, UniProtKB/TrEMBL
	A6IEJ4_RAT	UniProtKB/TrEMBL
	MKLN1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mkln1	muskelin 1	LOC103690249	uncharacterized LOC103690249	Data merged from RGD:9099271	737654	PROVISIONAL
2015-12-02	Mkln1	muskelin 1	Mkln1	muskelin 1, intracellular mediator containing kelch motifs	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103690249	uncharacterized LOC103690249			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Mkln1	muskelin 1, intracellular mediator containing kelch motifs		muskelin	Name updated	1299863	APPROVED
2002-08-07	Mkln1	muskelin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA