Mkln1 (muskelin 1) - Rat Genome Database

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Pathways
Gene: Mkln1 (muskelin 1) Rattus norvegicus
Analyze
Symbol: Mkln1
Name: muskelin 1
RGD ID: 620076
Description: Enables protein homodimerization activity. Involved in regulation of receptor internalization. Located in cytosol. Orthologous to human MKLN1 (muskelin 1); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690249; muskelin; muskelin 1, intracellular mediator containing kelch motifs; uncharacterized LOC103690249
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,939,239 - 61,095,214 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl460,937,817 - 61,095,210 (+)EnsemblGRCr8
mRatBN7.2459,815,912 - 60,124,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl460,002,464 - 60,123,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx464,972,547 - 65,093,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,888,753 - 61,009,664 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0459,290,700 - 59,412,013 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,693,384 - 58,817,924 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl458,693,384 - 58,817,691 (+)Ensemblrn6Rnor6.0
Rnor_5.0458,448,153 - 58,570,396 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4458,475,702 - 58,600,770 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera455,092,934 - 55,213,778 (+)NCBICelera
RGSC_v3.1458,751,831 - 58,876,900 (+)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Bufotalin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cylindrospermopsin  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
glafenine  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH. Adams JC and Zhang L, Cytogenet Cell Genet 1999;87(1-2):19-21.
2. The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization. Delto CF, etal., Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9724633   PMID:11006128   PMID:17467196   PMID:18710924   PMID:21586270   PMID:29911972  


Genomics

Comparative Map Data
Mkln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,939,239 - 61,095,214 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl460,937,817 - 61,095,210 (+)EnsemblGRCr8
mRatBN7.2459,815,912 - 60,124,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl460,002,464 - 60,123,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx464,972,547 - 65,093,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,888,753 - 61,009,664 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0459,290,700 - 59,412,013 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,693,384 - 58,817,924 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl458,693,384 - 58,817,691 (+)Ensemblrn6Rnor6.0
Rnor_5.0458,448,153 - 58,570,396 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4458,475,702 - 58,600,770 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera455,092,934 - 55,213,778 (+)NCBICelera
RGSC_v3.1458,751,831 - 58,876,900 (+)NCBI
Cytogenetic Map4q22NCBI
MKLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387131,110,094 - 131,496,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7131,110,096 - 131,496,632 (+)Ensemblhg38GRCh38
GRCh377130,794,853 - 131,181,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367130,663,175 - 130,831,931 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347130,469,892 - 130,638,645NCBI
Celera7125,545,899 - 125,932,352 (+)NCBICelera
Cytogenetic Map7q32.3NCBI
HuRef7125,110,633 - 125,497,059 (+)NCBIHuRef
CHM1_17130,728,553 - 131,115,275 (+)NCBICHM1_1
T2T-CHM13v2.07132,427,607 - 132,814,224 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27130,134,571 - 130,521,037 (+)NCBI
Mkln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39631,333,833 - 31,493,744 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl631,375,670 - 31,493,746 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38631,398,828 - 31,516,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl631,398,735 - 31,516,811 (+)Ensemblmm10GRCm38
MGSCv37631,348,828 - 31,459,482 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36631,329,008 - 31,439,645 (+)NCBIMGSCv36mm8
Celera631,385,689 - 31,497,090 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.57NCBI
Mkln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541036,251,987 - 36,542,802 (-)Ensembl
ChiLan1.0NW_00495541036,251,987 - 36,568,537 (-)NCBIChiLan1.0ChiLan1.0
MKLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26167,930,262 - 168,320,858 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1719,940,570 - 20,331,104 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07123,075,319 - 123,463,509 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17135,806,585 - 135,976,926 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7135,806,585 - 135,968,032 (+)EnsemblpanPan2panpan1.1
MKLN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1145,636,148 - 5,799,882 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl145,636,162 - 5,799,833 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha145,298,099 - 5,625,705 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0145,374,406 - 5,699,541 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl145,371,337 - 5,699,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1145,577,443 - 5,905,031 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,322,616 - 5,650,615 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0145,465,309 - 5,793,416 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mkln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511823,841,621 - 24,179,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365793,982,296 - 4,150,063 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365793,982,296 - 4,150,071 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKLN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1817,501,857 - 17,832,503 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11817,493,806 - 17,832,519 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21818,593,094 - 18,776,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12199,952,000 - 100,123,380 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21100,007,890 - 100,123,139 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660423,255,971 - 3,434,499 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mkln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247834,900,654 - 5,074,740 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247834,891,874 - 5,074,769 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mkln1
1086 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000016633
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
D4Rat23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8461,041,057 - 61,041,206 (+)Marker Load Pipeline
Rnor_5.0458,518,430 - 58,518,579NCBIRnor5.0
Rnor_5.0458,518,376 - 58,518,669NCBIRnor5.0
RGSC_v3.4458,550,170 - 58,550,462RGDRGSC3.4
RGSC_v3.4458,550,224 - 58,550,372UniSTSRGSC3.4
Celera455,163,661 - 55,163,809UniSTS
RGSC_v3.1458,826,300 - 58,826,592RGD
RH 3.4 Map4354.6RGD
RH 3.4 Map4354.6UniSTS
RH 2.0 Map4381.6RGD
SHRSP x BN Map432.83RGD
Cytogenetic Map4q22UniSTS
RH128619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2460,123,707 - 60,123,926 (+)MAPPERmRatBN7.2
Rnor_6.0458,817,642 - 58,817,860NCBIRnor6.0
Rnor_5.0458,570,114 - 58,570,332UniSTSRnor5.0
RGSC_v3.4458,600,488 - 58,600,706UniSTSRGSC3.4
Celera455,213,496 - 55,213,714UniSTS
RH 3.4 Map4347.93UniSTS
Cytogenetic Map4q22UniSTS
AU047206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2460,017,354 - 60,017,509 (+)MAPPERmRatBN7.2
Rnor_6.0458,708,239 - 58,708,393NCBIRnor6.0
Rnor_5.0458,463,008 - 58,463,162UniSTSRnor5.0
RGSC_v3.4458,490,561 - 58,490,715UniSTSRGSC3.4
Celera455,107,789 - 55,107,943UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001428641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000081707   ⟹   ENSRNOP00000075084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl460,945,875 - 61,095,210 (+)Ensembl
mRatBN7.2 Ensembl460,002,464 - 60,123,993 (+)Ensembl
Rnor_6.0 Ensembl458,693,384 - 58,817,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111994   ⟹   ENSRNOP00000078385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl460,938,243 - 61,095,210 (+)Ensembl
mRatBN7.2 Ensembl460,002,489 - 60,123,986 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113146   ⟹   ENSRNOP00000077228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl460,970,110 - 61,091,297 (+)Ensembl
mRatBN7.2 Ensembl460,002,882 - 60,123,993 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120594   ⟹   ENSRNOP00000098233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl460,938,243 - 61,095,210 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163527   ⟹   ENSRNOP00000103896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl460,937,817 - 61,095,210 (+)Ensembl
RefSeq Acc Id: NM_031359   ⟹   NP_112649
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,969,818 - 61,091,300 (+)NCBI
mRatBN7.2460,002,498 - 60,123,990 (+)NCBI
Rnor_6.0458,693,384 - 58,817,924 (+)NCBI
Rnor_5.0458,448,153 - 58,570,396 (+)NCBI
RGSC_v3.4458,475,702 - 58,600,770 (+)RGD
Celera455,092,934 - 55,213,778 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108443   ⟹   XP_038964371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,249 - 61,095,214 (+)NCBI
mRatBN7.2459,942,800 - 60,124,047 (+)NCBI
RefSeq Acc Id: XM_039108446   ⟹   XP_038964374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,970,374 - 61,095,214 (+)NCBI
mRatBN7.2460,003,011 - 60,124,047 (+)NCBI
RefSeq Acc Id: XM_039108448   ⟹   XP_038964376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8461,000,166 - 61,095,214 (+)NCBI
mRatBN7.2460,002,455 - 60,124,047 (+)NCBI
RefSeq Acc Id: XM_063286754   ⟹   XP_063142824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,767 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286755   ⟹   XP_063142825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,767 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286756   ⟹   XP_063142826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,239 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286757   ⟹   XP_063142827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,239 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286758   ⟹   XP_063142828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,239 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286759   ⟹   XP_063142829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,241 - 61,095,214 (+)NCBI
RefSeq Acc Id: XM_063286760   ⟹   XP_063142830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,767 - 61,070,962 (+)NCBI
RefSeq Acc Id: XM_063286761   ⟹   XP_063142831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,239 - 61,095,214 (+)NCBI
RefSeq Acc Id: XR_010065709
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8460,939,767 - 61,075,985 (+)NCBI
RefSeq Acc Id: NP_112649   ⟸   NM_031359
- UniProtKB: Q99PV3 (UniProtKB/Swiss-Prot),   A6IEJ3 (UniProtKB/TrEMBL),   A0A0G2K9Q2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075084   ⟸   ENSRNOT00000081707
RefSeq Acc Id: XP_038964371   ⟸   XM_039108443
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964376   ⟸   XM_039108448
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038964374   ⟸   XM_039108446
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000077228   ⟸   ENSRNOT00000113146
Ensembl Acc Id: ENSRNOP00000078385   ⟸   ENSRNOT00000111994
RefSeq Acc Id: XP_063142828   ⟸   XM_063286758
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142826   ⟸   XM_063286756
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142827   ⟸   XM_063286757
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142831   ⟸   XM_063286761
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063142829   ⟸   XM_063286759
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142824   ⟸   XM_063286754
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063142825   ⟸   XM_063286755
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142830   ⟸   XM_063286760
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000098233   ⟸   ENSRNOT00000120594
Ensembl Acc Id: ENSRNOP00000103896   ⟸   ENSRNOT00000163527
Protein Domains
CTLH   LisH   Muskelin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PV3-F1-model_v2 AlphaFold Q99PV3 1-735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692943
Promoter ID:EPDNEW_R3468
Type:initiation region
Name:Mkln1_1
Description:muskelin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0458,693,375 - 58,693,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620076 AgrOrtholog
BioCyc Gene G2FUF-45315 BioCyc
Ensembl Genes ENSRNOG00000054514 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081707.2 UniProtKB/Swiss-Prot
  ENSRNOT00000111994 ENTREZGENE
  ENSRNOT00000113146 ENTREZGENE
  ENSRNOT00000120594 ENTREZGENE
  ENSRNOT00000163527 ENTREZGENE
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
InterPro Beta-prop_ATRN-MKLN-like UniProtKB/Swiss-Prot
  CTLH_C UniProtKB/Swiss-Prot
  CTLH_complex_component UniProtKB/Swiss-Prot
  Gal_Oxase/kelch_b-propeller UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  LisH UniProtKB/Swiss-Prot
  Muskelin_N UniProtKB/Swiss-Prot
KEGG Report rno:83536 UniProtKB/Swiss-Prot
NCBI Gene 83536 ENTREZGENE
PANTHER MUSKELIN UniProtKB/Swiss-Prot
  MUSKELIN UniProtKB/Swiss-Prot
Pfam Beta-prop_ATRN-LZTR1 UniProtKB/Swiss-Prot
  Kelch_3 UniProtKB/Swiss-Prot
  Muskelin_N UniProtKB/Swiss-Prot
PhenoGen Mkln1 PhenoGen
PROSITE CTLH UniProtKB/Swiss-Prot
  LISH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054514 RatGTEx
SMART LisH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF50965 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Q2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5I8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G1Q3_RAT UniProtKB/TrEMBL
  A6IEJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IEJ4_RAT UniProtKB/TrEMBL
  MKLN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mkln1  muskelin 1  LOC103690249  uncharacterized LOC103690249  Data merged from RGD:9099271 737654 PROVISIONAL
2015-12-02 Mkln1  muskelin 1  Mkln1  muskelin 1, intracellular mediator containing kelch motifs  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690249  uncharacterized LOC103690249      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Mkln1  muskelin 1, intracellular mediator containing kelch motifs    muskelin  Name updated 1299863 APPROVED
2002-08-07 Mkln1  muskelin      Symbol and Name status set to provisional 70820 PROVISIONAL