Mkln1 (muskelin 1) - Rat Genome Database

Name: Mkln1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Mkln1 (muskelin 1) Rattus norvegicus

Analyze

Symbol:

Mkln1

Name:

muskelin 1

RGD ID:

620076

Description:

Exhibits protein homodimerization activity. Involved in regulation of receptor internalization. Localizes to cytosol. Orthologous to human MKLN1 (muskelin 1); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LOC103690249; muskelin; muskelin 1, intracellular mediator containing kelch motifs; uncharacterized LOC103690249

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MKLN1 (muskelin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MKLN1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mkln1 (muskelin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MKLN1 (muskelin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	muskelin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	59,815,912 - 60,124,047 (+)	NCBI
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	58,751,831 - 58,876,900 (+)	NCBI
Celera	4	55,092,934 - 55,213,778 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cylindrospermopsin (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP)

glafenine (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propanal (ISO)

propiconazole (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

thimerosal (ISO)

topotecan (EXP)

torcetrapib (ISO)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton reorganization (IEA,ISO,ISS)

cell-matrix adhesion (IEA,ISO,ISS)

regulation of cell shape (IEA,ISO,ISS)

regulation of receptor internalization (IMP)

Cellular Component

cell cortex (IEA,ISO,ISS)

cytoplasm (IBA,ISO)

cytosol (IDA,IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

postsynapse (IEA)

ruffle (IEA,ISO,ISS)

ubiquitin ligase complex (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IDA)

References

References - curated


1.	Adams JC and Zhang L, Cytogenet Cell Genet 1999;87(1-2):19-21.
2.	Delto CF, etal., Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	GOA data from the GO Consortium
5.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9724633	PMID:11006128	PMID:17467196	PMID:18710924	PMID:21586270	PMID:29911972

Genomics

Comparative Map Data

Mkln1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	59,815,912 - 60,124,047 (+)	NCBI
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	58,751,831 - 58,876,900 (+)	NCBI
Celera	4	55,092,934 - 55,213,778 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

MKLN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	7	131,110,096 - 131,496,632 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	7	131,110,094 - 131,496,637 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	7	130,794,853 - 131,181,391 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	130,663,175 - 130,831,931 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	7	130,469,892 - 130,638,645	NCBI
Celera	7	125,545,899 - 125,932,352 (+)	NCBI
Cytogenetic Map	7	q32.3	NCBI
HuRef	7	125,110,633 - 125,497,059 (+)	NCBI		HuRef
CHM1_1	7	130,728,553 - 131,115,275 (+)	NCBI		CHM1_1
CRA_TCAGchr7v2	7	130,134,571 - 130,521,037 (+)	NCBI

Mkln1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	31,333,833 - 31,493,744 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	31,375,670 - 31,493,746 (+)	Ensembl
GRCm38	6	31,398,828 - 31,516,809 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	31,398,735 - 31,516,811 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	31,348,828 - 31,459,482 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	31,329,008 - 31,439,645 (+)	NCBI			mm8
Celera	6	31,385,689 - 31,497,090 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI

Mkln1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	36,251,987 - 36,542,802 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	36,251,987 - 36,568,537 (-)	NCBI	ChiLan1.0	ChiLan1.0

MKLN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	7	135,806,585 - 135,976,926 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	135,806,585 - 135,968,032 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	7	123,075,319 - 123,463,509 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MKLN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	5,636,148 - 5,799,882 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	5,636,162 - 5,799,833 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	5,298,099 - 5,625,705 (-)	NCBI
ROS_Cfam_1.0	14	5,374,406 - 5,699,541 (-)	NCBI
UMICH_Zoey_3.1	14	5,577,443 - 5,905,031 (-)	NCBI
UNSW_CanFamBas_1.0	14	5,322,616 - 5,650,615 (-)	NCBI
UU_Cfam_GSD_1.0	14	5,465,309 - 5,793,416 (-)	NCBI

Mkln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	23,841,621 - 24,179,321 (-)	NCBI
SpeTri2.0	NW_004936579	3,982,296 - 4,150,071 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MKLN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	17,501,855 - 17,832,503 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	17,493,806 - 17,832,519 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	18,593,094 - 18,776,077 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MKLN1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	99,952,000 - 100,123,380 (+)	NCBI
ChlSab1.1 Ensembl	21	100,007,890 - 100,123,139 (+)	Ensembl

Mkln1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624783	4,891,874 - 5,074,769 (-)	NCBI

Position Markers

D4Rat23

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	4	58,518,376 - 58,518,669	NCBI	Rnor5.0
Rnor_5.0	4	58,518,430 - 58,518,579	NCBI	Rnor5.0
RGSC_v3.4	4	58,550,224 - 58,550,372	UniSTS	RGSC3.4
RGSC_v3.4	4	58,550,170 - 58,550,462	RGD	RGSC3.4
RGSC_v3.1	4	58,826,300 - 58,826,592	RGD
Celera	4	55,163,661 - 55,163,809	UniSTS
RH 3.4 Map	4	354.6	RGD
RH 3.4 Map	4	354.6	UniSTS
RH 2.0 Map	4	381.6	RGD
SHRSP x BN Map	4	32.83	RGD
Cytogenetic Map	4	q22	UniSTS

RH128619

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	60,123,707 - 60,123,926 (+)	MAPPER
Rnor_6.0	4	58,817,642 - 58,817,860	NCBI	Rnor6.0
Rnor_5.0	4	58,570,114 - 58,570,332	UniSTS	Rnor5.0
RGSC_v3.4	4	58,600,488 - 58,600,706	UniSTS	RGSC3.4
Celera	4	55,213,496 - 55,213,714	UniSTS
RH 3.4 Map	4	347.93	UniSTS
Cytogenetic Map	4	q22	UniSTS

AU047206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	60,017,354 - 60,017,509 (+)	MAPPER
Rnor_6.0	4	58,708,239 - 58,708,393	NCBI	Rnor6.0
Rnor_5.0	4	58,463,008 - 58,463,162	UniSTS	Rnor5.0
RGSC_v3.4	4	58,490,561 - 58,490,715	UniSTS	RGSC3.4
Celera	4	55,107,789 - 55,107,943	UniSTS
Cytogenetic Map	4	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	3043231	79575658	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	3043231	145254791	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	3044017	64915903	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	7342404	92484039	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	7850904	182171018	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	16149941	61149941	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	18222187	61039065	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	23850384	169318094	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	23991721	76238799	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	23991721	76238799	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	24631874	69631874	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	26654749	81874227	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	29549895	112807890	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	31825560	83531021	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	31825560	83531021	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	31825560	83531021	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	33637803	61708341	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	34277932	99067150	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	36615599	145611886	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	37685175	73066691	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	37703272	75345433	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	37703272	115372927	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	39208222	84208222	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	39208247	84208247	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	42415777	87415777	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	43414605	155469929	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	43414792	146942075	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	43414792	146942075	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	46898276	145611886	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	49906054	145611886	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	55324857	79575658	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	55324857	79575658	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	55324857	79575658	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	55324857	79575658	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	55324953	148360954	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	55375865	125671711	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	55791564	82134846	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	55791564	92484312	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	55791834	79557856	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	56092756	101092756	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	56092756	101092756	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	57101077	92990863	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	57307075	79578854	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58166424	103166424	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58640017	154427984	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	58640017	154427984	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	58640017	154427984	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	31
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000016633
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005503321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB046442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000081707 ⟹ ENSRNOP00000075084

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	58,693,384 - 58,817,691 (+)	Ensembl

RefSeq Acc Id:

NM_031359 ⟹ NP_112649

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	60,002,498 - 60,123,990 (+)	NCBI
Rnor_6.0	4	58,693,384 - 58,817,924 (+)	NCBI
Rnor_5.0	4	58,448,153 - 58,570,396 (+)	NCBI
RGSC_v3.4	4	58,475,702 - 58,600,770 (+)	RGD
Celera	4	55,092,934 - 55,213,778 (+)	RGD

Sequence:

show sequence

ATGGCGGCTGGCGGGGCTGTTGCTGCGGCGCCCGAGTGCCGGCTTCTGCCCTACGCGCTGCATA
AGTGGAGCTCCTTCTCCTCCACCTACCTTCCCGAGAACATTTTAGTGGATAAACCAAATGATCA
GTCTTCCAGATGGTCTTCAGAGAGCAACTATCCTCCCCAGTACTTGATTCTGAAGCTTGAAAGG
CCTGCTATAGTTCAGAATATTACATTTGGAAAATATGAGAAAACTCATGTCTGCAATTTGAAGA
AATTCAAAGTTTTCGGTGGAATGAATGAAGAAAATATGACAGAGCTGCTGTCCAGCGGCTTGAA
GAATGATTATAACAAAGAGACATTTACCTTGAAACATAAAATTGATGAACAGATGTTCCCTTGT
CGATTCATTAAAATTGTTCCACTTTTGTCCTGGGGGCCCAGCTTTAATTTTAGCATCTGGTATG
TTGAACTCAGTGGCATTGATGATCCTGATATAGTGCAGCCCTGTCTGAACTGGTACAGCAAGTA
CCGCGAACAGGAAGCCATTCGCCTTTGTCTAAAACACTTCAGACAACACAACTATACAGAGGCT
TTTGAATCCCTGCAGAAGAAAACCAAGATTGCACTGGAGCATCCAATGTTGACAGATATGCACG
ACAAATTGGTGTTAAAGGGTGACTTTGATGCTTGCGAGGAGTTGATTGAAAAAGCGGTAAATGA
TGGCTTGTTCAATCAGTATATCAGTCAACAGGAGTATAAGCCACGGTGGAGTCAGATTATTCCT
AAGAGCACCAAAGGTGATGGAGAAGATAACCGTCCAGGAATGAGAGGGGGCCATCAGATGGTCA
TTGATGTTCAGACAGAGACTGTTTATTTGTTTGGTGGCTGGGATGGAACACAAGATCTTGCTGA
CTTCTGGGCATACAGTGTGAAGGAGAACCAGTGGACATGTATTTCTAGAGACACTGAGAAAGAG
AATGGTCCTAGTGCCAGATCATGTCATAAAATGTGCATTGATATTCAGCGGAGACAAATCTACA
CATTGGGCCGTTACTTGGATTCCTCTGTGAGGAACAGCAAATCTCTGAAAAGTGATTTCTACCG
TTACGACATTGACACCAACACCTGGATGTTACTAAGTGAAGACACTGCTGCCGACGGTGGACCA
AAATTGGTGTTTGATCATCAGATGTGTATGGACTCAGAAAAGCATATGATCTATACCTTTGGTG
GTAGGATTTTGACATGTAATGGCAGTGTAGATGACAGCAGAGCCAGTGAACCACAATTCAGTGG
GCTGTTTGCATTCAACTGCCAGTGTCAAACCTGGAAACTTCTTCGAGAGGACTCCTGTAACGCA
GGCCCTGAGGACATCCAGTCTCGGATTGGACACTGCATGCTGTTCCACTCGAAAAACCGTTGTT
TATACGTGTTTGGTGGCCAGAGATCTAAGACCTATTTGAATGATTTTTTTAGTTATGATGTGGA
CTCTGATCATGTAGACATAATTTCAGATGGCACCAAGAAAGACTCTGGAATGGTTCCAATGACC
GGATTCACACAGAGAGCAACTATTGATCCAGAACTGAATGAAATACATGTTTTATCCGGACTTA
GCAAAGACAAAGAAAAGAGGGAAGAGAATGTCAGAAATTCATTCTGGATTTATGACATTGTGAG
GAATAGCTGGTCTTGTGTCTATAAGAATGATCAAGCTGCAAAAGAGAATCTGAGTAAAAGTCTT
CAGGAAGAAGAACCATGTCCAAGGTTTGCCCATCAGCTCGTTTATGATGAATTACACAAGGTTC
ATTATTTATTTGGTGGGAATCCAGGAAAGTCTTGCTCTCCAAAGATGAGACTAGATGACTTCTG
GTCGCTGAAGTTGTGCAGACCTTCGAAGGACTACTTACTGAGGCATTGCAAGTACCTCATCAGG
AAGCACAGGTTTGAAGAAAAGGCCCAGATGGATCCCCTTAGTGCTCTGAAGTATTTACAGAATG
ATCTTTATATAACTGTGGATCATTCGGACCCAGAAGAGACAAAAGAGTTTCAACTCCTAGCCTC
AGCCCTGTTCAAATCTGGCTCAGATTTCACAGCTTTAGGCTTTTCAGACGTGGATCACACCTAT
GCTCAGAGAACTCAGCTCTTTGACACCTTAGTGAATTTCTTTCCTGACAGCATGACTCCTCCTA
AGGGCAACCTGGTAGACCTCATCACACTGTAACTGGGCGTGGATTGAGGAGTTACTGGGCTCAG
AAGTGGAGACAGGAACCGGAGGTTGCTGTTTGTGTGGGCAGAGGTGACGTTGCAGTGACTGAGG
ACTGAGGACTGCATCCGAGTTTTGAAGGATCCTTACTGTCACAAGTTTTAACCCTCTTCCTTCA
TACCTGACCTCAATCCCCTTTTCCTTATATTCCTGCATTAGGCTAATAAAGTGAAATTGATATA
CTTCCCATTAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039108443 ⟹ XP_038964371

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	59,942,800 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108444 ⟹ XP_038964372

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	59,815,912 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108445 ⟹ XP_038964373

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	59,964,292 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108446 ⟹ XP_038964374

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	60,003,011 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XM_039108447 ⟹ XP_038964375

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	60,002,441 - 60,103,652 (+)	NCBI

RefSeq Acc Id:

XM_039108448 ⟹ XP_038964376

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	60,002,455 - 60,124,047 (+)	NCBI

RefSeq Acc Id:

XR_005503321

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	60,002,441 - 60,108,675 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_112649	(Get FASTA)	NCBI Sequence Viewer
	XP_038964371	(Get FASTA)	NCBI Sequence Viewer
	XP_038964372	(Get FASTA)	NCBI Sequence Viewer
	XP_038964373	(Get FASTA)	NCBI Sequence Viewer
	XP_038964374	(Get FASTA)	NCBI Sequence Viewer
	XP_038964375	(Get FASTA)	NCBI Sequence Viewer
	XP_038964376	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB21439	(Get FASTA)	NCBI Sequence Viewer
	EDM15280	(Get FASTA)	NCBI Sequence Viewer
	EDM15281	(Get FASTA)	NCBI Sequence Viewer
	Q99PV3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_112649 ⟸ NM_031359

- UniProtKB:

Q99PV3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLER
PAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPC
RFIKIVPLLSWGPSFNFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEA
FESLQKKTKIALEHPMLTDMHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIP
KSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKE
NGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGP
KLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNA
GPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMT
GFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKENLSKSL
QEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIR
KHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTY
AQRTQLFDTLVNFFPDSMTPPKGNLVDLITL

hide sequence

RefSeq Acc Id:

ENSRNOP00000075084 ⟸ ENSRNOT00000081707

RefSeq Acc Id:	XP_038964372 ⟸ XM_039108444
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038964371 ⟸ XM_039108443
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038964373 ⟸ XM_039108445
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038964375 ⟸ XM_039108447
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038964376 ⟸ XM_039108448
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038964374 ⟸ XM_039108446
- Peptide Label:	isoform X2

Protein Domains

CTLH LisH

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692943

Promoter ID:

EPDNEW_R3468

Type:

initiation region

Name:

Mkln1_1

Description:

muskelin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	58,693,375 - 58,693,435	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620076	AgrOrtholog
Ensembl Genes	ENSRNOG00000054514	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000075084	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081707	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.80	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.120.260	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CTLH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gal_Oxase/kelch_b-propeller	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch_1	UniProtKB/Swiss-Prot
	LisH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Muskelin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83536	UniProtKB/Swiss-Prot
NCBI Gene	83536	ENTREZGENE
Pfam	Kelch_1	UniProtKB/Swiss-Prot
	Muskelin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mkln1	PhenoGen
PROSITE	CTLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LISH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LisH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF117281	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50965	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K9Q2_RAT	UniProtKB/TrEMBL
	MKLN1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mkln1	muskelin 1	LOC103690249	uncharacterized LOC103690249	Data Merged	737654	PROVISIONAL
2015-12-02	Mkln1	muskelin 1	Mkln1	muskelin 1, intracellular mediator containing kelch motifs	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103690249	uncharacterized LOC103690249			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Mkln1	muskelin 1, intracellular mediator containing kelch motifs		muskelin	Name updated	1299863	APPROVED
2002-08-07	Mkln1	muskelin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar